公开(公告)号：US20240251826A1

公开(公告)日：2024-08-01

申请号：US17280313

申请日：2019-10-02

Applicant: West Invest SA

Inventor： Stanislas Baudouin ,  Eric Reynaud

IPC: A23L2/78 ,  A23L2/04 ,  A23L2/08 ,  B01D15/18 ,  B01D15/36 ,  B01J39/05 ,  B01J39/16 ,  B01J39/26

CPC classification number: A23L2/78 ,  A23L2/04 ,  A23L2/08 ,  B01D15/185 ,  B01D15/362 ,  B01J39/05 ,  B01J39/16 ,  B01J39/26

Abstract: This disclosure relates to an proanthocyanidin extract, extract comprising sugars of a fruit juice processes for preparing same as well as the use of the extract or a composition thereof as food or neutraceutical composition.

公开(公告)号：US20220297029A1

公开(公告)日：2022-09-22

申请号：US17836412

申请日：2022-06-09

Applicant: Repligen Corporation

Inventor： Alan Kit Ho Chan ,  James Roland Peyser

IPC: B01D15/10 ,  B01D15/36 ,  B01J39/04 ,  B01J39/19 ,  B01J39/26 ,  G01N30/50 ,  B01D15/20 ,  G01N30/60

Abstract: Methods and systems for removing gases and/or pressure formed during the sterilization, e.g., the gamma irradiation, of prepacked chromatography systems (column plus attached tube and valve set) are described. The methods include purging the gas and/or pressure through specially designed tube and valve sets without breaching the sterility of the prepacked sterile chromatography system. The systems include a sterile or aseptic pre-packed chromatography column including a column having an inlet and an outlet, a tubing and valve set attached to the inlet and the outlet, and a pump configured to pump sterile or aseptic liquid from the fluid source along the tubing and valve set, into the column tube inlet and out of the column tube outlet along a first flow path, thereby removing any entrapped gas and/or pressure from the chamber.

公开(公告)号：US11448626B2

公开(公告)日：2022-09-20

申请号：US16865696

申请日：2020-05-04

Applicant: DIONEX CORPORATION

Inventor： Manikandan Jayaraman ,  Christopher A. Pohl ,  Charanjit Saini

IPC: G01N30/96 ,  B01D15/36 ,  B01J39/20 ,  B01J39/26 ,  B01J41/20 ,  B01J39/05 ,  B01J39/07 ,  B01J41/07 ,  B01D15/20 ,  B01J47/02

Abstract: An ion exchange chromatographic packing material is described that includes support resin particles and a copolymer grafted to the support resin particles. The copolymer includes polymerized functional monomers such as a first ion exchange group monomer and a second ion exchange group monomer. At a first pH, the first ion exchange group monomer is configured to have a first charge at a first pH, and the second ion exchange group monomer is configured to have a net neutral charge. At a second pH, the first ion exchange group monomer is configured to have the first charge at a second pH, and the second ion exchange group monomer is configured to have a second charge at the second pH where the first charge and second charge both have a same polarity.

公开(公告)号：US20220266170A1

公开(公告)日：2022-08-25

申请号：US17741394

申请日：2022-05-10

Applicant: Cytiva BioProcess R&D AB

Inventor： Jan Bergstrom ,  Gunnar Glad ,  Bo-Lennart Johansson ,  Jean-Luc Maloisel ,  Nils Norrman ,  Tobias E. Soderman

IPC: B01D15/32 ,  B01J20/285 ,  B01J20/287 ,  B01J39/26 ,  B01J20/28 ,  B01J20/32 ,  C07K1/20 ,  C07K16/00 ,  C12N7/00 ,  G01N1/40

Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.

公开(公告)号：US11383229B2

公开(公告)日：2022-07-12

申请号：US17095184

申请日：2020-11-11

Applicant: Merck Millipore Ltd.

Inventor： Amro Ragheb ,  Gary Skarja

IPC: B01J39/19 ,  C07K1/22 ,  B01J20/26 ,  B01J20/28 ,  B01J20/29 ,  B01D15/34 ,  B01J39/26 ,  C07K1/18 ,  B01J20/291

Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.

公开(公告)号：US20210308358A1

公开(公告)日：2021-10-07

申请号：US17352596

申请日：2021-06-21

Applicant: PENUMBRA, INC.

Inventor： Karthik Raman ,  Colin Yee ,  Chia-Hung Sze ,  Arthur John Lockhart ,  David Barry

IPC: A61M1/36 ,  B01J39/04 ,  B01J39/26

Abstract: Doxorubicin is extracted from blood using anionic material, such as a resin comprising sulfonated polystyrene divinylbenzene beads, and polyethersulfone membrane, or both. After exposing the resin and/or membrane to blood in order to remove doxorubicin therefrom, the doxorubicin maybe extracted from the resin and/or membrane by exposing the material to an extraction solution, sonicating the extraction solution to enhance release of the doxorubicin, and repeating the exposure and sonication in order to remove substantially all of doxorubicin from the resin.

公开(公告)号：US20210162370A1

公开(公告)日：2021-06-03

申请号：US17078435

申请日：2020-10-23

Applicant: Puridify Ltd.

Inventor： Oliver Hardick ,  Daniel Gilbert Bracewell ,  Stewart Dods

IPC: B01J20/26 ,  B01D15/38 ,  C07K1/18 ,  B01J20/285 ,  B01J20/24 ,  B01J20/30 ,  B01D15/36 ,  B01J20/28 ,  B01D15/32 ,  B01J39/05 ,  B01J41/13 ,  B01J41/07 ,  B01J39/19 ,  B01D39/14 ,  B01D39/16 ,  B01J20/287 ,  B01J20/288 ,  B01J39/26 ,  B01J41/20 ,  B29C65/02 ,  B29C65/00 ,  B32B5/02 ,  B32B27/08 ,  B32B27/12 ,  B32B27/32 ,  B32B37/06 ,  B32B37/10 ,  B32B37/18 ,  C07K1/16 ,  C07K1/20 ,  C07K1/22

Abstract: The present invention provides a process for preparing a functionalised polymeric chromatography medium, which process comprises (I) providing two or more non-woven sheets stacked one on top of the other, each said sheet comprising one or more polymer nanofibres, (II) simultaneously heating and pressing the stack of sheets to fuse points of contact between the nanofibres of adjacent sheets, and (III) contacting the pressed and heated product with a reagent which functionalises the product of step (II) as a chromatography medium.

公开(公告)号：US20210047387A1

公开(公告)日：2021-02-18

申请号：US16999123

申请日：2020-08-21

Applicant: Adimab, LLC

Inventor： Juergen Hermann Nett ,  K. Dane Wittrup ,  Maximiliano Vasquez

IPC: C07K16/00 ,  C07K1/18 ,  B01D15/36 ,  B01D15/38 ,  B01D15/16 ,  B01J39/26 ,  B01J41/20

Abstract: Methods for purifying multispecific antibodies on interest (MAIs) that co-engage at least two different antigens or epitopes (also referred to targets, used interchangeably throughout), from compositions comprising the MAI and parental homodimeric antibody species are provided, as well as reagents which may be used to practice such methods.

公开(公告)号：US20200047086A1

公开(公告)日：2020-02-13

申请号：US16100319

申请日：2018-08-10

Applicant: CLEMSON UNIVERSITY

Inventor： JINXIANG ZHOU

IPC: B01D15/38 ,  B01J20/28 ,  B01J20/32 ,  B01J39/26 ,  B01J47/014 ,  B01J47/02 ,  C07K1/18

Abstract: Ion exchange membranes (e.g., anion exchange membranes) and methods of using the membranes are described. The ion exchange membranes are multi-modal ion exchange membranes containing a plurality of multi-modal exchange ligands. The membranes can achieve high dynamic and equilibrium binding capacities at solution conductivities typical for production of biologics (e.g., greater than about 10 mS/cm) and can provide excellent binding at high flow rates. Systems incorporating the membranes can dramatically increase isolation and purification speeds. Membranes are disclosed for use in production of biologics.

公开(公告)号：US10537887B2

公开(公告)日：2020-01-21

申请号：US14913333

申请日：2014-08-25

Applicant: BOEHRINGER INGELHEIM RCV GMBH & CO KG ,  SANDOZ AG

Inventor： Rainer Hahn ,  Alois Jungbauer ,  Alexandru Trefilov ,  Moritz Imendoerffer

IPC: B01J39/20 ,  B01J39/04 ,  C12N9/02 ,  C07K1/18 ,  B01J39/26 ,  B01J41/14 ,  B01J41/20 ,  B01J47/04 ,  B01D15/36 ,  C07K14/435 ,  C07K16/00 ,  B01J39/05 ,  B01J39/07 ,  B01J41/05 ,  B01J41/07

Abstract: The present invention provides a novel adsorbent composition for recovering biomolecules from a fluid. The composition comprises positively and negatively charged microparticles in the form of ground particles. The adsorbent is particularly useful for purification of biomolecules from the cell culture.