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    Production of urethane compounds
    1.
    发明授权
    Production of urethane compounds 失效
    生产氨基甲酸酯化合物

    公开(公告)号：US4621149A

    公开(公告)日：1986-11-04

    申请号：US681061

    申请日：1984-12-10

    申请人： Shinsuke Fukuoka ,  Masazumi Chono

    发明人： Shinsuke Fukuoka ,  Masazumi Chono

    IPC分类号： C07C271/06 ,  C07C125/077 ,  C07C125/065 ,  C07C125/067 ,  C07C125/073 ,  C07C125/075

    CPC分类号： C07C271/06

    摘要： A process for producing a urethane compound which comprises reacting at least one compound selected from the group consisting of a primary amine, a secondary amine and a urea compound with carbon monoxide and an organic hydroxyl compound in the presence of a catalyst system comprising:(a) at least one member selected from the group consisting of platinum group metals and compounds containing at least one platinum group element; and(b) at least one halogen-containing compound selected from the group consisting of alkali or alkaline earth metal halides, onium halides, compounds capable of forming onium halides in the reaction, oxo acids of halogen atoms and their salts, complex compounds containing halogen ions, organic halides and halogen molecules,in the presence of molecular oxygen and/or an organic nitro compound as an oxidizing agent at a temperature of from about 80.degree. C. to about 300.degree. C. under a pressure of from about 1 Kg/cm.sup.2 to about 500 Kg/cm.sup.2.

    摘要翻译： 一种制备氨基甲酸酯化合物的方法，包括在催化剂体系存在下使至少一种选自伯胺，仲胺和脲化合物的化合物与一氧化碳和有机羟基化合物反应，所述催化剂体系包含：（a ）选自铂族金属和含有至少一个铂族元素的化合物中的至少一种; 和（b）至少一种选自碱金属或碱土金属卤化物，卤化铪，能够在反应中形成卤化铪的化合物，卤素原子的卤代酸及其盐的卤素化合物，含卤素的络合物 离子，有机卤化物和卤素分子，在分子氧和/或有机硝基化合物作为氧化剂的存在下，在约80℃至约300℃的温度下，在约1kg / cm2至约500Kg / cm2。

    Process for producing diphenylmethane dicarbamates
    2.
    发明授权
    Process for producing diphenylmethane dicarbamates 失效
    生产二苯基甲烷二氨基甲酸酯的方法

    公开(公告)号：US4552974A

    公开(公告)日：1985-11-12

    申请号：US559114

    申请日：1983-12-07

    申请人： Shinsuke Fukuoka ,  Tomonari Watanabe

    发明人： Shinsuke Fukuoka ,  Tomonari Watanabe

    IPC分类号： C07C271/06 ,  C07C125/073 ,  C07C125/075

    CPC分类号： C07C271/06

    摘要： A process for producing a diphenylmethane dicarbamate by reacting an N-phenylcarbamate with a methylenating agent is disclosed. The process is carried out by condensing N-phenylcarbamate in two steps using a combination of two different types of acid catalysts. The catalysts exhibit a strong catalyzing effect and yet can be readily separated from the reaction mixture. The process produces dineuclear diphenylmethane dicarbamates in high selectivity. The acid catalysts can be easily recovered from the reaction mixtures and put to another use.

    摘要翻译： 公开了通过使N-苯基氨基甲酸酯与亚甲基化试剂反应制备二苯基甲烷二氨基甲酸酯的方法。 该方法通过使用两种不同类型的酸催化剂的组合在两个步骤中冷凝N-苯基氨基甲酸酯进行。 催化剂表现出强烈的催化作用，并且可以容易地从反应混合物中分离出来。 该方法以高选择性产生二核二苯基甲烷二氨基甲酸酯。 酸催化剂可以容易地从反应混合物中回收并投入另一种用途。

    Bronchospasmolytic carbamate derivatives
    4.
    发明授权
    Bronchospasmolytic carbamate derivatives 失效
    支气管痉挛性氨基甲酸酯衍生物

    公开(公告)号：US4419364A

    公开(公告)日：1983-12-06

    申请号：US279672

    申请日：1981-07-01

    申请人： O. A. Torsten Olsson ,  Leif A. Svensson ,  Kjell I. L. Wetterlin

    发明人： O. A. Torsten Olsson ,  Leif A. Svensson ,  Kjell I. L. Wetterlin

    IPC分类号： C07C215/60 ,  A61K20060101 ,  A61K31/137 ,  A61K31/27 ,  A61K31/375 ,  A61P11/00 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  C07C20060101 ,  C07C67/00 ,  C07C215/00 ,  C07C215/34 ,  C07C239/00 ,  C07C269/06 ,  C07C271/44 ,  C07C271/58 ,  C07C125/067 ,  C07C125/075

    CPC分类号： A61K31/27 ,  A61K31/375

    摘要： New bronchospasmolytically active compounds exhibiting long duration of action and reduced undesired side effects of the structural formula ##STR1## and therapeutically acceptable salts thereof, in which formula R is selected from the group consisting of --C(CH.sub.3).sub.3, ##STR2## R.sup.1 is selected from the group consisting of H and R.sup.2, R.sup.2 represents the radical of the formula ##STR3## wherein R.sup.3 is selected from the group consisting of (a) H(b) alkyl groups containing 1-3 carbon atoms ##STR4## wherein R.sup.5 is selected from the group consisting of (e) OH(b) alkoxy groups containing 1-3 carbon atoms and whereinR.sup.4 is selected from the group consisting of(a) H(b) alkyl groups containing 1-3 carbon atoms, with the proviso that R.sup.3 and R.sup.4 are combined as follows:______________________________________ when R.sup.3 is then is R.sup.4 ______________________________________ H H alkyl group of 1-3 carbon atoms H or an alkyl group of 1-3 carbon atoms ##STR5## H ______________________________________ processes for the preparation thereof, chemical intermediates at their preparation, pharmaceutical preparations containing them, and their medicinal use.

    摘要翻译： 新的支气管扩张活性化合物显示出长时间的作用和减少结构式I的不期望的副作用及其治疗上可接受的盐，其中式R选自-C（CH 3）3， 其中R 3选自（a）H（b）含有1-3个碳原子的烷基，其中R 5选自H和R 2的基团，R 2表示式 选自（e）含有1-3个碳原子的（b）烷氧基，其中R 4选自（a）H（b）含有1-3个碳原子的烷基，和 条件是R 3和R 4如下组合： - 当R 3是具有1-3个碳原子的R 4 -HH-烷基时，或1-3个碳原子的烷基 - 其制备方法，其制备中的化学中间体，含有的药物制剂 他们和他们的药用。

    Naphthalene anti-psoriatic agents
    6.
    发明授权
    Naphthalene anti-psoriatic agents 失效
    萘抗牛皮癣药

    公开(公告)号：US4786652A

    公开(公告)日：1988-11-22

    申请号：US23591

    申请日：1987-03-09

    申请人： Michael C. Venuti

    发明人： Michael C. Venuti

    IPC分类号： C07C46/00 ,  C07C50/10 ,  C07C50/24 ,  C07C50/32 ,  A61K31/27 ,  A61K31/265 ,  C07C69/96 ,  C07C125/075

    CPC分类号： C07C46/00 ,  C07C50/10 ,  C07C50/24 ,  C07C50/32 ,  Y10S514/863

    摘要： Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is lower alkoxy or optionally substituted phenoxy,R.sup.2 is the same as R.sup.1, or R.sup.2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl,R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halo, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl or optionally substituted phenyl-lower-alkoxy, and m is 1 or 2;X is the same and is either --C(O)OR.sup.4 or --C(O)NR.sup.5 R.sup.6,whereinR.sup.4 is alkyl, phenyl or benzyl optionally substituted with one or two lower alkyl groups, lower alkoxy groups or halo; andR.sup.5 and R.sup.6 are independently hydrogen, lower alkyl, cycloalkyl or phenyl optionally substituted with one or two lower alkyl groups, lower alkoxy groups or halo.

    摘要翻译： 哺乳动物中的牛皮癣通过局部施用下式的萘来减轻：其中：R 1是低级烷氧基或任选取代的苯氧基，R 2与R 1相同，或R 2是氢，低级烷基，任选取代的苯基或任选地 取代的苯基烷基，R 3是氢，低级烷基，低级烷氧基，卤素，任选取代的苯基，任选取代的苯基 - 低级烷基或任选取代的苯基 - 低级烷氧基，m是1或2; X是相同的并且是-C（O）OR 4或-C（O）NR 5 R 6，其中R 4是烷基，任选地被一个或两个低级烷基，低级烷氧基或卤素取代的苯基或苄基; 且R 5和R 6独立地为氢，低级烷基，环烷基或任选被一个或两个低级烷基，低级烷氧基或卤素取代的苯基。

    Preparation of 1,3-di(alkoxycarbonylamino)propanes
    7.
    发明授权
    Preparation of 1,3-di(alkoxycarbonylamino)propanes 失效
    制备1,3-二（烷氧基羰基氨基）丙烷

    公开(公告)号：US4672137A

    公开(公告)日：1987-06-09

    申请号：US856971

    申请日：1986-04-29

    申请人： Franz Merger ,  Joerg Liebe

    发明人： Franz Merger ,  Joerg Liebe

    IPC分类号： C07B61/00 ,  B01J23/00 ,  B01J23/44 ,  B01J25/00 ,  B01J25/02 ,  C07C67/00 ,  C07C239/00 ,  C07C269/00 ,  C07C271/06 ,  C07C125/07 ,  C07C125/073 ,  C07C125/075

    CPC分类号： C07C271/06

    摘要： 1,3-Di(alkoxycarbonylamino)propanes of the general formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 can be identical or different and each is hydrogen, or an aliphatic, cycloaliphatic, araliphatic or aromatic radical, and R.sup.4 is an aliphatic, cycloaliphatic or araliphatic radical, are prepared by reacting an .alpha.,.beta.-unsaturated aldehyde with a carbamic acid ester by reacting in a first stage as the .alpha.,.beta.-unsaturated aldehyde a compound of the general formula II ##STR2## where R.sup.1, R.sup.2 and R.sup.3 have the abovementioned meanings, with a carbamic acid ester of the general formula III ##STR3## where R.sup.4 has the abovementioned meanings, at 0.degree.-150.degree. C. to give a 1,1,3-tri(alkoxycarbonylamino)propane of the general formua IV ##STR4## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the abovementioned meanings, and in a second stage heating the compound of the general formula (IV) in the presence of a hydrogenation catalyst and hydrogen under 1-300 bar at 100.degree.-300.degree. C.

    摘要翻译： 通式I（I）的1,3-二（烷氧基羰基氨基）丙烷，其中R 1，R 2和R 3可以相同或不同，各自为氢，或脂族，脂环族，芳脂族或芳族基，R4为 通过使α，β-不饱和醛与氨基甲酸酯反应，通过在第一阶段中作为α，β-不饱和醛与通式II的化合物（II）反应来制备脂族，脂环族或芳脂族基团 ）其中R 1，R 2和R 3具有上述含义，与0℃-150℃下具有上述含义的通式III（III）的氨基甲酸酯反应，得到1,1， （IV）的3-三（烷氧基羰基氨基）丙烷，其中R 1，R 2，R 3和R 4具有上述含义，在第二阶段中，在通式（Ⅳ）的化合物存在下加热通式 氢化催化剂和在1-300巴下在100-300℃的氢气

    Naphthalene anti-psoriatic agents
    9.
    发明授权
    Naphthalene anti-psoriatic agents 失效
    萘抗牛皮癣药

    公开(公告)号：US4758587A

    公开(公告)日：1988-07-19

    申请号：US23590

    申请日：1987-03-09

    申请人： Michael C. Venuti

    发明人： Michael C. Venuti

    IPC分类号： C07C46/00 ,  C07C50/10 ,  C07C50/24 ,  C07C50/32 ,  C07C69/96 ,  A61K31/265 ,  A61K31/27 ,  C07C125/075

    CPC分类号： C07C50/10 ,  C07C46/00 ,  C07C50/24 ,  C07C50/32

    摘要： Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is lower alkoxy or optionally substituted phenoxy;R.sup.2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl;R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halo, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl or optionally substituted phenyl-lower-alkoxy, and m is 1 or 2;X and Y are different and are either R.sup.4 or --C(O)W whereinR.sup.4 is lower alkyl or optionally substituted phenyl-lower-alkyl;W is --OR.sup.5 or --NR.sup.6 R.sup.7,whereinR.sup.5 is alkyl, optionally substituted phenyl or optionally substituted benzyl; andR.sup.6 and R.sup.7 are independently hydrogen, lower alkyl, cycloalkyl or optionally substituted phenyl.

    摘要翻译： 哺乳动物的银屑病通过局部施用下式的萘来缓解：其中：R1是低级烷氧基或任意取代的苯氧基; R 2是氢，低级烷基，任选取代的苯基或任选取代的苯基烷基; R 3是氢，低级烷基，低级烷氧基，卤素，任选取代的苯基，任选取代的苯基 - 低级烷基或任选取代的苯基 - 低级烷氧基，m是1或2; X和Y不同，为R 4或-C（O）W，其中R 4为低级烷基或任选取代的苯基 - 低级 - 烷基; W是-OR 5或-NR 6 R 7，其中R 5是烷基，任选取代的苯基或任选取代的苄基; 且R 6和R 7独立地为氢，低级烷基，环烷基或任选取代的苯基。