公开(公告)号：US06252096B1

公开(公告)日：2001-06-26

申请号：US09525753

申请日：2000-03-14

Applicant: Hans Peter Spielmann ,  Kareem Abdel Hassan Chehade

Inventor： Hans Peter Spielmann ,  Kareem Abdel Hassan Chehade

IPC: C07C24710

CPC classification number: C07C247/16 ,  C07C311/44

Abstract: The invention is directed to a novel compounds comprising 4-azidotetrafluoroaniline and the alkyl, acyl and sulfonamide derivatives thereof and to methods of making and using the same. The novel compounds are useful as a photoaffinity probe to study protein structure and function. Two methods for preparing 4-azidotetrafluoroaniline are disclosed, each employing a stable carbamate intermediate from which the 4-azidotetrafluoroaniline is derived.

Abstract translation: 本发明涉及包含4-叠氮四氟四苯胺及其烷基，酰基和磺酰胺衍生物的新化合物及其制备和使用方法。 新型化合物可用作光亲和性探针来研究蛋白质结构和功能。 公开了制备4-叠氮四氟苯胺的两种方法，每种方法使用得自4-叠氮四氟乙苯的稳定的氨基甲酸酯中间体。