公开(公告)号：US11185851B2

公开(公告)日：2021-11-30

申请号：US16074473

申请日：2017-02-16

申请人： TAKASAGO INTERNATIONAL CORPORATION

发明人： Yoshimasa Matsushima ,  Takashi Ohshima

IPC分类号： B01J31/16 ,  C07J9/00 ,  C07D473/16 ,  C07C68/06 ,  C07C69/96 ,  C07C43/23 ,  C07C69/145 ,  C07C31/125 ,  C07C33/32 ,  C07C201/12 ,  B01J31/06 ,  C07C33/02 ,  C07C205/43 ,  C07C213/06 ,  C07C219/14 ,  C07C67/03 ,  C07C39/20 ,  C07C69/24 ,  C07C33/22 ,  C07C69/78 ,  C07F7/18 ,  C07D317/38 ,  C07C69/14 ,  C07C37/055 ,  C07C41/16 ,  C07C69/157 ,  B01J37/04 ,  C07C29/128 ,  C07C67/02 ,  C07C67/08 ,  C07D317/36 ,  C07B61/00

摘要： A macromolecules containing a metal and a use thereof as a catalyst are disclosed. The macromolecules containing a metal may be obtained by causing a ligand to react with a zinc compound or a cobalt compound. The ligand has an imidazole group that is bonded to a macromolecule via a linker. The metal-containing macromolecules are highly active as a catalyst, stable, and easy to recover and reuse.

公开(公告)号：US20180305296A1

公开(公告)日：2018-10-25

申请号：US15562222

申请日：2016-03-07

申请人： Zhejiang Yuejia Pharmaceuticals Co., Ltd

发明人： Jing Zhang

IPC分类号： C07C219/14 ,  C07C213/06

CPC分类号： C07C219/14 ,  A61K31/621 ,  C07B2200/13 ,  C07C213/06

摘要： Disclosed are an acetylsalicylic acid derivative, i.e. a 2-(diethylamino)ethyl 2-acetoxy-benzoate hydrochloride crystal, and a preparation method and use thereof. The X-ray powder diffraction (XRPD) pattern of the crystal has characteristic peaks at the following 2θ angle: 11.0°±0.2°, 20.6°±0.2°, 25.1°±0.2°, 8.2°±0.2°, 16.5°±0.2°, 13.4°±0.2°, 25.4°±0.2°.

公开(公告)号：US09434682B2

公开(公告)日：2016-09-06

申请号：US14805715

申请日：2015-07-22

申请人： AEKYUNG CHEMICAL CO., LTD.

发明人： Yoon-Tae Jeon ,  Do-Yeon Kim ,  Yun-Sun Do ,  Gi-Woo Lee ,  Hueong-Nam Park ,  Kwang-Sik Choi

IPC分类号： C07C69/00 ,  C07C249/02 ,  C07C219/14 ,  C09K19/38 ,  C09K19/06 ,  C09K19/20 ,  C09K19/22 ,  C07C65/00 ,  C07C45/64 ,  C07C51/367 ,  C07C67/40 ,  C07D309/12 ,  C09K19/04

CPC分类号： C07C249/02 ,  C07C45/64 ,  C07C51/367 ,  C07C65/00 ,  C07C67/40 ,  C07C219/14 ,  C07D309/12 ,  C09K19/062 ,  C09K19/2014 ,  C09K19/22 ,  C09K19/38 ,  C09K2019/0448 ,  C07C65/21 ,  C07C251/24

摘要： Disclosed are a novel reactive mesogen compound having superior thermostability, high birefringence and a simple preparation process while possessing unique liquid crystal characteristics having molecular orientation by forming a polymer network through photopolymerization, and a method of preparing the same. The novel reactive mesogen compound according to the present invention is represented by Formula 3 below.

公开(公告)号：US4608383A

公开(公告)日：1986-08-26

申请号：US538693

申请日：1983-10-03

申请人： Fritz Wiedemann, deceased ,  Wolfgang Kampe ,  Karl Dietmann, deceased ,  Gisbert Sponer

发明人： Fritz Wiedemann, deceased ,  Wolfgang Kampe ,  Karl Dietmann, deceased ,  Gisbert Sponer

IPC分类号： A61K31/38 ,  A61K31/045 ,  A61K31/135 ,  A61K31/138 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/47 ,  A61K31/472 ,  A61K31/473 ,  A61K31/495 ,  A61K31/498 ,  A61K31/50 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P9/00 ,  A61P9/04 ,  C07C217/32 ,  C07C217/72 ,  C07C217/78 ,  C07C219/06 ,  C07C219/08 ,  C07C219/14 ,  C07D209/48 ,  C07D213/74 ,  C07D215/46 ,  C07D217/22 ,  C07D219/12 ,  C07D231/06 ,  C07D231/20 ,  C07D231/32 ,  C07D231/38 ,  C07D231/46 ,  C07D231/52 ,  C07D231/56 ,  C07D237/20 ,  C07D239/42 ,  C07D239/54 ,  C07D239/545 ,  C07D239/557 ,  C07D239/56 ,  C07D239/84 ,  C07D239/95 ,  C07D241/44 ,  C07D249/18 ,  C07D333/36 ,  C07D473/16 ,  C07D473/32 ,  C07D473/34 ,  C07D487/00 ,  C07D487/04 ,  C07D231/54 ,  C07D233/48 ,  C07D233/88

CPC分类号： C07D473/16 ,  C07D209/48 ,  C07D213/74 ,  C07D215/46 ,  C07D217/22 ,  C07D219/12 ,  C07D231/06 ,  C07D231/20 ,  C07D231/32 ,  C07D231/38 ,  C07D231/52 ,  C07D231/56 ,  C07D237/20 ,  C07D239/42 ,  C07D239/545 ,  C07D239/557 ,  C07D239/56 ,  C07D239/84 ,  C07D239/95 ,  C07D333/36 ,  C07D473/34 ,  C07D487/04

摘要： The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are hydrogen or halogen atoms or lower alkyl, cyano, carboxamide, hydroxyl, lower acyloxy, lower alkoxy, lower alkenyloxy or aryl lower alkoxy radicals, R.sub.5 and R.sub.6, which may be the same or different, are hydrogen atoms or lower alkyl radicals, X is a straight or branched alkylene chain containing 2 to 6 carbon atoms, A is a mono-, bi- or tricyclic heteroaromatic or hydroheteroaromatic radical or, when at least one of the symbols R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is other than a hydrogen atom, may also be a phenyl radical, with the proviso that when A is a uracil-6-yl radical, the 5-position of the uracil moiety does not contain a hydrogen atom, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11, which may be the same or different, are mono- or divalent substituents selected from hydrogen, halogen, notro, hydraxylamino, amino, lower acylamino, lower alkylamino, di-(lower alkyl)-amino, hydroxyethylamino, di-(hydroxyethyl)-amino, hydroxyl, lower alkoxy, allyloxy, methoxy lower alkoxy, cyano, carboxamido, carboxy, lower alkoxycarbonyl, hydroxymethyl, lower alkoxymethyl, halomethyl, aminomethyl, lower acylaminomethyl, halomethyl, aminomethyl, lower acylaminomethyl, di(lower alkyl)-aminomethyl, pyrrolidinomethyl, piperidinomethyl, di-(hydroxyethyl)-amino, hydroxyl, lower alkoxy, allyloxy, methoxy lower alkoxy, cyano, carboxamido, carboxy, lower alkoxycarbonyl, hydroxymethyl, lower alkoxymethyl, halomethyl, aminomethyl, lower acyaminomethyl, di-(lower alkyl)-aminomethyl, pyrrolidinomethyl, piperidinomethyl, di-(hydroxyethyl)-aminomethyl, morpholinomethyl, piperazinomethyl, 4-lower acylpiperazinomethyl, 4-lower alkylpiperazinomethyl, lower alkyl, lower alkenyl, 2-cyanoethyl, 2-hydroxyethyl, phenyl lower alkyl and phenyl, the phenyl radicals being optionally substituted with 1 or 2 hydroxyl or methoxy radicals, or from oxygen or sulphur; the optically-active forms and the racemic mixtures thereof, and the pharmacologically compatible salts thereof.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. These compounds are useful for the prophylaxis and combatting of cardiac and circulatory diseases.

公开(公告)号：US4154951A

公开(公告)日：1979-05-15

申请号：US532910

申请日：1974-12-16

申请人： Ulrich Pintschovius

发明人： Ulrich Pintschovius

IPC分类号： C07D263/56 ,  C07C51/00 ,  C07C57/50 ,  C07C63/34 ,  C07C67/00 ,  C07C69/76 ,  C07C213/00 ,  C07C219/14 ,  C07C253/00 ,  C07C255/54 ,  C07C255/62 ,  C07C301/00 ,  C07C303/22 ,  C07C303/26 ,  C07C303/30 ,  C07C303/32 ,  C07C303/40 ,  C07C309/38 ,  C07C309/58 ,  C09B57/00 ,  D06L3/12 ,  C07C63/60 ,  C07C121/60

CPC分类号： C07C57/50 ,  D06L3/12

摘要： A compound of the formula (1) ##STR1## in which X and X' stand for an optionally functionally modified carboxy or sulfo group and wherein the naphthalene nuclei may carry further non- chromophoric substituents and a process for their preparation. These compounds are valuable optical brighteners and can be applied by the methods known in this field.

摘要翻译： 式（1）的化合物其中X和X'代表任选的官能改性的羧基或磺基，并且其中萘核可以携带另外的非发色取代基及其制备方法。 这些化合物是有价值的荧光增白剂，可以通过本领域已知的方法应用。

公开(公告)号：US3959351A

公开(公告)日：1976-05-25

申请号：US274716

申请日：1972-07-24

申请人： Richard A. Day ,  Rasikkumar N. Gohil

发明人： Richard A. Day ,  Rasikkumar N. Gohil

IPC分类号： C07C219/14 ,  C07C93/20

CPC分类号： C07C219/14

摘要： There are provided certain novel halo lower alkyl benzoyl esters of di(lower alkyl amino) lower alkanols and the quaternary salts thereof, in particular the bromomethyl benzoyl esters of dimethyl aminoethanol and choline which possess activity as insecticides and cholinesterase inhibitors. The corresponding formyl benzoyl esters exhibit similar activity.

摘要翻译： 提供了二（低级烷基氨基）低级链烷醇及其季盐，特别是具有作为杀虫剂和胆碱酯酶抑制剂的二甲基氨基乙醇和胆碱的溴甲基苯甲酰酯的某些新的卤代低级烷基苯甲酰酯。 相应的苯甲酰基甲酰基酯具有相似的活性。

公开(公告)号：US3847953A

公开(公告)日：1974-11-12

申请号：US31723972

申请日：1972-12-21

申请人： RICHARDSON MERRELL INC

发明人： SILL A ,  FLEMING R

IPC分类号： C07D211/14 ,  A61K31/235 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  C07C20060101 ,  C07C67/00 ,  C07C69/76 ,  C07C213/00 ,  C07C219/14 ,  C07D295/14 ,  C07C93/20

CPC分类号： C07C225/24

摘要： 1. A BIS-BASIC ESTER OF ANTHRAQUINONE HAVING THE GENERAL FORMULA:

BIS((-R1-R-)>N-(CH2)N-OOC-)-ANTHRAQUINONE

WHEREIN N IS AN INTEGER OF FROM 2 TO 6; R AND R1 ARE EACH SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL HAVING FROM 1 TO 6 CARBON ATOMS, CYCLOALKYL HAVING FROM 3 TO 6 CARBON ATOMS, ALKENYL HAVING FROM 3 TO 6 CARBON ATOMS IN WHICH THE SATURATION IS IN A POSITION OTHER THAN IN THE 1-POSITION OF THE ALKENYL GROUP, AND WHEN R AND R1 ARE TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED REPRESENT THE PYRROLIDINYL, PIPERIDINO OR MORPHOLINO RADICALS; AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF.

公开(公告)号：US09728420B2

公开(公告)日：2017-08-08

申请号：US15091336

申请日：2016-04-05

申请人： SHIN-ETSU CHEMICAL CO., LTD.

发明人： Daisuke Kori ,  Kazumi Noda ,  Kazunori Maeda ,  Rie Kikuchi ,  Tsutomu Ogihara

IPC分类号： H01L21/31 ,  C07C219/32 ,  G03F7/11 ,  C07C69/94 ,  C07C317/22 ,  C07C69/84 ,  H01L21/32 ,  H01L21/324 ,  H01L21/3105 ,  H01L21/311 ,  C07C69/33 ,  C07C69/76 ,  C07C219/14 ,  G03F7/09

CPC分类号： H01L21/31 ,  C07C69/33 ,  C07C69/76 ,  C07C69/84 ,  C07C69/94 ,  C07C219/14 ,  C07C317/22 ,  C07C2603/18 ,  C07C2603/24 ,  G03F7/091 ,  G03F7/094 ,  H01L21/0332 ,  H01L21/31056 ,  H01L21/31058 ,  H01L21/31116 ,  H01L21/31138 ,  H01L21/31144 ,  H01L21/32 ,  H01L21/324

摘要： An organic film composition including a compound represented by the following general formula (1), wherein n1 and n2 each independently represent 0 or 1; “W” represents a single bond or any of structures represented by the following formula (2); R1 represents any of structures represented by the following general formula (3); m1 and m2 each independently represent an integer of 0 to 7, with the proviso that m1+m2 is 1 to 14. There can be provided an organic film composition for forming an organic film having dry etching resistance as well as advanced filling/planarizing characteristics.

公开(公告)号：US09718766B2

公开(公告)日：2017-08-01

申请号：US14854616

申请日：2015-09-15

申请人： Techfields Pharma Co., Ltd.

发明人： Chongxi Yu ,  Lina Xu

IPC分类号： A61K31/195 ,  C07C219/06 ,  C07C317/44 ,  A61K31/137 ,  C07C229/36 ,  A61K31/198 ,  A61K31/277 ,  C07C271/16 ,  C07C271/22 ,  C07D321/12 ,  C07C219/10 ,  C07C219/14 ,  C07C219/28 ,  C07C229/12 ,  C07C327/30 ,  C07C229/58 ,  C07D455/02 ,  C07D471/04 ,  C07C237/06 ,  C07C237/20 ,  C07D207/16 ,  C07K5/083 ,  C07D211/62 ,  C07K5/097 ,  A61K31/197 ,  A61K31/24 ,  A61K31/40 ,  C07C219/32 ,  C07C237/08 ,  C07C327/36

CPC分类号： C07D471/04 ,  A61K31/137 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/24 ,  A61K31/277 ,  A61K31/40 ,  C07C217/60 ,  C07C219/06 ,  C07C219/10 ,  C07C219/14 ,  C07C219/28 ,  C07C219/32 ,  C07C229/12 ,  C07C229/36 ,  C07C229/58 ,  C07C237/06 ,  C07C237/08 ,  C07C237/20 ,  C07C271/16 ,  C07C271/22 ,  C07C317/44 ,  C07C327/30 ,  C07C327/36 ,  C07C2602/08 ,  C07D207/16 ,  C07D211/62 ,  C07D321/12 ,  C07D455/02 ,  C07K5/0806 ,  C07K5/0823 ,  A61K2300/00

摘要： One aspect of the invention provides a composition of novel high penetration compositions (HPC) or a high penetration prodrug (HPP) for treatment of Parkinson's disease. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

公开(公告)号：US09180115B2

公开(公告)日：2015-11-10

申请号：US14220381

申请日：2014-03-20

申请人： Asana Biosciences, LLC

发明人： Scott Kevin Thompson ,  Roger Astbury Smith ,  Sandeep Gupta ,  Tony Priestley ,  Nicholas James Laping ,  Ashis K. Saha ,  Sonali Rudra

IPC分类号： A61K31/69 ,  A01N43/40 ,  A01N55/08 ,  A61K31/40 ,  C07D309/14 ,  C07D333/38 ,  C07D333/40 ,  C07D333/70 ,  C07C219/12 ,  C07C219/14 ,  C07D207/34 ,  A61K45/06 ,  A61K31/215 ,  A61K31/235 ,  A61K31/24 ,  A61K31/351 ,  A61K31/381 ,  C07C63/49 ,  C07C65/26 ,  C07D333/72

CPC分类号： A61K31/40 ,  A61K31/215 ,  A61K31/235 ,  A61K31/24 ,  A61K31/351 ,  A61K31/381 ,  A61K45/06 ,  C07C63/49 ,  C07C65/26 ,  C07C219/12 ,  C07C219/14 ,  C07C2601/14 ,  C07D207/34 ,  C07D309/14 ,  C07D333/38 ,  C07D333/40 ,  C07D333/70 ,  C07D333/72 ,  A61K2300/00

摘要： The present application provides novel compounds and methods for preparing and using these compounds. These compounds are useful in treating pain, itch, overactive bladder and/or interstitial cystitis in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) and a TRPV1 receptor activator. In one embodiment, the TRPV1 receptor activator is lidocaine.

摘要翻译： 本申请提供了用于制备和使用这些化合物的新型化合物和方法。 这些化合物可用于通过向患者施用一种或多种化合物来治疗患者的疼痛，瘙痒，膀胱过度活动和/或间质性膀胱炎。 所述方法包括施用式（I）化合物和TRPV1受体激活剂。 在一个实施方案中，TRPV1受体激活剂是利多卡因。