公开(公告)号：US20230117425A1

公开(公告)日：2023-04-20

申请号：US17838400

申请日：2022-06-13

申请人： CHEMOCENTRYX, INC.

发明人： Christopher LANGE ,  Viengkham MALATHONG ,  Darren J. McMURTRIE ,  Sreenivas PUNNA ,  Rajinder SINGH ,  Ju YANG ,  Penglie ZHANG

IPC分类号： A61K31/085 ,  C07D211/40 ,  A61P35/00 ,  C07C215/12 ,  C07F5/02 ,  C07D401/14 ,  C07D213/30 ,  C07D405/12 ,  C07C229/22 ,  C07D319/18 ,  C07D417/12 ,  A61K45/06 ,  C07C235/42 ,  C07C235/20 ,  C07D239/42 ,  C07C255/54 ,  C07D213/61 ,  C07D413/12 ,  C07D205/04 ,  A61P31/00 ,  C07D237/08 ,  C07D401/12 ,  C07D213/85 ,  C07D239/30 ,  C07D405/14 ,  C07D401/04 ,  C07D409/12 ,  C07D213/80 ,  A61P29/00 ,  C07C317/22 ,  C07F9/58 ,  A61K31/015 ,  A61K31/03 ,  A61K31/277 ,  A61K38/00 ,  C07C43/168

摘要： Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20220304958A1

公开(公告)日：2022-09-29

申请号：US17611036

申请日：2020-06-04

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE UNIVERSITY OF NEW MEXICO

发明人： Alexandre GINGRAS ,  Mark GINSBERG, ,  Carlo BALLATORE ,  Larry SKLAR ,  Karol Rogelle Karagdag FRANCISCO

IPC分类号： A61K31/166 ,  A61K31/196 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/4406 ,  A61K31/245 ,  A61K31/44 ,  A61K31/135 ,  A61K31/423 ,  A61K31/472 ,  A61K31/235 ,  A61K31/05 ,  A61K31/192 ,  A61K31/337 ,  A61K31/085 ,  A61K31/095 ,  A61K31/10 ,  A61K31/055 ,  A61K31/121 ,  A61K31/451 ,  A61K31/136 ,  A61K31/397 ,  A61K31/222 ,  A61K31/137 ,  A61K31/381 ,  A61K31/11 ,  A61P9/14 ,  C07C251/24 ,  C07D249/14 ,  C07D257/06 ,  C07D213/74 ,  C07C229/56 ,  C07C233/81 ,  C07C251/48 ,  C07D261/20 ,  C07D217/16 ,  C07C215/50 ,  C07C65/19 ,  C07C65/105 ,  C07D305/08 ,  C07C317/22 ,  C07C39/38 ,  C07C49/83 ,  C07D295/112 ,  C07D205/08 ,  C07C69/738 ,  C07C255/56 ,  C07C47/575 ,  C07D333/22

摘要： Compositions and methods for treating thrombosis, inflammation, and atherosclerosis by administration of a compound that binds to KRIT1 to inhibit binding with HEG1.

公开(公告)号：US20220267262A1

公开(公告)日：2022-08-25

申请号：US17612902

申请日：2020-05-20

申请人： Inese REINE

发明人： Inese REINE

IPC分类号： C07C317/22 ,  C07C59/255 ,  A61P25/16

摘要： There is disclosed a salt of Formula III, a method for manufacturing thereof as well as uses thereof. (Formula III), wherein X is H or OH, Y is H or a cation selected from the group consisting of Li, Na and K, is a single bond or a double bond, and n is 0.5 or 1.

公开(公告)号：US20210387957A1

公开(公告)日：2021-12-16

申请号：US17404589

申请日：2021-08-17

申请人： The University of British Columbia ,  Provincial Health Services Authority

发明人： Raymond J. Andersen ,  Marianne Dorothy Sadar ,  Kunzhong Jian ,  Nasrin R. Mawji ,  Jun Wang ,  Carmen Adriana Banuelos ,  Yu-Chi Yang

IPC分类号： C07D295/088 ,  C07C311/51 ,  C07C69/28 ,  C07C233/18 ,  C07C311/04 ,  A61K31/09 ,  A61K31/10 ,  A61K31/145 ,  A61K31/4164 ,  A61K31/5375 ,  A61K45/06 ,  C07C43/23 ,  C07C317/18 ,  C07C317/22 ,  C07C317/28 ,  C07D233/60

摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

公开(公告)号：US20210053916A1

公开(公告)日：2021-02-25

申请号：US16475637

申请日：2018-01-11

申请人： HONSHU CHEMICAL INDUSTRY CO., LTD.

发明人： Akihito NASU

IPC分类号： C07C317/22

摘要： The present invention addresses the problem of providing a novel alkoxymethyl-substituted bisphenol compound having exceptional storage stability and exceptional solvent solubility, heat resistance, and optical properties when used as a resin raw material. This problem can be solved by using an alkoxymethyl-substituted bisphenol compound represented by General Formula (1): (wherein each R independently represents an alkyl group having 1 to 4 carbon atoms).

公开(公告)号：US20200317628A1

公开(公告)日：2020-10-08

申请号：US16848061

申请日：2020-04-14

申请人： The University of British Columbia ,  Provincial Health Services Authority

发明人： Raymond J. Andersen ,  Marianne Dorothy Sadar ,  Kunzhong Jian ,  Nasrin R. Mawji ,  Jun Wang ,  Carmen Adriana Banuelos ,  Yu-Chi Yang

IPC分类号： C07D295/088 ,  C07C311/51 ,  C07C69/28 ,  C07C233/18 ,  C07C311/04 ,  A61K31/09 ,  A61K31/10 ,  A61K31/145 ,  A61K31/4164 ,  A61K31/5375 ,  A61K45/06 ,  C07C43/23 ,  C07C317/18 ,  C07C317/22 ,  C07C317/28 ,  C07D233/60

摘要： Compounds having a structure of Formula I or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

公开(公告)号：US20200308109A1

公开(公告)日：2020-10-01

申请号：US16670264

申请日：2019-10-31

申请人： JAPAN TOBACCO INC.

发明人： Takahisa Motomura ,  Hironobu NAGAMORI ,  Koichi SUZAWA ,  Hirotsugu ITO ,  Toru MORITA ,  Satoru KOBAYASHI ,  Hisashi SHINKAI

IPC分类号： C07D205/04 ,  C07F7/08 ,  A61K31/045 ,  A61K31/05 ,  A61K31/085 ,  A61K31/10 ,  A61K31/121 ,  A61K31/136 ,  A61K31/166 ,  A61K31/167 ,  A61K31/192 ,  A61K31/235 ,  A61K31/277 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/401 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4523 ,  A61K31/5375 ,  C07C35/52 ,  C07C39/42 ,  C07C43/23 ,  C07C43/253 ,  C07C49/83 ,  C07C59/56 ,  C07C59/72 ,  C07C65/17 ,  C07C69/712 ,  C07C69/732 ,  C07C69/76 ,  C07C215/44 ,  C07C215/70 ,  C07C217/20 ,  C07C233/18 ,  C07C233/25 ,  C07C235/42 ,  C07C235/66 ,  C07C255/12 ,  C07C255/53 ,  C07C259/10 ,  C07C271/16 ,  C07C271/30 ,  C07C311/04 ,  C07C317/22 ,  C07D231/12 ,  C07D239/26 ,  C07D249/08 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D275/02 ,  C07D295/08 ,  C07D295/18 ,  C07D333/22 ,  C07D401/06 ,  C07D403/12 ,  C07D401/12 ,  C07D207/04 ,  C07D211/06 ,  C07D213/30 ,  C07D213/56 ,  C07D295/192

摘要： The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.

公开(公告)号：US10400087B2

公开(公告)日：2019-09-03

申请号：US15508323

申请日：2015-09-03

申请人： SOLVAY SPECIALTY POLYMERS USA, LLC

发明人： Joel Pollino ,  Satchit Srinivasan

IPC分类号： C08K5/41 ,  C08G85/00 ,  C08G65/48 ,  C08G75/23 ,  C08L81/06 ,  C07C315/04 ,  C07C317/22 ,  C08G75/20

摘要： The invention relates to hydroxybenzophenone-based compounds of formula (I) that are used to improve UV, thermal, and thereto-oxidative stability of high performance aromatic polymers in a blend or as end-cappers of the same polymers.

公开(公告)号：US20190192475A1

公开(公告)日：2019-06-27

申请号：US16292406

申请日：2019-03-05

申请人： Janssen Pharmaceutica NV

发明人： Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan R. DeAngelis

IPC分类号： A61K31/277 ,  C07C323/20 ,  C07D333/28 ,  C07D333/16 ,  C07C323/62 ,  A61K31/192 ,  C07C317/22 ,  C07C59/70 ,  C07C59/68 ,  C07C323/60

CPC分类号： A61K31/277 ,  A61K31/192 ,  C07C59/68 ,  C07C59/70 ,  C07C317/22 ,  C07C323/20 ,  C07C323/60 ,  C07C323/62 ,  C07D333/16 ,  C07D333/28

摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

公开(公告)号：US10299475B2

公开(公告)日：2019-05-28

申请号：US14911642

申请日：2014-08-22

申请人： ISHIHARA SANGYO KAISHA, LTD.

发明人： Koji Higuchi ,  DamdinSuren Boldbaatar ,  Yuta Tazawa ,  Michiko Kanuma

IPC分类号： A01N37/22 ,  C07F7/08 ,  A01N37/34 ,  A01N37/38 ,  A01N43/08 ,  A01N43/10 ,  A01N43/16 ,  A01N43/18 ,  A01N43/20 ,  A01N43/30 ,  A01N43/36 ,  A01N43/38 ,  A01N43/40 ,  A01N43/90 ,  A01N47/20 ,  C07C255/54 ,  C07C271/28 ,  C07C317/22 ,  C07C323/42 ,  C07C235/42 ,  C07C235/84 ,  C07C235/88 ,  C07C237/30 ,  C07C255/29 ,  C07D213/75 ,  C07D309/04 ,  C07D317/46 ,  C07D317/64 ,  C07D231/40 ,  C07D333/28 ,  C07D333/36 ,  C07D335/02 ,  C07C323/18 ,  C07D453/02 ,  C07D207/09 ,  C07C243/38 ,  C07D207/50 ,  C07D209/08 ,  C07D211/26 ,  C07D211/98 ,  C07D213/30 ,  C07D213/61 ,  C07D305/08 ,  C07D307/14 ,  A01N55/00 ,  C07C231/14 ,  C07C235/46

摘要： To provide a compound highly active against pests, a pesticide using the compound, and a method for controlling pests by applying the compound.A phenoxyalkylbenzamide compound represented by the formula (I) or its salt; a pesticide containing it as an active ingredient, and a controlling method, which comprises applying an effective amount of the compound: wherein R1, Y and R3 are a hydrogen atom or the like, and Ar is as follows: wherein R4 and R7 are halogen or the like, R5 and R6 are a hydrogen atom or the like, m is from 0 to 5, and n is from 0 to 3.