公开(公告)号：US11530404B2

公开(公告)日：2022-12-20

申请号：US16306563

申请日：2017-05-25

Applicant: Northwestern University

Inventor： Omar K. Farha ,  Peng Li ,  Justin A. Modica ,  Milan Mrksich ,  Joseph T. Hupp

IPC: C12N11/02 ,  C12N11/14 ,  C12P9/00 ,  A62D3/02 ,  C12N9/16 ,  C12N9/18 ,  A62D101/02 ,  A62D101/26

Abstract: Enzyme-immobilizing MOFs and methods for their use in enzymatically catalyzed reactions are provided. The MOFs are channel-type MOFs that present a hierarchical pore structure comprising a first set of large channels sized for enzyme immobilization and a second set of smaller channels running alongside of the large channels that remain enzyme-free and allow for reactant delivery to the enzymes and product expulsion from the larger channels.

公开(公告)号：US11008554B2

公开(公告)日：2021-05-18

申请号：US16274304

申请日：2019-02-13

Applicant: PlantVax, Inc.

Inventor： Yvonne J. Rosenberg

IPC: C12N15/82 ,  C12N9/18 ,  C07K7/08 ,  A61K38/46 ,  A61K47/36 ,  A62D3/02 ,  C12Q1/46 ,  A61K38/00 ,  A62D101/02 ,  A62D101/26

Abstract: Disclosed herein are methods for the large-scale production of a highly thermally stable acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Additionally, the expression methods disclosed herein can produce ChE preparations consisting of extract or purified forms that can be produced in high amounts and are highly thermally stable. These ChE products can be used in vitro detection, detoxification and decontamination methods.

公开(公告)号：US10421952B1

公开(公告)日：2019-09-24

申请号：US15883331

申请日：2018-01-30

Applicant: U.S. Army Edgewood Chemical Biological Center

Inventor： Steven P Harvey ,  Mark A Guelta

IPC: C12N9/16 ,  A62D3/02 ,  A61K38/00 ,  A62D101/26 ,  A62D101/02

Abstract: The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolases (OPPAs) having three or more site mutations, methods of production, kits and methods of use to effectively degrade toxic V-agent type chemical compounds such as VX, VR, CVX, and VM.

公开(公告)号：US10369396B1

公开(公告)日：2019-08-06

申请号：US16186059

申请日：2018-11-09

Applicant: Battelle Memorial Institute

Inventor： Erik W. Edwards ,  Steven Risser ,  Jeffrey Boyce

IPC: A62D3/30 ,  B65D81/32 ,  A62D101/26 ,  A62D101/02

Abstract: An assembly containing a shelf-stable formulation for decontaminating skin exposed to toxic compounds located in a package formed with water and potassium bicarbonate in a first chamber; and a sponge, diacetylmonoxime (DAM), and polyethylene glycol (PEG) located in a second chamber. The package includes a barrier between the first chamber and the second chamber, with the barrier being configured to be rapidly removed when needed to enable the water and potassium bicarbonate to enter the second chamber. The package is made by placing the water and potassium bicarbonate in the first chamber of a package; mixing the DAM with PEG to form a DAM:PEG mixture; infusing the sponge with the DAM:PEG mixture to distribute DAM within the sponge; and placing the sponge, DAM and PEG in a second chamber of the package. Infusing the sponge includes solubilizing the DAM:PEG mixture in ethanol or another low boiling point solvent to form an ethanol-DAM-PEG solution and applying the ethanol-DAM-PEG solution evenly to the sponge. The ethanol is removed by applying heat and/or vacuum to the sponge.

公开(公告)号：US10335465B1

公开(公告)日：2019-07-02

申请号：US15880747

申请日：2018-01-26

Applicant: U.S. Army Edgewood Chemical Biological Center

Inventor： Steven P Harvey ,  Melissa M Dixon ,  Mark A Guelta ,  Leslie R McMahon

IPC: C12N9/16 ,  A61K38/16 ,  A62D7/00 ,  A61K38/46 ,  A62D3/02 ,  A62D101/26 ,  A62D101/02

Abstract: The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2,2′-dimethylcyclopentyl methylphosphonofluoridate).

公开(公告)号：US20180346892A1

公开(公告)日：2018-12-06

申请号：US16057501

申请日：2018-08-07

Applicant: Novozymes A/S

Inventor： Bjarne Gram Hansen ,  Steffen Danielsen ,  Lars Kobberosee Skov ,  Leonardo De Maria ,  Julie Bille Rannes

IPC: C12N9/16 ,  A62D3/30 ,  A62D3/02 ,  A62D101/02 ,  A62D101/26 ,  A62D101/04

CPC classification number: C12N9/16 ,  A62D3/02 ,  A62D3/30 ,  A62D2101/02 ,  A62D2101/04 ,  A62D2101/26 ,  C12Y301/08002

Abstract: The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

公开(公告)号：US09925520B1

公开(公告)日：2018-03-27

申请号：US15711195

申请日：2017-09-21

Applicant: U.S. Army Edgewood Chemical Biological Center

Inventor： Jennifer R Soliz ,  Christopher J Karwacki

IPC: A62D3/33 ,  B01J20/28 ,  G01N27/72 ,  B01J20/06 ,  C01G49/00 ,  G01N21/33 ,  G01N21/65 ,  G01N21/35 ,  B01D53/04 ,  A62D101/02

CPC classification number: B01J20/28009 ,  A62D3/33 ,  A62D2101/02 ,  A62D2101/26 ,  A62D2101/28 ,  A62D2101/45 ,  A62D2101/47 ,  B01D53/02 ,  B01D53/04 ,  B01D53/30 ,  B01D53/72 ,  B01D53/82 ,  B01D2253/112 ,  B01D2253/1124 ,  B01D2253/1128 ,  B01D2253/30 ,  B01D2255/2073 ,  B01D2255/20738 ,  B01D2255/20746 ,  B01D2255/20753 ,  B01D2255/20761 ,  B01D2257/204 ,  B01D2257/2045 ,  B01D2257/2064 ,  B01D2257/2066 ,  B01D2257/302 ,  B01D2257/304 ,  B01D2257/306 ,  B01D2257/40 ,  B01D2257/406 ,  B01D2257/556 ,  B01D2257/70 ,  B01D2257/93 ,  B01D2259/4583 ,  B01J20/06 ,  C01G49/0054 ,  C01P2002/82 ,  C01P2006/42 ,  G01N21/75 ,  G01N27/021 ,  G01N27/125 ,  G01N27/72 ,  Y02P20/154

Abstract: A method and composition of matter for detecting and decontaminating hazardous chemicals, the composition of matter including: a magnetic material for any of chemisorbing, molecularly dissociating, or decomposing a hazardous chemical, wherein the magnetic material changes its magnetic moment upon any of chemisorption, decomposition, and molecular dissociation of the hazardous chemical and the change in magnetic moment is used to detect the presence of the hazardous chemical, and wherein the hazardous chemical includes any of toxic industrial chemicals, chemical warfare agents, and chemical warfare agent related compounds.

公开(公告)号：US09610468B2

公开(公告)日：2017-04-04

申请号：US14178949

申请日：2014-02-12

Applicant: General Sciences, Incorporated

Inventor： Peter Zavitsanos ,  Anthony Rozanski ,  Charles Files ,  Noah Stotz

IPC: C06B33/00 ,  C06B33/12 ,  D03D23/00 ,  D03D43/00 ,  A62D3/38 ,  F42D1/04 ,  C06B33/06 ,  C06B33/02 ,  C06B45/00 ,  C06B21/00 ,  A62D3/40 ,  A62D101/02

CPC classification number: A62D3/38 ,  A62D3/40 ,  A62D2101/02 ,  C06B21/0091 ,  C06B33/00 ,  C06B33/02 ,  C06B33/06 ,  C06B33/12 ,  C06B45/00 ,  F42D1/04

Abstract: Compositions, devices, and methods for destroying chemical warfare agents, independent of their chemical make-up, include (i) at least one reactive metal; (ii) at least one oxidizer; and (iii) a binder. In one embodiment, the self-sustaining reactive composition includes magnesium powder, iron oxide powder, potassium perchlorate powder, and silicone gel. In another embodiment, the self-sustaining reactive composition includes manganese powder, lithium perchlorate powder, lithium peroxide powder, and silicone gel. The reactive metal(s), oxidizer(s), binder, and their respective amounts, are selected such that, following ignition of the composition, the composition is capable of producing a solid mass of ash (wicking composition) that increases the surface area of the chemical agent material and provides a site for combustion and/or thermal degradation of the chemical agent to occur.

公开(公告)号：US09592414B1

公开(公告)日：2017-03-14

申请号：US14465358

申请日：2014-08-21

Applicant: U.S. Army Edgewood Chemical and Biological Command

Inventor： Timothy A. Blades ,  Raymond A. DiBerardo ,  Adam P. Baker ,  Jeffery A. Gonce ,  Jason J. Adamek ,  Brian J. O'Donnell ,  David J. Kline

IPC: A62D3/35 ,  B01J19/24 ,  A62D101/02

CPC classification number: A62D3/35 ,  A62D2101/02 ,  B01J2219/0002 ,  B01J2219/00022

Abstract: A transportable and modular field-deployable hydrolysis system for neutralizing toxic chemical agents is described. The system comprises a transportable chemical process plant that is capable of operating in a remote location without significant site infrastructure. The system is also capable of operating in a maritime, shipboard environment. A flexible design allows processing of chemical agents in both batch and continuous flow modes, as well as collection and accumulation of agents from a variety of containers whose form and size may not be known until the system is on-site.

Abstract translation: 描述了用于中和有毒化学试剂的可运输和模块化现场可部署水解系统。 该系统包括一个可运输的化学工艺设备，能够在远程位置运行而无需重要的现场基础设施。 该系统还能够在海运，船上环境中运行。 灵活的设计允许以批量和连续流动模式处理化学试剂，以及来自各种容器的试剂的收集和积累，其形式和尺寸在系统现场之前可能是未知的。

公开(公告)号：US09512413B2

公开(公告)日：2016-12-06

申请号：US14403949

申请日：2013-05-31

Applicant: NOVOZYMES A/S

Inventor： Bjarne Gram Hansen ,  Steffen Danielsen ,  Lars Kobberoee Skov ,  Leonardo De Maria ,  Julie Bille Rannes

IPC: C12P7/02 ,  A62D3/02 ,  C12N9/16 ,  A62D3/30 ,  A62D101/02

CPC classification number: C12N9/16 ,  A62D3/02 ,  A62D3/30 ,  A62D2101/02 ,  A62D2101/04 ,  A62D2101/26 ,  C12Y301/08002

Abstract: The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

Abstract translation: 本发明涉及具有有机磷水解酶活性的分离的多肽和编码多肽的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。