公开(公告)号：US20240343682A1

公开(公告)日：2024-10-17

申请号：US18755058

申请日：2024-06-26

申请人： City of Hope

发明人： Linda H. Malkas ,  David Horne ,  Robert J. Hickey ,  Long Gu

IPC分类号： C07C233/76 ,  A61K31/167 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4725 ,  A61K33/243 ,  A61P35/00 ,  A61P35/02 ,  C07C237/22 ,  C07D213/68 ,  C07D217/26 ,  C07D401/12

CPC分类号： C07C233/76 ,  A61K31/167 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4725 ,  A61K33/243 ,  A61P35/00 ,  A61P35/02 ,  C07C237/22 ,  C07D213/68 ,  C07D217/26 ,  C07D401/12

摘要： Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

公开(公告)号：US20240342105A1

公开(公告)日：2024-10-17

申请号：US18630721

申请日：2024-04-09

申请人： SHANDONG UNIVERSITY

发明人： Xinyi JIANG ,  Ying LIU ,  Chunwei TANG ,  Longyu BO ,  Kun ZHAO ,  Chen CHEN ,  Weiqiang JING ,  Ying ZHI ,  Xiaotian ZHAO ,  Maosen HAN

IPC分类号： A61K9/51 ,  A61K31/7105 ,  C07C237/22 ,  B82Y40/00

CPC分类号： A61K9/5123 ,  A61K9/5192 ,  A61K31/7105 ,  B82Y40/00 ,  C07C237/22 ,  B82Y5/00

摘要： An ionizable lipid based on cyclohexanediamine and a lipid nanoparticle, and a preparation method therefor and use thereof. The ionizable lipid based on cyclohexanediamine is a compound represented by formula (a),




wherein n is independently selected from natural numbers of 0-8; R1, R2, R3 and R4 are independently selected from C8-C24 alkyl, C8-C24 alkyl substituted by a substituent group, C8-C24 alkenyl, C8-C24 alkenyl substituted by a substituent group, and C8-C24 alkynyl and C8-C24 alkynyl substituted by a substituent group. The lipid nanoparticle formed by the ionizable lipid based on cyclohexanediamine has the advantages of biodegradability, high in-vivo and in-vitro transfection efficiency, and the like, and has a good clinical application prospect.

公开(公告)号：US12065407B2

公开(公告)日：2024-08-20

申请号：US16640919

申请日：2018-08-21

申请人： PLEX PHARMACEUTICALS, INC.

发明人： Surya Kanta De ,  Sridhar G. Prasad ,  Marshall C. Peterman

IPC分类号： C07D213/30 ,  A61K31/4184 ,  A61K47/30 ,  C07C237/22 ,  C07D209/42 ,  C07D231/56 ,  C07D235/08 ,  C07D235/10 ,  C07D235/14 ,  C07D235/30 ,  A61K9/00

CPC分类号： C07D213/30 ,  A61K47/30 ,  C07C237/22 ,  C07D209/42 ,  C07D231/56 ,  C07D235/10 ,  C07D235/14 ,  C07D235/30 ,  A61K9/0043

摘要： Provided are novel compounds of Formulas (I) and (II), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful as dual FKBP12/FKABP inhibitors. Also provided are pharmaceutical compositions comprising the novel compounds of Formulas (I) and (II) and their use in treating Parkinson's disease.

公开(公告)号：US12054447B2

公开(公告)日：2024-08-06

申请号：US17730948

申请日：2022-04-27

申请人： City of Hope

发明人： Linda H. Malkas ,  David Horne ,  Robert J. Hickey ,  Long Gu

IPC分类号： C07C233/76 ,  A61K31/167 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4725 ,  A61K33/243 ,  A61P35/00 ,  A61P35/02 ,  C07C237/22 ,  C07D213/68 ,  C07D217/26 ,  C07D401/12

CPC分类号： C07C233/76 ,  A61K31/167 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4725 ,  A61K33/243 ,  A61P35/00 ,  A61P35/02 ,  C07C237/22 ,  C07D213/68 ,  C07D217/26 ,  C07D401/12 ,  A61K33/24 ,  A61K2300/00 ,  A61K31/4725 ,  A61K2300/00 ,  A61K31/4418 ,  A61K2300/00

摘要： Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

公开(公告)号：US20230417779A1

公开(公告)日：2023-12-28

申请号：US18204859

申请日：2023-06-01

申请人： ARK Diagnostics, Inc.

发明人： Johnny Valdez ,  Byung Sook Moon ,  Alejandro A. Orozco ,  Gonzalo Naranjo

IPC分类号： G01N33/94 ,  C07K16/44 ,  C07C237/22 ,  C12N9/96 ,  C12N9/04 ,  G01N33/58 ,  A61K39/00 ,  C07C229/04

CPC分类号： G01N33/9406 ,  C07K16/44 ,  C07C237/22 ,  C12N9/96 ,  C12N9/0006 ,  G01N33/581 ,  A61K39/00 ,  C07C229/04 ,  C07K2317/33 ,  C12Y101/01049

摘要： Compounds and methods for use in detecting pregabalin in a sample suspected of containing pregabalin are disclosed. Pregabalin derivatives are described for producing pregabalin conjugates. A pregabalin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-pregabalin antibody. A pregabalin-detectable label conjugate may be used in a signal producing system in pregabalin assays.

公开(公告)号：US11632957B2

公开(公告)日：2023-04-25

申请号：US16794955

申请日：2020-02-19

申请人： CORTEVA AGRISCIENCE LLC

发明人： Ronald J. Heemstra ,  Ronald Ross, Jr. ,  Kyle A. DeKorver ,  Kaitlyn Gray ,  Daniel I. Knueppel ,  Peter Vednor ,  Timothy P. Martin ,  Joseph D. Eckelbarger ,  John F. Daeuble, Sr. ,  Ricky Hunter ,  David A. Demeter ,  Tony K. Trullinger ,  Erich W. Baum ,  Zoltan L. Benko ,  Nakyen Choy ,  Gary D. Crouse ,  Fangzheng Li ,  Jeffrey Nissen ,  Monica B. Olson ,  Michelle Riener ,  Thomas C. Sparks ,  Frank J. Wessels ,  Maurice C. Yap

IPC分类号： A01N53/00 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D213/75 ,  C07D213/81 ,  C07D309/14 ,  C07D231/12 ,  C07D331/04 ,  C07D333/36 ,  C07D249/08 ,  C07D207/10 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07D307/33 ,  C07D333/48 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07D307/52 ,  C07D333/60 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07 ,  C07D487/04

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US11478461B2

公开(公告)日：2022-10-25

申请号：US17047247

申请日：2019-04-15

申请人： Merck Sharp & Dohme Corp.

发明人： Liangqin Guo ,  Hongjun Zhang ,  Ping Chen ,  Dane Clausen ,  Xavier Fradera ,  Yongxin Han ,  Shuwen He ,  Xianhai Huang ,  Alexander Pasternak ,  Qinglin Pu ,  Li Xiao ,  Feng Ye

IPC分类号： A61K31/44 ,  A61K45/06 ,  C07C237/22 ,  C07C255/60 ,  C07D213/75 ,  C07C271/36 ,  C07C233/78 ,  C07C271/24 ,  C07C233/79 ,  C07D213/81 ,  C07D271/06 ,  C07D239/28 ,  C07D215/48 ,  C07C275/30 ,  C07C275/28 ,  C07D239/42 ,  C07D305/06 ,  C07D261/08 ,  C07D471/04 ,  C07D261/20 ,  C07D209/34 ,  C07D277/56 ,  C07D217/02 ,  C07D231/14 ,  C07D237/28 ,  C07D241/24 ,  C07D217/26 ,  A61K31/167 ,  A61K31/27 ,  A61K31/4245 ,  A61K31/47 ,  A61K31/17 ,  A61K31/505 ,  A61K31/337 ,  A61K31/437 ,  A61K31/42 ,  A61K31/426 ,  A61K31/472 ,  A61K31/415 ,  A61K31/4965

摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11242312B2

公开(公告)日：2022-02-08

申请号：US17051896

申请日：2019-05-03

申请人： LANDSTEINER GENMED, S.L.

发明人： Jesús Llenas Calvo ,  Miriam Royo Expósito ,  Unai Elezcano Donaire ,  Enrique Vázquez Tatay ,  Marta Melgarejo Díaz ,  Marta Isabel Barranco Gallardo ,  Eva Ma Medina Fuentes

IPC分类号： C07C235/84 ,  C07K5/02 ,  C07C237/22 ,  C07C259/06

摘要： The present invention relates to dipeptidyl ketoamide m-methoxyphenyl derivatives and their use in the treatment of diseases and conditions associated with elevated calpain activity, such as heart injury caused by infarction, ischemia with or without reperfusion, neurodegenerative disorders, malaria, diabetic nephropathy, neurotoxicity induced by HIV virus, cancer, and fibrotic diseases.

公开(公告)号：US20210395203A1

公开(公告)日：2021-12-23

申请号：US17362688

申请日：2021-06-29

申请人： Plex Pharmaceuticals, Inc.

发明人： Surya Kanta DE ,  Sridhar G. PRASAD ,  Marshall C. PETERMAN

IPC分类号： C07D213/30 ,  A61K47/30 ,  C07C237/22 ,  C07D209/42 ,  C07D231/56 ,  C07D235/10 ,  C07D235/14 ,  C07D235/30

摘要： Provided are novel compounds of Formulas (I) and (II), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful as dual FKBP12/FKABP inhibitors. Also provided are pharmaceutical compositions comprising the novel compounds of Formulas (I) and (II) and their use in treating Parkinson's disease.

公开(公告)号：US11174233B1

公开(公告)日：2021-11-16

申请号：US17377530

申请日：2021-07-16

申请人： King Abdulaziz University

发明人： Moustafa E. El-Araby ,  Abdelsattar M. Omar ,  Ahmed Esmat ,  Farid Ahmed ,  Azizah M. Malebari ,  Ashraf B. Abdel-Naim ,  Thikryat Neamatallah

IPC分类号： C07D233/96 ,  C07D405/06 ,  C07D307/52 ,  C07C237/22

摘要： Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.