公开(公告)号：US12121644B2

公开(公告)日：2024-10-22

申请号：US17311874

申请日：2019-10-30

申请人： Gambro Lundia AB

发明人： Sture Hobro ,  Jonas Alson ,  Anders Nilsson ,  Innas Forsal

IPC分类号： A61M1/36 ,  A61M1/34

CPC分类号： A61M1/3672 ,  A61M1/3434 ,  A61M1/3437 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2230/20

摘要： A monitoring device operates to monitor regional citrate anticoagulation (RCA) in a blood treatment system which is configured to administrate citrate to an extracorporeal blood circuit (10) upstream of a dialyzer (11) during a treatment session. At consecutive time steps during the treatment session, the monitoring device obtains a current measurement value of systemic ionized calcium (iCaSYS) or systemic total calcium (CaSYS), operates a predefined algorithm on the current measurement value to generate a current computation value that represents ionized calcium (iCa2, iCa3) in blood at a selected location (loc2, loc3) downstream or upstream of the dialyzer (11) in the extracorporeal blood circuit (10), and presents and/or evaluates the current computation value for assessment of the regional citrate anticoagulation. The need for conventional blood sampling and blood analysis upstream and/or downstream of the dialyzer, e.g. during CRRT, is thereby reduced significantly.

公开(公告)号：US20240325616A1

公开(公告)日：2024-10-03

申请号：US18618801

申请日：2024-03-27

申请人： Fenwal, Inc.

发明人： Thomas Gniadek

IPC分类号： A61M1/34 ,  A61K31/194 ,  A61K35/14 ,  A61M1/36

CPC分类号： A61M1/3403 ,  A61K31/194 ,  A61K35/14 ,  A61M1/3401 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2205/3303 ,  A61M2205/3334

摘要： Methods and systems for performing an apheresis procedure with a reduced risk of citrate reaction occurrences are described. The volume of body water in the apheresis subject is used to predict the likelihood of a citrate reaction during infusion of a blood component to the subject and allows for establishing and maintaining an optimal flow rate of the infused blood component.

公开(公告)号：US12102746B2

公开(公告)日：2024-10-01

申请号：US17311058

申请日：2019-12-02

申请人： Nikkiso Company Limited

发明人： Hikaru Ito ,  Fumitoshi Henmi ,  Takayuki Suzuki ,  Masahiro Toyoda

IPC分类号： A61M1/36 ,  A61M1/34 ,  A61M39/10 ,  A61M39/20

CPC分类号： A61M1/367 ,  A61M1/3609 ,  A61M39/10 ,  A61M39/20 ,  A61M1/3413 ,  A61M2039/1072 ,  A61M2205/3331

摘要： A connection structure includes a chamber comprising a hollow housing, a diaphragm dividing the inside of the housing into a first space and a second space, and an output port outputting a gas in the second space with deformation of the diaphragm caused by pressure of a fluid flowing into the first space; a connection part comprising a coupling connected to the output port and being attached to a pressure detection device comprising a pressure sensor for detecting pressure of the gas output from the coupling; and a seal member being sandwiched between a side surface of the output port and a side surface of the coupling and moving while changing a sealing position when connecting or extracting the chamber to/from the connection part.

公开(公告)号：US20240316257A1

公开(公告)日：2024-09-26

申请号：US18025190

申请日：2023-03-07

申请人： YKRITA LIFESCIENCES POIVATE LIMITED

发明人： Dr. MAHESH GOPASETTY ,  PROF. JAGADEESH GOPALAN ,  Dr. AKSHAY DATEY

IPC分类号： A61M1/36 ,  A61M1/34 ,  A61M60/113 ,  A61M60/279 ,  A61M60/37 ,  A61M60/531

CPC分类号： A61M1/3689 ,  A61M1/3496 ,  A61M1/3638 ,  A61M1/3672 ,  A61M60/113 ,  A61M60/279 ,  A61M60/37 ,  A61M60/531 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3368

摘要： An EBDLR system includes a multi-layered bio purifier having a plurality of layers. Each layer includes a membrane, a first type of cells on a first side of the membrane in a first channel, and a second type of cells on a second side of the membrane in a second channel. The EBDLR includes a plasma separator to receive blood from a subject and separate a plasma component from the blood, a first reservoir to collect the plasma component, and a second pump to move the plasma component from the first reservoir to the multi-layered bio purifier. The multi-layered bio purifier distributes the plasma component into the first and second channels of each layer to purify the plasma component. The EBDLR includes a second reservoir to collect the purified plasma component and a third pump to infuse the purified plasma component from the second reservoir into the subject.

公开(公告)号：US20240285839A1

公开(公告)日：2024-08-29

申请号：US18653903

申请日：2024-05-02

申请人： Lyfspn, Inc.

发明人： Dobri Kiprov

IPC分类号： A61M1/34 ,  A61B5/00 ,  A61B5/11

CPC分类号： A61M1/3496 ,  A61B5/0022 ,  A61B5/1118 ,  A61B5/1122 ,  A61B5/1114

摘要： Described herein are compositions and methods for performing plasmapheresis. The compositions and methods for performing plasmapheresis are innovative at least in their application towards the treatment and prevention of aging and conditions associated with aging. Plasmapheresis compositions and methods described herein are directed towards reducing or eliminating conditions associated with aging.

公开(公告)号：US20240277911A1

公开(公告)日：2024-08-22

申请号：US18653906

申请日：2024-05-02

申请人： Lyfspn, Inc.

发明人： Dobri Kiprov

IPC分类号： A61M1/34 ,  A61K35/17 ,  A61M1/36 ,  A61M1/38 ,  A61P43/00 ,  G01N33/569

CPC分类号： A61M1/3496 ,  A61K35/17 ,  A61P43/00 ,  G01N33/56972 ,  A61M1/342 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/362 ,  A61M1/3693 ,  A61M1/38

摘要： Described herein are compositions and methods for performing plasmapheresis. The compositions and methods for performing plasmapheresis are innovative at least in their application towards the treatment and prevention of aging and conditions associated with aging. Plasmapheresis compositions and methods described herein are directed towards reducing or eliminating conditions associated with aging.

公开(公告)号：US20240269357A1

公开(公告)日：2024-08-15

申请号：US18020939

申请日：2020-08-27

申请人： SHANGHAI XINGUANG BIO-PHARMACEUTICAL LTD.

发明人： XIANGHAI LI

IPC分类号： A61M1/16 ,  A61M1/28 ,  A61M1/34 ,  A61M1/36 ,  B01D61/02 ,  B01D61/12 ,  B01D61/14 ,  B01D61/22 ,  B01D65/02

CPC分类号： A61M1/1601 ,  A61M1/1629 ,  A61M1/1635 ,  A61M1/1698 ,  A61M1/28 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3672 ,  B01D61/025 ,  B01D61/027 ,  B01D61/12 ,  B01D61/145 ,  B01D61/147 ,  B01D61/22 ,  B01D65/02 ,  A61M2205/18 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2206/16 ,  A61M2209/10 ,  B01D2315/10 ,  B01D2321/02

摘要： A fluid treatment method, a fluid treatment device, a cycle separation device, a cycle treatment system, a medical device, and a computer readable storage medium are provided. The fluid treatment method intercepts the target substance in the fluid, and cyclically enriches the target substance in the enrichment pipeline. In a cycle enrichment mode, the flow rate at the inlet is equal to that of the outlet in the enrichment pipeline so as to dynamically balance a total amount of the fluid in the enrichment pipeline. The present disclosure treats the fluid sustainably, collect particular components of the fluid, and a fluid discharged from the first outlet of the enrichment pipeline is introduced into the treatment module or is returned to an original system. The present disclosure effectively avoids continuous loss of beneficial components when filtering out harmful components in the process of component separation/exchange of the fluid through membrane separation.

公开(公告)号：US12059657B2

公开(公告)日：2024-08-13

申请号：US18143324

申请日：2023-05-04

申请人： GAMBRO LUNDIA AB

发明人： Markus Hornung ,  Bernd Krause ,  Markus Storr ,  Philipp Herbst ,  Arnd Wochner ,  Adriana Boschetti-De-Fierro ,  Manuel Voigt ,  Carina Zweigart ,  Joachim Loercher ,  Reinhold Buck ,  Heinrich Behr ,  Werner Beck

IPC分类号： A61M1/34 ,  B01D61/24 ,  B01D63/02 ,  B01D69/08 ,  B01D71/38 ,  B01D71/44 ,  B01D71/68

CPC分类号： B01D71/68 ,  A61M1/3479 ,  B01D61/243 ,  B01D63/0233 ,  B01D69/084 ,  B01D69/087 ,  B01D71/381 ,  B01D71/441 ,  B01D2323/06 ,  B01D2323/12 ,  B01D2325/022 ,  B01D2325/20

摘要： The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

公开(公告)号：US12048937B2

公开(公告)日：2024-07-30

申请号：US16607343

申请日：2018-05-11

申请人： SCINOGY PRODUCTS PTY LTD

发明人： Ian Fitzpatrick ,  David James ,  Stephen Wilson

IPC分类号： B04B5/06 ,  A61M1/02 ,  A61M1/26 ,  A61M1/30 ,  A61M1/34 ,  A61M1/36 ,  A61M39/10 ,  A61M39/12 ,  A61M39/22 ,  A61M39/28 ,  A61M60/10 ,  A61M60/104 ,  A61M60/109 ,  B04B1/06 ,  B04B5/04 ,  B04B5/12 ,  B04B7/00 ,  B04B9/02 ,  B04B11/04 ,  B04B13/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M3/04 ,  G01N33/49 ,  A61M39/02

CPC分类号： B04B5/06 ,  A61M1/0259 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/029 ,  A61M1/26 ,  A61M1/262 ,  A61M1/308 ,  A61M1/3496 ,  A61M1/3604 ,  A61M1/3606 ,  A61M1/3616 ,  A61M1/3621 ,  A61M1/3622 ,  A61M1/3693 ,  A61M1/3696 ,  A61M39/10 ,  A61M39/1011 ,  A61M39/105 ,  A61M39/12 ,  A61M39/22 ,  A61M39/28 ,  A61M60/104 ,  A61M60/109 ,  B04B1/06 ,  B04B5/04 ,  B04B5/0442 ,  B04B5/12 ,  B04B7/00 ,  B04B9/02 ,  B04B11/04 ,  B04B13/00 ,  B04B13/003 ,  C12M23/26 ,  C12M23/28 ,  C12M27/10 ,  C12M29/00 ,  C12M33/10 ,  C12M37/04 ,  C12M47/04 ,  G01N33/491 ,  A61M1/3603 ,  A61M2039/0276 ,  A61M2039/226 ,  B04B2005/0435 ,  B04B2005/0464 ,  B04B2005/0471 ,  B04B2005/0478 ,  B04B2005/0492

摘要： Provided is a chamber configuration for a reverse flow centrifuge, and a reverse flow centrifuge system configured for low fluid volume and small radius rotation. The compact reverse flow centrifuge system has a reusable subsystem and a single use replaceable subsystem. The replaceable subsystem comprises a separation chamber, fluid delivery manifold and rotational mounting connecting the separation chamber to the fluid manifold. The single use replaceable subsystem provides a closed environment for execution of reverse flow centrifugation processes. The separation chamber has a substantially conical fluid enclosure portion connected to a neck portion, and a dip tube extends centrally through the conical fluid enclosure to provide a fluid path to the tip of the conical fluid enclosure.

公开(公告)号：US12048794B2

公开(公告)日：2024-07-30

申请号：US15926222

申请日：2018-03-20

申请人： GRIFOLS WORLDWIDE OPERATIONS LIMITED

发明人： Carlos Roura Fernandez ,  Carlos Roura Salietti ,  Antonio Manuel Paez Regadera

IPC分类号： A61M1/34 ,  A61M1/16 ,  A61M1/30 ,  A61M1/36 ,  A61M5/168

CPC分类号： A61M1/3496 ,  A61M1/1603 ,  A61M1/1621 ,  A61M1/30 ,  A61M1/342 ,  A61M1/3672 ,  A61M5/16827 ,  A61M2202/0014 ,  A61M2202/0415 ,  A61M2205/3334

摘要： A device for therapeutic plasma exchange includes an extracorporeal circuit, which includes a blood supply line, a separating unit, a line for infusion of formed elements, a line for infusion of replacement fluid, a blood plasma line, an anticoagulant line and at least one independent line for therapeutic drugs. The independent line can include a storage for the therapeutic drug, a conveyer of therapeutic drug, a propelling device and a controller configured to control flow of the therapeutic drug.