公开(公告)号：US12071392B2

公开(公告)日：2024-08-27

申请号：US17947817

申请日：2022-09-19

申请人： Panorama Research, Inc.

发明人： Cyrus K. Becker ,  Meenakshi S. Venkatraman ,  Xiaoming Zhang ,  James W. Larrick ,  Stuart Arthur Lipton

IPC分类号： C07C219/24 ,  A61K31/16 ,  A61P11/00 ,  A61P25/00 ,  C07C211/19 ,  C07C211/27 ,  C07C217/60 ,  C07C219/32

CPC分类号： C07C219/24 ,  A61K31/16 ,  A61P11/00 ,  A61P25/00 ,  C07C211/19 ,  C07C211/27 ,  C07C217/60 ,  C07C219/32 ,  C07C2603/74

摘要： The present disclosure provides adamantyl compounds having one or more amine groups and one or more nitrate groups. The aminoadamantyl nitrate compounds can be used to treat disorders of the central nervous system, including neurodegenerative and non-neurodegenerative diseases.

公开(公告)号：US20240230171A1

公开(公告)日：2024-07-11

申请号：US18285899

申请日：2022-04-07

申请人： President and Fellows of Harvard College

发明人： Jarad A. MASON ,  Jinyoung SEO

IPC分类号： F25B23/00 ,  C07C211/15 ,  C07C211/27 ,  C07C211/63 ,  C07C215/08 ,  C07C217/08 ,  C07C229/08

CPC分类号： F25B23/00 ,  C07C211/15 ,  C07C211/27 ,  C07C211/63 ,  C07C215/08 ,  C07C217/08 ,  C07C229/08

摘要： The invention provides methods, compositions, and systems for barocaloric applications such as cooling, heating, and energy storage.

公开(公告)号：US20230302030A1

公开(公告)日：2023-09-28

申请号：US18326423

申请日：2023-05-31

申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY ,  CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL

发明人： Jian Hui WU ,  Gerald BATIST ,  Anne-Marie MES-MASSON ,  Diane PROVENCHER ,  Euridice CARMONA ,  Xiaolong LI ,  Xiaochong TIAN ,  Zied BOUDHRAA

IPC分类号： A61K31/7034 ,  A61P35/00 ,  A61K33/243 ,  A61K31/075 ,  A61K31/09 ,  A61K31/135 ,  A61K31/14 ,  A61K31/166 ,  A61K31/17 ,  A61K31/18 ,  A61K31/277 ,  A61K31/341 ,  A61K31/381 ,  A61K31/41 ,  A61K31/426 ,  A61K31/444 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  C07C43/205 ,  C07C211/27 ,  C07C233/66 ,  C07C255/58 ,  C07C275/40 ,  C07D241/04 ,  C07D257/04 ,  C07D277/56 ,  C07D401/06 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07H15/207

CPC分类号： A61K31/7034 ,  A61P35/00 ,  A61K33/243 ,  A61K31/075 ,  A61K31/09 ,  A61K31/135 ,  A61K31/14 ,  A61K31/166 ,  A61K31/17 ,  A61K31/18 ,  A61K31/277 ,  A61K31/341 ,  A61K31/381 ,  A61K31/41 ,  A61K31/426 ,  A61K31/444 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  C07C43/2055 ,  C07C211/27 ,  C07C233/66 ,  C07C255/58 ,  C07C275/40 ,  C07D241/04 ,  C07D257/04 ,  C07D277/56 ,  C07D401/06 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07H15/207

摘要： Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

公开(公告)号：US20230257349A1

公开(公告)日：2023-08-17

申请号：US17885683

申请日：2022-08-11

申请人： Arena Pharmaceuticals, Inc.

发明人： Robert M. Jones ,  Daniel J. Buzard ,  Sangdon Han ,  Sun Hee Kim ,  Juerg Lehmann ,  Brett Ullman ,  Jeanne V. Moody ,  Xiuwen Zhu ,  Scott Stirn

IPC分类号： C07D209/94 ,  A61K31/404 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/198 ,  A61K31/137 ,  C07D209/70 ,  C07D209/88 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07C211/27 ,  C07C229/26 ,  C07C255/03 ,  C07C279/14 ,  C07D401/14

CPC分类号： C07D209/94 ,  A61K31/404 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/198 ,  A61K31/137 ,  C07D209/70 ,  C07D209/88 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07C211/27 ,  C07C229/26 ,  C07C255/03 ,  C07C279/14 ,  C07D401/14 ,  Y02A50/30

摘要： The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor.




Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.

公开(公告)号：US11680132B2

公开(公告)日：2023-06-20

申请号：US17269403

申请日：2019-10-01

申请人： SIKA TECHNOLOGY AG

发明人： Edis Kasemi ,  Andreas Kramer ,  Ursula Stadelmann ,  Urs Burckhardt

IPC分类号： C08G59/50 ,  C07C211/27 ,  C09D163/00 ,  C09J163/00

CPC分类号： C08G59/5033 ,  C07C211/27 ,  C08G59/5006 ,  C09D163/00 ,  C09J163/00

摘要： A curing agent for epoxy resins has N-benzylethane-1,2-diamine and N,N′-dibenzylethane-1,2-diamine in a weight ratio in the range from 65/35 to 95/5. The curing agent is easy to prepare, thins epoxy resins particularly well, and enables low-emission epoxy resin products that have good workability and a long pot-life, cure reliably and surprisingly fast and can be walked on after a short time, in particular even in cold conditions. Coatings of particularly high mechanical grade, with a high surface quality and a minimal tendency to yellowing, can thus be produced. Epoxy resins of this type are particularly suitable for coating floors.

公开(公告)号：US20230135108A1

公开(公告)日：2023-05-04

申请号：US17642658

申请日：2021-07-23

申请人： Canopy Growth Corporation

发明人： Mahmood Azizpour FARD ,  Ben GEILING ,  Mohammadmehdi HAGHDOOST MANJILI

IPC分类号： C07D311/80 ,  C07C211/27 ,  C07C63/64

摘要： Disclosed herein are cannabinoid salt compounds formed by mixing an acidic cannabinoid compound with a base. According to embodiments of the present disclosure, the base is selected at least for having a low toxicity. Also disclosed are methods of preparing cannabinoid salt compounds. Further, the present disclosure provides use of the cannabinoid salt compounds as an intermediate for isolating an ultra-high purity cannabinoid from a cannabis plant material or extract thereof.

公开(公告)号：US20230102879A1

公开(公告)日：2023-03-30

申请号：US17573405

申请日：2022-01-11

申请人： President and Fellows of Harvard College

发明人： Daniel E. Kahne ,  Vadim Baidin

IPC分类号： C07F5/02 ,  A61P31/04 ,  C07C211/27 ,  C07C211/40 ,  C07C215/28 ,  C07D209/04 ,  C07D213/38 ,  C07D213/643 ,  C07D215/06 ,  C07D215/12 ,  C07D221/04 ,  C07D221/20 ,  C07D231/12 ,  C07D231/56 ,  C07D239/26 ,  C07D239/34 ,  C07D261/08 ,  C07D267/10 ,  C07D295/13 ,  C07D307/14 ,  C07D307/79 ,  C07D307/87 ,  C07D309/04 ,  C07D311/74 ,  C07D317/58 ,  C07D319/08 ,  C07D327/06 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D495/04 ,  C07D498/08

摘要： Disclosed herein are secondary amine compounds that inhibit tRNA synthetase. The compounds of the invention are useful in inhibiting tRNA synthetase in Gram-negative bacteria and are useful in killing Gram-negative bacteria. The secondary amine compounds of the invention are also useful in the treatment of tuberculosis.

公开(公告)号：US11352315B2

公开(公告)日：2022-06-07

申请号：US16593143

申请日：2019-10-04

申请人： Curza Global, LLC ,  University of Utah Research Foundation

发明人： Ryan E. Looper ,  Dustin Williams ,  Paul R. Sebahar ,  Travis J. Haussener ,  Hariprasada R. Kanna Reddy

IPC分类号： C07C211/27 ,  A61P17/02

摘要： Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In some aspects, the present invention relates to polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms. In some aspects, the present invention relates to compositions and methods comprising the polyamine compound. In some aspects, the compounds, compositions, and methods enhance wound healing.

公开(公告)号：US11319405B2

公开(公告)日：2022-05-03

申请号：US16343325

申请日：2017-10-26

申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： Yuiga Asai ,  Takuma Hanaoka

IPC分类号： C08G59/50 ,  C07C211/27

摘要： A curing agent for a water-based epoxy resin, including a reaction composition (A) containing a reaction product of styrene and an amine compound represented by the following formula (1), a water-based epoxy resin composition containing the same, and a cured product thereof. H2N—CH2-A-CH2—NH2  (1) wherein A is a 1,2-phenylene group, a 1,3-phenylene group, or a 1,4-phenylene group.

公开(公告)号：US11285151B2

公开(公告)日：2022-03-29

申请号：US16549226

申请日：2019-08-23

申请人： Emory University

发明人： Michael G. Natchus ,  Richard Arrendale ,  Dennis Liotta ,  Ketan Desai ,  Hyunsuk Shim

IPC分类号： A61K31/506 ,  A61K45/06 ,  A61K31/4166 ,  A61K31/57 ,  A61K31/575 ,  A61K31/58 ,  A61K31/505 ,  A61K31/137 ,  A61K31/138 ,  A61K31/167 ,  A61K31/444 ,  A61K38/20 ,  C07D403/12 ,  C07D213/74 ,  C07D401/12 ,  C07D239/42 ,  C07D213/72 ,  C07C211/53 ,  C07C233/64 ,  C07C255/58 ,  C07C211/52 ,  C07C229/60 ,  C07C279/04 ,  C07C279/18 ,  C07C211/27 ,  C07C233/11 ,  C07C233/58 ,  C07C233/65 ,  C07C233/75 ,  C07C237/40

摘要： The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.