公开(公告)号：US11498935B2

公开(公告)日：2022-11-15

申请号：US17620233

申请日：2020-06-09

申请人： NIPPON CHEMICAL INDUSTRIAL CO., LTD.

发明人： Tsuneo Imamoto ,  Ken Tamura ,  Natsuhiro Sano

IPC分类号： C07F9/50 ,  B01J31/24 ,  C07B53/00

摘要： There is provided a novel optically active bisphosphinomethane useful as a ligand for an asymmetric catalyst, excellent in oxidation resistance in air, and easy in handling. There is also provided a transition metal complex using the optically active bisphosphinoraethane having excellent asymmetric catalytic ability as a ligand. The optically active bisphosphinomethane is represented by the general formula (1), and the transition metal complex has the optically active bisphosphinomethane as a ligand. (In the formula, R1 represents an adamantyl group; R2 represents a branched alkyl group having 3 or more carbon atoms; and * represents an asymmetric center on a phosphorus atom.)

公开(公告)号：US11434253B2

公开(公告)日：2022-09-06

申请号：US16772284

申请日：2018-12-12

申请人： UNIVERSITE DE STRASBOURG ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Quentin Dherbassy ,  Joanna Wencel-Delord ,  Françoise Colobert ,  Gaspard Hedouin

IPC分类号： C07F9/00 ,  C07B53/00 ,  B01J31/00 ,  C07F9/50 ,  B01J31/24

摘要： Enantiopure terphenyl presenting two ortho-located chiral axes having the following structural formula (I): their process of synthesis and their use as mono or bidentate ligands for asymmetric organometallic reactions, as organocatalysts, as chiral base and as generator, with metal, of isolable chiral metallic complexes for applications in asymmetric catalysis and others.

公开(公告)号：US11325875B2

公开(公告)日：2022-05-10

申请号：US16060424

申请日：2016-12-12

申请人： ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. ,  SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES

发明人： Kuiling Ding ,  Yuxi Cao ,  Zhiyao Zheng ,  Qinglei Chong ,  Zheng Wang

IPC分类号： C07C13/72 ,  B01J31/22 ,  C07C39/17 ,  C07C43/21 ,  C07C43/225 ,  C07F9/6571 ,  C07B53/00 ,  C07C231/12 ,  C07C233/51

摘要： Chiral spirobiindane skeleton compound and preparation method thereof is disclosed in the present invention. The spirobiindane skeleton compound of the present invention having the structure formula of I or I′; the preparation method for synthesizing the spirobiindane skeleton compound of the present invention comprising the following steps: in the presence of solvent and catalysts, the structure formula compound III reacted through intramolecular Friedel-Crafts reaction to obtain the compound of formula I; the catalyst is a Browsteric acidor Lewis acid. The preparation method of chiral fused spirobiindane skeleton compound of the present invention does not need to adopt chiral starting materials or chiral resolving agents, does not require chiral resolving steps, is simple in method, is simple in post-treatment, and is economic and environment friendly. High product yield, high product optical purity and chemical purity. The catalyst for the asymmetric reaction is obtained from the chiral spirobiindane skeleton ligand of the present invention, under the catalytic reagent of transition metal, the catalyzed hydrogenation reaction can arrive at a remarkable catalytic effect with a product yield of >99%, and a product ee value of up to >99%.

公开(公告)号：US20220119364A2

公开(公告)日：2022-04-21

申请号：US17344152

申请日：2021-06-10

申请人： MITSUBISHI TANABE PHARMA CORPORATION

发明人： Takao TESHIMA ,  Takafumi YAMAGAMI ,  Tetsuo YAMAGUCHI ,  Junki ANDO

IPC分类号： C07D401/10 ,  C07B53/00

摘要： The present invention provides a process for preparing a compound represented by formula (VII), which comprises reacting a compound represented by formula (VI) with a malonic acid derivative in the presence of a base and an asymmetric catalyst in a two layer solvent system of hydrophobic solvent and water. (wherein R2 and R3 each independently represents a protecting group for carboxyl group),

公开(公告)号：US20210355091A1

公开(公告)日：2021-11-18

申请号：US17382591

申请日：2021-07-22

申请人： CROSSING SRL

发明人： Valentina BEGHETTO

IPC分类号： C07D251/26 ,  C07D251/46 ,  C07B43/04 ,  C07B53/00 ,  C08J3/24 ,  C14C3/26

摘要： A method for stabilization of collagen matrices and of condensation of natural and synthetic polymers that uses 2-halo-4,6-dialkoxy-1,3,5-triazines in the presence of one or more amines as activating agents for reactions of crosslinking, condensation, grafting, and curing of collagen matrices, cellu lose, modified celluloses, polysaccharides, acid unsaturated polymers, and chiral and non-chiral amines, etc. Forming an integral part of the present invention is also the method for production on an industrial scale of 2-halo-4,6-dialkoxy-1,3,5-triazines.

公开(公告)号：US10710061B2

公开(公告)日：2020-07-14

申请号：US16087582

申请日：2017-03-22

申请人： Nanyang Technological University

发明人： Choon-Hong Tan ,  Xinyi Ye ,  Lili Zong

IPC分类号： B01J31/22 ,  C07C315/02 ,  B01J31/02 ,  C07D403/12 ,  C07D401/12 ,  C07D333/18 ,  C07D333/34 ,  C07D277/76 ,  C07D213/71 ,  C07D405/12 ,  C07D235/28 ,  B01J27/051 ,  B01J27/18 ,  B01J35/00 ,  B01J37/12 ,  C07B53/00 ,  C07C317/06 ,  C07C279/16 ,  C07C317/14 ,  C07C317/24 ,  C07C317/44

摘要： D The present invention relates to ion pair catalysts (I) comprising the cationic bisguanidinium ligand (A) and diperoxomolybdate anion (B). The present invention also relates to ion pair catalysts (III) comprising the cationic bisguanidinium ligand (C) and peroxotungstate anion (D). It further relates to the use of the said catalysts in the manufacture of enantiomerically enriched sulfoxides.

公开(公告)号：US20200172548A9

公开(公告)日：2020-06-04

申请号：US16031165

申请日：2018-07-10

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Motoshi YAMAUCHI ,  Keiji NAKAYAMA

IPC分类号： C07D487/10 ,  C07D491/20 ,  B01J31/22 ,  B01J31/14 ,  B01J31/02 ,  B01J31/24 ,  B01J31/04 ,  C07B53/00

摘要： The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

公开(公告)号：US20190276404A1

公开(公告)日：2019-09-12

申请号：US16296324

申请日：2019-03-08

申请人： Dow AgroSciences LLC

发明人： Brian A. Loy ,  Nicolaas Vermeulen ,  Brannon Sam ,  Kevin G. Meyer ,  Chenglin Yao ,  Nicholas R. Babij ,  Jeff Petkus

IPC分类号： C07D213/81 ,  C07D213/83 ,  C07C271/18 ,  C07D333/08 ,  C07C229/28 ,  A01N43/40 ,  A01N43/10 ,  A01N37/02 ,  A01N47/18 ,  C07B53/00

摘要： This disclosure relates to picolinamides of Formula I and their use as fungicides.

公开(公告)号：US20190232266A1

公开(公告)日：2019-08-01

申请号：US16381879

申请日：2019-04-11

申请人： THE UNIVERSITY OF TOKYO ,  TOWA PHARMACEUTICAL CO. LTD.

发明人： Eiichi NAKAMURA ,  Laurean ILIES ,  Yoji ODERAOTOSHI ,  Takuhiro IZUMI ,  Shigenobu NISHIGUCHI

IPC分类号： B01J31/22 ,  C07D401/12 ,  C07C251/24 ,  C07D471/04 ,  C07B53/00 ,  B01J31/00 ,  C07F15/02 ,  B01J23/745

摘要： A highly pure optically active proton pump inhibitor compound can be produced safely and inexpensively in a high yield and enantioselectivity by a method of producing an optically active sulfoxide of Formula 2 or a salt thereof, comprising oxidizing a sulfide of Formula 1 or a salt thereof with hydrogen peroxide using an iron salt in the presence of a chiral ligand of Formula 3; wherein A is CH or N; R1 is hydrogen atom, an alkyl optionally substituted by halogen(s), or an alkoxy optionally substituted by halogen(s); one to three R2 may exist, and each of R2 is independently an alkyl, a dialkylamino, or an alkoxy optionally substituted by halogen(s) or alkoxy(s); each of R3 is independently hydrogen atom, a halogen, cyano or the like; R4 is a tertiary alkyl; and * and ** represent respectively R configuration or S configuration.

公开(公告)号：US20190194122A1

公开(公告)日：2019-06-27

申请号：US16223326

申请日：2018-12-18

申请人： Apotex Inc.

发明人： Prabhudas Bodhuri ,  Eduardo Gustavo Cammisa ,  Melanie R.A. Green ,  Gamini Weeratunga ,  Boris Gorin

IPC分类号： C07C209/70 ,  C07C209/62 ,  C07C209/28 ,  C07B53/00

CPC分类号： C07C209/70 ,  C07B53/00 ,  C07B2200/07 ,  C07C209/28 ,  C07C209/62 ,  C07C211/42 ,  C07C249/02 ,  C07C2602/10

摘要： The present invention provides processes for the preparation of Dasotraline (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (2), or a salt thereof, and its deprotection to afford Dasotraline (1).