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    Method for operating a chromatography setup
    1.
    发明授权
    Method for operating a chromatography setup 有权

    公开(公告)号：US12201922B2

    公开(公告)日：2025-01-21

    申请号：US17687237

    申请日：2022-03-04

    Applicant: Sartorius Stedim Chromatography Systems Ltd.

    Inventor： Fabrizio Pelella ,  Jason Forte ,  Mark Allen Pagkaliwangan

    IPC: B01D15/18 ,  B01D15/14 ,  B01D15/22 ,  G01N30/20 ,  G01N30/26 ,  G01N30/46 ,  G01N30/60 ,  G01N30/88

    Abstract: A method for operating a chromatography setup of a bioprocess installation with a plurality of chromatography columns, each with a column inlet and a column outlet, and a valve switching cassette with a group of inlet ports, a group of outlet ports, a group of column-in ports and a group of column-out ports. It is prosed, that a first liquid stream of concentrated buffer is introduced into a first internal liquid line via a first inlet port and that a second liquid stream of diluent is introduced into a second internal liquid line via a second inlet port, that in a dilution process, the array of valve units is switched as to create a third liquid stream by merging the first liquid stream and the second liquid stream at a merging location within the valve switching cassette.

    Chromatography column positioning assemblies
    2.
    发明授权
    Chromatography column positioning assemblies 有权

    公开(公告)号：US12181453B2

    公开(公告)日：2024-12-31

    申请号：US17512864

    申请日：2021-10-28

    Applicant: Waters Technologies Corporation

    Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Michael O. Fogwill

    IPC: G01N30/60 ,  B01D15/22 ,  G01N30/46

    Abstract: The exemplary embodiments provide chromatography column positioning assemblies that can ensure that the distance between face seals or other sealing surfaces/mechanisms at the respective ends of a liquid chromatography column is a desired distance (i.e., the length of the liquid chromatography column). The exemplary embodiments can adjust the separation between the face seals to accommodate different length liquid chromatography columns. For example, a chromatography column positioning assembly of an exemplary embodiment can set the distance between face seals to accommodate a 25 mm column, a 50 mm column or a 100 mm column.

    Method and Apparatus for Packing a Chromatography Column Assembly
    4.
    发明申请
    Method and Apparatus for Packing a Chromatography Column Assembly 有权

    公开(公告)号：US20240402142A1

    公开(公告)日：2024-12-05

    申请号：US18748622

    申请日：2024-06-20

    Applicant: CYTIVA BIOPROCESS R&D AB

    Inventor： Klaus Gebauer ,  Dan Hermansson

    IPC: G01N30/60 ,  B01D15/20 ,  B01D15/22 ,  G01N30/56

    Abstract: A method for packing a chromatography column with chromatography media, comprising the steps of: providing a system comprising a column tube having a closed first end comprising an inlet/outlet, a media inlet adjacent a second end of the column tube and an adaptor positioned inside the column tube initially adjacent the second end of the column tube for sliding and sealing contact with an inner face of the column tube, the column tube and adaptor arranged initially such that they define an internal volume and such that the media inlet is in fluid connection with the internal volume; connecting a media slurry source to the media inlet; at least partially filling the internal volume with media slurry via the media inlet; forcing the adaptor towards the first end of the column tube to reduce the internal volume such that the media inlet is no longer in fluid connection with the reduced internal volume.

    SPIN COLUMN
    5.
    发明申请
    SPIN COLUMN 有权

    公开(公告)号：US20240382869A1

    公开(公告)日：2024-11-21

    申请号：US18661828

    申请日：2024-05-13

    Applicant: LABTURBO BIOTECH CORPORATION

    Inventor： Chi-Sheng TAI ,  Shih Jeng DAI ,  Shih Tsung HUANG

    IPC: B01D15/22

    Abstract: The spin column of the present invention is used for filtering and extracting biological molecules, such as nucleic acids and proteins. When the spin column is used, it is placed inside a collection tube, which is then placed in a centrifuge slot and the centrifuge is activated. The internal volume of the spin column of the present invention is larger than that of a conventional spin column, allowing it to accommodate a larger amount of specimens. Additionally, the filter membrane positioned inside the spin column of the present invention is smaller than that of conventional spin columns. The amount of washing solution required to wash the biological molecules from the filter membrane is proportional to the size of the filter membrane. Therefore, less washing solution is required in the present invention. Since the spin column of the present invention can accommodate a larger amount of specimen, the number of biomolecules contained in the specimen is also larger. Since less washing solution is required to dissolve and recover the biomolecules from the filter membrane, the concentration of collected biological molecules in the washing solution is higher.

    Sample size chromatography device
    6.
    发明授权
    Sample size chromatography device 有权

    公开(公告)号：US12145082B2

    公开(公告)日：2024-11-19

    申请号：US17420338

    申请日：2020-01-08

    Applicant: Solventum Intellectual Properties Company

    Inventor： Kannan Dasharathi ,  Jon P. Kragness

    IPC: B01D15/22 ,  B01D15/36 ,  G01N30/06

    Abstract: A chromatography device having a housing formed from an upper housing ultrasonically welded to a lower housing. A compression extension and a boss located inside of the housing with the media disposed between the compression extension and the boss such that a perimeter of the media is compressed between the compression extension and the boss forming a liquid impermeable seal along the perimeter after the upper housing is ultrasonically welded to the lower housing.

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