公开(公告)号：US12128158B2

公开(公告)日：2024-10-29

申请号：US18108038

申请日：2023-02-10

申请人： DSM IP Assets B.V.

发明人： Noel L. Davison ,  Henricus Johannes Arts ,  Aylvin Jorge Angelo Athanasius Dias ,  Anne Marie Persson ,  Ruud Jozef Regina Wilhelmus Peters

IPC分类号： A61L31/08 ,  A61L17/04 ,  A61L17/14 ,  A61L27/18 ,  A61L27/32 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  C08L75/04

CPC分类号： A61L31/086 ,  A61L17/04 ,  A61L17/145 ,  A61L27/18 ,  A61L27/32 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  C08L75/04 ,  A61L2420/02 ,  A61L2430/02 ,  A61L2430/38

摘要： The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.

公开(公告)号：US12083247B2

公开(公告)日：2024-09-10

申请号：US17485766

申请日：2021-09-27

申请人： Prosidyan, Inc.

发明人： Charanpreet S. Bagga ,  Steve B. Jung ,  Hyun W. Bae

IPC分类号： A61L27/56 ,  A61L27/10 ,  A61L27/12 ,  A61L27/30 ,  A61L27/32 ,  A61L27/42 ,  A61L27/44 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  C08L71/02

CPC分类号： A61L27/56 ,  A61L27/10 ,  A61L27/12 ,  A61L27/306 ,  A61L27/32 ,  A61L27/425 ,  A61L27/427 ,  A61L27/446 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  C08L71/02 ,  A61L2430/02

摘要： Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.

公开(公告)号：US20240207482A1

公开(公告)日：2024-06-27

申请号：US18543587

申请日：2023-12-18

申请人： Rohit Khanna

发明人： Rohit Khanna

IPC分类号： A61L27/32 ,  A61L27/06 ,  A61L27/54 ,  A61L27/56 ,  B33Y70/00 ,  B33Y80/00 ,  C25D11/02 ,  C25D11/26

CPC分类号： A61L27/32 ,  A61L27/06 ,  A61L27/54 ,  A61L27/56 ,  B33Y70/00 ,  B33Y80/00 ,  C25D11/024 ,  C25D11/026 ,  C25D11/26 ,  A61L2300/412 ,  A61L2400/12 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2430/02 ,  C23C24/087

摘要： A method of producing a bioactive surface on a medical device configured for cementless implantation is disclosed. The method can include treating a titanium metal or titanium alloy medical device, optionally having a titanium metal or titanium alloy porous coating, with a series of steps to obtain the bioactive surface having a nanofibrous network of titanate overlaid with hydroxyapatite particles or film. The steps can include treating the medical device with an acidic solution to obtain an activated surface; oxidizing the activated surface using plasma electrolytic oxidation to obtain an oxide layer having bioactive elements, compounds, or phases; treating the oxide layer with an alkaline solution to obtain the bioactive surface; and treating the bioactive surface with an iodine containing compound to obtain an antibacterial and bioactive surface.

公开(公告)号：US11998659B2

公开(公告)日：2024-06-04

申请号：US17673651

申请日：2022-02-16

申请人： KYOCERA CORPORATION ,  Takao Hotokebuchi

发明人： Takao Hotokebuchi ,  Iwao Noda

IPC分类号： A61L27/32 ,  A61L27/06 ,  A61L27/30 ,  A61L27/42 ,  A61L27/54

CPC分类号： A61L27/32 ,  A61L27/06 ,  A61L27/306 ,  A61L27/425 ,  A61L27/54 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2430/24

摘要： To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 10% to 90% is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film to suppress adhesion of bacteria.

公开(公告)号：US11992578B2

公开(公告)日：2024-05-28

申请号：US17319145

申请日：2021-05-13

申请人： Orbray Co., Ltd. ,  Tokyo Metropolitan Public University Corporation

发明人： Hikaru Muto ,  Satoshi Kobayashi

IPC分类号： A61L27/32 ,  A61L27/10 ,  C04B35/488 ,  C04B41/85

CPC分类号： A61L27/32 ,  A61L27/10 ,  C04B35/488 ,  C04B41/85 ,  A61L2430/02

摘要： A zirconia material manufacturing method includes: dispersing hydroxyapatite powder in water to prepare a slurry having a hydroxyapatite powder concentration of 1%; and dipping zirconia in the slurry to form, on the zirconia, a coating layer containing hydroxyapatite.

公开(公告)号：US20240024535A1

公开(公告)日：2024-01-25

申请号：US18372863

申请日：2023-09-26

申请人： DEPUY SYNTHES PRODUCTS, INC.

发明人： Rajendra Kasinath ,  Craig Ernsberger ,  Stephanie Vass ,  Steven N. Ginn ,  Haibo Qu ,  Weidong Tong

IPC分类号： A61L27/32 ,  A61L27/06 ,  A61L27/56 ,  A61L27/58 ,  A61L27/04 ,  A61L27/50 ,  A61L27/54

CPC分类号： A61L27/32 ,  A61L27/06 ,  A61L27/56 ,  A61L27/58 ,  A61L27/045 ,  A61L27/50 ,  A61L27/54 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2300/606 ,  A61L2420/02 ,  B05D1/18

摘要： An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.

公开(公告)号：US20230347019A1

公开(公告)日：2023-11-02

申请号：US17796529

申请日：2021-01-29

申请人： Wright Medical Technology, Inc.

发明人： Barbara E. Blum ,  Jon P. Moseley

IPC分类号： A61L27/42 ,  A61L27/32

CPC分类号： A61L27/427 ,  A61L27/32 ,  A61L2430/02 ,  A61L2400/06 ,  A61L2300/802

摘要： The present disclosure relates to bone graft substitute formulations with a liquid weight to powder weight ratio (L/P) of about 0.35 to about 0.40. The formulations disclosed herein have significantly longer set times than formulations with lower L/P ratios, and yet the cement resulting from the formulations disclosed herein have comparable dissolution rates to those of formulations having a lower L/P. The present disclosure also relates to kits for making the bone graft substitute formulations and methods of treating bone defects with said formulations.

公开(公告)号：US20230147429A1

公开(公告)日：2023-05-11

申请号：US17915432

申请日：2020-03-30

申请人： SAGA UNIVERSITY ,  KYOCERA CORPORATION

发明人： Masaaki MAWATARI ,  Iwao NODA

IPC分类号： A61F2/36 ,  A61L27/32 ,  A61F2/30 ,  B05D3/12 ,  B05D5/02

CPC分类号： A61F2/3662 ,  A61F2/3094 ,  A61L27/32 ,  B05D3/12 ,  B05D5/02 ,  A61F2002/30321 ,  A61F2002/30324 ,  A61F2002/30326

摘要： In the present disclosure, an artificial joint stem includes a base and a coating film located on the base. The base includes a first region, a second region, and a third region located in sequence. The coating film contains a calcium phosphate-based material and an antimicrobial material. The coating film is located across the first region and the second region, and the third region is exposed from the coating film. The surface of the coating film located in the first region has a larger surface roughness than the surface of the base in the third region.

公开(公告)号：US20230032701A1

公开(公告)日：2023-02-02

申请号：US17784178

申请日：2020-12-09

申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

发明人： Harald HOLECZEK

IPC分类号： A61F2/28 ,  A61L27/54 ,  A61L27/30 ,  A61L27/32

摘要： An implant and/or an implant component is made available, having a main body which, at least on a surface, contains or consists of an electrically conductive material, and having a layer of calcium hydroxide applied to the electrically conductive material of the main body. The implant or the implant component is characterized in that the layer of calcium hydroxide contains calcium phosphate, specifically in a percentage by weight that is less than the percentage by weight of calcium hydroxide in this layer. A method for making available the implant according to the invention or the implant component according to the invention is also proposed. The implant made available and the implant component made available are characterized in that they have a local and temporary antimicrobial action, prevent formation of antibiotic-resistant microorganisms, act on bone substance in a manner that promotes growth, and produce no adverse side effects in the body.

公开(公告)号：US11497619B2

公开(公告)日：2022-11-15

申请号：US16535172

申请日：2019-08-08

申请人： DePuy Synthes Products, Inc.

发明人： Robert Flower ,  Christopher Warren ,  Fausto Olmos

IPC分类号： A61F2/44 ,  A61L27/32 ,  A61F2/30

摘要： An adjustable spinal fusion intervertebral implant including upper and lower body portions each having proximal and distal surfaces at proximal and distal ends thereof. The implant can include a proximal wedge member disposed at the proximal ends of the respective ones of the upper and lower body portions, and a distal wedge member disposed at the distal ends of the respective ones of the upper and lower body portions. First and second linkages can connect the upper and lower body portions. Rotation of an actuator shaft can cause the distal and proximal wedge members to be drawn together such that longitudinal movement of the distal wedge member against the distal surfaces and the longitudinal movement of the proximal wedge member against the proximal surfaces causes separation of the upper and lower body portions.