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157 条记录 (耗时 0.022 秒)

    Pancake spectrometer
    1.
    发明申请
    Pancake spectrometer 有权
    煎饼光谱仪

    公开(公告)号：US20040232325A1

    公开(公告)日：2004-11-25

    申请号：US10824674

    申请日：2004-04-14

    申请人： Sionex Corporation

    发明人： Raanan A. Miller ,  Mark C. Terrell

    IPC分类号： B01D059/44

    CPC分类号： G01N27/624 ,  H01J49/42

    摘要： Method and apparatus for identification of chemical compounds in a sample based on differences in ion mobility, wherein the filter and detector electrodes are formed radially spaced on facing substrates.

    摘要翻译： 基于离子迁移率的差异来鉴定样品中的化合物的方法和装置，其中过滤器和检测器电极在面对的衬底上径向间隔地形成。

    Mass analyzing method using an ion trap type mass spectrometer
    2.
    发明申请
    Mass analyzing method using an ion trap type mass spectrometer 有权
    使用离子阱型质谱仪的质谱分析方法

    公开(公告)号：US20040159785A1

    公开(公告)日：2004-08-19

    申请号：US10780634

    申请日：2004-02-19

    发明人： Yoshiaki Kato

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/424 ,  H01J49/427 ,  H01J49/429

    摘要： An object of the present invention is to provide a method of discriminating singly-charged ions from multiply-charged ions by the use of an ion trap type mass spectrometer which is an inexpensive mass spectrometer. This object is achieved by a mass-analyzing method using an ion trap type mass spectrometer which is equipped with a ring electrode and one pair of end cap electrodes and temporarily traps ions in a three-dimensional quadrupole field to mass-analyze a sample, comprising a first step of applying a main high frequency voltage to said ring electrode to form a three-dimensional quadrupole field, a second step of generating ions in said mass analyzing unit or injecting ions from the outside and trapping ions of a predetermined mass-to-charge ratio range in said mass analyzing unit, a third step of applying a supplementary AC voltage having a plurality of frequency components between said end cap electrodes and scanning the frequency components of said supplementary AC voltage, and a fourth step of scanning said main high frequency voltage and ejecting ions from said mass analyzing unit and detecting thereof. With this, chemical noises can be reduced dramatically.

    摘要翻译： 本发明的目的是提供一种通过使用廉价的质谱仪的离子阱型质谱仪来区分来自多电荷离子的单电荷离子的方法。 该目的通过使用离子阱型质谱仪的质量分析方法来实现，该离子阱型质谱仪装备有环形电极和一对端盖电极，并在三维四极场中临时捕获离子以质量分析样品，包括 将主高频电压施加到所述环形电极以形成三维四极场的第一步骤;在所述质量分析单元中产生离子或从外部注入离子并捕获预定质量 - 所述质量分析单元中的充电比范围，第三步骤，在所述端盖电极之间施加具有多个频率分量的辅助AC电压，并扫描所述辅助AC电压的频率分量，以及第四步骤，扫描所述主高频 电压并从所述质量分析单元喷射离子并进行检测。 因此，化学噪声可以大大降低。

    Laser desorption ionization mass spectrometric method and sample plate used in such a method
    3.
    发明申请
    Laser desorption ionization mass spectrometric method and sample plate used in such a method 有权
    激光解吸电离质谱法和样品板用于这种方法

    公开(公告)号：US20040094708A1

    公开(公告)日：2004-05-20

    申请号：US10699821

    申请日：2003-11-04

    发明人： Masaru Furuta

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/0031 ,  G01N27/44717 ,  H01J49/0418

    摘要： The present invention relates to a sample plate that is preferably constituted by a metal plate on which a membrane is affixed by a conductive double-sided tape. In the case where a sample, developed on a medium such as an electrophoresis gel, is transferred onto the membrane, in the same manner as a conventional blotting operation, a medium such as gel and the sample plate are sandwiched between flat plate electrodes so that the medium and the membrane are made in closely contact with each other, and a voltage is applied between both of the electrodes. Thus, the sample developed on the medium is transferred on the membrane through electrophoresis. Upon laser desorption ionization mass spectrometry, the sample plate is compatibly used as a plate for mass spectrometry.

    摘要翻译： 本发明涉及一种样品板，其优选由金属板构成，其上通过导电双面胶带粘贴膜。 在将诸如电泳凝胶的介质上显影的样品转移到膜上的情况下，以与常规的印迹操作相同的方式，将诸如凝胶和样品板的介质夹在平板电极之间，使得 使介质和膜彼此紧密接触，并且在两个电极之间施加电压。 因此，在培养基上显影的样品通过电泳转移到膜上。 在激光解吸电离质谱法中，样品板兼容地用作质谱板。

    Method and device for detecting and identifying bio-aerosol particles in the air
    6.
    发明申请
    Method and device for detecting and identifying bio-aerosol particles in the air 有权
    用于检测和识别空气中的生物气溶胶颗粒的方法和装置

    公开(公告)号：US20040075049A1

    公开(公告)日：2004-04-22

    申请号：US10450638

    申请日：2003-12-10

    发明人： Michael Anthony Stowers ,  Arjan Laurens Wuijckhuijse ,  Johannes Cornelis Maria Marijnissen ,  Charles Eliza Kientz

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/164 ,  G01N15/14 ,  H01J49/0445 ,  H01J49/40

    摘要： In a method for detecting and identifying bioaerosol particles in the air, the bioaerosol particles in a particle stream are selected in an ATOFMS (aerosol time-of-flight mass spectrometer) by means of fluorescence techniques, and only the selected bioaerosol particles are ionized, for instance on the basis of MALDI (matrix-assisted laser desorption/ionization), after which the resulting ions are detected and the bioaerosol particles are identified.The selection of bioaerosol particles takes place by means of laser radiation, generated by a first laser device, of a wavelength which in specifice substances in bioaerosol particles effects a fluorescence, after which by means of a fluorescence detector the bioaerosol particles are selected and a second laser device is triggered to emit light of a wavelength which effects the ionization of the bioaerosol particles selected only by the fluorescence detector.

    摘要翻译： 在用于检测和鉴定空气中的生物气溶胶颗粒的方法中，通过荧光技术在ATOFMS（气溶胶飞行时间质谱仪）中选择颗粒物流中的生物气溶胶颗粒，并且仅选择的生物气溶胶颗粒被电离， 例如基于MALDI（基质辅助激光解吸/电离），之后检测所得到的离子并识别生物溶胶颗粒。生物溶胶颗粒的选择通过由第一激光装置产生的激光辐射 ，其中生物气溶胶颗粒中的物质中的物质影响荧光，之后通过荧光检测器选择生物气溶胶颗粒，并且第二激光装置被触发以发射使所选择的生物气溶胶颗粒电离的波长的光 只有通过荧光检测器。

    Mass spectrometer
    7.
    发明申请
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US20040065824A1

    公开(公告)日：2004-04-08

    申请号：US10636811

    申请日：2003-08-08

    发明人： Robert Harold Bateman ,  Jeff Brown

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/42 ,  H01J49/004

    摘要： A mass spectrometer is disclosed comprising at least first and second ion traps which are arranged in series. A relatively high AC or RF voltage is applied to the electrodes forming the first ion trap in order to improve the trapping of energetic or high mass to charge ratio ions. The relatively high AC or RF voltage applied to the first ion trap also has the effect of raising the low mass cut-off of the first ion trap. The second ion trap, arranged downstream of the first ion trap, is arranged to have a lower low mass cut-off than the first ion trap, and hence ions which are not trapped in the first ion trap are trapped in the second ion trap.

    摘要翻译： 公开了一种质谱仪，其包括串联布置的至少第一和第二离子阱。 对形成第一离子阱的电极施加相对较高的AC或RF电压，以改善高能或高质量与电荷比离子的捕获。 施加到第一离子阱的相对较高的AC或RF电压也具有提高第一离子阱的低质量截止的效果。 布置在第一离子阱的下游的第二离子阱被布置成具有比第一离子阱低的低质量截止值，因此未被捕获在第一离子阱中的离子被捕获在第二离子阱中。

    Mass spectrometer with improved mass accuracy
    8.
    发明申请
    Mass spectrometer with improved mass accuracy 审中-公开
    质谱质量提高，质量精度提高

    公开(公告)号：US20040031918A1

    公开(公告)日：2004-02-19

    申请号：US10453908

    申请日：2003-06-02

    发明人： Alan E. Schoen ,  Rexford T. Heller ,  Hans Schweingruber

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/0009 ,  H01J49/28 ,  H01J49/4205 ,  H05K1/0212 ,  H05K1/167

    摘要： Mass spectrometers, and methods and apparatus, including computer program products, for operating the same, implement techniques for measuring mass of one or more analyte ions with high mass accuracy. The techniques include a calibration procedure that includes multiple calibration steps to account for system non-linearities. Components of a control system can be disposed in a thermally-controlled environment on a printed circuit board.

    摘要翻译： 质谱仪，以及用于其操作的计算机程序产品的方法和装置，实现用于以高质量精度测量一种或多种分析物离子的质量的技术。 这些技术包括校准过程，其包括多个校准步骤以解决系统非线性。 控制系统的组件可以布置在印刷电路板上的热控环境中。

    Mass spectrometer
    9.
    发明申请
    Mass spectrometer 有权

    公开(公告)号：US20040021070A1

    公开(公告)日：2004-02-05

    申请号：US10439225

    申请日：2003-05-16

    申请人： Micromass UK Limited

    发明人： Robert Harold Bateman ,  John Brian Hoyes ,  Jason Lee Wildgoose

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/421 ,  H01J49/0081

    摘要： A mass spectrometer includes an ion detector positioned upstream of a quadrupole mass filter/analyser. Ions are passed through the quadrupole mass filter/analyser, stored in an ion trap and then passed back through the same mass filter/analyser before being detected by the upstream ion detector. With this arrangement, MS/MS experiments can be performed using an apparatus having only a single mass filter/analyser.

    High resolution detection for time-of-flight mass
    10.
    发明申请
    High resolution detection for time-of-flight mass 有权
    飞行时间质量的高分辨率检测

    公开(公告)号：US20030218129A1

    公开(公告)日：2003-11-27

    申请号：US10366578

    申请日：2003-02-13

    申请人： Bruker Daltonik GMBH

    发明人： Oliver Rather

    IPC分类号： H01J049/00 ,  B01D059/44

    CPC分类号： H01J49/025 ,  H01J49/40

    摘要： The invention covers a method for detecting ions in high resolution time-of-flight mass spectrometers which operate with secondary electron multiplier multichannel plates and in which many single spectra are acquired and added to produce a sum spectrum. The invention involves (a) using an analog digital converter (ADC) for converting electron currents from secondary electron multipliers, instead of a time-to-digital converter (TDC) which was previously used for highest possible signal resolution, (b) performing a separate rapid peak recognition procedure for the ion signals of each spectrum by a fast calculation method, thereby collecting flight time and intensity value pairs for the ion peaks, and (c) constructing a time-of-flight/intensity histogram, which is further processed as a composite time-of-flight spectrum. The invention retains the significantly higher measurement dynamics of an ADC and achieves the improved resolution capability of a TDC, but without showing the latter's known signal distortion due to dead times.

    摘要翻译： 本发明涉及用二次电子倍增器多通道板操作的高分辨率飞行时间质谱仪中的离子检测方法，其中获得并添加许多单个光谱以产生和光谱。 本发明涉及（a）使用用于转换来自二次电子倍增器的电子电流的模拟数字转换器（ADC）而不是先前用于最高可能信号分辨率的时间 - 数字转换器（TDC），（b）执行 通过快速计算方法对每个光谱的离子信号进行单独的快速峰识别程序，从而收集离子峰的飞行时间和强度值对，（c）构建飞行时间/强度直方图，进一步处理 作为复合飞行时间谱。 本发明保留了ADC的显着更高的测量动态，并且实现了TDC的改进的分辨率能力，但是没有显示后者由于死时间而已知的信号失真。