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    N-acetyl beta alanine methods of use
    3.
    发明授权
    N-acetyl beta alanine methods of use 有权
    N-乙酰基β丙氨酸使用方法

    公开(公告)号：US08802731B2

    公开(公告)日：2014-08-12

    申请号：US13446416

    申请日：2012-04-13

    申请人： Ronald Kramer ,  Alexander Nikolaidis

    发明人： Ronald Kramer ,  Alexander Nikolaidis

    IPC分类号： A01N37/12 ,  A01N37/44 ,  A61K31/195 ,  C07C233/00 ,  C07C235/00 ,  C07C237/00 ,  C07C239/00 ,  A61K31/197

    CPC分类号： A61K31/198 ,  A61K31/197

    摘要： Methods for increasing athletic performance, preventing paresthesia, increasing beta alanine absorption and cell membrane permeability through both passive diffusion and active transport, and increasing the half-life of beta alanine present in a blood stream in a human or animal are disclosed. Each method includes administering to the human or animal a pharmaceutically effective amount of N-Acetyl Beta Alanine or an N-Acetyl Beta Alanine composition.

    摘要翻译： 公开了增加运动性能，预防感觉异常，通过被动扩散和主动转运增加β丙氨酸吸收和细胞膜通透性以及增加存在于人或动物血液中的β-丙氨酸的半衰期的方法。 每种方法包括向人或动物施用药学有效量的N-乙酰基β-丙氨酸或N-乙酰基β-丙氨酸组合物。

    Cationic amphiphiles with mannose-mimicking head-groups and a process for the preparation thereof
    4.
    发明授权
    Cationic amphiphiles with mannose-mimicking head-groups and a process for the preparation thereof 有权
    具有甘露糖模拟头基的阳离子两亲物及其制备方法

    公开(公告)号：US08703824B2

    公开(公告)日：2014-04-22

    申请号：US13812703

    申请日：2011-09-14

    申请人： Ramishetti Srinivas ,  Arup Garu ,  Sachin B. Agawane ,  Arabinda Chaudhuri

    发明人： Ramishetti Srinivas ,  Arup Garu ,  Sachin B. Agawane ,  Arabinda Chaudhuri

    IPC分类号： A01N37/18 ,  A61K31/165 ,  A61K31/16 ,  C07C233/00 ,  C07C235/00 ,  C07C237/00 ,  C07C239/00

    CPC分类号： C07C237/24 ,  C07C231/12 ,  C07C237/22 ,  C07C2601/14 ,  C07C2601/16

    摘要： The present invention discloses novel cationic amphiphiles containing mannose-mimicking shikimic and quinic acid head-groups and a process for preparing cationic amphiphiles with mannose-mimicking polar head-groups such as, shikimic and quinic acids. The findings described herein also demonstrate that compounds of the present invention can target model DNA vaccines to antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs), via mannose receptors expressed on the cell surface of APCs. The cationic amphiphiles disclosed herein show enhanced cellular and humoral immune response compared to their mannosyl counterpart in dendritic cell (DC, the most professional APC) based genetic immunization in mice. Cationic amphiphiles with mannose-mimicking quinic and shikimic acid head-groups described in the present invention are likely to find future applications in the field of genetic immunization.

    摘要翻译： 本发明公开了含有甘露糖模拟莽草酸和奎尼酸头基的新型阳离子两亲物和用甘露糖模拟极性头基如莽草酸和奎尼酸制备阳离子两亲物的方法。 本文所述的发现还证明本发明的化合物可以通过在APC的细胞表面上表达的甘露糖受体将模拟DNA疫苗靶向抗原呈递细胞（APCs）如巨噬细胞和树突状细胞（DC）。 本文公开的阳离子两亲物与其在小鼠中的树突状细胞（DC，最专业的APC）基于遗传免疫的它们的甘露糖基配对相比显示出增强的细胞和体液免疫应答。 本发明中描述的具有甘露糖模拟奎尼克酸和莽草酸头团的阳离子两亲物可能在遗传免疫领域中找到未来的应用。