公开(公告)号：US20240360074A1

公开(公告)日：2024-10-31

申请号：US18635809

申请日：2024-04-15

申请人： Geron Corporation

发明人： Jennifer E. Albaneze-Walker

IPC分类号： C07C233/18 ,  B01D9/00 ,  C07C231/24

CPC分类号： C07C233/18 ,  B01D9/0031 ,  B01D2009/0086 ,  C07B2200/13 ,  C07C231/24

摘要： Aspects of the disclosure include crystalline solids of 3-palmitoyl-amido-1,2-propanediol and 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane. Methods for preparing the crystalline solids of 3-palmitoyl-amido-1,2-propanediol and single crystals of 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane are also provided. Methods for preparing a 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane from a crystalline solid of 3-palmitoyl-amido-1,2-propanediol are also described.

公开(公告)号：US12013640B2

公开(公告)日：2024-06-18

申请号：US17329767

申请日：2021-05-25

申请人： SHIN-ETSU CHEMICAL CO., LTD.

发明人： Takayoshi Nakahara ,  Takeru Watanabe ,  Daisuke Kori ,  Yusuke Biyajima ,  Tsutomu Ogihara

IPC分类号： G03F7/11 ,  C07C233/18 ,  C07C233/47 ,  C07C233/55 ,  C07D251/34 ,  C07D487/04 ,  C08F38/00 ,  C09D149/00 ,  G03F7/09

CPC分类号： G03F7/11 ,  C07C233/18 ,  C07C233/47 ,  C07C233/55 ,  C07D251/34 ,  C07D487/04 ,  C08F38/00 ,  C09D149/00 ,  G03F7/094 ,  C07C2603/18

摘要： A resist underlayer film material used in multilayer resist method contains (A) compound shown by following general formula (1), and (B) organic solvent, where X independently represents monovalent organic group shown by following general formula (2); W contains an “m” number of partial structures each independently shown by following formula (3); “m” and “n” each represent an integer of 1 to 10; broken lines represent bonding arms; Z represents aromatic group; A represents single bond or —O—(CH2)p—; “k” represents integer of 1 to 5; “p” represents integer of 1 to 10; R01 represents hydrogen atom or monovalent organic group having 1 to 10 carbon atoms. Material is capable of forming resist underlayer film excellent in planarizing property in fine patterning process by multilayer resist method in semiconductor-device manufacturing process; and patterning processes and methods for forming resist underlayer film use material.

公开(公告)号：US20240099993A1

公开(公告)日：2024-03-28

申请号：US18506138

申请日：2023-11-10

申请人： INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES

发明人： Chengyu JIANG ,  Yuhao QIN ,  Xiaoyun LI ,  Cong ZHANG

IPC分类号： A61K31/133 ,  A61K9/00 ,  A61K31/14 ,  A61K31/661 ,  A61K31/7016 ,  A61K31/702 ,  A61K47/18 ,  A61K47/24 ,  A61P35/00 ,  C07C69/003 ,  C07C69/587 ,  C07C215/10 ,  C07C233/18 ,  C07F9/10 ,  C12N15/113

CPC分类号： A61K31/133 ,  A61K9/0053 ,  A61K31/14 ,  A61K31/661 ,  A61K31/7016 ,  A61K31/702 ,  A61K47/18 ,  A61K47/24 ,  A61P35/00 ,  C07C69/003 ,  C07C69/587 ,  C07C215/10 ,  C07C233/18 ,  C07F9/10 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/32

摘要： The invention provides an artificially synthesized single sphingosine lipid and use of delivering a nucleic acid thereof. More particularly, the invention provides Use or method for delivering a nucleic acid to a cell or a subject using a compound of Formula (I), a stereoisomer or a pharmaceutical acceptable salt thereof, or a combination comprising a compound of Formula (I), a stereoisomer or a pharmaceutical acceptable salt thereof,

公开(公告)号：US20240075163A1

公开(公告)日：2024-03-07

申请号：US18493428

申请日：2023-10-24

申请人： Acuitas Therapeutics, Inc.

发明人： Steven M. Ansell ,  Xinyao Du

IPC分类号： A61K48/00 ,  A61K9/127 ,  A61K47/18 ,  C07C219/06 ,  C07C229/12 ,  C07C229/16 ,  C07C233/18 ,  C07C255/24 ,  C12N9/02

CPC分类号： A61K48/0033 ,  A61K9/127 ,  A61K47/18 ,  C07C219/06 ,  C07C229/12 ,  C07C229/16 ,  C07C233/18 ,  C07C255/24 ,  C12N9/0069 ,  C12Y113/12007

摘要： Compounds are provided having the following structure:




or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

公开(公告)号：US11524933B2

公开(公告)日：2022-12-13

申请号：US16887367

申请日：2020-05-29

申请人： Givaudan SA

发明人： Feng Shi ,  Harry Renes ,  Esther Van Ommeren ,  Susanna Magdalena Vorster ,  Yili Wang ,  Adri De Klerk ,  Xiaogen Yang

IPC分类号： C07C235/74 ,  A23L2/56 ,  C07C233/47 ,  C07C233/49 ,  C07C233/52 ,  C07D207/16 ,  A23C9/13 ,  A23C9/156 ,  A23C11/10 ,  A23C15/12 ,  A23C19/09 ,  C12G3/06 ,  C12C5/02 ,  A23L27/20 ,  A23L27/50 ,  A23L27/60 ,  A23L23/10 ,  A23F5/24 ,  A23L19/18 ,  A23L27/21 ,  C07C323/59 ,  A23L19/20 ,  A23L7/161 ,  C07C237/22 ,  A23L11/50 ,  A23L11/65 ,  C07C233/18 ,  A23L23/00 ,  A23L13/50 ,  A23C13/12 ,  A23F5/46

摘要： A flavour composition comprising a compound according to the formula (I) or edible salts thereof, wherein R1 is alkyl residue containing 6 to 20 carbon atoms, or an alkene residue containing from 9 to 25 carbon atoms with 1 to 6 double bonds, R1 together with the carbonyl to which it is attached is a residue carboxylic acid, and NR2R3, in which R3 is H or together with R2 and the N-atom to which they are attached, a 5-membered ring, is a residue of an amino acid, in particular proteinogenic amino acid, ornithine, gamma-aminobutyric acid or beta alanine, or a 1-amino cycloalkyl carboxylic acid.

公开(公告)号：US11365175B2

公开(公告)日：2022-06-21

申请号：US16760056

申请日：2018-11-02

申请人： ISAGRO S.p.A.

发明人： Marilena Gusmeroli ,  Paolo Bellandi ,  Silvia Mormile ,  Paolo Boggio ,  Paolo Bravini ,  Matteo Vazzola ,  Christian Badaracco ,  Riccardo Liguori

IPC分类号： C07C327/34 ,  A01N37/40 ,  A01N37/44 ,  A01N55/00 ,  C07C233/18 ,  C07C323/63 ,  C07F7/08 ,  C07D309/12 ,  C07C323/62 ,  C07F7/18 ,  C07C237/44

摘要： Aromatic amides are described, having general formula (I): suitably substituted and having a high fungicidal activity, together with their use for controlling phytopathogenic fungi of important agricultural crops.

公开(公告)号：US20220064114A1

公开(公告)日：2022-03-03

申请号：US17500593

申请日：2021-10-13

申请人： TriOptoTec GmbH

发明人： Andreas SPÄTH ,  Anja EICHNER

IPC分类号： C07D213/30 ,  C07C49/755 ,  C07C69/56 ,  C07C69/76 ,  C07C211/62 ,  C07C233/18 ,  C07C233/20 ,  C07C317/22 ,  C07D303/18 ,  C07D309/14 ,  C07F7/02 ,  C07F7/18

摘要： A phenalene-1-one compound, a photosensitizer composition including the phenalene-1-one compound, an article including the phenalene-1-one compound and/or photosensitizer composition and the use thereof.

公开(公告)号：US11098008B2

公开(公告)日：2021-08-24

申请号：US16776091

申请日：2020-01-29

申请人： THE UNIVERSITY OF KANSAS

发明人： Brian S. J. Blagg ,  Rick T. Dobrowsky ,  Mercy Anyika

IPC分类号： C07D311/08 ,  C07C233/18 ,  C07D309/10 ,  C07H15/203 ,  C07D307/20 ,  C07D311/16

摘要： Provided herein are compounds of the formulas: wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.

公开(公告)号：US20210238124A1

公开(公告)日：2021-08-05

申请号：US17049230

申请日：2019-04-22

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： David R. ELMALEH ,  Timothy M. SHOUP

IPC分类号： C07C233/18 ,  C07C219/28 ,  C07C217/60 ,  A61K51/04 ,  A61K51/12

摘要： The present disclosure relates to pharmaceutical compositions including a compound derived from a parent compound having a hydroxyl or amino moiety, wherein the hydroxyl in the parent compound is presented as an ester in the compound or the amino in the parent compound is presented as an amide in the compound, and their use to prevent or treat neurological disease.

公开(公告)号：US11021439B2

公开(公告)日：2021-06-01

申请号：US16700523

申请日：2019-12-02

申请人： SWIMC LLC

发明人： Sebastien Gibanel ,  Benoit Prouvost ,  Bernard Boutevin

IPC分类号： C07C235/34 ,  C07C233/18 ,  C07C235/50 ,  C09D171/08 ,  C08G65/332 ,  C09D171/02 ,  C08G65/331 ,  B65D85/72 ,  C07C231/02 ,  C08G63/685 ,  C08G64/16 ,  C08G65/40 ,  C08G71/04 ,  C09D167/00 ,  C09D169/00 ,  C09D171/00 ,  C09D175/12

摘要： Di(amido(alkyl)phenol) compounds and upgraded molecular weight polymers made from such compounds have particular utility in coating compositions, especially for use on food and beverage contact substrates that are formed into or will be formed into containers or container components.