公开(公告)号：US10736850B2

公开(公告)日：2020-08-11

申请号：US12680701

申请日：2008-08-12

申请人： Manish S. Shah ,  Ray Difalco

发明人： Manish S. Shah ,  Ray Difalco

IPC分类号： A61K9/24 ,  A61K9/28 ,  A61K9/32 ,  A61K9/20 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458 ,  A61K9/48 ,  A61K31/485 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US10688053B2

公开(公告)日：2020-06-23

申请号：US13040979

申请日：2011-03-04

申请人： Manish S. Shah ,  Ray Difalco

发明人： Manish S. Shah ,  Ray Difalco

IPC分类号： A61K9/24 ,  A61K9/28 ,  A61K9/32 ,  A61K9/20 ,  A61K31/138 ,  A61K31/437 ,  A61K31/4458 ,  A61K9/48 ,  A61K31/485 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

公开(公告)号：US09597293B2

公开(公告)日：2017-03-21

申请号：US12598138

申请日：2007-05-07

申请人： Fang Liu ,  Abdul W. Basit ,  Rosario Lizio ,  Hans-Ulrich Petereit ,  Christian Meier ,  Michael Damm

发明人： Fang Liu ,  Abdul W. Basit ,  Rosario Lizio ,  Hans-Ulrich Petereit ,  Christian Meier ,  Michael Damm

IPC分类号： A61K9/32 ,  A61K47/12 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K9/50

CPC分类号： A61K9/5073 ,  A61K9/5026

摘要： The present invention provides a solid dosage form including an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating; wherein the inner coating includes a partially neutralized anionic polymeric material, and at least a carboxylic acid having 2 to 16 carbon atoms the salts thereof or mixtures of the acid and its salt; wherein the outer coating includes an anionic polymeric material which is less or not at all neutralized than the material of the inner coating.

公开(公告)号：US09241945B2

公开(公告)日：2016-01-26

申请号：US14361554

申请日：2012-11-29

申请人： Takeda Pharmaceutical Company Limited

发明人： Tetsuya Kawano ,  Yasushi Mima ,  Yumiko Ishii

IPC分类号： A61K9/16 ,  A61K9/28 ,  A61K9/32 ,  A01N43/00 ,  A61K31/616 ,  A61K9/24 ,  A61K31/4439 ,  A61K45/06 ,  A61K9/20 ,  A61K9/50

摘要： Provided is a dry coated tablet showing high stability of the active ingredient (proton pump inhibitor, acetylsalicylic acid), which stably and rapidly expresses the pharmacological effect of the active ingredient after administration. A dry coated tablet having an inner core and an outer layer, wherein the inner core is an enteric-coated tablet containing acetylsalicylic acid, and the outer layer contains enteric micro granules containing a proton pump inhibitor.

公开(公告)号：US09119809B2

公开(公告)日：2015-09-01

申请号：US14255529

申请日：2014-04-17

申请人： Ironshore Pharmaceuticals & Development, Inc

发明人： David Lickrish ,  Feng Zhang

IPC分类号： A61K31/137 ,  A61K9/16 ,  A61K9/22 ,  A61K9/32 ,  A61K9/52 ,  A61K9/58 ,  A61K9/50 ,  A61K31/4458

CPC分类号： A61K9/2866 ,  A61K9/0053 ,  A61K9/4808 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K9/5073 ,  A61K9/5078 ,  A61K9/5084 ,  A61K31/137 ,  A61K31/4458

摘要： Therapeutic compositions and methods for treatment of attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) include dosage forms that deliver a therapeutic amount of active drug in a delayed and controlled release formulation. The dosage form can be administered at night and drug release is delayed for from 5 to 8 hours or longer, followed by a prolonged release.

摘要翻译： 用于治疗注意力缺陷障碍（ADD）或注意缺陷多动障碍（ADHD）的治疗组合物和方法包括在延迟和控制释放制剂中递送治疗量的活性药物的剂型。 剂型可以在夜间施用，药物释放延迟5到8小时或更长时间，然后延长释放。

公开(公告)号：US08790693B2

公开(公告)日：2014-07-29

申请号：US12671529

申请日：2008-08-01

申请人： Maximilian Angel ,  Karl Kolter ,  Hartwig Voβ

发明人： Maximilian Angel ,  Karl Kolter ,  Hartwig Voβ

IPC分类号： A61K9/32 ,  C08F2/08 ,  C08K5/06 ,  C08L33/10 ,  C08L39/00 ,  A23L1/29

CPC分类号： C08K3/20 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/1635 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/5026 ,  A61K47/32 ,  C08F2/22 ,  C08F220/14 ,  C08F220/34 ,  C09D133/14 ,  C09J133/14

摘要： The present invention relates to a process for preparing an aqueous polymer dispersion by free-radical emulsion polymerization of a monomer mixture which comprises N,N-diethylaminoethyl methacrylate, to the polymer dispersion obtainable by this process, and to the use thereof.

摘要翻译： 本发明涉及一种通过使含有甲基丙烯酸N，N-二乙基氨基乙酯的单体混合物通过该方法获得的聚合物分散体的自由基乳液聚合制备聚合物水分散体的方法及其用途。

公开(公告)号：US08747898B2

公开(公告)日：2014-06-10

申请号：US12835863

申请日：2010-07-14

申请人： Boyong Li ,  Avinash Nangia ,  Chih Ming Chen ,  Xiu Xiu Cheng

发明人： Boyong Li ,  Avinash Nangia ,  Chih Ming Chen ,  Xiu Xiu Cheng

IPC分类号： A61K9/22 ,  A61K9/32

CPC分类号： A61K31/137 ,  A61K9/1676 ,  A61K9/2081 ,  A61K9/5078 ,  A61K9/5084

摘要： A once a day bupropion salt formulation is disclosed.

摘要翻译： 公开了一天一次的安非他酮盐配方。

公开(公告)号：US08715730B2

公开(公告)日：2014-05-06

申请号：US13257820

申请日：2010-03-29

申请人： Suguru Takaki ,  Kotoe Ohta ,  Yasuhide Horiuch

发明人： Suguru Takaki ,  Kotoe Ohta ,  Yasuhide Horiuch

IPC分类号： A61K9/32

CPC分类号： A61K31/133 ,  A61K9/0056 ,  A61K9/2077 ,  A61K9/2826 ,  A61K9/284 ,  A61K9/2866 ,  A61K31/18 ,  A61K31/426 ,  A61K31/4422 ,  A61K31/4439 ,  A61K31/4515 ,  A61K31/5517

摘要： The present invention relates to a stable orally disintegrating coated tablet containing a drug, wherein the tablet is coated with a coating layer containing a water-soluble substance and a polyvinyl alcohol resin of not less than 5% by weight based on the weight of the coating layer, the water-soluble substance dissolving in an amount of 1 g or more in less than 10 mL of water at 20° C., having a hydroxyl group(s) in its molecule, and having a molecular weight of not more than 200 per a unit hydroxyl group. There is provided a stable orally disintegrating coated tablet which does not cause a crack in the coating layer even when the orally disintegrating tablet has been swollen by moisture absorption under high humidity, while ensuring rapid disintegration properties in an oral cavity. In the case of an orally disintegrating tablet containing a light-unstable drug, degradation of the drug can be suppressed by blending a light shading agent in the coating layer.

摘要翻译： 本发明涉及一种含有药物的稳定的口腔崩解型包衣片剂，其中片剂的涂层含有不少于5重量％的水溶性物质和聚乙烯醇树脂，基于涂层的重量 层，在20℃下在少于10mL的水中溶解1g或更多的水溶性物质，其分子中具有羟基，分子量不大于200 每单位羟基。 提供了一种稳定的口腔崩解性包衣片剂，即使在口腔崩解片剂在高湿度下通过吸湿而膨胀，同时确保口腔中快速崩解性能，也不会在包衣层中引起裂纹。 在含有光不稳定药物的口腔崩解片剂的情况下，可以通过在遮光层中混合遮光剂来抑制药物的降解。

公开(公告)号：US08715729B2

公开(公告)日：2014-05-06

申请号：US13331439

申请日：2011-12-20

申请人： Karl Kolter ,  Silke Gebert ,  Yoshitaka Katsuno

发明人： Karl Kolter ,  Silke Gebert ,  Yoshitaka Katsuno

IPC分类号： A61K9/28 ,  A61K9/20 ,  A61K9/32

CPC分类号： A61K9/284

摘要： Rapidly disintegrating, solid coated dosage form comprising a solid core consisting of at least 60% by weight of an auxiliary mixture, up to 40% by weight of at least one active ingredient, and optionally further auxiliaries, coated with at least one film coating comprising completely or partially hydrolyzed, rapidly water-soluble polyether-vinyl ester graft polymers, methods for the production thereof, and their use.

摘要翻译： 包含由至少60重量％的辅助混合物，至多40重量％的至少一种活性成分和任选的其它助剂组成的固体芯片的快速崩解的固体涂层剂型，涂覆有至少一种薄膜包衣，包括 完全或部分水解的快速水溶性聚醚 - 乙烯基酯接枝聚合物，其制备方法及其用途。

公开(公告)号：US08652521B2

公开(公告)日：2014-02-18

申请号：US13201546

申请日：2010-03-03

申请人： Yuki Hayashi ,  Ryoji Yoshii ,  Yasuhide Horiuchi

发明人： Yuki Hayashi ,  Ryoji Yoshii ,  Yasuhide Horiuchi

IPC分类号： A61K31/19 ,  A61K9/32

CPC分类号： A61K9/284 ,  A61K9/2813 ,  A61K31/19

摘要： A coated solid preparation includes an active ingredient including valproic acid or a pharmacologically acceptable salt thereof, and a coating layer containing polyvinyl alcohol and swelling clay coating the active ingredient wherein mass ratio of the polyvinyl alcohol to the swelling clay is 8:2 to 3:7 and the swelling clay is dispersed as a laminated structure.

摘要翻译： 包衣固体制剂包括包括丙戊酸或其药理学上可接受的盐的活性成分，以及包含聚乙烯醇和膨胀粘土的涂层，其中涂覆有活性成分，其中聚乙烯醇与膨胀粘土的质量比为8:2至3:1。 并且膨胀粘土作为层压结构分散。