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    Fibrin and/or dialdehyde starch hydrolysate materials, and preparation and use thereof
    7.
    发明授权
    Fibrin and/or dialdehyde starch hydrolysate materials, and preparation and use thereof 有权

    公开(公告)号：US11311643B2

    公开(公告)日：2022-04-26

    申请号：US16156340

    申请日：2018-10-10

    申请人： Cook Biotech Incorporated

    发明人： Niraj Ramachandran ,  Brooke Lynn Davisson

    IPC分类号： A61K38/00 ,  A61L24/04 ,  A61L24/08 ,  A61L24/10 ,  A61L24/00 ,  B29C39/00

    摘要： Various compositions of matter, methods of making compositions of matter, and methods of using compositions of matter, e.g. for inducing hemostasis, are disclosed. In some embodiments, a starting fibrin material is subjected to controlled hydrolysis, desirably base-catalyzed, to prepare a fibrin hydrolysate material with increased water sorption capacity. Such fibrin hydrolysate materials, alone or combined with one or more additional substances, can be used in the preparation of hemostasis promoting foams, powders or gels. In some embodiments, a starting dialdehyde starch material is subjected to controlled hydrolysis to prepare a dialdehyde starch hydrolysate material. Such dialdehyde starch hydrolysate materials, alone or combined with one or more additional substances, in some cases combined with a fibrin hydrolysate material, can be used in the preparation of hemostasis promoting foams, powders or gels.

    Blood Coagulation-Promoting Silk Fibroin-Polypeptide Electrospun Membrane and Preparation Method Thereof
    9.
    发明申请
    Blood Coagulation-Promoting Silk Fibroin-Polypeptide Electrospun Membrane and Preparation Method Thereof 有权

    公开(公告)号：US20220088266A1

    公开(公告)日：2022-03-24

    申请号：US17542473

    申请日：2021-12-05

    申请人： Zhejiang University

    发明人： Mingying Yang ,  Fang Lei ,  Yajun Shuai

    IPC分类号： A61L24/10 ,  A61L24/00

    摘要： The present invention discloses a blood coagulation-promoting silk fibroin-polypeptide electrospun membrane and a preparation method thereof. The electrospun membrane is made by using silkworm silk fibroin as a carrier and adding the polypeptide GPRPPSEHLQIT. It is mainly used for promoting blood coagulation, and is a blood coagulation material that can targetedly bind to human fibrinogen. The preparation method includes the steps of dissolving, filtering, dialyzing, concentrating and freeze-drying silkworm cocoons after degumming to obtain silk fibroin freeze-dried powder. The polypeptide used in the present invention is a polypeptide obtained by self-screening. Compared with other polypeptides, it can specifically targetedly bind to human fibrinogen.

    Methods and kits for producing a fibrin matrix
    10.
    发明授权
    Methods and kits for producing a fibrin matrix 有权

    公开(公告)号：US11266762B2

    公开(公告)日：2022-03-08

    申请号：US16294698

    申请日：2019-03-06

    申请人： Kuros Biosurgery AG

    发明人： Lorenz Vogt ,  Alistair Simpson Irvine ,  Philippe Paul Saudan

    IPC分类号： A61L24/10 ,  A61L27/22 ,  A61L27/54

    摘要： Methods for producing a fibrin matrix comprising a fusion peptide are described herein. In some embodiments, the method includes providing three different components, including a first component containing fibrinogen or a fibrinogen precursor and optionally, transglutaminase or a transglutaminase precursor, a second component containing thrombin or a thrombin precursor, and a third component containing a fusion peptide. In these embodiments, neither the first component nor the second component includes the fusion peptide. In some embodiments, the first or second components are premixed with the third component. The first, second and third components are mixed to form a fibrin matrix comprising a covalently linked fusion peptide. The mixing is carried out in a time frame of not more than 5 days. A kit for producing the fibrin matrix comprising a covalently linked fusion peptide is also described herein.