公开(公告)号：US12128120B2

公开(公告)日：2024-10-29

申请号：US18217568

申请日：2023-07-02

申请人： Next Science IP Holdings Pty Ltd

发明人： Matthew F. Myntti

IPC分类号： A61K8/49 ,  A01N25/02 ,  A01N25/08 ,  A01N25/30 ,  A01N37/36 ,  A01N41/04 ,  A01N59/00 ,  A01N59/26 ,  A01N61/00 ,  A61K8/19 ,  A61K8/34 ,  A61K8/365 ,  A61K8/37 ,  A61K8/39 ,  A61K8/41 ,  A61K8/44 ,  A61K8/46 ,  A61K8/55 ,  A61K8/60 ,  A61K8/86 ,  A61K9/00 ,  A61K9/06 ,  A61K31/14 ,  A61K31/19 ,  A61K31/194 ,  A61K33/00 ,  A61K33/02 ,  A61K33/04 ,  A61K33/20 ,  A61K33/24 ,  A61K33/32 ,  A61K33/42 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/34 ,  A61L26/00 ,  A61P17/02 ,  A61P31/04 ,  A61Q11/00 ,  A61Q17/00 ,  A61K9/08

CPC分类号： A61K8/498 ,  A01N25/02 ,  A01N25/08 ,  A01N25/30 ,  A01N37/36 ,  A01N41/04 ,  A01N59/00 ,  A01N59/26 ,  A01N61/00 ,  A61K8/19 ,  A61K8/34 ,  A61K8/347 ,  A61K8/365 ,  A61K8/37 ,  A61K8/39 ,  A61K8/41 ,  A61K8/416 ,  A61K8/44 ,  A61K8/463 ,  A61K8/466 ,  A61K8/4926 ,  A61K8/4973 ,  A61K8/55 ,  A61K8/602 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/0063 ,  A61K9/06 ,  A61K31/14 ,  A61K31/19 ,  A61K31/194 ,  A61K33/00 ,  A61K33/02 ,  A61K33/04 ,  A61K33/20 ,  A61K33/24 ,  A61K33/32 ,  A61K33/42 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/34 ,  A61L26/0066 ,  A61P17/02 ,  A61P31/04 ,  A61Q11/00 ,  A61Q17/005 ,  A61K9/08 ,  A61L2300/404 ,  A01N37/36 ,  A01N59/26 ,  A01N2300/00 ,  A01N25/02 ,  A01N25/30 ,  A01N59/00 ,  A01N61/00 ,  A01N25/08 ,  A01N25/30 ,  A01N59/00 ,  A01N61/00

摘要： An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. This composition, as well as an acidic counterpart and solid materials, can be used in a variety of applications such as wound care, oral care, medical equipment reprocessing, healthcare acquired infection and implant treatment.

公开(公告)号：US12128068B2

公开(公告)日：2024-10-29

申请号：US18214964

申请日：2023-06-27

申请人： The University of Melbourne

发明人： Eric Charles Reynolds

IPC分类号： A61K33/42 ,  A61K8/21 ,  A61K8/24 ,  A61K8/64 ,  A61K9/68 ,  A61K47/42 ,  A61Q11/00

CPC分类号： A61K33/42 ,  A61K8/21 ,  A61K8/24 ,  A61K8/64 ,  A61K9/0058 ,  A61K47/42 ,  A61Q11/00 ,  A61K2800/28 ,  A61K2800/592

摘要： The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.

公开(公告)号：US12121601B2

公开(公告)日：2024-10-22

申请号：US17614548

申请日：2021-02-04

申请人： SHANGHAI JIAO TONG UNIVERSITY

发明人： Guangyin Yuan ,  Wenjiang Ding ,  Yueling Li ,  Li Shen ,  Jianxiong Yuan

IPC分类号： A61K8/19 ,  A61K8/25 ,  A61K8/34 ,  A61K8/46 ,  A61K8/73 ,  A61K8/81 ,  A61K8/9789 ,  A61K33/06 ,  A61P1/02 ,  A61Q11/00

CPC分类号： A61K8/19 ,  A61K8/25 ,  A61K8/345 ,  A61K8/463 ,  A61K8/73 ,  A61K8/731 ,  A61K8/8176 ,  A61K8/9789 ,  A61K33/06 ,  A61P1/02 ,  A61Q11/00 ,  A61K2800/28 ,  A61K2800/412 ,  A61K2800/75

摘要： The-use of magnesium hydride in the preparation of a composition for preventing and treating chronic periodontitis, and a magnesium hydride toothpaste are provided. In the composition or the magnesium hydride toothpaste, magnesium hydride has a weight percentage of 1% to 3%. The toothpaste has the functions of disinfection, anti-inflammation, anti-oxidation, removing tooth stains, improving bad breath, alleviating gingival swelling, bleeding, and recession, and improving periodontitis symptoms. An appropriate amount of magnesium hydride fine particles is added in toothpaste, and the magnesium hydride particles can be hydrolyzed into hydrogen and magnesium ions with anti-inflammatory effects, which can also inhibit alveolar bone resorption. The magnesium hydride-containing composition is safe in use, and can effectively prevent the occurrence and development of periodontal diseases after long-term use.

公开(公告)号：US20240335361A1

公开(公告)日：2024-10-10

申请号：US18290873

申请日：2022-07-20

申请人： Firmenich SA

发明人： Nicholas IMPELLIZZERI ,  Huda JERRI

IPC分类号： A61K8/11 ,  A61K8/19 ,  A61K8/23 ,  A61K8/24 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q19/10 ,  B01J13/08 ,  B01J13/22 ,  C11D3/00 ,  C11D3/50

CPC分类号： A61K8/11 ,  A61K8/19 ,  A61K8/23 ,  A61K8/24 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q19/10 ,  B01J13/08 ,  B01J13/22 ,  C11D3/0015 ,  C11D3/505 ,  A61K2800/56

摘要： Described herein are microcapsules including a hydrophobic material-based core, preferably a perfume or a flavour, a shell and a mineral layer onto the shell. Also described herein is a process for the preparation of the microcapsules. Also described herein are perfuming compositions and consumer products including the microcapsules, in particular perfumed consumer products in the form of fine fragrance, home care or personal care products.

公开(公告)号：US12109284B2

公开(公告)日：2024-10-08

申请号：US16347948

申请日：2017-11-07

申请人： DENTHERAPY LTD

发明人： David Andrew Smillie ,  Richard James Willson

IPC分类号： A61K8/24 ,  A61K8/19 ,  A61K8/64 ,  A61Q11/00

CPC分类号： A61K8/24 ,  A61K8/19 ,  A61K8/64 ,  A61Q11/00 ,  A61K2800/52 ,  A61K2800/805 ,  A61K2800/92

摘要： The present invention relates to methods for preparing compositions comprising calcium and fluoride, and, in particular, to methods for preparing compositions comprising calcium that is stabilised with a stabilising agent and fluoride. For example, the method is for the preparation of compositions comprising amorphous calcium phosphate stabilised by phosphopeptides, and free fluoride. The invention also extends to various compositions produced by such methods, including oral care products.

公开(公告)号：US20240325275A1

公开(公告)日：2024-10-03

申请号：US18579107

申请日：2022-07-11

申请人： DENTHERAPY LTD

发明人： Richard WILLSON

IPC分类号： A61K8/64 ,  A61K8/19 ,  A61Q11/00

CPC分类号： A61K8/64 ,  A61K8/19 ,  A61Q11/00

摘要： The present invention relates to compositions for use in oral care and various methods of their use. In particular, it relates to compositions comprising phosphoproteins and their use in the treatment and prevention of dentine hypersensitivity and the treatment and prevention of xerostomia. Preferred compositions comprise osteopontin and derivatives thereof.

公开(公告)号：US20240325263A1

公开(公告)日：2024-10-03

申请号：US18613863

申请日：2024-03-22

申请人： CORNING INCORPORATED

发明人： Qiang Fu ,  Charisse Marye Spier ,  Nicholas Michael Stone-Weiss

IPC分类号： A61K8/25 ,  A61K8/19 ,  A61K8/21 ,  A61K8/28 ,  A61Q11/00

CPC分类号： A61K8/25 ,  A61K8/19 ,  A61K8/21 ,  A61K8/28 ,  A61Q11/00 ,  A61K2800/28 ,  A61K2800/30

摘要： Glass compositions comprising 15-50 wt. % SiO2, 25-60 wt. % CaO, 3-30 wt. % P2O5, 0.5-15 wt. % ZrO2, and >0-5 wt. % F, wherein, when subjected to artificial saliva, the glass composition forms a bioactive crystalline phase, such as apatite. A matrix comprising the glass composition, wherein the glass composition is attached to the matrix or mixed therein, in which the matrix includes at least one of: a toothpaste, mouthwash, gel, varnish, rinse, spray, ointment, salve, cream, bandage, polymer film, oral formulation, pill, capsule, or transdermal formulation. The matrix may be a dentifrice composition. A method comprising applying the matrix to a tooth, in which the method remineralizes enamel of the tooth, treats caries of the tooth, treats dentin hypersensitivity of the tooth, or any combination thereof.

公开(公告)号：US20240325262A1

公开(公告)日：2024-10-03

申请号：US18613825

申请日：2024-03-22

申请人： CORNING INCORPORATED

发明人： Qiang Fu

IPC分类号： A61K8/21 ,  A61K8/19 ,  A61K8/24 ,  A61K8/25 ,  A61K8/28 ,  A61Q11/00 ,  C03B32/02 ,  C03C4/00 ,  C03C10/16

CPC分类号： A61K8/21 ,  A61K8/19 ,  A61K8/24 ,  A61K8/25 ,  A61K8/28 ,  A61Q11/00 ,  C03B32/02 ,  C03C4/0021 ,  C03C10/16 ,  C03C2204/00

摘要： A glass composition and method of making, the glass composition comprising 15-45 wt. % SiO2, 10-30 wt. % P2O5, 30-60 wt. % CaO, 0.5-15 wt. % ZrO2, and 0.1-10 wt. % F. In some aspects, the glass composition comprises a glass-ceramic comprising a fluorapatite crystal phase. A matrix comprising the glass composition, in which the matrix is a dentifrice composition in some aspects. A method for applying the matrix to a tooth, in which the method remineralizes enamel of a tooth, treats caries of a tooth, treats dentin hypersensitivity of the tooth. A method of making the matrix comprising combining a carrier with the glass composition.

公开(公告)号：US12102708B2

公开(公告)日：2024-10-01

申请号：US18600658

申请日：2024-03-09

申请人： Imam Abdulrahman Bin Faisal University

发明人： Abdul Samad Khan

IPC分类号： A61K8/9789 ,  A61K8/25 ,  A61K8/27 ,  A61K8/29 ,  A61K8/34 ,  A61K8/368 ,  A61K8/46 ,  A61K8/73 ,  A61Q11/00

CPC分类号： A61K8/9789 ,  A61K8/25 ,  A61K8/27 ,  A61K8/29 ,  A61K8/345 ,  A61K8/368 ,  A61K8/463 ,  A61K8/731 ,  A61Q11/00 ,  A61K2800/28 ,  A61K2800/48 ,  A61K2800/524

摘要： A tooth paste composition comprising black cumin oil (Nigella sativa) and fluoride-doped bioactive glass, zinc oxide, and/or titanium oxide is disclosed.

公开(公告)号：US12102701B2

公开(公告)日：2024-10-01

申请号：US17435314

申请日：2020-02-27

申请人： CURASEPT A.D.S. S.R.L.

发明人： Lorenzo Emiliano Boiocchi

IPC分类号： A61K8/43 ,  A61K8/23 ,  A61K8/60 ,  A61K8/67 ,  A61K8/81 ,  A61Q11/00

CPC分类号： A61K8/43 ,  A61K8/23 ,  A61K8/606 ,  A61K8/676 ,  A61K8/8182 ,  A61Q11/00

摘要： The present invention relates to an oral care product, such as a mouthwash, periodontal gel or a toothpaste comprising chlorhexidine and sodium DNA. Said oral care product presents an antibacterial effect effective against gingivitis, bacterial plaque and periodontitis combined with a healing and anti-inflammatory activity and which, moreover, counteracts the oxidative stress so as to limit the onset and the progression of irritations of the oral mucosae and promote their trophism.