SYSTEMS AND METHODS FOR BEAD-BASED ASSAYS IN FERROFLUIDS

    公开(公告)号:US20220107311A1

    公开(公告)日:2022-04-07

    申请号:US17554956

    申请日:2021-12-17

    申请人: Ancera LLC

    发明人: Hur KOSER

    摘要: Some embodiments of the present disclosure are directed to systems and methods for separating, directing, and/or extracting a target molecule from a mix of molecules and may comprise a plurality of non-magnetic beads suspended in a ferro fluid, where the non-magnetic beads may be functionalized with at least one predetermined first molecule configured to bind with a target particle. A microfluidic device may be included which may comprise at least one microfluidic channel, the device configured to dynamically and/or statically receive an amount of the mix. Magnetic field means may be included and may be configured to apply a magnetic field to at least a portion of the at least one channel to exert an indirect force on the non-magnetic heads in the ferro fluid mix, and separate the non-magnetic beads from the ferrofluid. The beads may then be directed to at least one receptor region. At least one outlet may be provided which is arranged to be in communication with the at least one microfluidic channel, the at least one outlet may be configured to receive and extract the separated non-magnetic beads from the ferrofluid.

    Separation of a mixture using magnetic carrier particles

    公开(公告)号:US11110468B2

    公开(公告)日:2021-09-07

    申请号:US16627846

    申请日:2018-08-02

    申请人: BASF SE

    IPC分类号: B03C1/01 H01F1/03 B03C1/32

    摘要: The present invention relates to a process for separating at least one first material from a mixture comprising this at least one first material, at least one second material and at least one third material, which comprises at least the following steps: (A) providing a mixture comprising at least one first material, at least one second material, at least one third material and at least one hydrocarbon in an amount of more than 0.4% by weight, based on the sum of mixture, in the presence or 10 absence of at least one dispersion medium, (B) if appropriate, addition of at least one dispersion medium to the mixture obtained in step (A) in order to obtain a dispersion, (C) treatment of the dispersion from step (A) or (B) with at least one hydrophobic magnetic particle, so that the at least one first material and the at least one magnetic particle agglomerate, (D) separation of the adduct from step (C) from the mixture by application of a magnetic field, (E) if appropriate, dissociation of the adduct which has been separated off in step (D) in order to obtain the at least one first material and the at least one magnetic particle separately.

    TUNABLE AFFINITY SYSTEM AND METHOD FOR FERROFLUID-BASED CAPTURE ASSAYS

    公开(公告)号:US20190339262A1

    公开(公告)日:2019-11-07

    申请号:US16419982

    申请日:2019-05-22

    申请人: Ancera LLC

    发明人: Hur KOSER

    摘要: Devices, methods, and systems are provided for extracting particles from a ferrofluid and for rapid affinity measurements. Such systems may comprise a fluidic channel or chamber configured to include a ferrofluid having a plurality of target particles and background particles. The systems may include a capture region configured to capture at least a portion of the plurality of target particles. In addition, the systems include a first magnetic field generator and a second magnetic field generator. The first magnetic field generator may be arranged proximate to the fluidic channel, the first magnetic field generator being configured to generate a first magnetic field configured to direct the plurality of target particles towards the capture region. The second magnetic field generator can be arranged to be proximate to the capture region, and is further configured to generate an affinity thresholding magnetic field configured to remove background particles from the capture region.