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    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES
    1.
    发明申请
    PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES 有权

    公开(公告)号：US20220363619A1

    公开(公告)日：2022-11-17

    申请号：US17749293

    申请日：2022-05-20

    申请人： NEONC Technologies, Inc.

    发明人： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

    IPC分类号： C07C29/92 ,  C07C67/14 ,  C07C201/12 ,  A61K31/045 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/86

    摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

    PROCESS FOR PURIFICATION OF PRODUCTS
    2.
    发明申请
    PROCESS FOR PURIFICATION OF PRODUCTS 有权

    公开(公告)号：US20210284592A1

    公开(公告)日：2021-09-16

    申请号：US17183204

    申请日：2021-02-23

    申请人： LanzaTech, Inc.

    发明人： Ralph Gillespie ,  Michelle Kocal ,  Wyatt Eric Allen ,  Richard R Rosin ,  Donovan Tran

    IPC分类号： C07C29/84 ,  C07C29/76 ,  C07C29/88 ,  C12P7/06 ,  B01D3/00 ,  B01D3/14 ,  B01D15/36

    摘要： The disclosure is directed to an apparatus and method for recovering ethanol from a fermentation broth. The fermentation broth comprises microbial biomass, ethanol, methanol, ethyl acetate, at least one thiol, and at least one compound having 3 or more carbon atoms. The method comprises separating at least microbial biomass from the fermentation broth to generate a process stream; removing, in any order, from the process stream: ethyl acetate by reacting ethyl acetate with a base compound followed by distillation; at least one thiol by adsorption or reaction to disulfide; methanol by distillation; compounds having 3 or more carbon atoms by distillation; and recovering ethanol by distillation; wherein the distillations may be conducted in a single column or two or more columns.

    Pharmaceutical compositions comprising monoterpenes
    4.
    发明授权
    Pharmaceutical compositions comprising monoterpenes 有权

    公开(公告)号：US10457618B2

    公开(公告)日：2019-10-29

    申请号：US15220135

    申请日：2016-07-26

    申请人： NEONC Technologies, Inc.

    发明人： Thomas Chen ,  Daniel Levin ,  Satish Puppali

    IPC分类号： C07C29/92 ,  A61K31/045 ,  C07C67/14 ,  C07C201/12 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/86

    摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

    Method for producing 1,4-butanediol
    6.
    发明授权
    Method for producing 1,4-butanediol 有权

    公开(公告)号：US10144687B2

    公开(公告)日：2018-12-04

    申请号：US14147885

    申请日：2014-01-06

    申请人： MITSUBISHI CHEMICAL CORPORATION

    发明人： Yusuke Izawa ,  Masaru Utsunomiya ,  Kouta Tanaka ,  Norikazu Konishi

    IPC分类号： C07C29/80 ,  C07C29/88

    摘要： An object of the present invention is to provide an industrially advantageous production method of 1,4BG, ensuring that generation of THF in the crude 1,4BG can be also suppressed and at the same time, the concentration of 2-(4-hydroxybutoxy)-tetrahydrofuran can be reduced. The present invention relates to a method for producing 1,4-butanediol, comprising heating crude 1,4-butanediol containing from 0.01 to 0.5 wt % of 2-(4-hydroxybutoxy)-tetrahydrofuran and from 1 to 25 wt % of water at 80° C. or more in the presence of an amine to obtain purified 1,4-butanediol.

    PROCESS FOR CLEANING CONTAMINATED FLUID
    7.
    发明申请
    PROCESS FOR CLEANING CONTAMINATED FLUID 审中-公开

    公开(公告)号：US20170233320A1

    公开(公告)日：2017-08-17

    申请号：US15404918

    申请日：2017-01-12

    申请人： Evan Koslow ,  Blake Smith

    发明人： Evan Koslow ,  Blake Smith

    IPC分类号： C07C41/44 ,  C07C29/88

    CPC分类号： C07C41/44 ,  C07C29/76 ,  C07C29/88 ,  C07C31/20 ,  C07C31/202

    摘要： A process for cleaning contaminated fluid includes combining the contaminated fluid with an acid and water to yield a mixture in which at least some contaminants in the contaminated fluid are insoluble. The insoluble contaminants precipitate to yield precipitated contaminants. At least a portion of the precipitated contaminants are separated from the mixture. At least a portion of the acid and a portion of the water in the mixture are separated from the glycol in the mixture to yield cleaned fluid.

    System And Process For Removal Of Organic Carboxylates From Mono Ethylene Glycol (MEG) Water Streams By Acidification And Vaporization Under Vacuum
    8.
    发明申请
    System And Process For Removal Of Organic Carboxylates From Mono Ethylene Glycol (MEG) Water Streams By Acidification And Vaporization Under Vacuum 有权
    通过真空酸化和蒸发从单乙二醇（MEG）水流中去除有机羧酸盐的系统和方法

    公开(公告)号：US20160244388A1

    公开(公告)日：2016-08-25

    申请号：US15044752

    申请日：2016-02-16

    申请人： Cameron Solutions, Inc.

    发明人： Brian E. Messenger

    IPC分类号： C07C29/88 ,  C07C29/78 ,  C07C29/76 ,  C10L3/10

    CPC分类号： C07C29/88 ,  B01D3/009 ,  C07C29/50 ,  C07C29/76 ,  C07C29/78 ,  C10L3/107 ,  C10L2290/12 ,  C10L2290/54 ,  C07C31/202

    摘要： A system and method for removing organic carboxylates from a mono ethylene glycol (“MEG”) stream includes a reaction vessel; means for cooling and diluting the MEG stream being routed to the reaction vessel; means for acidifying the cooled and diluted MEG stream during its residence time within the reaction vessel; and means for removing an acetic-rich overhead stream from the reaction vessel. The acidification of the cooled and diluted MEG stream occurs under a vacuum. The reaction vessel may be located downstream of a calcium removal vessel and receive a filtered bottom stream from that vessel, or it may be a single reaction vessel that cycles between a calcium removal mode and an acetate removal mode, with the pressure of the single vessel being greater during the calcium removal mode than during the acetate removal mode.

    摘要翻译： 从单乙二醇（“MEG”）流中除去有机羧酸盐的体系和方法包括反应容器; 用于冷却和稀释流向反应容器的MEG流的装置; 用于在冷却和稀释的MEG流在其停留时间内在反应容器内酸化的装置; 以及用于从反应容器中除去富含乙酸的塔顶馏出物流的装置。 冷却和稀释的MEG流的酸化在真空下发生。 反应容器可以位于钙去除容器的下游并且接收来自该容器的过滤的底部流，或者其可以是在钙去除模式和乙酸盐去除模式之间循环的单个反应容器，单个容器的压力 在钙去除模式期间比在乙酸盐去除模式期间更大。