公开(公告)号：US20210163386A1

公开(公告)日：2021-06-03

申请号：US17106345

申请日：2020-11-30

申请人： Massachusetts Institute of Technology

发明人： Mircea Dinca ,  Constanze Nicole Neumann

IPC分类号： C07C29/44 ,  C07C31/125 ,  C07C31/12 ,  B01J31/16 ,  C07C29/16

摘要： Compositions and methods of use related to metal organic frameworks (MOFs) and/or nanoparticles are generally described. In some embodiments, methods and compositions for the catalytic upgrading of alcohols using MOFs and/or nanoparticles associated with MOFs are generally described. In some embodiments, a catalytic MOF composition is provided, wherein the MOF composition comprises a MOF compound and a plurality of metal catalytic compounds. In some embodiments, an alcohol may be exposed to the MOF composition and/or a plurality of nanoparticles associated with the MOF composition such that the alcohol is converted to a higher order alcohol. Advantageously, in some embodiments, the alcohol conversion occurs at a relatively high turnover frequency and/or with a relatively high selectivity as compared to traditional methods for converting alcohols.

公开(公告)号：US10590059B2

公开(公告)日：2020-03-17

申请号：US16194141

申请日：2018-11-16

申请人： Io Therapeutics, Inc.

发明人： Roshantha A. Chandraratna ,  Vidyasagar Pradeep Vuligonda ,  Thomas Jacks ,  Peter Wade ,  Andrew Thompson

IPC分类号： C07C57/50 ,  C07C51/255 ,  C07C29/44 ,  A61K31/198 ,  C07C33/38 ,  A61K31/192 ,  C07C33/36

摘要： Provided herein are compounds useful for the preparation of compounds that have retinoid-like biological activity. Also provided herein are processes for the preparation of compounds that have retinoid-like biological activity.

公开(公告)号：US20200055032A1

公开(公告)日：2020-02-20

申请号：US16556516

申请日：2019-08-30

申请人： BASF Corporation

发明人： Keenan Lee Deutsch ,  Rostam J. MADON

IPC分类号： B01J23/843 ,  C07C29/141 ,  B01J37/02 ,  B01J35/00 ,  B01J35/10 ,  B01J21/08 ,  B01J37/16 ,  B01J37/08 ,  C07C29/44 ,  C07C29/154 ,  B01J37/00 ,  B01J35/08 ,  B01J35/02 ,  B01J23/72

摘要： A process for preparing a catalyst includes impregnating a metal oxide carrier with an aqueous solution to form an impregnated carrier; drying the impregnated carrier to form a dried, impregnated carrier; and heat-treating the dried, impregnated carrier in air to form the catalyst; wherein: the aqueous solution includes a copper salt; and from about 3 wt % to about 15 wt % of a C3-C6 multifunctional carboxylic acid; and the catalyst includes from about 5 wt % to about 50 wt % copper oxide.

公开(公告)号：US20190152888A1

公开(公告)日：2019-05-23

申请号：US16194141

申请日：2018-11-16

申请人： Io Therapeutics, Inc.

发明人： Roshantha A. Chandraratna ,  Vidyasagar Pradeep Vuligonda ,  Thomas Jacks ,  Peter Wade ,  Andrew Thompson

IPC分类号： C07C57/50 ,  C07C51/255 ,  C07C29/44 ,  A61K31/198 ,  A61K31/192 ,  C07C33/38

CPC分类号： C07C57/50 ,  A61K31/192 ,  A61K31/198 ,  C07B2200/07 ,  C07C29/44 ,  C07C33/36 ,  C07C33/38 ,  C07C51/255 ,  C07C2601/02 ,  C07C2602/10

摘要： Provided herein are compounds useful for the preparation of compounds that have retinoid-like biological activity. Also provided herein are processes for the preparation of compounds that have retinoid-like biological activity.

公开(公告)号：US10118169B2

公开(公告)日：2018-11-06

申请号：US15129851

申请日：2015-03-30

申请人： The University of Chicago ,  The University of North Carolina at Chapel Hill

发明人： Wenbin Lin ,  Joseph M. Falkowski ,  Takahiro Sawano

IPC分类号： B01J31/16 ,  C07C45/69 ,  C07C231/02 ,  B01J31/18 ,  B01J31/24 ,  C07C227/04 ,  C07C29/44 ,  C07C41/09 ,  C07C67/303 ,  C07D307/93

摘要： Metal-organic framework (MOFs) compositions based on chiral phosphine-, chiral oxazoline-, chiral pyridine-, and chiral diene-derived organic bridging ligands were synthesized and then post-synthetically metalated with metal precursors such as Ru and Rh complexes. The metal complexes could also be directly incorporated into the MOFs. The MOFs provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of asymmetric organic transformations, including the addition of arylboronic acids to α,β-unsaturated ketones and alkimines, the hydrogenation of substituted alkene and carbonyl compounds, and cyclization reactions. The solid catalysts can also be integrated into a flow reactor or a supercritical fluid reactor.

公开(公告)号：US09452961B2

公开(公告)日：2016-09-27

申请号：US14652303

申请日：2013-12-18

申请人： DSM IP ASSETS B.V.

发明人： Werner Bonrath ,  Thomas Netscher ,  Jonathan Alan Medlock ,  René Tobias Stemmler ,  Johannes Tschumi ,  Gerardus Karel Maria Verzijl ,  Andreas Hendrikus Maria De Vries

IPC分类号： C07C45/53 ,  C07C49/00 ,  C07C29/00 ,  C07D309/00 ,  C07C29/17 ,  C07C29/44 ,  C07C45/51 ,  C07C45/59 ,  C07C45/62 ,  C07C45/67 ,  C07C45/71 ,  C07C45/90 ,  C07F9/50 ,  C07F15/00 ,  C07D311/58 ,  C07D319/06

CPC分类号： C07C29/17 ,  C07B2200/07 ,  C07C29/44 ,  C07C45/511 ,  C07C45/59 ,  C07C45/62 ,  C07C45/67 ,  C07C45/71 ,  C07C45/90 ,  C07D311/58 ,  C07D319/06 ,  C07F9/5045 ,  C07F15/0033 ,  C07C49/203 ,  C07C49/04 ,  C07C33/025 ,  C07C33/042

摘要： The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimetylpentadecan-2-one in a multistep synthesis from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.

摘要翻译： 本发明涉及从6,10-二甲基十烯-5-烯-2-酮或6,10-二甲基十一碳烯的多步合成中制备（6R，10R）-6,10,14-三甲基十五烷-2-酮的方法 -5,9-二烯-2-酮。 该方法非常有利，因为它以有效的方式形成来自起始产物的立体异构体的混合物的所需手性产物。

公开(公告)号：US09416079B2

公开(公告)日：2016-08-16

申请号：US14709948

申请日：2015-05-12

申请人： BASF SE

发明人： Rudolf Schuch ,  Stefan Rüdenauer ,  Klaus Ebel ,  Ralf Pelzer ,  Andreas Keller

IPC分类号： C07C33/18 ,  C07C29/44 ,  C07C29/19 ,  C07C29/80 ,  B01J23/46 ,  B01J23/56 ,  B01J35/10 ,  B01J37/18 ,  B01J21/08 ,  B01J33/00 ,  B01J35/00 ,  B01J35/02 ,  B01J35/08 ,  B01J37/02

CPC分类号： C07C29/44 ,  B01J21/08 ,  B01J23/462 ,  B01J23/56 ,  B01J33/00 ,  B01J35/0026 ,  B01J35/008 ,  B01J35/023 ,  B01J35/08 ,  B01J35/1019 ,  B01J35/1042 ,  B01J35/1061 ,  B01J35/108 ,  B01J37/0203 ,  B01J37/18 ,  C07C29/19 ,  C07C29/80 ,  C07C2601/14 ,  C11B9/0061 ,  C07C33/20 ,  C07C31/1355

摘要： A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising: a) reaction of styrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics, where the molar ratio of the styrene used in step a) to the isopropanol used in step a) is in the range from 1:below 5 to 1:0.5.

公开(公告)号：US20150018577A1

公开(公告)日：2015-01-15

申请号：US14376143

申请日：2013-02-01

申请人： Fabrice Gallou ,  Joerg Matthias Sedelmeier ,  Caspar Vogel

发明人： Fabrice Gallou ,  Joerg Matthias Sedelmeier ,  Caspar Vogel

IPC分类号： C07C249/12 ,  C07C25/18 ,  C07C47/55 ,  C07C22/08 ,  C07C29/14 ,  C07C17/35 ,  C07C17/04 ,  C07C51/15 ,  C07C29/147 ,  C07C45/27 ,  C07C251/52 ,  C07C29/44

CPC分类号： C07C251/52 ,  C07C17/04 ,  C07C17/12 ,  C07C17/14 ,  C07C17/26 ,  C07C17/35 ,  C07C17/354 ,  C07C22/08 ,  C07C25/18 ,  C07C29/14 ,  C07C29/147 ,  C07C29/44 ,  C07C33/50 ,  C07C45/27 ,  C07C47/546 ,  C07C47/55 ,  C07C49/82 ,  C07C51/15 ,  C07C249/04 ,  C07C249/12 ,  C07C259/04 ,  C07C2101/14 ,  C07C2101/16 ,  C07C2601/14 ,  C07C2601/16 ,  C07D205/04

摘要： This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes.

摘要翻译： 本发明涉及用于合成N-（4-环己基-3-三氟甲基 - 苄氧基） - 乙亚胺酸乙酯的新方法和下述式I的化合物和用于这些方法的其它中间体。

公开(公告)号：US20130072726A1

公开(公告)日：2013-03-21

申请号：US13616147

申请日：2012-09-14

申请人： Rudolf Schuch ,  Stefan Rüdenauer ,  Klaus Ebel ,  Ralf Pelzer ,  Andreas Keller

发明人： Rudolf Schuch ,  Stefan Rüdenauer ,  Klaus Ebel ,  Ralf Pelzer ,  Andreas Keller

IPC分类号： C07C29/44

CPC分类号： C07C29/44 ,  B01J21/08 ,  B01J23/462 ,  B01J23/56 ,  B01J33/00 ,  B01J35/0026 ,  B01J35/008 ,  B01J35/023 ,  B01J35/08 ,  B01J35/1019 ,  B01J35/1042 ,  B01J35/1061 ,  B01J35/108 ,  B01J37/0203 ,  B01J37/18 ,  C07C29/19 ,  C07C29/80 ,  C07C2601/14 ,  C11B9/0061 ,  C07C33/20 ,  C07C31/1355

摘要： A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising: a) reaction of styrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics, where the molar ratio of the styrene used in step a) to the isopropanol used in step a) is in the range from 1:below 5 to 1:0.5.

公开(公告)号：US20120029237A1

公开(公告)日：2012-02-02

申请号：US12740617

申请日：2010-04-09

申请人： Nicka Chinkov ,  Aleksander Warm ,  Erick Carreira

发明人： Nicka Chinkov ,  Aleksander Warm ,  Erick Carreira

IPC分类号： C07C29/44 ,  C07C231/12 ,  C07C213/00

CPC分类号： C07C231/18 ,  C07B2200/07 ,  C07C29/42 ,  C07C213/00 ,  C07C2601/02 ,  C07C33/28 ,  C07C215/70 ,  C07C233/25

摘要： An autocatalytic process for the synthesis of chiral propargylic alcohols.

摘要翻译： 用于合成手性炔丙醇的自催化方法。