公开(公告)号：US12060398B2

公开(公告)日：2024-08-13

申请号：US17254019

申请日：2019-06-21

申请人： President and Fellows of Harvard College

发明人： Arjirios Sourlis ,  Anna Duraj-Thatte ,  Avinash Manjula Basavanna ,  Neel Satish Joshi

IPC分类号： C07K14/47 ,  A61L15/32 ,  A61L15/42 ,  A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  A61L27/52 ,  B33Y70/00 ,  C07K14/75 ,  C07K14/78 ,  C09D11/04

CPC分类号： C07K14/4711 ,  A61L15/32 ,  A61L15/42 ,  A61L24/0031 ,  A61L24/108 ,  A61L27/227 ,  A61L27/52 ,  B33Y70/00 ,  C07K14/75 ,  C07K14/78 ,  C09D11/04 ,  C07K2319/00

摘要： Disclosed herein are engineered bacteria that manufacture biofilms from bacterial amyloid structures. These biofilms and biofilm matrices are capable of generating fibrous proteinaceous networks and being used as 3D-printing inks.

公开(公告)号：US11992554B2

公开(公告)日：2024-05-28

申请号：US17405866

申请日：2021-08-18

申请人： RXOS Medical Inc.

发明人： Richard M. Millis ,  Jeffrey A. Niezgoda ,  Rajagopalan Sridhar

IPC分类号： A61K9/06 ,  A61K9/00 ,  A61K31/13 ,  A61K31/15 ,  A61K31/216 ,  A61K31/445 ,  A61K33/38 ,  A61K45/06 ,  A61K47/32 ,  A61L15/32 ,  A61L15/44 ,  A61L15/60

CPC分类号： A61K9/06 ,  A61K9/0014 ,  A61K31/13 ,  A61K31/15 ,  A61K31/216 ,  A61K31/445 ,  A61K33/38 ,  A61K45/06 ,  A61K47/32 ,  A61L15/325 ,  A61L15/44 ,  A61L15/60 ,  A61K33/38 ,  A61K2300/00 ,  A61K31/13 ,  A61K2300/00 ,  A61K31/15 ,  A61K2300/00

摘要： A polyfunctional radical scavenger hydrogel formulation providing extended protection of the extracellular space within a wound site. The polyfunctional radical scavenger hydrogel formulation is generally formed from a hydrogel, a first radical scavenger and a second radical scavenger differing from the first radical scavenger with respect to at least one property. A portion of the first radical scavenger included with the formation and/or second radical scavenger included within the formulation may be dissolved, suspended and/or bonded to a polymer of the hydrogel.

公开(公告)号：US11986562B2

公开(公告)日：2024-05-21

申请号：US16387267

申请日：2019-04-17

申请人： Marquette University

发明人： Chieu D. Tran

IPC分类号： A61L15/46 ,  A61L15/18 ,  A61L15/28 ,  A61L15/32 ,  A61L15/42 ,  A61L15/44 ,  C08L1/00 ,  C08L5/08 ,  C08L101/00

CPC分类号： A61L15/28 ,  A61L15/18 ,  A61L15/32 ,  A61L15/42 ,  A61L15/44 ,  A61L15/46 ,  C08L101/00 ,  A61L2300/102 ,  A61L2300/114 ,  A61L2300/406 ,  A61L2400/12 ,  A61L15/28 ,  C08L5/08 ,  A61L15/28 ,  C08L1/00

摘要： Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically include structural polymers and nitric oxide releasing agents, and preferably photo-reactive nitric oxide releasing compounds or complexes. The composite materials may be prepared from ionic liquid compositions comprising the structural polymers and the nitric oxide releasing agent, where the ionic liquid is removed from the ionic liquid compositions to obtain the composite materials. The composite materials may be used in applications include dressing for wounds, where the nitric oxide releasing agents may be induced to release nitric oxide in order to inhibit microbial growth and promote healing.

公开(公告)号：US11975113B2

公开(公告)日：2024-05-07

申请号：US16642887

申请日：2018-08-31

申请人： NATIONAL INSTITUTE FOR MATERIALS SCIENCE

发明人： Tetsushi Taguchi ,  Akihiro Nishiguchi

IPC分类号： A61L15/32 ,  A61F13/02 ,  A61L31/04

CPC分类号： A61L15/32 ,  A61F13/02 ,  A61L31/045

摘要： A wound dressing material includes a particle having a crosslinked gelatin derivative, the gelatin derivative having the structure represented by the following formula (1):

GltnNH—CHR1R2  (1)

wherein “Gltn” represents a gelatin residue, R1 represents an alkyl group having 1-17 carbon atoms, and R2 represents a hydrogen atom or an alkyl group having 1-17 carbon atoms, and the particle having a particle size ranging from 1 to 1,000 μm.

公开(公告)号：US20240043500A1

公开(公告)日：2024-02-08

申请号：US18483108

申请日：2023-10-09

申请人： COLZYX AB

发明人： Matthias MÖRGELIN ,  Suado ABDILLAHI

IPC分类号： C07K14/78 ,  A61L27/54 ,  A61L15/44 ,  C07K14/47 ,  A61P17/02 ,  A61P31/04 ,  A01N47/44 ,  A61L15/32 ,  A61L17/00 ,  A61L17/14 ,  A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/60 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  C07K14/755

CPC分类号： C07K14/78 ,  A61L27/54 ,  A61L15/44 ,  C07K14/4723 ,  A61P17/02 ,  A61P31/04 ,  A01N47/44 ,  A61L15/32 ,  A61L15/325 ,  A61L17/005 ,  A61L17/145 ,  A61L24/0015 ,  A61L24/102 ,  A61L24/108 ,  A61L27/227 ,  A61L27/24 ,  A61L27/34 ,  A61L27/60 ,  A61L29/045 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/044 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  C07K14/755 ,  A61L2300/404 ,  A61K9/7023

摘要： The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.

公开(公告)号：US11877910B2

公开(公告)日：2024-01-23

申请号：US16760984

申请日：2018-11-01

申请人： SYSTAGENIX WOUND MANAGEMENT, LIMITED

发明人： Craig Delury ,  Breda Mary Cullen ,  Alexander Waite ,  Derek Silcock

IPC分类号： A61F13/00 ,  A61L15/28 ,  A61L15/32

CPC分类号： A61F13/00063 ,  A61F13/00012 ,  A61F13/00046 ,  A61L15/28 ,  A61L15/325 ,  A61F2013/00255 ,  A61L2300/104 ,  A61L2300/404

摘要： A dressing configured to be positioned adjacent to a tissue site is disclosed herein. The dressing may include oxidized regenerated cellulose (ORC), collagen, and at least one nutrient including glutamine. Methods of treating a tissue site are also disclosed herein.

公开(公告)号：US11814422B2

公开(公告)日：2023-11-14

申请号：US17474434

申请日：2021-09-14

申请人： COLZYX AB

发明人： Matthias Mörgelin ,  Suado Abdillahi

IPC分类号： C07K14/78 ,  A61L27/54 ,  A61K38/00 ,  A61L15/44 ,  C07K14/47 ,  A61P17/02 ,  A61P31/04 ,  A01N47/44 ,  A61L15/32 ,  A61L17/00 ,  A61L17/14 ,  A61L24/00 ,  A61L24/10 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/60 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  C07K14/755 ,  A61K9/70 ,  A61K9/00

CPC分类号： C07K14/78 ,  A01N47/44 ,  A61L15/32 ,  A61L15/325 ,  A61L15/44 ,  A61L17/005 ,  A61L17/145 ,  A61L24/0015 ,  A61L24/102 ,  A61L24/108 ,  A61L27/227 ,  A61L27/24 ,  A61L27/34 ,  A61L27/54 ,  A61L27/60 ,  A61L29/045 ,  A61L29/048 ,  A61L29/085 ,  A61L29/16 ,  A61L31/044 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  A61P17/02 ,  A61P31/04 ,  C07K14/4723 ,  C07K14/755 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/7023 ,  A61K38/00 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/00 ,  A61L2430/34 ,  C07K2319/00

摘要： The present invention provides polypeptides comprising or consisting of an amino acid sequence derived from collagen type VI or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant of derivative thereof, wherein the polypeptide, fragment, variant, fusion or derivative is capable of killing or attenuating the growth of microorganisms. Related aspects of the invention provide corresponding isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of microbial infections and in wound care. Also provided are a method of killing microorganisms in vitro and a medical device associated with the pharmaceutical composition.

公开(公告)号：US20230302190A1

公开(公告)日：2023-09-28

申请号：US18327311

申请日：2023-06-01

申请人： PolyMedics Innovations GmbH

发明人： Heinrich Planck ,  Erhard Mueller ,  Svenja Reimer ,  Christian Planck

IPC分类号： A61L15/32 ,  A61L15/22 ,  A61L15/42

CPC分类号： A61L15/325 ,  A61L15/225 ,  A61L15/42

摘要： A two-dimensional material for the medical wound area treatment is disclosed. A non-woven fabric consists of resorbable polymer filaments and collagen particles which have a particle size I >80 μm and are disposed on and/or in the non-woven fabric.

公开(公告)号：US20230226250A1

公开(公告)日：2023-07-20

申请号：US18190836

申请日：2023-03-27

申请人： Mehrdad Mark Mofid

发明人： Mehrdad Mark Mofid

IPC分类号： A61L15/32 ,  A61L15/40 ,  A61L15/58

CPC分类号： A61L15/32 ,  A61L15/40 ,  A61L15/58 ,  A61L2300/64

摘要： The present disclosure includes a method of adhering an external wound dressing formed of an animal-derived bioprotein scaffolding around a site on a patient, for example, where a medical apparatus is entering the patient. The animal-derived bioprotein scaffolding can be formed of bioprotein fibers woven together. An adhesive can be integrated with the animal-derived bioprotein scaffolding and the external wound dressing can be affixed to the medical apparatus to secure the medical apparatus to the patient.

公开(公告)号：US11622892B2

公开(公告)日：2023-04-11

申请号：US16995771

申请日：2020-08-17

申请人： Ension, Inc.

发明人： Ali Hussain ,  Patrick Cahalan ,  Linda Cahalan

IPC分类号： A61F13/00 ,  C07K14/78 ,  A61L15/32 ,  A61L15/42 ,  A61L27/20 ,  B32B5/10 ,  A61K38/39 ,  A61L27/24 ,  A61L31/14 ,  A61L31/04

摘要： A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.