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公开(公告)号：US20240360177A1
公开(公告)日：2024-10-31
申请号：US18687807
申请日：2022-09-01
发明人： Laurene Wang , David E. Pereira , Dale J. . Christensen , Kara S. Keedy , Gregory J. Pacofsky , Derek J. Nunez
摘要： The disclosure includes peptides of Formula (I): S1-[block-1]m-x-[block-2]n-y-[block-3]o-z-[block-4]p-S2. Also included are pharmaceutical compositions containing the peptides and methods of treating microbial infections using the peptides.
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公开(公告)号：US20240350445A1
公开(公告)日：2024-10-24
申请号：US18681326
申请日：2022-08-03
IPC分类号： A61K31/201 , A01N33/04 , A01N33/08 , A01N37/06 , A01N37/36 , A01P3/00 , A61K9/00 , A61K31/131 , A61K31/132 , A61K31/133 , A61K31/19 , A61P31/10
CPC分类号： A61K31/201 , A01N33/04 , A01N33/08 , A01N37/06 , A01N37/36 , A01P3/00 , A61K9/0014 , A61K31/131 , A61K31/132 , A61K31/133 , A61K31/19 , A61P31/10
摘要： The present invention provides anti-fungal compositions comprising at least one unsaturated fatty acid or a pharmaceutically acceptable salt thereof: at least one alpha-hydroxy acid or a pharmaceutically acceptable salt thereof; and at least one amino alcohol.
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公开(公告)号：US12115201B1
公开(公告)日：2024-10-15
申请号：US18384288
申请日：2023-10-26
摘要： Amaranthus hybridus silver nanoparticles can be synthesized by mixing an extract of Amaranthus hybridus with a silver nitrate solution to provide a mixture including Amaranthus hybridus silver nanoparticles. The Amaranthus hybridus silver nanoparticles can have an average particle size ranging from about 45 nm to about 100 nm. The AH-AgNPs can have antifungal properties and can be particularly effective agents against Madurella mycetomatis, for the treatment of eumycetoma.
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公开(公告)号：US12109176B1
公开(公告)日：2024-10-08
申请号：US18304192
申请日：2023-04-20
申请人： Thomas Bryan
发明人： Thomas Bryan
IPC分类号： A61K31/047 , A61K31/198 , A61K45/06 , A61P31/04 , A61P31/10 , C02F1/50
CPC分类号： A61K31/047 , A61K31/198 , A61K45/06 , A61P31/04 , A61P31/10 , C02F1/50 , C02F2303/04
摘要： A method of desensitizing microbes to pro-biofilm amino acids and amino acid derivatives in plasma comprising administering a sufficient amount of glycerol. A method of sensitizing microbes to anti-biofilm amino acids and amino acid derivatives in plasma comprising administering a sufficient amount of glycerol. Methods of increasing a plasma concentration of glycerol comprising administering a sufficient amount of glycerol. A method of treating an infection and/or contamination comprising applying glycerol and anti-biofilm amino acids and/or amino acid derivatives to a surface to be treated and/or water to be treated. A method of treating a biofilm producing viral infection comprising administering a sufficient, non-toxic concentration of glycerol. A method of treating a protozoal infection comprising administering a sufficient, non-toxic concentration of glycerol. A method of treating a hybrid infection comprising administering a sufficient, non-toxic concentration of glycerol and anti-biofilm amino acids and/or amino acid derivatives.
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公开(公告)号：US20240317791A1
公开(公告)日：2024-09-26
申请号：US18577782
申请日：2022-07-08
申请人： BIOSEUTICA B.V.
发明人： Valerio Maria Ferrari , Maria Carla Baggio , Mario Vigilante , Alessandro Calizzi , Tiberio Bruzzese , Paride Grisenti
CPC分类号： C07H17/08 , A61K9/0075 , A61K31/7048 , A61K45/06 , A61K47/26 , A61P31/10 , C07H1/06
摘要： The invention relates to a process for the production of amcipatricin diascorbate and the use of the same for an improved treatment of invasive fungal infections having proof/prevalence of resistance to traditional antifungal agents.
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6.发明授权公开(公告)号：US12090143B1
公开(公告)日：2024-09-17
申请号：US18436833
申请日：2024-02-08
发明人： Hany Mohamed Abd El-Lateef Ahmed , Mai Mostafa Khalaf Ali , Antar Ahmed Abdelhamid Ahmed , Amer A. Amer
IPC分类号： A61K31/4245 , A61P31/04 , A61P31/10 , C07D271/113
CPC分类号： A61K31/4245 , A61P31/04 , A61P31/10 , C07D271/113
摘要： A 4-chloro-N′-(2-(5-phenyl-1,3,4-oxadiazol-2-ylthio)acetoxy)benzimidamide compound, its synthesis, and its use as an antimicrobial agent.
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公开(公告)号：US12070477B2
公开(公告)日：2024-08-27
申请号：US17019677
申请日：2020-09-14
申请人： KoBioLabs, Inc.
发明人： Gwang Pyo Ko , Hyun Ju You , Bo Mi Kwon
IPC分类号： A61K35/747 , A23C9/123 , A23L2/52 , A23L33/00 , A23L33/135 , A61P15/02 , A61P31/04 , A61P31/10 , A61P31/20 , C12N1/20 , C12R1/225
CPC分类号： A61K35/747 , A23C9/1234 , A23L33/135 , A23L33/40 , A61P15/02 , A61P31/04 , A61P31/10 , A61P31/20 , C12N1/205 , A23L2/52 , A23V2002/00 , A23V2400/11 , A23V2400/143 , A23V2400/145 , A23V2400/149 , C12R2001/225
摘要： The present invention relates to a novel Lactobacillus sp. isolation strain having an activity to inhibit the growth of vaginitis pathogens, and a pharmaceutical composition, a health functional food, and a cleansing product, comprising the strain as an active ingredient. Therefore, the present invention exhibits an effect of inhibiting the growth of Sneathia spp. pathogens associated with the infection with human papillomavirus (HPV) and the incidence of bacterial vaginitis, Gardnerella vaginalis as a vaginitis pathogen, and Candida albicans as a causative yeast of Candidal vaginitis, and an effect of recovering and maintaining the vaginal microflora, and thus can be used for the prevention and treatment of female vaginitis.
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![9-(2-hydroxyquinoline-3-YL)-10-[3-(dimethylamino)propyl]-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione as an antimicrobial compound](/abs-image/US/2024/08/20/US12065425B1/abs.jpg.150x150.jpg)
公开(公告)号：US12065425B1
公开(公告)日：2024-08-20
申请号：US18435999
申请日：2024-02-07
IPC分类号： C07D401/04 , A61P31/04 , A61P31/10
CPC分类号： C07D401/04 , A61P31/04 , A61P31/10 , C07B2200/13
摘要： A 9-(2-hydroxyquinoline-3-yl)-10-[3-(dimethylamino)propyl]-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione compound, its synthesis, and its use as an antimicrobial agent.
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公开(公告)号：US12065424B1
公开(公告)日：2024-08-20
申请号：US18425923
申请日：2024-01-29
发明人： Hany Mohamed Abd El-Lateef Ahmed , Mai Mostafa Khalaf Ali , Antar Ahmed Abdelhamid Ahmed , Amer A. Amer
IPC分类号： C07D401/04 , A61P31/04 , A61P31/10
CPC分类号： C07D401/04 , A61P31/04 , A61P31/10
摘要： A 6′-(4-methoxyphenyl)-2′-alkoxy-3,4′-bipyridine-3′-carbonitrile compound, its synthesis, and its use as an antimicrobial agent.
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公开(公告)号：US20240269198A1
公开(公告)日：2024-08-15
申请号：US18031723
申请日：2021-10-13
申请人： DermBiont, Inc.
发明人： Robert BRUCKER , Yanjun HUANG , Nikola JOVANOVIC , Bhanu Prakash Chowdary SAKHAMURI , Ida LISTER , Xuecheng ZHANG , Sanjay JAIN , Emma Jean Mildred TAYLOR
IPC分类号： A61K35/742 , A61K9/00 , A61K9/19 , A61K35/00 , A61K35/741 , A61K47/26 , A61P31/04 , A61P31/10
CPC分类号： A61K35/742 , A61K9/0014 , A61K9/19 , A61K35/741 , A61K47/26 , A61P31/04 , A61P31/10 , A61K2035/115
摘要： Among other things, disclosed herein are compositions and methods for using human-isolated or synthetic Alcaligenes faecalis, Bacillus altitudinis, Bacillus pumilus, Bacillus subtilis, or Janthinobacterium lividum. Compositions may improve skin health. Methods may include applying human-isolated or synthetic Alcaligenes faecalis, Bacillus altitudinis, Bacillus pumilus, Bacillus subtilis, or Janthinobacterium lividum over a host or host area, such as skin or mucosa to minimize the presence of one or more pathogenic microbes, maximize therapeutic effects of one or more additional therapeutics, and/or improve health of a host or host area. A method to minimize a pathogenic microbe may include applying to a surface a composition including human-isolated or synthetic Alcaligenes faecalis, Bacillus altitudinis, Bacillus pumilus, Bacillus subtilis, or Janthinobacterium lividum and an acceptable carrier. Compositions and methods may include a prebiotic or another microbe to maximize growth and/or metabolites (e.g., resulting from growth of a probiotic). Compositions and methods may include human-isolated or synthetic Alcaligenes faecalis, Bacillus altitudinis, Bacillus pumilus, Bacillus subtilis, or Janthinobacterium lividum metabolites.
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