公开(公告)号：US20250058092A1

公开(公告)日：2025-02-20

申请号：US18935304

申请日：2024-11-01

Applicant: Caliber Therapeutics, LLC

Inventor： William R. Baumbach ,  Darren R. Sherman ,  Robert S. Burgermeister

IPC: A61M25/10 ,  A61K9/107 ,  A61K31/00 ,  A61K31/436 ,  A61L29/14 ,  A61L29/16

Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for stent deployment, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.

公开(公告)号：US20250032680A1

公开(公告)日：2025-01-30

申请号：US18551105

申请日：2022-03-21

Applicant: IONOMR INNOVATIONS, INC.

Inventor： Benjamin Britton ,  Heidi M. Britton ,  Bobak Gholamkhass ,  Timothy J. Peckham

IPC: A61L31/10 ,  A01N43/52 ,  A01P1/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/16

Abstract: The present disclosure features a method of inhibiting microorganisms on a surface, including applying to the surface a polymer including a repeating unit, the repeating unit including: a benzimidazolium-containing moiety; an imidazolium-containing moiety; or any combination thereof.

公开(公告)号：US12150449B2

公开(公告)日：2024-11-26

申请号：US17056183

申请日：2018-12-28

Applicant: FUNDACION COPEC UNIVERSIDAD CATOLICA ,  UNIVERSIDAD DE VALPARAISO

Inventor： Alejandro Dinamarca ,  Claudia Ibacache ,  Juan Ojeda ,  Natalia Romo

IPC: A61K36/00 ,  A01N25/10 ,  A01N25/12 ,  A01N63/20 ,  A61L29/00 ,  A61L29/16 ,  C12P7/6409

Abstract: The invention relates to a method for obtaining a bacterial extract produced by the bacteria Kocuria marina sp., which prevents biofilm formation, to said extract, and to the use thereof for incorporation into natural or synthetic polymers intended to form structures with active surfaces for preventing microbial biofilm formation, whether for biomedical uses, including clinical uses, industrial uses, or even domestic uses.

公开(公告)号：US20240247115A1

公开(公告)日：2024-07-25

申请号：US18415889

申请日：2024-01-18

Applicant: Becton, Dickinson and Company

Inventor： Leandro Forciniti

IPC: C08J5/18 ,  A61L29/08 ,  A61L29/16 ,  A61L33/00 ,  C08F299/00

CPC classification number: C08J5/18 ,  A61L29/085 ,  A61L29/16 ,  A61L33/0011 ,  A61L33/0094 ,  C08F299/00 ,  A61L2300/236 ,  A61L2300/42 ,  C08J2353/00

Abstract: Provided are conductive films including a heparin modified polymer. The heparin modified polymer comprises heparin covalently bound to a beta-substituted monomer having a conjugated backbone that is co-polymerized to its non-functionalized pair. The heparin modified polymer on a conductive film can be manufactured by co-polymerizing a beta-substituted monomer with a non-functionalized monomer to form a polymer on a conductive film. The polymer is reacted with N,N′-Dicyclohexylcarbodiimide (DCC) and acetic acid to form an anhydride of the polymer on the conductive film. The anhydride is then reacted with heparin to form the heparin modified polymer on the conductive film. Medical devices having a coating comprising the conductive film are also described.

公开(公告)号：US12022822B2

公开(公告)日：2024-07-02

申请号：US17179795

申请日：2021-02-19

Applicant: Oerlikon Surface Solutions AG, Pfaffikon

Inventor： Carmen Leonor Colmenares Mora ,  Arnd Mueller ,  Albert Peter Gerhard Janssen

IPC: A61L27/52 ,  A01N25/08 ,  A01N59/16 ,  A61L27/28 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16

CPC classification number: A01N25/08 ,  A01N59/16 ,  A61L27/28 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/608

Abstract: A medical product including an antibacterial hard material coating, which is applied to a main body and which includes biocide. The hard material coating includes at least one inner layer and one outer layer, wherein the biocide concentration in the outer layer is substantially constant and greater than the biocide concentration in the inner layer and the biocide concentration in the inner layer is greater than or equal to 0.2 at %.

公开(公告)号：US20240188983A1

公开(公告)日：2024-06-13

申请号：US18416199

申请日：2024-01-18

Applicant: Daniel Ezra Walzman

Inventor： Daniel Ezra Walzman

IPC: A61B17/3207 ,  A61B17/00 ,  A61B17/12 ,  A61B17/22 ,  A61B90/00 ,  A61F2/82 ,  A61F2/852 ,  A61F2/91 ,  A61L29/14 ,  A61L29/16 ,  A61L31/02 ,  A61L31/04 ,  A61L31/10 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61M25/00 ,  A61M25/10

CPC classification number: A61B17/320758 ,  A61B17/12031 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12172 ,  A61B17/12177 ,  A61B17/1219 ,  A61F2/852 ,  A61F2/91 ,  A61L29/145 ,  A61L31/022 ,  A61L31/04 ,  A61L31/10 ,  A61L31/125 ,  A61L31/14 ,  A61L31/145 ,  A61L31/146 ,  A61L31/16 ,  A61B2017/00477 ,  A61B2017/00867 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2017/00991 ,  A61B2017/1205 ,  A61B2017/1209 ,  A61B17/12122 ,  A61B17/22032 ,  A61B2017/320716 ,  A61B2090/3966 ,  A61B2217/005 ,  A61B2217/007 ,  A61F2002/823 ,  A61F2002/826 ,  A61F2220/0033 ,  A61F2250/0063 ,  A61L29/16 ,  A61L2430/06 ,  A61M2025/0057 ,  A61M25/10 ,  A61M2210/125

Abstract: An endovascular treatment mesh device for closing outpouchings by affixing at least one amorphous hydrogel layer expandable in vivo to any or all surfaces of an expandable body comprising at least one material adapted to close said outpouching in the body. The treatment mesh further includes a telescoping center-support bar disposed therein, the center-support bar having at least two telescoping elements that act as reinforcing extension elements to minimize the risk of collapse. Hydrogel is affixed to the surface of the telescoping elements to inhibit retraction. An embodiment wherein the treatment mesh device is a stent.

公开(公告)号：US12005159B2

公开(公告)日：2024-06-11

申请号：US17774440

申请日：2020-11-06

Applicant: CORNELL UNIVERSITY

Inventor： Nazanin Farokhnia ,  Alexandre Caprio ,  Varun Umesh Kashyap ,  Subhi Al' Aref ,  Bobak Mosadegh ,  James K. Min ,  Simon Dunham

IPC: A61B18/14 ,  A61L29/08 ,  A61L29/16 ,  A61B18/00

CPC classification number: A61L29/16 ,  A61L29/08 ,  A61B2018/0022

Abstract: Systems, methods, and devices having improved conformal properties for biomedical signal measurement are disclosed. A device can have a first polymer substrate coupled to a conductive layer forming a conductive trace electrically coupled to a conductive pad exposed via an opening. The device can have a second polymer substrate forming a first cavity between the first polymer substrate and the second polymer substrate. The device can have a first inlet portion that receives a fluid that expands the first cavity causing the device to conform to an anatomical structure. The structure can be an atrium, such as the left atrium, of the heart of a patient. The device can conform to the walls of the tissue structure, and the conductive pad exposed via the opening can detect a signal from the wall of the tissue structure. The signal can be provided to an external measurement device for processing.

公开(公告)号：US20240164989A1

公开(公告)日：2024-05-23

申请号：US18528125

申请日：2023-12-04

Applicant: Guill Tool & Engineering Co., Inc.

Inventor： Richard Guillemette ,  Robert Peters ,  Christopher Hummel

IPC: A61J3/00 ,  A61J3/06 ,  A61J3/07 ,  A61K9/00 ,  A61K9/20 ,  A61L27/50 ,  A61L27/54 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61J3/00 ,  A61J3/06 ,  A61J3/07 ,  A61K9/0092 ,  A61K9/2072 ,  A61L27/50 ,  A61L27/54 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61L2400/12 ,  A61L2400/18

Abstract: The present disclosure relates to medical devices containing time-release drug substance, and more particularly, to medical tubing, catheters, stents, cables (including fiber optic cables), pills, capsules, sheaths, threads, clamps, sutures, and endotracheal devices. The invention also generally relates to a method for extruding multiple laminated flow streams using microlayer coextrusion to create these various time-release drug delivery products.

公开(公告)号：US20240148943A1

公开(公告)日：2024-05-09

申请号：US18414450

申请日：2024-01-16

Applicant: BROSMED MEDICAL CO., LTD.

Inventor： Liwei Wang ,  Junyi Huang ,  Zhijun Zhang ,  Bin Li

IPC: A61L29/16 ,  A61L29/04 ,  A61L29/08

CPC classification number: A61L29/16 ,  A61L29/049 ,  A61L29/085 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2300/62 ,  A61L2420/02 ,  A61L2420/06

Abstract: A drug coated balloon includes a balloon body and a drug loaded coating layer. The drug loaded coating layer includes a first drug loaded coating component having at least two controllable sustained release drugs with different drug release kinetics, and a second drug loaded coating component including an active drug. The second drug loaded coating component is dispersed among the controllable sustained release drugs and couples the controllable sustained release drugs on the balloon body. The first and second drug loaded coating components are both non-hydrophilic compositions. The drug coated balloon provides sufficient initial drug loading dosage to the lesion site, and has adjustable drug release rate, thereby allowing the drug coated balloon to provide bioactive drugs to the treatment site at different stages of the cascade reaction of vascular restenosis, providing the controllable long-acting therapeutic drugs, and improving the overall vascular drug release efficacy.

公开(公告)号：US11969567B2

公开(公告)日：2024-04-30

申请号：US15354237

申请日：2016-11-17

Applicant: SPECTRANETICS LLC

Inventor： Blaine Schneider

IPC: A61M25/10 ,  A61L29/08 ,  A61L29/16 ,  A61B17/22 ,  A61B17/3207

CPC classification number: A61M25/104 ,  A61L29/085 ,  A61L29/16 ,  A61B2017/22061 ,  A61B17/320725 ,  A61L2300/22 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2400/12 ,  A61M25/1011 ,  A61M2025/105

Abstract: A method for treating a target vascular portion of a subject including: providing an angioplasty balloon system including a balloon carrying a first therapeutic agent and a second therapeutic agent on a surface of the balloon, wherein the first therapeutic agent is an anti-proliferative or anti-mitotic agent and the second therapeutic agent is a drug that aids in vascular healing on a surface of the balloon; positioning the balloon proximate the target vascular portion; expanding the balloon to engage the target vascular portion; thereby delivering at least a portion of the active agent to the target vascular portion; and withdrawing the balloon from the subject.