公开(公告)号：US12233418B2

公开(公告)日：2025-02-25

申请号：US16969891

申请日：2019-02-15

Applicant: ASTREGO DIAGNOSTICS AB

Inventor： Özden Baltekin ,  Ove Öhman ,  Martin Lovmar ,  Johan Elf ,  Mikael Olsson

IPC: B01L3/00 ,  B01D61/18 ,  B01D63/00 ,  G01N33/50

Abstract: A capturing of target cells from a biological sample is achieved by inducing a flow of the biological sample in a flow channel (30, 60) of an upstream microfluidic device (1). Target cells present in the biological sample are captured in cell channels (20) of the upstream microfluidic device (1). Once at least a minimum number of target cells are captured in the cell channels (20), the flow of the biological sample in the flow channel is reduced and are verse flow is applied at the upstream microfluidic device (1) to release the target cells captured in the cell channels (20) of the upstream microfluidic device (1) and enable transfer the target cells into cell channels (120) of a downstream microfluidic device (100).

公开(公告)号：US20240228943A1

公开(公告)日：2024-07-11

申请号：US18441850

申请日：2024-02-14

Applicant: EMD Millipore Corporation

Inventor： David Dixon Newbold ,  Clinton Boyd Pepper ,  David Andrew Hansen

IPC: C12M1/00 ,  B01D27/08 ,  B01D35/26 ,  B01D61/18 ,  B01D63/00 ,  B01D63/02 ,  B01L1/00 ,  B01L3/00 ,  C12M1/12 ,  C12M1/26 ,  C12M3/00 ,  H04W74/0808 ,  H04W84/12

CPC classification number: C12M47/02 ,  B01D61/18 ,  B01D63/02 ,  B01L3/502 ,  C12M23/28 ,  C12M23/42 ,  C12M29/04 ,  C12M29/16 ,  C12M33/04 ,  C12M33/14 ,  H04W74/0808 ,  B01D27/08 ,  B01D35/26 ,  B01D63/005 ,  B01D63/028 ,  B01D2313/203 ,  B01D2313/24 ,  B01D2315/10 ,  B01L1/52 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/0403 ,  B01L2400/0475 ,  B01L2400/0478 ,  C12M1/126 ,  C12M37/02 ,  H04W84/12

Abstract: A filtration system, having a filtration unit comprising a housing with a sample inlet, a sample outlet, one or more valves, a first actuator, and a second actuator and a third actuator; and a cassette adapted to fit the filtration unit, the cassette having a filter; a first reservoir in fluid communication with the filter, the first reservoir being arranged to couple to the first actuator for imparting flow to a cell-containing solution in a first direction through the filter; a second reservoir in fluid communication with the filter, the second reservoir being arranged to couple to the second actuator for imparting flow to a cell-containing solution in a second direction through said filter, wherein the second direction opposes the first direction; and a third reservoir.

公开(公告)号：US11865478B2

公开(公告)日：2024-01-09

申请号：US17878981

申请日：2022-08-02

Applicant: Repligen Corporation

Inventor： Rudolf Pavlik

IPC: B01D29/90 ,  B01D35/26 ,  B01D29/11 ,  B01D37/04 ,  B01D63/00 ,  B01D63/02 ,  C12M1/36 ,  C12M1/00

CPC classification number: B01D29/908 ,  B01D29/11 ,  B01D35/26 ,  B01D37/04 ,  B01D63/00 ,  B01D63/02 ,  C12M29/00 ,  C12M29/04 ,  C12M29/16 ,  C12M41/48 ,  C12M47/10

Abstract: A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.

公开(公告)号：US11691107B2

公开(公告)日：2023-07-04

申请号：US16762688

申请日：2018-11-01

Applicant: EMD Millipore Corporation

Inventor： Elizabeth M. Goodrich ,  Akshat Gupta ,  Herbert Lutz

IPC: B01D63/00 ,  B01D61/18 ,  B01D61/14 ,  B01D61/22 ,  B01D65/02

CPC classification number: B01D61/146 ,  B01D61/18 ,  B01D61/22 ,  B01D65/02 ,  B01D2311/04 ,  B01D2311/08 ,  B01D2311/25 ,  B01D2313/18 ,  B01D2313/243 ,  B01D2313/50 ,  B01D2315/10 ,  B01D2315/14 ,  B01D2315/16 ,  B01D2317/022 ,  B01D2317/04 ,  B01D2321/16

Abstract: Processes and systems for filtering a liquid sample are provided. Batches of a liquid sample can be routed to two or more cycling tanks (e.g., first and second cycling tanks). Upon filling a first cycling tank, a first batch of the liquid sample can be routed to a filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the first cycling tank or to a collection vessel. Upon filling a second cycling tank, a second batch of the liquid sample is routed to the filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the second cycling tank or to the collection vessel. The filling and continuous diafiltration of batches of the liquid sample continues to alternate between the two or more cycling tanks until a total product volume is processed.

公开(公告)号：US11684898B2

公开(公告)日：2023-06-27

申请号：US15517638

申请日：2015-09-24

Applicant: ENTEGRIS, INC.

Inventor： Kalyan Madhavaram ,  Bryan Carl Cochran ,  John Paul Puglia ,  J. Karl Niermeyer ,  Krishna Kamath ,  Christopher Paul Barck ,  Yoshikimi Douglas Hisano

IPC: B01D46/00 ,  B01D71/68 ,  B01D46/52 ,  B01D29/07 ,  B01D29/52 ,  B01D29/56 ,  B01D35/30 ,  B01D63/14 ,  B01D46/12 ,  B01D46/58 ,  B01D46/62 ,  B01D19/00 ,  B01D46/42 ,  B01D46/54 ,  B01D63/00 ,  B01D71/26 ,  B01D71/34 ,  B01D71/36 ,  B01D71/56 ,  H01L21/67

CPC classification number: B01D71/68 ,  B01D19/0031 ,  B01D29/07 ,  B01D29/52 ,  B01D29/56 ,  B01D35/30 ,  B01D35/308 ,  B01D46/12 ,  B01D46/42 ,  B01D46/521 ,  B01D46/543 ,  B01D46/58 ,  B01D46/62 ,  B01D63/00 ,  B01D63/14 ,  B01D71/26 ,  B01D71/34 ,  B01D71/36 ,  B01D71/56 ,  H01L21/67023 ,  B01D2265/06 ,  B01D2319/02 ,  B01D2319/04 ,  B01D2325/20 ,  B01D2325/42

Abstract: Embodiments provide a filter with a generally rectangular, non-cylindrical profile. The filter may have multiple pleat packs positioned between pleat covers that define regions and flow channels in a cavity of the filter body. The pleat covers have openings that allow a fluid to flow through the multiple pleat packs via parallel flows or series flows. End caps bonded to the body define flow passages for directing the fluid from an inlet to an outlet via the pleat packs for series or parallel filtration. The pleat packs may be made of the same or different materials and may be configured with the same or different heights based on flow requirements. A cage or a separator may be positioned between the pleat packs. The pleat packs may be made of a continuous pleated membrane with bridges defining a space between the pleat packs to accommodate the cage or separator.

公开(公告)号：US11471838B1

公开(公告)日：2022-10-18

申请号：US16531600

申请日：2019-08-05

Applicant: Triad National Security, LLC

Inventor： Enkeleda Dervishi ,  Justin R. Marquez ,  Quinn McCulloch ,  Stephen L. Yarbro ,  Eric L. Auchter

IPC: B01D69/12 ,  B01D71/02 ,  B01D63/00 ,  B81B3/00

Abstract: A microfluidic assembly can include a first microchannel substrate defining one or more first microchannels, a second microchannel substrate defining one or more second microchannels. The assembly can further include a membrane positioned between the first and second microchannel substrates and comprising a first polymeric layer, a second polymeric layer, and one or more graphene layers disposed between the first and second polymeric layers. At least a portion of the first microchannels can overlap at least a portion of the second microchannels such that, when a first fluid is present in the first microchannels and a second fluid is present in the second microchannels, the first fluid and the second fluid contact opposite sides of the membrane.

公开(公告)号：US11433356B2

公开(公告)日：2022-09-06

申请号：US16333402

申请日：2017-09-15

Applicant: Nitto Denko Corporation

Inventor： Mieko Nishi ,  Yasuhiro Uda

IPC: B01D63/10 ,  B01D69/10 ,  B01D69/12 ,  B01D63/00 ,  D04B21/00 ,  C08J5/22 ,  D04B21/06

Abstract: Provided is a spiral membrane element that has a restricted outer diameter and is capable of being decreased in operation energy therefor. The element is a spiral membrane element including plural membrane leaves in each of which a permeation-side flow-channel member is interposed between opposed separation membranes a supply-side flow-channel member interposed between any two of the membrane leaves a perforated central pipe on which the membrane leaves and the supply-side flow-channel member are wound and a sealing part that prevents a supply-side flow-channel member from being mixed with a permeation-side flow-channel member. This element has an efficiency index E of 0.005 to 0.10, and the thickness of the supply-side flow-channel member is from 10 to 110 mil.

公开(公告)号：US11433326B2

公开(公告)日：2022-09-06

申请号：US17014465

申请日：2020-09-08

Applicant: REPLIGEN CORPORATION

Inventor： Rudolf Pavlik

IPC: B01D29/90 ,  B01D35/26 ,  B01D29/11 ,  B01D37/04 ,  B01D63/00 ,  B01D63/02 ,  C12M1/36 ,  C12M1/00

Abstract: A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.

公开(公告)号：US11364470B2

公开(公告)日：2022-06-21

申请号：US16632630

申请日：2018-07-23

Applicant: AMOGREENTECH CO., LTD.

Inventor： Ui Young Jeong ,  In Yong Seo

IPC: B01D63/00 ,  B01D63/08 ,  B01D69/02 ,  B01D69/06 ,  B01D69/10 ,  B01D71/34 ,  D04H1/728 ,  B01D67/00

Abstract: A filter medium including: a porous first support; nanofiber webs respectively stacked at the upper and lower parts of the first support, and made of a plurality of nanofibers of which the diameters have a standard deviation of 300 nm or less; and a porous second support interposed between the first support and the nanofiber web. The filter medium is implemented by fibers having uniform diameters, and thus is easily manufactured to have a predetermined pore diameter and simultaneously has excellent uniformity of the pore diameters, thereby having excellent filtering efficiency and being more suitable when selectively separating specific objects. Backwashing is enabled at uniform pressure during backwashing such that high cleaning power is obtained. The filter medium has excellent water permeability and excellent mechanical strength so as to minimize the shape and structural deformation and damage of the filter medium.

公开(公告)号：US11077405B2

公开(公告)日：2021-08-03

申请号：US16080692

申请日：2017-03-03

Applicant: Asahi Kasei Kabushiki Kaisha

Inventor： Masato Mikawa ,  Yasutaka Kurishita ,  Azusa Yamanaka

IPC: B01D53/22 ,  B01D63/02 ,  B01D69/10 ,  B01D69/12 ,  B01D71/34 ,  B01D71/68 ,  B01D69/00 ,  B01D63/00 ,  B01D61/00

Abstract: Module for gas separation that maintains moisture retention of a gas separation active layer at a uniform level has a composite hollow-fiber membrane configured as the interior of an exterior body and has a porous hollow-fiber support body and a gas separation active layer disposed on the surface of the hollow-fiber support body. The exterior body has a supply port and a discharge port for a first gas passing through the outer side of the composite hollow-fiber membrane, and a supply port and a discharge port for a second gas passing through the inner side of the composite hollow-fiber membrane. The first gas flows through a first space enclosed by the exterior body and the outer side of the composite hollow-fiber membrane and the second gas flows through a second space separated by the composite hollow-fiber membrane and the exterior body. The first space is filled with an absorbing solution.