公开(公告)号：US12016948B2

公开(公告)日：2024-06-25

申请号：US16475894

申请日：2018-01-05

申请人： The Regents of the University of California

发明人： Joseph Wang ,  Liangfang Zhang

IPC分类号： A61K9/46 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61B5/00

CPC分类号： A61K9/0007 ,  A61K9/0053 ,  A61K9/2009 ,  A61K9/2027 ,  A61K9/204 ,  A61K9/205 ,  A61K9/2086 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/501 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5036 ,  A61B5/4222

摘要： Disclosed are nano/micromotor devices, systems, and methods for providing payloads in the gastrointestinal system. In one aspect, a micromotor for a gastrointestinal tract includes a micromotor body including a one or more material layers to provide a structure that surrounds a hollow interior region and has an opening to an exterior of the micromotor body; one or more particles including a biocompatible metal element, the one or more particles contained in the interior region of the micromotor body; a coating coupled to the structure of the micromotor body; and a payload material, in which the micromotor is structured to move in a fluid of a gastrointestinal system based on a reaction between the one or more particles and a constituent or a condition of the fluid, such that the reaction generates bubbles that accelerate out of the opening of the micromotor body to propel the micromotor in the fluid.

公开(公告)号：US11844781B1

公开(公告)日：2023-12-19

申请号：US18221183

申请日：2023-07-12

申请人： KING FAISAL UNIVERSITY

发明人： Mai Mostafa Khalaf Ali ,  Hany Mohamed Abd El-Lateef Ahmed ,  Ahmed Mohammed Abu-Dief Mohammed ,  Amr Embaby Elsayed Karamany ,  Mahmoud Ibrahim Mahmoud Abdelmagid ,  Mohammed Sherif Saddik Ibrahim ,  Ali Khames Abd Eltwab Morsy

IPC分类号： A61K31/4174 ,  A61P27/16 ,  A61P31/10 ,  A61K9/46 ,  A61K47/10 ,  A61K47/38 ,  A61K9/70 ,  A61K9/00

CPC分类号： A61K31/4174 ,  A61K9/0046 ,  A61K9/7007 ,  A61K47/10 ,  A61K47/38 ,  A61P27/16 ,  A61P31/10

摘要： The polymeric clotrimazole biofilm for the treatment of otomycosis contains clotrimazole or a pharmaceutically acceptable salt thereof as the active pharmaceutical ingredient in a polymer biofilm thug delivery vehicle. The polymer may be a bio compatible polymer, such as hydroxypropylmethylcellulose (HPMC). Propylene glycol may be added to the mixture as a plasticizer to promote formation of the film. The drug and the polymer may be solvated in a casting solvent and then mixed in a 1:3 ratio of drug:polymer. About 15% propylene glycol may be added to the mixture, which is then heated at 40° C. until a thin, flexible film forms. A round, knife-thick patch of the biofilm may be applied to the patient's ear through the external canal and over the tympanic membrane.

公开(公告)号：US20230381477A1

公开(公告)日：2023-11-30

申请号：US18229388

申请日：2023-08-02

申请人： Georgia Tech Research Corporation

发明人： Mark R. Prausnitz ,  Richard N. Terry ,  Wei Li

IPC分类号： A61M37/00 ,  A61K9/46 ,  A61K9/00 ,  A61K31/57

CPC分类号： A61M37/0015 ,  A61K9/0007 ,  A61K9/0024 ,  A61K31/57 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061

摘要： Separable microneedle arrays and microneedle patches are provided that may achieve sustained release of drug. The microneedle arrays may include one or more features that facilitate separation of the microneedles, such as a bubble structure. The microneedle arrays may include an effervescent material.

公开(公告)号：US11766413B2

公开(公告)日：2023-09-26

申请号：US16738819

申请日：2020-01-09

申请人： Nacuity Pharmaceuticals, Inc.

发明人： G. Michael Wall

IPC分类号： A61K31/16 ,  A61P27/02 ,  A61K9/00 ,  A61K47/26 ,  A61K9/10 ,  A61K9/20 ,  A61K9/48 ,  A61K9/46 ,  A61K9/08 ,  A61P27/06 ,  A61K45/06

CPC分类号： A61K31/16 ,  A61K9/006 ,  A61K9/0007 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/10 ,  A61K9/2004 ,  A61K9/4841 ,  A61K47/26 ,  A61P27/02 ,  A61P27/06 ,  A61K9/0053 ,  A61K45/06

摘要： The present invention includes a method for the treatment of age-related macular degeneration, glaucoma, or diabetic retinopathy in a human that comprises administering to the human a therapeutically effective amount of N-acetylcysteine amide (NACA) or (2R,2R′)-3,3′-disulfanediyl bis(2-acetamidopropanamide) (diNACA) sufficient to treat or reduce the symptoms of the age-related macular degeneration, glaucoma, or diabetic retinopathy.

公开(公告)号：US20230292992A1

公开(公告)日：2023-09-21

申请号：US17698303

申请日：2022-03-18

申请人： CAPSOVISION, Inc.

发明人： Alexa Nazarian ,  Phat TRINH ,  Mikael TROLLSAS

IPC分类号： A61B1/00 ,  A61B1/04 ,  A61K9/46

CPC分类号： A61B1/00082 ,  A61B1/041 ,  A61K9/0007

摘要： A capsule device with thermally-stable specific gravity control is disclosed. The capsule device comprises a capsule unit adapted to be swallowable by a human subject and an inflatable balloon comprising a thermally-stable effervescent formulation inside the inflatable balloon, where the thermally-stable effervescent formulation has a particular particle size between a first mesh size and a second mesh size, and the inflatable balloon is attached to the capsule unit. After the capsule unit with the inflatable balloon attached is swallowed, the inflatable balloon starts to inflate so as to lower specific gravity of a combination of the capsule unit and the inflatable balloon when the inflatable balloon is exposed to body fluid and the body fluid gets in touch with the thermally-stable effervescent formulation inside the inflatable balloon.

公开(公告)号：US11517521B2

公开(公告)日：2022-12-06

申请号：US16002199

申请日：2018-06-07

申请人： SpecGX LLC

发明人： Alex Micka ,  Kai Feng ,  Tsz Chung Lai ,  Jonathan Gaik

IPC分类号： A61K31/485 ,  A61K9/20 ,  A61K9/28 ,  A61K9/46 ,  A61K45/06

摘要： The present disclosure provides pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. In particular, the pharmaceutical compositions comprise at least one pharmaceutically active ingredient, at least one non-cellulose polysaccharide, at least one hydrophilic gelling polymer, and an effervescent system.

公开(公告)号：US20220241238A1

公开(公告)日：2022-08-04

申请号：US17588326

申请日：2022-01-30

申请人： Michael Roth ,  Kevin Hazen ,  Mason Cave

发明人： Michael Roth ,  Kevin Hazen ,  Mason Cave

IPC分类号： A61K31/352 ,  A23L2/54 ,  A23L2/68 ,  A23P10/28 ,  A23L33/105 ,  A61K9/00 ,  A61K9/46

摘要： The invention comprises a method and apparatus for forming a beverage, comprising the steps of: dissolving a tablet in the beverage, the tablet containing tetrahydrocannabinol; forming gas bubbles, such as carbon dioxide, within the beverage through a chemical reaction; and mixing the tetrahydrocannabinol in the beverage through motion of the gas bubbles, such as where the tetrahydrocannabinol is maintained, after the step of mixing, in suspension in the beverage for a period of at least five minutes through at least movement of the gas bubbles.

公开(公告)号：US20220233432A1

公开(公告)日：2022-07-28

申请号：US17687364

申请日：2022-03-04

申请人： The University of British Columbia ,  The General Hospital Corporation

发明人： Christian Kastrup ,  Ju Hun Yeon ,  James Baylis ,  Thomas Frederick Burke

IPC分类号： A61K9/46 ,  A61L29/10 ,  C01F11/18 ,  A61K9/14 ,  A61K9/16 ,  A61L29/16 ,  A61L31/08 ,  A61L31/14 ,  A61L31/16 ,  A61L15/18 ,  A61L15/44 ,  A61K38/18 ,  A61K38/48 ,  A61L15/20 ,  A61L15/42 ,  A61L29/08 ,  A61L29/14

摘要： A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 μm or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.

公开(公告)号：US20220192973A1

公开(公告)日：2022-06-23

申请号：US17445918

申请日：2021-08-25

申请人： STEERLIFE INDIA PRIVATE LIMITED

发明人： Babu PADMANABHAN ,  Rakshit SHETTY ,  Vijay KULKARNI ,  Himadri SEN ,  Indu BHUSHAN

IPC分类号： A61K9/46 ,  A61K31/546 ,  A61K9/16 ,  A61K45/06 ,  A61K9/00 ,  A61K9/20 ,  A61K31/198 ,  A61K31/616

摘要： The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.

公开(公告)号：US20210378948A1

公开(公告)日：2021-12-09

申请号：US17340621

申请日：2021-06-07

申请人： NICOVENTURES TRADING LIMITED

发明人： Anthony Richard Gerardi ,  Ross Jay Oden ,  Matthew Evan Lampe ,  Kristen Ann Spielbauer ,  Nicolas von Cosmos ,  Michael Andrew Zawadzki

IPC分类号： A61K9/46 ,  A61K9/00 ,  A61K47/12 ,  A61K47/02 ,  A61K47/26 ,  A61K9/20 ,  A61K31/375 ,  A61K31/522 ,  A61K31/198 ,  A61K47/36 ,  A23L29/30 ,  A23L29/00 ,  A23L33/15 ,  A23L33/175 ,  A23L33/105 ,  A23L33/16 ,  A23L33/125 ,  A24B15/16 ,  A24B13/00

摘要： The disclosure provides an effervescent composition adapted for oral use, the composition including an effervescent material; one or more fillers in a total amount of at least about 30% by weight, the one or more fillers including at least one sugar alcohol; at least one active ingredient; and optionally, a lipid in an amount of at least about 20% by weight. Melting effervescent compositions are also provided, which include the lipid.