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![Process for the preparation of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8- dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one derivatives](/abs-image/US/2024/10/22/US12122791B2/abs.jpg.150x150.jpg)
公开(公告)号：US12122791B2
公开(公告)日：2024-10-22
申请号：US17842612
申请日：2022-06-16
发明人： Jean-Michel Adam , Serena Maria Fantasia , Daniel Vincent Fishlock , Fabienne Hoffmann-Emery , Gerard Moine , Christophe Pfleger , Christian Moessner
IPC分类号： C07D519/00 , B01J23/44 , B01J23/755
CPC分类号： C07D519/00 , B01J23/44 , B01J23/755
摘要： The present invention relates to a process for the preparation of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.
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公开(公告)号：US12109558B2
公开(公告)日：2024-10-08
申请号：US16991555
申请日：2020-08-12
发明人： Nancy Jean Halas , Peter Nordlander , Hossein Robatjazi , Dayne Francis Swearer , Chao Zhang , Hangqi Zhao , Linan Zhou
IPC分类号： B01J35/39 , B01J19/12 , B01J21/02 , B01J21/04 , B01J21/10 , B01J23/00 , B01J23/38 , B01J23/44 , B01J23/50 , B01J23/52 , B01J23/58 , B01J23/72 , B01J23/78 , B01J23/89 , B01J27/04 , B01J27/14 , B01J27/20 , B01J27/22 , B01J27/24 , B01J31/06 , B01J35/00 , B01J35/23 , B01J35/30 , B01J35/33 , B01J35/50 , B01J35/64 , B01J37/02 , B01J37/03 , B01J37/08 , B01J37/34 , C01B3/04 , C01B3/40 , C01B4/00 , C01B5/00 , C01B21/02 , C01B32/40 , B01J31/16
CPC分类号： B01J35/39 , B01J19/123 , B01J19/127 , B01J21/02 , B01J21/04 , B01J21/10 , B01J23/002 , B01J23/38 , B01J23/44 , B01J23/50 , B01J23/52 , B01J23/58 , B01J23/72 , B01J23/78 , B01J23/8926 , B01J23/8946 , B01J27/04 , B01J27/14 , B01J27/20 , B01J27/22 , B01J27/24 , B01J31/06 , B01J35/19 , B01J35/23 , B01J35/30 , B01J35/33 , B01J35/393 , B01J35/397 , B01J35/50 , B01J35/651 , B01J37/0203 , B01J37/0225 , B01J37/03 , B01J37/031 , B01J37/035 , B01J37/08 , B01J37/344 , C01B3/047 , C01B3/40 , C01B4/00 , C01B5/00 , C01B21/02 , C01B32/40 , B01J31/1691 , B01J2219/00635 , B01J2523/00 , B01J2540/66 , C01B2203/0238 , C01B2203/1076 , C01B2203/1082 , C01B2203/1241 , B01J2523/00 , B01J2523/17 , B01J2523/22 , B01J2523/31 , B01J2523/821
摘要： A multicomponent photocatalyst includes a reactive component optically, electronically, or thermally coupled to a plasmonic material. A method of performing a catalytic reaction includes loading a multicomponent photocatalyst including a reactive component optically, electronically, or thermally coupled to a plasmonic material into a reaction chamber; introducing molecular reactants into the reaction chamber; and illuminating the reaction chamber with a light source.
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公开(公告)号：US12102985B2
公开(公告)日：2024-10-01
申请号：US17312246
申请日：2020-02-21
发明人： Jae Hyuk Kim , Hak Lae Lee
IPC分类号： B01J23/52 , A61K9/51 , B01J21/08 , B01J23/44 , B01J23/745 , B01J31/02 , B01J35/00 , B01J35/33 , B01J35/60 , B01J37/02 , B01J37/04 , B01J37/06
CPC分类号： B01J23/52 , A61K9/5115 , B01J21/08 , B01J23/44 , B01J23/745 , B01J31/0237 , B01J35/19 , B01J35/33 , B01J35/60 , B01J37/0217 , B01J37/04 , B01J37/06
摘要： A hollow mesoporous organic silica nano/microparticle having metal particles deposited thereon, and a method for preparing the same. The method may prepare a spherical nanoparticle by coating a porous organic silica layer on an inorganic silica particle having the metal particles deposited thereon and via selective etching of the layer. In addition, two or more types of metals pre-synthesized together with a magnetic particle, or different shapes of metals may be deposited on the nanoparticle at a target concentration. Thus, the nano/microparticle may be used for a drug delivery matrix, a catalyst, and a photothermal effect.
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公开(公告)号：US20240308950A1
公开(公告)日：2024-09-19
申请号：US18365645
申请日：2023-08-04
IPC分类号： C07C67/333 , B01J21/18 , B01J23/44
CPC分类号： C07C67/333 , B01J21/18 , B01J23/44
摘要： A method to make mono- or di-hydroxy-hexanoates. Triacetic acid lactone is converted to a δ-hexalactone or a 4-hydroxy-δ-hexalactone intermediate. The intermediate is treated with an acid in the presence of an alcohol to yield a 5-hydroxy-hexanoate or 4,5-dihydroxy-hexanoate.
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公开(公告)号：US20240308931A1
公开(公告)日：2024-09-19
申请号：US18578559
申请日：2022-07-14
发明人： Jin-Quan YU , Zhen WANG , Liang HU
IPC分类号： C07B35/04 , B01J23/44 , C07B37/10 , C07C51/377 , C07C67/317
CPC分类号： C07B35/04 , B01J23/44 , C07B37/10 , C07C51/377 , C07C67/317
摘要： Disclosed herein are palladium-catalyzed dehydrogenation processes of carboxylic acids to make α, β-unsaturated carboxylic acids or γ-alkylidene butenolides. The processes allow the chemoselective dehydrogenation of carboxylic acids in the presence of other enolizable functionalities such as ketones, providing reactivity that is inaccessible with existing carbonyl desaturation protocols.
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6.发明公开公开(公告)号：US20240287119A1
公开(公告)日：2024-08-29
申请号：US18192609
申请日：2023-03-29
发明人： Keming YUN , Zhuoyi WANG , Ying WANG , Yuping LU , Xianlian WANG , Hongliang SU , Chao ZHANG , Zhiwen WEI , Lele WANG , Ruili WANG
IPC分类号： C07H15/203 , B01J21/18 , B01J23/44 , G01N33/53
CPC分类号： C07H15/203 , B01J21/18 , B01J23/44 , G01N33/5308 , G01N2800/42
摘要： The present disclosure provides a 3-phenoxybenzoic acid-glucuronic acid conjugate, and a preparation method and use thereof, and belongs to the technical field of pesticide detection. Compared with 3-phenoxybenzoic acid, the 3-phenoxybenzoic acid-glucuronic acid conjugate provided by the present disclosure features structural stability, high specificity, long limit of detection, and high content in urine, and can better serve as a marker that identifies whether an organism is killed due to pyrethroid pesticide poisoning. Namely, the 3-phenoxybenzoic acid-glucuronic acid conjugate can detect whether a toxicant (pyrethroid pesticides) is taken antemortem or exposed postmortem, and has an excellent application prospect in pyrethroid pesticide detection. The present disclosure provides a preparation method of a 3-phenoxybenzoic acid-glucuronic acid conjugate. The preparation method provided by the present disclosure features high product yield, simple operation, wide raw material sources, low costs, and suitability for industrial production.
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公开(公告)号：US20240286978A1
公开(公告)日：2024-08-29
申请号：US18656750
申请日：2024-05-07
申请人： OMV Downstream GmbH , BASF SE
CPC分类号： C07C5/2556 , B01D3/007 , B01D3/143 , B01J21/04 , B01J23/42 , B01J23/44 , C07C7/005 , C07C7/04 , C07C2521/04 , C07C2523/42 , C07C2523/44
摘要： A process for the purification of isobutene from a C4 stream with at least 1-butene, 2-butene, isobutane and isobutene includes isomerizing 1-butene from a stream of material which is concentrated in isobutane and isobutene obtained from the C4 stream into 2-butene, using a catalyst in an isomerization reactor; supplying a product stream from the isomerization reactor to a rectification column; and providing a stream of material which is concentrated in isobutene. A processing facility is utilized for the purification of isobutene from the C4 stream.
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公开(公告)号：US20240278216A1
公开(公告)日：2024-08-22
申请号：US18606738
申请日：2024-03-15
IPC分类号： B01J23/44 , B01J31/06 , B01J35/30 , B01J35/40 , B01J37/04 , B01J37/08 , B01J37/16 , C07C1/26
CPC分类号： B01J23/44 , B01J31/06 , B01J35/393 , B01J35/40 , B01J37/04 , B01J37/08 , B01J37/16 , C07C1/26 , B01J2231/4211 , B01J2231/4261 , C07C2523/44
摘要： A solid-supported Pd catalyst is suitable for C—C bond formation, e.g., via Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions, with a support that is reusable, cost-efficient, regioselective, and naturally available. Such catalysts may contain Pd nanoparticles on jute plant sticks (GS), i.e., Pd@GS, and may be formed by reducing, e.g., K2PdCl4 with NaBH4 in water, and then used this as a “dip catalyst.” The dip catalyst can catalyze Suzuki-Miyaura and Mizoroki-Heck cross coupling-reactions in water. The catalysts may have a homogeneous distribution of Pd nanoparticles with average dimensions, e.g., within a range of 7 to 10 nm on the solid support. Suzuki-Miyaura cross-coupling reactions may achieve conversions of, e.g., 97% with TOFs around 4692 h−1, Mizoroki-Heck reactions with conversions of, e.g., a 98% and TOFs of 237 h−1, while the same catalyst sample may be used for 7 consecutive cycles, i.e., without addition of any fresh catalyst.
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公开(公告)号：US20240278215A1
公开(公告)日：2024-08-22
申请号：US18606656
申请日：2024-03-15
IPC分类号： B01J23/44 , B01J31/06 , B01J35/30 , B01J35/40 , B01J37/04 , B01J37/08 , B01J37/16 , C07C1/26
CPC分类号： B01J23/44 , B01J31/06 , B01J35/393 , B01J35/40 , B01J37/04 , B01J37/08 , B01J37/16 , C07C1/26 , B01J2231/4211 , B01J2231/4261 , C07C2523/44
摘要： A solid-supported Pd catalyst is suitable for C—C bond formation, e.g., via Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions, with a support that is reusable, cost-efficient, regioselective, and naturally available. Such catalysts may contain Pd nanoparticles on jute plant sticks (GS), i.e., Pd@GS, and may be formed by reducing, e.g., K2PdCl4 with NaBH4 in water, and then used this as a “dip catalyst.” The dip catalyst can catalyze Suzuki-Miyaura and Mizoroki-Heck cross coupling-reactions in water. The catalysts may have a homogeneous distribution of Pd nanoparticles with average dimensions, e.g., within a range of 7 to 10 nm on the solid support. Suzuki-Miyaura cross-coupling reactions may achieve conversions of, e.g., 97% with TOFs around 4692 h−1, Mizoroki-Heck reactions with conversions of, e.g., a 98% and TOFs of 237 h−1, while the same catalyst sample may be used for 7 consecutive cycles, i.e., without addition of any fresh catalyst.
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10.发明公开公开(公告)号：US20240254150A1
公开(公告)日：2024-08-01
申请号：US18394056
申请日：2023-12-22
申请人： TCG GreenChem Inc.
发明人： Arun Dixith Reddy SHADA , Hari Prasad Reddy MANGUNURU , Gopal SIRASANI , Bo QU , Chris Hugh SENANAYAKE , Srinivasarao TENNETI
CPC分类号： C07F9/5004 , B01J23/44
摘要： The present disclosure provides a series of novel, water-soluble, sulfonate-based phosphorus ligand of formula (I) derived from a dihydrobenzo 1,3-oxaphosphole framework that has shown superior results for Suzuki coupling reactions for hindered substrates in aqueous media.
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