公开(公告)号：US20220242891A1

公开(公告)日：2022-08-04

申请号：US17725853

申请日：2022-04-21

申请人： Guangdong OXO Chem Ltd.

发明人： Runtong ZHANG ,  Jianghua PENG ,  Baode MA ,  Yongpeng ZHENG ,  Shaotao BAI

IPC分类号： C07F9/145 ,  C07C45/28 ,  C07C45/68 ,  C07C45/72 ,  C07C45/62 ,  C07C37/00 ,  C07C41/18 ,  C07C45/00 ,  C07F9/6561 ,  B01J31/02

摘要： Disclosed are a spiro-bisphosphorous compound, and a preparation and application thereof. The spiro-bisphosphorous compound is expressed in formula (I), (II) or (III).

公开(公告)号：US11242306B2

公开(公告)日：2022-02-08

申请号：US17274142

申请日：2019-09-03

申请人： BASF SE

发明人： Peter Zehner ,  Oliver Bey

IPC分类号： C07C45/62 ,  C07C29/00 ,  B01J19/00 ,  B01J19/18 ,  B01J31/24 ,  C07C29/17 ,  C07C31/04 ,  C07C33/14 ,  C07C47/21

摘要： Process for the continuous production of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of a homogeneous rhodium catalyst that has at least one chiral ligand, wherein a liquid reaction mixture comprising the prochiral α,β-unsaturated carbonyl compound is subjected in a first, backmixed reactor to a gas/liquid two-phase hydrogenation, and the liquid reaction mixture is then further hydrogenated in a second reactor, wherein the prochiral α,β-unsaturated carbonyl compound is employed in the first reactor in a concentration from 3% to 20% by weight. The process allows a high total conversion to the prochiral α,β-unsaturated carbonyl compound.

公开(公告)号：US11052377B2

公开(公告)日：2021-07-06

申请号：US16082080

申请日：2017-03-10

申请人： TOYO GOSEI CO., LTD.

发明人： Shin-ya Tashita ,  Takashi Miyazawa

IPC分类号： B01J23/44 ,  B01J23/10 ,  B01J23/20 ,  B01J27/224 ,  B01J27/236 ,  B01J31/06 ,  B01J31/12 ,  B01J31/26 ,  B01J31/36 ,  B01J37/02 ,  C07C41/30 ,  C07C45/00 ,  C07C45/62 ,  C07C67/343 ,  C07C211/48 ,  C07C253/14 ,  C07C269/06 ,  C07D209/08 ,  C07D239/26 ,  C07F7/08

摘要： A long-life catalyst which can be easily and inexpensively manufactured and has high activity and suppressed leakage of metal. A catalyst according to some embodiments includes: a substrate; and a first metal atom as a catalytic center. The substrate contains a non-metallic atom and a second metal atom, and the non-metallic atom is any one selected from the group consisting of a group 15 element, a group 16 element and a group 17 element.

公开(公告)号：US20210163384A1

公开(公告)日：2021-06-03

申请号：US17109719

申请日：2020-12-02

申请人： YALE UNIVERSITY

发明人： Laurene Petitjean ,  Paul Thomas Anastas ,  Tamara Marie DeWinter ,  Philip Coish ,  Hanno Christian Erythropel ,  Predrag Petrovic

IPC分类号： C07C29/145 ,  B01J23/72 ,  B01J21/10 ,  B01J21/04 ,  C07C45/62

摘要： The invention relates to novel, scalable synthetic routes that allow for direct reduction of enones to the corresponding saturated alcohols. The invention relates, in certain aspects, to synthetic routes that allow for the reduction of enones to the corresponding ketones. Such reactions take place under mild conditions, are compatible with a wide range of functional groups, and expand the repertoire of existing green chemistry methodology. In certain embodiments, the reactions are run in aqueous solvent.

公开(公告)号：US10919921B2

公开(公告)日：2021-02-16

申请号：US16099324

申请日：2017-05-05

申请人： BASF SE

发明人： Armin Boerner ,  Jens Holz ,  Katharina Rumpel

IPC分类号： C07F9/655 ,  C07F9/50 ,  C07C45/62 ,  C07F15/00 ,  C07F9/6584 ,  C07F9/46 ,  C07F9/6558 ,  B01J31/24 ,  C07C29/141 ,  C07C29/17

摘要： The present invention relates to chiral compounds with two optically active phosphorus atoms, chiral transition metal catalysts which comprise these compounds as ligands, a process for preparing the P-chiral compounds and processes for asymmetric synthesis using the chiral transition metal catalysts. The present invention specifically relates to a process for preparing an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of an optically active transition metal catalyst according to the invention. Yet more specifically, the present invention relates to a process for the asymmetric hydrogenation of citral, and also a process for preparing optically active menthol.

公开(公告)号：US20200290018A1

公开(公告)日：2020-09-17

申请号：US16082080

申请日：2017-03-10

申请人： TOYO GOSEI CO., LTD.

发明人： Shin-ya TASHITA ,  Takashi MIYAZAWA

IPC分类号： B01J23/44 ,  B01J23/10 ,  B01J27/236 ,  B01J27/224 ,  B01J23/20 ,  B01J31/12 ,  B01J31/06 ,  B01J31/26 ,  B01J31/36 ,  B01J37/02 ,  C07C45/62 ,  C07C67/343 ,  C07C45/00 ,  C07C269/06 ,  C07C41/30 ,  C07D209/08 ,  C07C211/48 ,  C07D239/26 ,  C07F7/08 ,  C07C253/14

摘要： A long-life catalyst which can be easily and inexpensively manufactured and has high activity and suppressed leakage of metal. A catalyst according to some embodiments includes: a substrate; and a first metal atom as a catalytic center. The substrate contains a non-metallic atom and a second metal atom, and the non-metallic atom is any one selected from the group consisting of a group 15 element, a group 16 element and a group 17 element.

公开(公告)号：US20190211040A1

公开(公告)日：2019-07-11

申请号：US16099324

申请日：2017-05-05

申请人： BASF SE

发明人： Armin BOERNER ,  Jens HOLZ ,  Katharina RUMPEL

IPC分类号： C07F9/655 ,  C07F9/50 ,  B01J31/24 ,  C07C45/62 ,  C07C29/17 ,  C07C29/141

CPC分类号： C07F9/65522 ,  B01J31/24 ,  C07B2200/07 ,  C07C29/141 ,  C07C29/17 ,  C07C45/62 ,  C07C2601/14 ,  C07F9/46 ,  C07F9/5022 ,  C07F9/65517 ,  C07F9/65586 ,  C07F9/65844 ,  C07F15/0073 ,  C07C47/21

摘要： The present invention relates to chiral compounds with two optically active phosphorus atoms, chiral transition metal catalysts which comprise these compounds as ligands, a process for preparing the P-chiral compounds and processes for asymmetric synthesis using the chiral transition metal catalysts. The present invention specifically relates to a process for preparing an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of an optically active transition metal catalyst according to the invention. Yet more specifically, the present invention relates to a process for the asymmetric hydrogenation of citral, and also a process for preparing optically active menthol.

公开(公告)号：US10253055B2

公开(公告)日：2019-04-09

申请号：US15306530

申请日：2015-04-23

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： Douglas Wade Stephan ,  Bidraha Bagh ,  Adam McKinty

IPC分类号： C07F15/00 ,  B01J31/18 ,  C07D233/58 ,  C07C209/70 ,  C07C5/03 ,  C07C253/30 ,  C08C19/02 ,  C07C45/62 ,  B01J31/16 ,  C08F236/12 ,  C07C5/08 ,  B01J31/22 ,  C07C5/10 ,  C07D249/06

摘要： The present invention relates to novel ruthenium-based triazole carbene complexes comprising specific ligands, their preparation and their use as catalysts in hydrogenation processes. Such complex catalysts are inexpensive, thermally robust, gel formation inhibiting and olefin selective.

公开(公告)号：US10189766B2

公开(公告)日：2019-01-29

申请号：US15687608

申请日：2017-08-28

申请人： NAN YA PLASTICS CORPORATION

发明人： Te-Chao Liao ,  Jung-Jen Chuang ,  Chung-Yu Chen ,  Chia-Ruey Tsai ,  Sung-Chieh Chao

IPC分类号： C07C45/62 ,  B01J21/00 ,  B01J23/00 ,  B01J21/18 ,  B01J23/44 ,  B01J35/00 ,  B01J35/02 ,  C07C45/79

摘要： A process for producing 2-ethylhexanal involves performing reaction using a reaction tank equipped with a gas-introducing mixer having extracting, exhausting, and stirring functions in the presence of a palladium on carbon catalyst having a carbon carrier with lower impurity content and higher specific surface area for hydrogenation, and introducing hydrogen gas evenly into reaction liquid; resulted in that the process minimizes operational pressure for hydrogenation and increases a yield of 2-ethylhexanal at least up to 98.0%.

公开(公告)号：US10065901B2

公开(公告)日：2018-09-04

申请号：US15565133

申请日：2016-11-29

申请人： ZHEJIANG NHU COMPANY LTD. ,  SHANDONG NHU PHARMACEUTICAL CO., LTD. ,  ZHEJIANG UNIVERSITY

发明人： Yougui Zhou ,  Ming Yu ,  Jintao Yuan ,  Lei Zhao ,  Xiandong Zhu ,  Guangxiong Yu ,  Weiwei Su ,  Weikang Shao ,  Xingxing Shi ,  Yin Zhang ,  Ming Feng ,  Zhirong Chen ,  Haoran Li ,  Yuhong Zhang

IPC分类号： C07C45/62 ,  C07B53/00 ,  B01J31/02 ,  B01J23/46 ,  C07D333/22 ,  C07C47/225 ,  C07C47/232 ,  C07C49/21 ,  C07C49/217 ,  C07D307/46 ,  C07C47/21

摘要： The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, use α, β-unsaturated aldehydes or α, β-unsaturated troponoid compounds to conduct asymmetric catalytic reaction to obtain the optically active carbonyl compound. This method comes in moderate reaction condition, simple operation, and catalytic amount of dihydropyridine compounds usage, the target product is easy to be separated and purified from the reaction system, and the metal catalyst can be recycled, it is economical.