公开(公告)号：US20240252653A1

公开(公告)日：2024-08-01

申请号：US18441882

申请日：2024-02-14

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Jayaprakash K. NAIR ,  Alexander V. KEL'IN ,  Pachamuthu KANDASAMY ,  Kallanthottathil G. RAJEEV ,  Muthiah MANOHARAN

IPC分类号： A61K47/54 ,  A61K31/7088 ,  C07C231/14 ,  C07D207/12 ,  C07H1/00 ,  C07H15/26 ,  C12N15/113

CPC分类号： A61K47/549 ,  A61K31/7088 ,  C07C231/14 ,  C07D207/12 ,  C07H1/00 ,  C07H15/26 ,  C12N15/113 ,  C12N2310/351 ,  C12N2320/32

摘要： This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.

公开(公告)号：US12037541B2

公开(公告)日：2024-07-16

申请号：US17451086

申请日：2021-10-15

申请人： CHINA PETROLEUM & CHEMICAL CORPORATION ,  SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY, SINOPEC

发明人： Yingcheng Li ,  Songyuan Gu ,  Weidong Zhang ,  Xinning Bao ,  Ou Sha ,  Zhiqin Shen ,  Yiqing Yang ,  Xiaodong Zhai

IPC分类号： C09K8/584 ,  C07C213/06 ,  C07C217/08 ,  C07C231/14 ,  C07C233/05 ,  C07C233/09 ,  C07C233/36 ,  C07C237/08 ,  C07C237/40 ,  C07C303/22 ,  C07C309/10 ,  C09K8/60

CPC分类号： C09K8/584 ,  C07C213/06 ,  C07C217/08 ,  C07C231/14 ,  C07C233/05 ,  C07C233/09 ,  C07C233/36 ,  C07C237/08 ,  C07C237/40 ,  C07C303/22 ,  C07C309/10 ,  C09K8/602

摘要： An anionic-cationic-nonionic surfactant represented by the formula (I)




exhibits significantly improved interfacial activity and stability as compared with the prior art. With the present anionic-cationic-nonionic surfactant, a flooding fluid composition for tertiary oil recovery with improved oil displacement efficiency and oil washing capability as compared with the prior art could be produced.

公开(公告)号：US20240174597A1

公开(公告)日：2024-05-30

申请号：US18514650

申请日：2023-11-20

申请人： Boston Scientific Scimed, Inc.

发明人： Yen-Hao Hsu

IPC分类号： C07C231/14 ,  C08G64/02

CPC分类号： C07C231/14 ,  C08G64/0233

摘要： In some embodiments, the present disclosure provides iodinated polyamino compounds having a plurality of primary amine groups, all of which are the same, as well as methods for forming the same. In some embodiments, the present disclosure pertains to systems for forming hydrogels, which systems comprise such an iodinated polyamino compound and a polymer that that forms crosslinks with the iodinated polyamino compound. In some embodiments, the present disclosure pertains to hydrogels that are formed using such systems.

公开(公告)号：US20230364048A1

公开(公告)日：2023-11-16

申请号：US18359271

申请日：2023-07-26

申请人： MBI Distributing

发明人： Ned L. Jensen

IPC分类号： A61K31/22 ,  A61K31/4045 ,  A61K47/24 ,  A61K47/10 ,  A61K47/14 ,  A61P25/06 ,  C07C231/14 ,  A61P15/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/20 ,  A61K9/127

CPC分类号： A61K31/22 ,  A61K31/4045 ,  A61K47/24 ,  A61K47/10 ,  A61K47/14 ,  A61P25/06 ,  C07C231/14 ,  A61P15/00 ,  A61P25/22 ,  A61P25/28 ,  A61P25/20 ,  A61K9/127

摘要： The present invention is directed to compositions comprising N-Acetyl Methyl GABA, methods of preparing N-Acetyl Methyl GABA and compositions including N-Acetyl Methyl GABA, and methods of using N-Acetyl Methyl GABA for instance to improve sleep and control anxiety.

公开(公告)号：US20230339870A1

公开(公告)日：2023-10-26

申请号：US17773349

申请日：2020-10-28

申请人： KYUNGSUNG UNIVERSITY INDUSTRY COOPERATION FOUNDATION ,  PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

发明人： Jae-Hwan KWAK ,  Young-Suk JUNG ,  Doyoung KWON ,  Min Woo KIM ,  Sou Hyun KIM

IPC分类号： C07D261/08 ,  C07C235/34 ,  C07C231/14

CPC分类号： C07D261/08 ,  C07C235/34 ,  C07C231/14

摘要： The present disclosure relates to a pharmaceutical composition containing a cinnamic amide derivative that activates FXR or an isomer, solvate, or pharmaceutically acceptable salt thereof, and a method for preparing the same.

公开(公告)号：US11724982B2

公开(公告)日：2023-08-15

申请号：US16868343

申请日：2020-05-06

申请人： Ming-Yu Ngai ,  Katarzyna N. Hojczyk

发明人： Ming-Yu Ngai ,  Katarzyna N. Hojczyk

IPC分类号： C07C233/25 ,  C07C259/06 ,  C07C259/10 ,  C07C269/06 ,  C07C273/18 ,  C07C231/14 ,  C07C253/30 ,  C07D213/75 ,  C07D213/76 ,  C07D347/00 ,  C07D239/47 ,  C07D239/91 ,  C07D473/40 ,  C07D263/57 ,  C07D209/08 ,  C07D215/40 ,  C07D401/04 ,  C07D471/04 ,  C07J43/00 ,  C07D417/04 ,  C07D405/04 ,  C07C231/12 ,  C07C233/33 ,  C07C233/54 ,  C07C233/80 ,  C07C233/81 ,  C07C255/60 ,  C07C255/58 ,  C07C271/38 ,  C07C275/34

CPC分类号： C07C233/25 ,  C07C231/12 ,  C07C231/14 ,  C07C233/33 ,  C07C233/54 ,  C07C233/80 ,  C07C233/81 ,  C07C253/30 ,  C07C255/58 ,  C07C255/60 ,  C07C259/06 ,  C07C259/10 ,  C07C269/06 ,  C07C271/38 ,  C07C273/1809 ,  C07C273/1854 ,  C07C275/34 ,  C07D209/08 ,  C07D213/75 ,  C07D213/76 ,  C07D215/40 ,  C07D239/47 ,  C07D239/91 ,  C07D263/57 ,  C07D347/00 ,  C07D401/04 ,  C07D405/04 ,  C07D417/04 ,  C07D471/04 ,  C07D473/40 ,  C07J43/003 ,  C07C273/1854 ,  C07C275/64 ,  C07C269/06 ,  C07C271/38 ,  C07C231/14 ,  C07C233/25 ,  C07C253/30 ,  C07C255/60 ,  C07C253/30 ,  C07C255/58 ,  C07C273/1809 ,  C07C275/34

摘要： The present invention provides a process of producing a trifluoromcthoxylated aryl or trifluoromothoxylated heteroaryl having the structure:




wherein

A is an aryl or heteroaryl, each with or without substitution; and

R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising:

(a) reacting a compound having the structure:





with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure:





and

(b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:

公开(公告)号：US11697634B2

公开(公告)日：2023-07-11

申请号：US17322798

申请日：2021-05-17

申请人： National Tsing Hua University

发明人： Chien-Chung Han ,  Suman Alishetty

IPC分类号： C07C231/14 ,  C07D307/68 ,  C07C253/02 ,  C07C249/04 ,  C07C233/57

CPC分类号： C07C231/14 ,  C07C233/57 ,  C07C249/04 ,  C07C253/02 ,  C07D307/68

摘要： A method for producing a homocyclic or heterocyclic compound includes reacting a compound of formula (I) with a compound of formula (II) in presence of a base:

R1—B-G  (I)





In formula (I), B is an unsaturated moiety selected from substituted or unsubstituted vinylene, ethynylene, aryleneethynylene, substituted or unsubstituted arylenevinylene, and a combination thereof, the vinylene or arylenevinylene has n (=0, 1 or 2) substituent(s) R2, G is an electron-withdrawing group, R1 is hydrogen or a substituent, and two of R1, R2 and G may joint together to form a ring. In formula (II), R3 and R4 are independently hydrogen or a substituent, R5 is an electron-withdrawing group, and two of R3, R4 and R5 may joint together to form a ring. The conjugate acid of the base has a pKa in the range of 1 to 15.

公开(公告)号：US11673862B2

公开(公告)日：2023-06-13

申请号：US16256596

申请日：2019-01-24

申请人： SUZHOU PENGXU PHARMATECH CO. LTD.

发明人： Peng Wang ,  Pixu Li ,  Qiang Wei ,  Yuanhua Liu

IPC分类号： C07D207/27 ,  A61K31/4015 ,  C07C53/19 ,  C07C53/50 ,  C07C67/307 ,  C07C69/63 ,  C07C71/00 ,  C07C209/08 ,  C07C231/14 ,  C07C233/05 ,  C07C237/06

CPC分类号： C07D207/27 ,  A61K31/4015 ,  C07C53/19 ,  C07C53/50 ,  C07C67/307 ,  C07C69/63 ,  C07C71/00 ,  C07C209/08 ,  C07C231/14 ,  C07C233/05 ,  C07C237/06

摘要： The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.

公开(公告)号：US20230159421A1

公开(公告)日：2023-05-25

申请号：US17788698

申请日：2020-12-23

申请人： Kynan Duke IP, LLC

发明人： Colin Charles Duke ,  Rujee Kyokajee DUKE ,  Van Hoan TRAN

IPC分类号： C07C43/23 ,  C07C41/26 ,  C07C51/367 ,  C07C201/12 ,  C07C209/04 ,  C07C303/40 ,  C07C231/12 ,  C07C231/14 ,  C07C277/08 ,  C07D235/26 ,  C07D263/58 ,  A61P35/00 ,  A61P17/06 ,  A61P17/00 ,  A61P29/00 ,  C07C217/80 ,  C07C65/28 ,  C07C217/82 ,  C07C311/08 ,  C07C233/01 ,  C07C237/04 ,  C07C225/06 ,  C07C235/74 ,  C07C279/18

CPC分类号： C07C43/23 ,  C07C41/26 ,  C07C51/367 ,  C07C201/12 ,  C07C209/04 ,  C07C303/40 ,  C07C231/12 ,  C07C231/14 ,  C07C277/08 ,  C07D235/26 ,  C07D263/58 ,  A61P35/00 ,  A61P17/06 ,  A61P17/00 ,  A61P29/00 ,  C07C217/80 ,  C07C65/28 ,  C07C217/82 ,  C07C311/08 ,  C07C233/01 ,  C07C237/04 ,  C07C225/06 ,  C07C235/74 ,  C07C279/18

摘要： The present disclosure relates to substituted hydroxystilbene compounds and derivatives, specifically 2-substituted hydroxystilbene compounds and derivatives, the synthesis of such compounds and their use in therapy.

公开(公告)号：US20230096826A1

公开(公告)日：2023-03-30

申请号：US18070827

申请日：2022-11-29

申请人： FMC Corporation ,  FMC Agro Singapore Pte. Ltd.

发明人： Liang CHEN ,  Yefeng FAN ,  Jianhua MAO ,  Zhijian XU

IPC分类号： C07D265/26 ,  C07C231/14 ,  C07C237/28 ,  C07D209/38

摘要： Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3-dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.