公开(公告)号：US20020017489A1

公开(公告)日：2002-02-14

申请号：US09977711

申请日：2001-10-15

发明人： David S. Utterberg

IPC分类号： B01D061/30

CPC分类号： A61M1/3643 ,  A61M1/16 ,  A61M1/3627 ,  A61M1/3639 ,  A61M1/3644 ,  A61M1/3647 ,  A61M2205/125

摘要： A blood processing system such as a dialysis system may be primed by passing priming solution in a first direction of flow through at least one of the sets, to cause the priming solution to enter an in-line chamber carried by the one set in a flow direction that is retrograde to the normal direction of blood flow through the chamber. Preferably, the in-line chamber carries a filter. Simultaneously, one removes air from the one set through a port. In another, preferably simultaneous step of the process, one passes priming solution in the second, reverse direction of flow to the first direction, through the connected sets for continuing to remove air from the system through the port, to complete priming of the system.

摘要翻译： 血液处理系统例如透析系统可以通过将启动溶液沿着第一流动方向通过至少一个组来引发，以使引发溶液进入由一组在流动中携带的在线室 方向逆行到通过腔室的血液流动的正常方向。 优选地，直列式室内装有过滤器。 同时，一个通过一个端口从一个组件中移除空气。 在另一个方案中，优选地同时进行该步骤的步骤中，一个通过所连接的组件沿第二反向的流动方向将启​​动溶液通过连接的组件，以继续通过端口从系统中移出空气，以完成系统的启动。

公开(公告)号：US20030010717A1

公开(公告)日：2003-01-16

申请号：US09905171

申请日：2001-07-13

申请人： NX Stage Medical, Inc.

发明人： James M. Brugger ,  Dennis M. Treu

IPC分类号： B01D061/00 ,  B01D061/20 ,  B01D061/30 ,  B01D037/00 ,  B01D036/00

CPC分类号： A61M1/3643 ,  A61M1/288 ,  A61M1/3462 ,  A61M1/3468 ,  A61M1/3644 ,  A61M1/3646

摘要： Systems and methods handle air and rinsing fluid during fluid processing. The systems and methods eliminate air from a fluid processing system prior to, during, and after use. The systems and methods provide a connector assembly for establishing fluid flow from a fluid source. The connector assembly has discrete first and second passages that prevent communication between the fluid in first passage and the fluid in the second passage. Prior to system use, the connector assembly may be utilized in a priming function to remove residual air from a fluid circuit prior to use. The connector assembly may also be utilized after use to perform a rinse-back function. The rinse-back function serves to remove residual fluid from the system after use. The connector assembly can comprise two, single lumen connectors or one connector with two lumens.

摘要翻译： 系统和方法在流体处理过程中处理空气和冲洗液。 系统和方法在使用之前，期间和之后都从流体处理系统中排除空气。 这些系统和方法提供了用于建立来自流体源的流体流动的连接器组件。 连接器组件具有分离的第一和第二通道，其防止第一通道中的流体和第二通道中的流体之间的连通。 在系统使用之前，连接器组件可用于起动功能，以在使用之前从流体回路中除去残余空气。 连接器组件也可以在使用之后用于执行冲洗功能。 冲洗功能用于在使用后从系统中除去残留液体。 连接器组件可以包括两个单腔连接器或具有两个腔的一个连接器。

公开(公告)号：US20010032818A1

公开(公告)日：2001-10-25

申请号：US09886987

申请日：2001-06-25

发明人： Taku Nikaido ,  Mistutaka Ueda

IPC分类号： B01D061/30

CPC分类号： A61M1/3643 ,  A61M1/1639 ,  A61M1/3427 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3635 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3649 ,  A61M1/365

摘要： A dialysis system which does not need to use a physiological saline in replenishing a solution or cleaning and priming the dialysis system, does not need a troublesome setting operation and can easily and accurately set a flow rate of a replenisher solution. The dialysis system includes a closed-type water-removal control apparatus 1, a dialyzer 2, a fresh dialysate line 3 as well as a used dialysate line 4, an RO water pressurizing line 5, an RO water pressurizing pump 51 provided in the RO water pressurizing line 5, an artery side blood line 6, a blood pump 61 provided at the artery side blood line 6 and a vein side blood line 7. According to the dialysis system, by pressurizing RO water into a communication line of the used dialysate, dialysate is made to flow from a dialysate flow path 21 into a blood flow path 22 through a dialysis membrane 23 of the dialyzer 2 and the inside of a blood circulation path can be cleaned and primed.

摘要翻译： 不需要使用生理盐水补充溶液或清洁和引发透析系统的透析系统不需要麻烦的设置操作，并且可以容易且准确地设定补充液的流量。 透析系统包括封闭式除水控制装置1，透析器2，新鲜透析液管线3以及透析液管线4，RO水加压管线5，设置在RO中的RO水加压泵51 水加压管线5，动脉侧血液线6，设置在动脉侧血液线6处的血液泵61和静脉侧血液管线7.根据透析系统，通过将RO水加压至所使用的透析液的通气管线 通过透析器2的透析膜23使透析液从透析液流路21流入血液流路22，并且可以清洗和引发血液循环路径的内部。

公开(公告)号：US20020130073A1

公开(公告)日：2002-09-19

申请号：US10099411

申请日：2002-03-16

发明人： John McCartney

IPC分类号： B01D061/28 ,  B01D061/30

CPC分类号： A61M1/16 ,  A61M2209/08 ,  F16L3/01

摘要： A kidney dialysis machine includes a number of flexible members extending from the machine to corresponding receptacles at a patient station. The flexible members are arranged in a cable bundle at a point intermediate of the machine and the ends of the members. A retaining member is wrapped around the bundle to hold the bundle together. The retaining member is attached to a spring that has one end connected to the retaining member and an opposite end attached to the kidney dialysis machine. The spring holds the bundle off the floor.

摘要翻译： 肾透析机包括从机器延伸到患者站处的相应容器的多个柔性部件。 柔性构件在机器的中间点和构件的端部处布置在电缆束中。 保持构件缠绕在束上以将束束夹在一起。 保持构件附接到弹簧，弹簧的一端连接到保持构件，另一端连接到肾脏透析机。 弹簧把捆绑在地板上。

公开(公告)号：US20010010298A1

公开(公告)日：2001-08-02

申请号：US09833616

申请日：2001-04-13

发明人： Aftab Alam

IPC分类号： B01D061/30

CPC分类号： B01D61/30 ,  B01D17/0217 ,  B01D17/085 ,  B01D61/28 ,  G01N2001/4016 ,  Y10T436/25375 ,  Y10T436/255

摘要： A method and a device for dialysis having a dialysis reservoir and a collection reservoir. A sample is placed in the dialysis reservoir for dialysis. After dialysis, dialysis reservoir is centrifuged and the dialyzed sample is collected in the collection reservoir.

公开(公告)号：US20040099596A1

公开(公告)日：2004-05-27

申请号：US10465198

申请日：2003-06-19

发明人： Morteza Naghavi ,  Hossein Eftekhari ,  S. Ward Casscells

IPC分类号： B01D061/30

CPC分类号： A61M1/14 ,  A61M2210/125

摘要： The present invention relates generally to a system and methods for local delivery of drugs directly to the coronary circulation which may be isolated from systemic circulation. More especially it relates to a dialysis system and methods of infusing beneficial drugs, therapeutic agents, and/or other beneficial substances, including high doses of these, such as HDL, therapeutic genes, and/or chelating agents to the coronary system. The multi-chambered dialysis machine in the present system is capable of removing unwanted/harmful substances from the blood, enriching and/or otherwise processing the blood, and re-circulating the processed blood back to the coronary circulation of patient. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

摘要翻译： 本发明一般涉及将药物局部递送到冠状动脉循环的系统和方法，所述系统和方法可直接从体循环分离。 更具体地说，涉及透析系统和将有益药物，治疗剂和/或其它有益物质（包括高剂量这些物质，如HDL，治疗基因和/或螯合剂）注入冠状动脉系统的方法。 本系统中的多室透析机能够从血液中除去不需要的/有害物质，富集和/或以其他方式加工血液，并将经处理的血液重新循环回患者的冠状动脉循环。 要强调的是，该摘要被提供以符合要求抽象的规则，这将允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

公开(公告)号：US20030080047A1

公开(公告)日：2003-05-01

申请号：US09871864

申请日：2001-06-01

发明人： Randolph H. Watkins ,  James S. Slepicka ,  Michael R. Prisco

IPC分类号： B01D065/00 ,  B01D061/30

CPC分类号： B01D63/02 ,  A61M1/16 ,  A61M1/1627 ,  A61M2202/0498 ,  A61M2205/15 ,  B01D61/20 ,  B01D2313/10 ,  B01D2313/12 ,  B01D2313/21

摘要： A dialyzer is provided comprising a casing defining an interior and including a dialysate inlet and a dialysate outlet. A plurality of fibers are located in the interior of the casing and define a fiber bundle. A dialysate inlet fluid channel is provided in fluid communication with the dialysate inlet and includes a plurality of flutes that extend into a portion of the fiber bundles, the flutes define an opening for allowing dialysate to flow from the inlet fluid channel into the interior of the casing. Methods of providing dialysis are also provided.

公开(公告)号：US20030010703A1

公开(公告)日：2003-01-16

申请号：US10231659

申请日：2002-08-30

申请人： Hass Medizintechnik GmbH

发明人： Manfred Pippert ,  Uwe Hildmann ,  Hans-Gunther Eigendorf

IPC分类号： B01D061/10 ,  B01D061/30

CPC分类号： A61M1/1654 ,  A61M1/1656 ,  A61M1/1664 ,  A61M1/1666 ,  A61M1/1668 ,  A61M2205/3368 ,  A61M2205/3382 ,  A61M2205/3386 ,  A61M2205/3653

摘要： In contrast to the prior art, the essential components of dialyzing liquids are not provided as a dry concentrate or as a genuine solution at the place of dialysis, but as a suspension of undissolved or incompletely dissolved substances, preferably sodium chloride, optionally sodium acetate, in a solution of the remaining components. The suspension is prepared, stored, transported and used in a form designated as an acid cartridge or acetate cartridge, respectively. At the place of dialysis a liquid dialysis concentrate is prepared from the suspension by means of an apparatus, which is here suggested, and can be processed into dialyzing liquid with the existing dosing and safety systems of commercially available dialyzers. The prestage of a dialysis concentrate, which is described in this invention as a suspension, constitutes the supply form with the highest substance density for the components of acid and acetate-containing dialyzing liquids. The cost-saving effects and advantages that can be achieved during transportation, storage and handling are achieved without lowering the standards for the patients' safety as are customary in the use of a conventional liquid concentrate.

摘要翻译： 与现有技术相反，透析液的基本组分不作为干浓缩物或作为透析剂的真正溶液提供，而是作为未溶解或不完全溶解的物质（优选氯化钠，任选的乙酸钠）的悬浮液， 在其余组件的解决方案中。 将悬浮液分别制备，储存，运输并分别以指定为酸性药筒或乙酸酯药筒的形式使用。 在透析的地方，借助于这里提出的装置，从悬浮液制备液体透析浓缩物，并且可以使用市售透析器的现有计量和安全系统加工成透析液。 在本发明中作为悬浮液描述的透析浓缩物的预处理构成了含酸和含乙酸盐的透析液的组分的物质密度最高的供应形式。 在运输，储存和处理过程中可以实现节省成本的效果和优点，而不会降低患者安全性的标准，这在常规液体浓缩物的使用中是常规的。

公开(公告)号：US20040069709A1

公开(公告)日：2004-04-15

申请号：US10650935

申请日：2003-08-27

发明人： James M. Brugger ,  Jeffrey H. Burbank ,  Dennis M. Treu

IPC分类号： B01D061/00 ,  B01D061/30 ,  A61M001/14 ,  A61M001/34

CPC分类号： B01D61/145 ,  A61M1/1692 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3462 ,  A61M1/3465 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2205/12 ,  A61M2205/705 ,  B01D61/18 ,  C02F1/444

摘要： A sterilized fluid management kit for use in renal replacement therapy isolates a replacement fluid container from touch contamination and provides for sterilization of replacement fluid by filtering using an installed filter that is hermetically connected to the replacement fluid container. A method is described where replacement fluid is automatically generated before treatment.

摘要翻译： 用于肾替代治疗的灭菌流体管理套件将置换液体容器与接触污染隔离，并通过使用安装的过滤器进行过滤来灭菌替换流体，该过滤器与替换流体容器密封连接。 描述了在治疗之前自动生成置换液的方法。

公开(公告)号：US20030010719A1

公开(公告)日：2003-01-16

申请号：US09905246

申请日：2001-07-12

申请人： NxStage Medical, Inc.

发明人： James M. Brugger ,  Jeffrey H. Burbank ,  Dennis M. Treu

IPC分类号： B01D061/00 ,  B01D061/20 ,  B01D061/30 ,  B01D037/00 ,  B01D036/00

CPC分类号： B01D61/145 ,  A61M1/1692 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3444 ,  A61M1/3462 ,  A61M1/3465 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2205/12 ,  A61M2205/705 ,  B01D61/18 ,  C02F1/444

摘要： A method and device for renal replacement therapy is described that sterile-filters solution that can subsequently be used as a replacement fluid in the same unit. The devices and methods include a pump that can be reversed from its normal forward-pumping direction to sterilize a container of replacement fluid to produce sterile replacement fluid. The sterile replacement fluid is captured in a fluid bag. Upon sterilization of the contents of the container, the pump switches to run in its normal forward-pumping direction. The sterile replacement fluid produced by the previous process is now injected into a patient to perform renal replacement therapy. The waste produced during the renal replacement therapy can be trapped in the container that previously held the non-sterile solution. Systems for sterile filtration and subsequent renal replacement therapy that include pre-connected, sterilized, disposable kits for fluid management and batch collection of sterilized fluid are also described.

摘要翻译： 描述了用于肾替代治疗的方法和装置，其可以随后在相同单元中用作替换流体的无菌过滤器溶液。 装置和方法包括可以从其正常向前泵送方向反向的泵，以对替换流体的容器进行消毒以产生无菌置换液体。 无菌置换液被捕获在流体袋中。 在消毒容器的内容物时，泵切换到正常的正向泵送方向。 现在将由先前方法产生的无菌置换液注射到患者中进行肾脏替代疗法。 在肾脏替代治疗期间产生的废物可以被捕获在以前保持非无菌溶液的容器中。 还描述了用于无菌过滤和随后的肾脏替代疗法的系统，其包括用于流体管理和无菌液体的批量收集的预先连接的，灭菌的一次性套件。