公开(公告)号：US20230026924A1

公开(公告)日：2023-01-26

申请号：US17781308

申请日：2020-11-27

申请人： RHODIA OPERATIONS

发明人： Olivier Back ,  Sergio Mastroianni

IPC分类号： C07C225/06 ,  C07D211/74

摘要： The invention concerns new keto-ammonium compounds with surfactant properties and improved biodegradability.

公开(公告)号：US11267781B2

公开(公告)日：2022-03-08

申请号：US16347977

申请日：2017-11-08

申请人： RHODIA OPERATIONS

发明人： Olivier Back ,  Rémy Leroy ,  Philippe Marion

IPC分类号： C07C45/48 ,  C07C215/18 ,  C07C221/00 ,  C07C225/06 ,  C07C41/03 ,  C07C67/03 ,  C07C29/145 ,  C08G65/08

摘要： Method (M) for the preparation of an end compound from an internal ketone, said method comprising: —synthesizing the internal ketone by a process (P) for the decarboxylative ketonization of a fatty acid, a fatty acid derivative or a mixture thereof in a liquid phase with a metal compound as catalyst in the substantial absence of added solvent, wherein the fatty acid, fatty acid derivative or mixture thereof is added in sequential steps, the first step taking place at a temperature sequentially at a temperature from 100° C. to 270° C., —causing the internal ketone to react in accordance with a single or multiple chemical reaction scheme involving at least one reagent other than the internal ketone, wherein at least one product of the chemical reaction scheme is the end compound that is not further caused to be chemically converted into another compound.

公开(公告)号：US20220054671A1

公开(公告)日：2022-02-24

申请号：US17517846

申请日：2021-11-03

申请人： UNIVERSITÄTSKLINIKUM REGENSBURG ,  UNIVERSITÄT SALZBURG

发明人： Andreas SPÄTH ,  Kristjan PLÄTZER ,  Tim MAISCH ,  Anja EICHNER

IPC分类号： A61L2/08 ,  A01N55/08 ,  A01N35/02 ,  A01N55/02 ,  A01N47/44 ,  A01N57/34 ,  C07F9/54 ,  C07C279/08 ,  C07C217/18 ,  C07C217/20 ,  C07C217/08 ,  A61L2/18 ,  C07C217/22 ,  C07C217/24 ,  C07C225/06 ,  C07F3/06 ,  C07F5/02

摘要： 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof.

公开(公告)号：US20210238158A1

公开(公告)日：2021-08-05

申请号：US17003051

申请日：2020-08-26

申请人： Vertex Pharmaceuticals Incorporated

发明人： Gerald J. Tanoury ,  Cristian Harrison ,  Benjamin Joseph Littler ,  Peter Jamison Rose ,  Robert Michael Hughes ,  Young Chun Jung ,  David Andrew Siesel ,  Elaine Chungmin Lee ,  Daniel T. Belmont ,  William A. Nugent

IPC分类号： C07D317/46 ,  C07D209/12 ,  C07D317/60 ,  C07D405/12 ,  C07C209/74 ,  C07C225/06

摘要： The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.

公开(公告)号：US11066374B2

公开(公告)日：2021-07-20

申请号：US16138440

申请日：2018-09-21

申请人： OP BIO FACTORY CO., LTD. ,  SEED RESEARCH INSTITUTE CO., LTD.

发明人： Teruhiko Ishikawa ,  Morita Iwami

IPC分类号： C07C225/06 ,  C07C271/18 ,  C07D261/04 ,  C07D498/04 ,  C07D211/46 ,  C07D211/74 ,  C07B33/00 ,  C07D211/44

摘要： Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.

公开(公告)号：US10351534B2

公开(公告)日：2019-07-16

申请号：US15828660

申请日：2017-12-01

申请人： JSC GRINDEKS

发明人： Ivars Kalvins ,  Edgars Liepins ,  Einars Loza ,  Maija Dambrova ,  Ilmars Stonans ,  Daina Lola ,  Janis Kuka ,  Osvalds Pugovics ,  Reinis Vilskersts ,  Solveiga Grinberga

IPC分类号： C07C229/12 ,  C07C227/18 ,  C07D239/10 ,  C07C55/10 ,  C07C57/15 ,  C07C227/08 ,  C07D239/557 ,  C07C69/157 ,  C07C225/06

摘要： Salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium, method of preparation thereof and use in the treatment of cardiovascular disease.

公开(公告)号：US10316010B2

公开(公告)日：2019-06-11

申请号：US15383935

申请日：2016-12-19

申请人： South Dakota Board of Regents

发明人： Grigoriy Sereda ,  Joseph Keppen

IPC分类号： C08K3/04 ,  C07D307/52 ,  C07C225/06 ,  C07C227/14 ,  C07D207/448 ,  C07D405/14 ,  C07F9/38 ,  C08J3/24 ,  C08K3/22 ,  C08K7/06 ,  C08K9/04

摘要： Disclosed is a non-destructive universal method of functionalization of graphitic carbonaceous materials that enables their alignment, cross-linking, and effective integration into composite materials.

公开(公告)号：US20180079728A1

公开(公告)日：2018-03-22

申请号：US15828660

申请日：2017-12-01

申请人： JSC GRINDEKS

发明人： Ivars KALVINS ,  Edgars LIEPINS ,  Einars LOZA ,  Maija DAMBROVA ,  IImars STONANS ,  Daina LOLA ,  Janis KUKA ,  Osvalds PUGOVICS ,  Reinis VILSKERSTS ,  Solveiga GRINBERGA

IPC分类号： C07D239/10 ,  C07D239/557 ,  C07C229/12 ,  C07C227/18 ,  C07C55/10 ,  C07C225/06 ,  C07C69/157 ,  C07C57/15 ,  C07C227/08

CPC分类号： C07D239/10 ,  C07C55/10 ,  C07C57/15 ,  C07C69/157 ,  C07C225/06 ,  C07C227/08 ,  C07C227/18 ,  C07C229/12 ,  C07D239/557

摘要： Salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium, method of preparation thereof and use in the treatment of cardiovascular disease.

公开(公告)号：US09528111B2

公开(公告)日：2016-12-27

申请号：US14362762

申请日：2012-12-29

申请人： BONAC CORPORATION

发明人： Tadaaki Ohgi ,  Hiroshi Suzuki ,  Tomohiro Hamasaki ,  Eriko Aoki

IPC分类号： C12N15/11 ,  C12N15/113 ,  C07C225/06 ,  A61K47/48

CPC分类号： C12N15/1136 ,  A61K47/60 ,  C07C225/06 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/3181 ,  C12N2310/531 ,  C12N2310/532 ,  C12N2310/533 ,  C12N2320/30 ,  C12N2320/51

摘要： The invention provides a single-stranded nucleic acid molecule containing an expression inhibitory sequence that inhibits expression of a target gene, region (X), linker region (Lx), and region (Xc), wherein the linker region (Lx) is linked between the region (Xc) and the region (Xc), the region (Xc) is complementary to the region (X), at least one of the region (X) and the region (Xc) contains the expression inhibitory sequence, and the linker region (Lx) contains an atomic group derived from an amino acid. The single-stranded nucleic acid molecule can inhibit expression of the target gene.

摘要翻译： 本发明提供了含有表达抑制性序列的单链核酸分子，其抑制靶基因，区域（X），接头区域（Lx）和区域（Xc）的表达，其中连接区域（Lx）连接在 区域（Xc）和区域（Xc），区域（Xc）与区域（X）互补，区域（X）和区域（Xc）中的至少一个含有表达抑制序列， 区域（Lx）含有衍生自氨基酸的原子团。 单链核酸分子可以抑制靶基因的表达。

公开(公告)号：US09421210B2

公开(公告)日：2016-08-23

申请号：US14630897

申请日：2015-02-25

申请人： Acucela Inc.

发明人： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuska ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, Jr. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, Jr. ,  Ryo Kubota

IPC分类号： C07C211/27 ,  C07C217/18 ,  A61K31/5375 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/16 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07D295/03 ,  C07C225/06 ,  C07C323/33 ,  C07D207/06 ,  C07D211/14 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495

CPC分类号： A61K31/5375 ,  A61K31/137 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/10 ,  C07C217/16 ,  C07C217/18 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/06 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07C323/33 ,  C07C2602/14 ,  C07C2602/16 ,  C07D207/06 ,  C07D211/14 ,  C07D295/03

摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.