公开(公告)号：US20230234850A1

公开(公告)日：2023-07-27

申请号：US18172695

申请日：2023-02-22

申请人： Merck Sharp & Dohme LLC

发明人： Akhilesh Bhambhani ,  Muneeswara Babu Medi ,  Maya Salnikova ,  William James Smith ,  David S. Thiriot

IPC分类号： C01B25/36 ,  A61K47/52 ,  A61K39/39

CPC分类号： C01B25/36 ,  A61K47/52 ,  A61K39/39 ,  A61K2039/55505

摘要： Vaccine formulations are described comprising physically separated, lyophilized antigens and adjuvant components, which may be in lyoparticle form, as well as methods of using and making such formulations. Reconstituted formulations are also described.

公开(公告)号：US20210107789A1

公开(公告)日：2021-04-15

申请号：US17057007

申请日：2019-05-22

申请人： The Research Foundation For Microbial Diseases of Osaka University

发明人： Noriyuki Kanzawa ,  Shunsuke Kano ,  Hiroshi Miyatake

IPC分类号： C01B25/36 ,  C07K1/14

摘要： The present invention provides a substance which is useful as a carrier for protein purification. Since an aluminum phosphate compound that is obtained by a method for producing an aluminum phosphate compound, which comprises a step for obtaining a mixture that contains an aluminum phosphate compound by mixing an aqueous solution A containing a phosphate ion with an aqueous solution B containing an aluminum ion and a sulfate ion, and at least one of a potassium ion or a magnesium ion, exhibits excellent protein adsorption properties, this aluminum phosphate compound is useful as a carrier for protein purification.

公开(公告)号：US10899618B2

公开(公告)日：2021-01-26

申请号：US16186246

申请日：2018-11-09

申请人： Dr. Paul Lohmann GmbH & Co. KGaA

发明人： Uwe Günther ,  Carsten Schweder ,  Mikulas Furdik ,  Jozef Harcarik

IPC分类号： C01B25/36

摘要： The invention relates to an aqueous solution containing aluminum ions, characterized in that the solution contains aluminum ions in a proportion of 0.5-15% (converted, if necessary, to Al3+) based on the total mass of the solution, as well as anions of lactic acid (lactate ions) and of phosphoric acid (phosphate ions), and has the theoretical composition Al3+A(C3H5O3−)x.ASM−y.A(H2PO4−)z.A(OH)−(3A-x.A-M.y.A-z.A), wherein S is the anion of an acid with the charge M, x is a value in the range of 0.5-2.8, y is a value in the range of 0-1.5, and z is a value in the range of 0.01-1.5.

公开(公告)号：US10745279B2

公开(公告)日：2020-08-18

申请号：US16017839

申请日：2018-06-25

申请人： EASYMINING SWEDEN AB

发明人： Yariv Cohen ,  Patrik Enfält

IPC分类号： C01B25/32 ,  C01B25/28 ,  C01B25/36 ,  C01B25/37 ,  C01G49/02 ,  C01G49/10 ,  C01G49/14 ,  C01F7/34 ,  C01F7/56 ,  C01F7/74 ,  C01G45/02 ,  C01G49/00 ,  C01G1/12 ,  C05B11/12 ,  C05B11/16 ,  C05F7/00 ,  C02F11/00 ,  C01F11/46 ,  C02F1/66 ,  C02F101/10

摘要： A method for production of phosphate compounds comprises dissolving of a raw material comprising phosphorus, aluminium and iron, in a mineral acid. Insoluble residues from the dissolving step are separated. Iron hydroxide is added causing precipitation of phosphate compounds. The precipitated phosphate compounds are removed. The phosphate compounds are dissolved by an alkaline solution. Iron hydroxide is filtered out. Lime is added, causing precipitation of calcium phosphate. The precipitated calcium phosphate is separated. The leach solution after the separating of precipitated calcium phosphate is recycled to be used for dissolving phosphate compounds by an alkaline solution.

公开(公告)号：US20200172466A1

公开(公告)日：2020-06-04

申请号：US16631945

申请日：2018-07-16

申请人： SHELL OIL COMPANY

发明人： Henri PREISING ,  Frederik Hendrik VAN DER STEEN ,  Garo Garbis VAPORCIYAN ,  Wolfgang Dirk LOSE ,  Silke Eva Sabine LEONHARDT

IPC分类号： C07C68/065 ,  C07C29/48 ,  C01B25/36 ,  B01J27/18 ,  B01J37/04 ,  B01J37/03 ,  B01J37/08

摘要： The invention relates to a process for the preparation of an alkanediol and a dialkyl carbonate comprising reacting an alkylene carbonate and an alkanol in the presence of a catalyst, wherein the catalyst is aluminum phosphate.

公开(公告)号：US20190240322A1

公开(公告)日：2019-08-08

申请号：US15772777

申请日：2016-06-13

申请人： BIOLOGICAL E LIMITED

发明人： Ravi Ganapathy ,  Nagireddy Gade ,  Manish Manohar ,  Vikram Madhusadan Paradkar ,  Mahima Datla

IPC分类号： A61K39/39 ,  A61K9/06 ,  C01B25/36

CPC分类号： A61K39/39 ,  A61K9/06 ,  A61K2039/55505 ,  C01B25/36 ,  C01P2004/51 ,  C01P2004/60 ,  C01P2004/61

摘要： The present invention relates to an improved process for production of Aluminium phosphate (AlPhos) gel wherein the solutions of aluminium salt and alkaline phosphate salt are added to water by maintaining the pH under stirring to obtain the precipitate, followed by sterilization of the said precipitate and finally obtaining the Aluminum phosphate gel.

公开(公告)号：US10240062B2

公开(公告)日：2019-03-26

申请号：US15503132

申请日：2015-07-14

申请人： KURARAY CO., LTD.

发明人： Yasutaka Inubushi ,  Ryoichi Sasaki ,  Yuji Shimizu ,  Masakazu Nakaya

IPC分类号： B32B27/34 ,  B32B27/32 ,  B32B15/08 ,  B32B15/20 ,  B32B27/28 ,  B32B27/06 ,  B32B27/10 ,  B32B27/08 ,  B32B27/36 ,  C09D133/02 ,  B32B7/02 ,  B32B9/00 ,  B65D65/40 ,  B65D81/24 ,  C01B25/36 ,  B05D3/00 ,  C09D123/02 ,  C09D123/04 ,  C09D129/04 ,  C09D185/02 ,  C08J7/04

摘要： The present invention provides a novel antistatic sheet having high gas barrier performance, high water vapor barrier performance, and antistatic performance, and a packaging material and an electronic device that include the antistatic sheet. The present invention relates to an antistatic sheet including a multilayer structure including a base (X), a layer (Z) containing an aluminum atom, and a layer (Y). The layer (Y) contains a polymer (A) having a vinylphosphonic acid unit, and the layer (Y) has a surface electrical resistivity of 1.0×106 Ω/sq or more and 4.0×1013 Ω/sq or less.

公开(公告)号：US20180166749A1

公开(公告)日：2018-06-14

申请号：US15578479

申请日：2016-06-02

申请人： TOAGOSEI CO., LTD.

发明人： Yasuharu ONO ,  Satoko ANDO

IPC分类号： H01M10/42 ,  H01M2/16 ,  H01M4/62 ,  H01M10/0525 ,  H01M10/0567 ,  C01B25/37 ,  C01B25/36

CPC分类号： H01M10/4235 ,  C01B25/36 ,  C01B25/372 ,  H01G11/20 ,  H01G11/52 ,  H01M2/1646 ,  H01M4/628 ,  H01M10/0525 ,  H01M10/0567

摘要： The invention provides an ion-trapping agent for a lithium-ion rechargeable battery, which traps impurity metal ions generated from constituent parts of a lithium-ion rechargeable battery with high selectivity, has high adsorption capacity per unit mass, suppresses the occurrence of short circuit derived from impurities, and renders a liquid neutral such that the lithium-ion rechargeable battery is unlikely to influence an electrolyte solution, thereby imparting a long-life lithium-ion rechargeable battery. The ion-trapping agent for a lithium-ion rechargeable battery of the invention contains at least one phosphate selected from: (A) α-zirconium phosphate having a specific composition in which a certain range of ion exchange groups are substituted by lithium ions; (B) α-titanium phosphate having a specific composition in which a certain range of ion exchange groups are substituted by lithium ions; or (C) aluminium dihydrogen triphosphate having a specific composition in which a certain range of ion exchange groups are substituted by lithium ions.

公开(公告)号：US20170267529A1

公开(公告)日：2017-09-21

申请号：US15479207

申请日：2017-04-04

申请人： Bunge Amorphic Solutions LLC

发明人： Raymond E. Foscante ,  Neil Maynard Johnson ,  Yucel Burdurlu Tavolara ,  Douglas Malcolm Harless ,  Melanie Astrid Micha-Schama

IPC分类号： C01B25/36 ,  C09C1/40

CPC分类号： C01B25/36 ,  C01P2006/12 ,  C01P2006/19 ,  C09C1/40

摘要： APs are made by binary condensation via base-to-acid or acid-to-base routes. In the base-to-acid route, an aluminum hydroxide slurry is added to phosphoric acid that reacts to produce an aluminum phosphate condensate. In the acid-to-base route, phosphoric acid is added to an aluminum hydroxide slurry that reacts to produce an aluminum phosphate condensate. In an alternative base-to-acid route, an acidic aluminum phosphate is first made by adding phosphoric acid to a first amount of aluminum hydroxide slurry, and such acidic aluminum phosphate is added to a remaining amount of aluminum hydroxide slurry to react and produce an aluminum phosphate condensate. The reactions can be controlled to form an in-situ layered aluminum phosphate. So-formed APs can be amorphous, crystalline, or a combination thereof, and have low oil absorption and surface area, making them particularly useful in such end-use applications as extender pigments in coating compositions, replacing up to 70 wt % of TiO2.

公开(公告)号：US20140314653A1

公开(公告)日：2014-10-23

申请号：US14359840

申请日：2012-11-19

申请人： David S. Thiriot ,  Patrick L. Ahl ,  Jyme Cannon ,  Gabriel M. Lobel

发明人： David S. Thiriot ,  Patrick L. Ahl ,  Jyme Cannon ,  Gabriel M. Lobel

IPC分类号： C01B25/36 ,  A61K39/39

CPC分类号： C01B25/36 ,  A61K39/39 ,  A61K2039/55505

摘要： The present invention relates to methods for preparing amorphous aluminum hydroxyphosphate. An aluminum salt and a phosphate solution are co-mixed at a constant ratio in the presence of a buffer. Preferably, an excess of the phosphate solution is used to act as a buffer. Due to the presence of a buffer, the pH is maintained constant during reaction (after initial rapid equilibration) without active adjustment. The methods are particularly applicable for the large scale manufacturing of aluminum phosphate adjuvant. Aluminum phosphate is used as an adjuvant in vaccine formulations, particularly those including a protein or saccharide antigen.

摘要翻译： 本发明涉及制备无定形羟基磷酸铝的方法。 在缓冲液存在下，以一定的比例将铝盐和磷酸盐溶液共混。 优选地，过量的磷酸盐溶液用作缓冲剂。 由于存在缓冲液，pH在反应期间（初始快速平衡后）保持恒定，无需主动调整。 该方法特别适用于大规模生产磷酸铝佐剂。 磷酸铝被用作疫苗制剂中的佐剂，特别是包括蛋白质或糖抗原的那些。