Sterile chromatography resin and use thereof in manufacturing processes

    公开(公告)号:US11369703B2

    公开(公告)日:2022-06-28

    申请号:US16543247

    申请日:2019-08-16

    摘要: Provided herein are methods of reducing bioburden of a chromatography resin that include exposing a container including a composition including (i) a chromatography resin and (ii) a liquid including at least on alcohol to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one alcohol are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and a liquid including at least one alcohol, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.

    Sustainable System and Method for Removing and Concentrating Per- and Polyfluoroalkyl Substances (PFAS) from Water

    公开(公告)号:US20220055923A1

    公开(公告)日:2022-02-24

    申请号:US17518037

    申请日:2021-11-03

    摘要: A sustainable system for removing and concentrating per- and polyfluoroalkyl substances (PFAS) from water. The system includes an anion exchange vessel having a selected anion exchange resin therein configured to remove PFAS from the water. A line coupled to the vessel introduces a flow of water contaminated with PFAS such that the PFAS bind to the selected anion exchange resin and are thereby removed from the water. A regenerant solution line is coupled to the anion exchange vessel to introduce an optimized regenerant solution to the anion exchange vessel to remove the PFAS from the anion exchange resin, thereby regenerating the anion exchange resin and generating a spent regenerate solution comprised of the removed PFAS and the optimized regenerant solution. A separation and recovery subsystem recovers the optimized regenerant solution for reuse and separates and concentrates the removed PFAS.

    Gas recovery and concentration device

    公开(公告)号:US10933371B2

    公开(公告)日:2021-03-02

    申请号:US16493647

    申请日:2018-06-07

    发明人: Hiroshi Okano

    摘要: An energy efficient and durable thermal swing type carbon dioxide recovery and concentration device can be made smaller and use low-temperature heat waste of 100° C. or less. A honeycomb rotor carries adsorption particles having a sorption capacity for carbon dioxide. The rotor is rotated in a sealed casing divided into at least an sorption zone and a desorption zone and is brought into contact with material gas that contains carbon dioxide in a state wherein the honeycombs in the sorption zone are moist so as to adsorb the carbon dioxide while carrying out evaporative cooling of water. Then, the honeycombs that have adsorbed the carbon dioxide are moved to the desorption zone and brought into contact with low pressure vapor so as to desorb high concentration carbon dioxide. Thus, it is possible to continuously recover carbon dioxide at a high recovery rate and high concentration.

    Ion exchange process
    9.
    发明授权

    公开(公告)号:US10682641B2

    公开(公告)日:2020-06-16

    申请号:US15303934

    申请日:2015-04-15

    摘要: Disclosed herein is a process for carrying out an ion exchange process which involves providing two interacting sets of banks of continuously stirred tank reactors (CSTR's) each containing a bed of ion exchange resin and causing the resin to move in one direction through each bank of reactors and the feed solution and/or or eluant in the opposite direction. In carrying out the process, a feed solution is introduced in a first reactor causing dissolved ions to be captured on the resin, eluant is introduced into a reactor upstream of the first reactor in the direction of resin movement causing ions captured on the resin to be removed into the eluant and eluant rich in ions removed from the resin will be taken from a reactor upstream of the reactor in which the eluant was introduced, for further processing. Thus, in this form of the invention there is, in effect, a loading bank of reactors in which ions from the feed solution are captured followed by a regenerating bank of reactors in which the eluant removes the ions captured on the resin and regenerates the resin.

    Sustainable System and Method For Removing and Concentrating Per- and Polyfluoroalkyl Substances (PFAS) From Water

    公开(公告)号:US20200180979A1

    公开(公告)日:2020-06-11

    申请号:US16794876

    申请日:2020-02-19

    摘要: A sustainable system for removing and concentrating per- and polyfluoroalkyl substances (PFAS) from water. The system includes an anion exchange vessel having a selected anion exchange resin therein configured to remove PFAS from the water. A line coupled to the vessel introduces a flow of water contaminated with PFAS such that the PFAS bind to the selected anion exchange resin and are thereby removed from the water. A regenerant solution line is coupled to the anion exchange vessel to introduce an optimized regenerant solution to the anion exchange vessel to remove the PFAS from the anion exchange resin, thereby regenerating the anion exchange resin and generating a spent regenerant solution comprised of the removed PFAS and the optimized regenerant solution. A separation and recovery subsystem recovers the optimized regenerant solution for reuse and separates and concentrates the removed PFAS.