公开(公告)号：US20250057521A1

公开(公告)日：2025-02-20

申请号：US18792363

申请日：2024-08-01

Applicant: PatchClamp MedTech, Inc

Inventor： Marc Robert Mayberg

IPC: A61B17/00 ,  A61L27/04 ,  A61L27/06 ,  A61L27/18 ,  A61L27/22 ,  A61L27/24 ,  A61L27/36 ,  A61L27/54 ,  A61L31/02 ,  A61L31/06 ,  A61L31/14

Abstract: Provided are tissue repair and sealing devices, and methods for the use of tissue repair and sealing devices, for use in both minimally invasive surgical (MIS) procedures and open, non-MIS procedures to rapidly repair tissue fenestrations and create a pressure-resistant, watertight seal in a tissue barrier. Tissue repair and sealing devices disclosed herein comprise an integrated graft and deployable clasp assembly and an applicator assembly having a clasp retain and release member that is slidably connected to a folded, deployable clasp. The applicator assembly places a graft on a tissue inner surface and a deployable clasp on a tissue outer surface to secure the graft to the tissue inner surface to, thereby, repair a tissue fenestration and create a watertight barrier.

公开(公告)号：US20250041476A1

公开(公告)日：2025-02-06

申请号：US18920664

申请日：2024-10-18

Applicant: The Curators of the University of Missouri

Inventor： Sheila Grant ,  David Grant ,  Colten Snider ,  Mitchell Bellrichard ,  Daniel Grant

IPC: A61L27/04 ,  A61F2/04 ,  A61F2/10 ,  A61F2/24 ,  A61K9/14 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: The present disclosure describes a treatment composition comprising a nanoparticle composition comprising nanoparticles functionalized with surface amine groups and a crosslinking composition comprising genipin. The disclosure also describes a kit comprising the treatment composition, and instructions for using the kit to crosslink the nanoparticles to a tissue graft. The treatment composition and kit can be used to crosslink nanoparticles to a tissue graft, and the resulting tissue graft can be used to replace defective tissue in a subject in need thereof.

公开(公告)号：US12150856B2

公开(公告)日：2024-11-26

申请号：US18296159

申请日：2023-04-05

Applicant: Polares Medical Inc.

Inventor： Alexander Khairkhahan ,  Michael D. Lesh

IPC: A61F2/24 ,  A61B17/04 ,  A61L27/04 ,  A61L27/06 ,  A61L27/36 ,  A61L27/50 ,  A61B17/064 ,  A61B17/068 ,  A61B90/00

Abstract: The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation enhancement element for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, catheter and driver; and a method for transcatheter implantation of a coaptation element across a heart valve.

公开(公告)号：US12134815B2

公开(公告)日：2024-11-05

申请号：US17618356

申请日：2020-02-28

Applicant: INSTITUTE OF METAL RESEARCH, CHINESE ACADEMY OF SCIENCES

Inventor： Ling Ren ,  Ke Yang ,  Shuyuan Zhang ,  Hai Wang ,  Sharafadeen Kunle Kolawole ,  Ziqing Sun

IPC: C22F1/18 ,  A61L27/04 ,  A61L27/06 ,  C22C14/00

Abstract: The present invention relates to the field of medical titanium alloy materials, and in particular, to a narrow-diameter high-strength implant-specific medical titanium alloy achieving immediate implant placement and a preparation method for the implant-specific medical titanium alloy. The medical titanium alloy is prepared from the following chemical components (by weight percentage), 14%-17% of Zr, 3.0%-10% of Cu, and the balance of Ti. The preparation method for the medical titanium alloy comprises: after cogging and forging and before rolling, performing heat preservation for 0.5-6 h at the temperature of 900-1200° C., and water cooling to the room temperature; and rolling at the temperature of 720-850° C., a strain rate being larger than 0.1 s−1, and a barstock obtained after rolling being used for subsequent implant processing. According to the narrow-diameter high-strength implant-specific medical titanium alloy achieving immediate implant placement provided in the present invention, immediate implant placement can be achieved without any surface treatment, and a firm combination of the implant and a bone tissue is achieved. According to the preparation method for the medical titanium alloy provided in the present invention, the implant having a narrow diameter (3.0-3.5 mm) can be prepared and is high in strength, and the purpose of firm implanting on a narrow teethridge missing a tooth is achieved.

公开(公告)号：US12123086B2

公开(公告)日：2024-10-22

申请号：US17185521

申请日：2021-02-25

Applicant: BIOTRONIK AG

Inventor： Heinz Mueller ,  Peter Uggowitzer ,  Joerg Loeffler

IPC: C22F1/06 ,  A61F2/82 ,  A61L27/04 ,  A61L27/58 ,  A61L31/02 ,  A61L31/14 ,  C22C23/02

CPC classification number: C22F1/06 ,  A61F2/82 ,  A61L27/047 ,  A61L27/58 ,  A61L31/022 ,  A61L31/148 ,  C22C23/02

Abstract: A method for producing a magnesium alloy having improved mechanical and electrochemical properties. The method includes generating a high-purity magnesium by vacuum distillation. A billet of the alloy is generated by synthesis of the high-purity magnesium with 2.0 to 10.0% by weight Al, the remainder being magnesium containing impurities, which promote electrochemical potential differences and/or the formation of precipitations and/or intermetallic phases, in a total amount of no more than 0.0063% by weight of Fe, Si, Mn, Co, Ni, Cu, Zr, Y, Sc or rare earths having the ordinal numbers 21, 57 to 71 and 89 to 103, Be, Cd, In, Sn and/or Pb as well as P, wherein the matrix of the alloy includes intermetallic phases formed of Mg and Al. The alloy is homogenized by annealing at a temperature between 150° C. and 450° C. The homogenized alloy is formed in the temperature range between 200° C. and 400° C.

公开(公告)号：US20240325121A1

公开(公告)日：2024-10-03

申请号：US18684385

申请日：2022-08-30

Applicant: Maruemu Works Co., Ltd.

Inventor： Kengo NARITA ,  Shigeru YAMANAKA

IPC: A61C8/00 ,  A61L27/04 ,  C23C14/02 ,  C23C14/18

CPC classification number: A61C8/0013 ,  A61L27/047 ,  C23C14/022 ,  C23C14/185

Abstract: The present invention provides a biocompatible material in which a hydrophilic substrate is protected by a metal film, the metal film being dissolved when the biocompatible material is used in a living body environment, enabling the protected hydrophilic substrate to be used in a state in which hydrophilicity is retained. The present invention provides a biocompatible material having: a biocompatible substrate that has a hydrophilic surface; and a metal film provided on the surface of the substrate, the metal film having the dissolution characteristic of dissolving in body fluids or simulated body fluids.

公开(公告)号：US20240315835A1

公开(公告)日：2024-09-26

申请号：US18731039

申请日：2024-05-31

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Travis Zenyo Oba ,  Matthew A. Peterson ,  Glen T. Rabito ,  Alexander H. Cooper ,  David Robert Landon ,  Jeremy Brent (aka J. Brent) Ratz ,  Seung-Beom Yi

IPC: A61F2/24 ,  A61L27/04 ,  A61L27/36

CPC classification number: A61F2/2409 ,  A61F2/2418 ,  A61L27/04 ,  A61L27/3625 ,  A61F2/2412 ,  A61F2/2436 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2230/0093 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61F2250/0063 ,  A61L2430/20

Abstract: A self-expanding prosthetic heart valve includes an inner frame and an outer sealing frame. A lower region of the outer sealing frame is coupled to a lower region of the inner frame. At least a portion of the outer frame has a D-shape cross-section for conforming to a shape of a native heart valve annulus. Elongate anchors are positioned outwardly from the outer sealing frame for anchoring to native leaflets. Preferably, the native leaflets are secured between the anchors and an outer surface of the outer sealing frame. A valve body is positioned within an interior lumen of the inner frame and provides a one-way valve mechanism for replacing the function of the native leaflets. For additional stability, a further anchoring mechanism may extend from the inner frame for attachment to a heart wall. The prosthetic heart valve is well-suited for replacing the function of a native tricuspid valve.

公开(公告)号：US12083011B2

公开(公告)日：2024-09-10

申请号：US17357816

申请日：2021-06-24

Applicant: Edwards Lifesciences CardiAQ LLC

Inventor： Jeremy Brent Ratz ,  Luca Pesce ,  Glen T. Rabito ,  Christine Thanh Nguyen

IPC: A61F2/24 ,  A61L27/04 ,  A61L27/36

CPC classification number: A61F2/2418 ,  A61F2/2445 ,  A61F2220/0008 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2250/0039 ,  A61F2250/0069

Abstract: A prosthesis for placement within a native heart valve preferably includes an expandable frame having locking tabs disposed along a proximal end. A plurality of distal anchors is disposed along a distal end of the frame. Each distal anchor is provided with a cushion cover. An outer fabric member surrounds the frame and may extend outwardly from the frame in an expanded condition for providing an improved seal in the region of a native annulus. A valve body is positioned within an interior of the expandable from for allowing blood flow in only one direction. In preferred embodiments, the cushions are positioned over enlarged head portions of the distal anchors for further reducing trauma on surrounding tissue.

公开(公告)号：US20240269345A1

公开(公告)日：2024-08-15

申请号：US18562997

申请日：2022-05-18

Applicant: University of Georgia Research Foundation, Inc.

Inventor： Hamid Asadi ,  Ramaraja P. Ramasamy

IPC: A61L27/34 ,  A61L27/04 ,  A61L27/58 ,  C09D5/08 ,  C09D101/02 ,  C09D189/00

CPC classification number: A61L27/34 ,  A61L27/047 ,  A61L27/58 ,  C09D5/08 ,  C09D101/02 ,  C09D189/00 ,  A61L2400/12 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2420/08 ,  A61L2430/02

Abstract: Biodegradable orthopedic implants and coatings for the implants are provided. The implant can include a Mg alloy and a coating, where the coating includes silk fibroin. The coating can be anticorrosive and can include a first layer comprising polydopamine and a second layer comprising silk fibroin. The silk fibroin can be combined with cellulose nanocrystals. Methods for making coated orthopedic implants are also provided.

公开(公告)号：US12053215B2

公开(公告)日：2024-08-06

申请号：US18147167

申请日：2022-12-28

Applicant: Bone Solutions, Inc.

Inventor： Frankie Morris ,  Drew Diaz ,  Brandon Roller

IPC: A61B17/86 ,  A61F2/30 ,  A61F2/44 ,  A61L27/04 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56

CPC classification number: A61B17/866 ,  A61F2/30771 ,  A61F2/3094 ,  A61F2/447 ,  A61L27/047 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61F2002/30827 ,  A61F2002/30985 ,  A61F2310/00023 ,  A61F2310/00041 ,  A61F2310/00359 ,  A61L2300/102 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2430/02 ,  A61L2430/24 ,  A61L2430/38

Abstract: The present disclosure provides a bone-implantable device and methods of use. The bone-implantable device comprises a body having an exterior surface, wherein a portion of the exterior surface includes a cured osteostimulative material comprising MgO.