-
公开(公告)号：US20230035796A1
公开(公告)日：2023-02-02
申请号：US17865037
申请日：2022-07-14
申请人： Valeria A. Stepanova
发明人： Valeria A. Stepanova
IPC分类号： C07C49/255 , C07C45/72 , A01N35/02 , A01P1/00
摘要： The present invention provides compounds including curcuminoids and analogs thereof, as well as methods of making the same. In various aspects, the method of making the compounds is free of added solvents.
-
公开(公告)号：US20220411373A1
公开(公告)日：2022-12-29
申请号：US17893399
申请日：2022-08-23
IPC分类号： C07D213/04 , C07D209/40 , C07J41/00 , C07C45/72
摘要： The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.
-
公开(公告)号：US20210163388A1
公开(公告)日：2021-06-03
申请号：US17174566
申请日：2021-02-12
IPC分类号： C07C39/08 , C07C37/00 , C07C50/24 , C07C51/38 , C07C69/716 , C07C67/03 , C07C67/293 , C07C59/353 , C07C45/63 , C07C51/09 , C07C67/343 , C07C45/72 , C07C45/54 , C07C37/07
摘要： The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.
-
公开(公告)号：US10774044B2
公开(公告)日：2020-09-15
申请号：US15613520
申请日：2017-06-05
IPC分类号： C07D213/04 , C07D209/40 , C07J41/00 , C07C45/72
摘要： The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.
-
公开(公告)号：US10351509B2
公开(公告)日：2019-07-16
申请号：US15385525
申请日：2016-12-20
IPC分类号： C07C209/28 , C07C51/43 , C07C51/08 , C07C45/80 , C07C45/72 , C07C209/84
摘要： Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and(c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also provided are compositions and pharmaceutical ingredients prepared according to the subject methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by weight in total of trifluoromethyl regioisomers.
-
公开(公告)号：US20180163158A1
公开(公告)日：2018-06-14
申请号：US15578629
申请日：2016-06-03
申请人： P2 SCIENCE, INC.
发明人： Patrick FOLEY , Yonghua YANG
IPC分类号： C11B9/00 , C07C29/143 , C07C45/72 , C07C45/69 , C07C49/543 , C07C33/14 , C07C43/162 , A23L27/20
CPC分类号： C11B9/0034 , A23L27/203 , A23V2002/00 , A61K8/34 , A61Q13/00 , C07C29/143 , C07C33/14 , C07C43/162 , C07C45/69 , C07C45/72 , C07C49/543 , C07C69/007 , C07C69/24 , C07C2601/16
摘要： The present application relates to the preparation of cyclohexyl-alkyl carbinols, including 1-(cyclohex-3-en-1-yl)-2-methylpropan-1-ol, which possesses a minty aroma that can be described as fresh, invigorating, and menthol-like, and also possesses cooling properties. The use of cyclohexyl-alkyl carbinols as readily accessible and cost effective fragrance, flavor, and cooling ingredients, and potential applications thereof is also described.
-
公开(公告)号：US20180148403A1
公开(公告)日：2018-05-31
申请号：US15884742
申请日：2018-01-31
IPC分类号： C07C209/28 , C07C211/29 , C07C209/84 , C07C51/43 , C07C51/08 , C07C45/80 , C07C45/72
CPC分类号： C07C209/28 , C07B2200/13 , C07C45/72 , C07C45/80 , C07C51/08 , C07C51/43 , C07C209/84 , C07C211/29 , C07C57/58 , C07C49/233
摘要： Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and (c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also provided are compositions and pharmaceutical ingredients prepared according to the subject methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by weight in total of trifluoromethyl regioisomers.
-
公开(公告)号：US20180141882A1
公开(公告)日：2018-05-24
申请号：US15316296
申请日：2015-06-08
IPC分类号： C07C13/465 , C07C17/14 , C07C22/04 , C07C45/42 , C07C45/46 , C07C45/63 , C07C45/64 , C07C45/65 , C07C45/72 , C07C45/81 , C07C49/788 , C07C49/792 , C07C49/794 , C07C49/82
CPC分类号： C07C13/465 , C07C17/14 , C07C22/04 , C07C45/42 , C07C45/46 , C07C45/63 , C07C45/64 , C07C45/65 , C07C45/72 , C07C45/81 , C07C49/788 , C07C49/792 , C07C49/794 , C07C49/82 , C07C2523/04 , C07C49/76 , C07C49/80
摘要： The present invention refers to a process for producing 5-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl]-3-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl-phenyl]-2,3-dihydro-1,1,3-trimethyl-1H-indene (dimer isomer 5) that comprises the synthesis from cumene and dimerization of 2-methyl-1-(4-(prop-1-en-2-yl)phenyl)propan-1-one in the presence of acid catalysts.
-
9.发明申请公开(公告)号：US20170327449A1
公开(公告)日：2017-11-16
申请号：US15536612
申请日：2015-12-16
发明人： Claude GRISON , Vincent ESCANDE , Andrii STANOVYCH
CPC分类号： C07C45/75 , C07C45/72 , C07C49/12 , C07C49/213 , C07C2601/10 , C07C49/597 , C07C49/203
摘要： Disclosed is a process for preparing a product of formula I: wherein the reaction is catalyzed both by thiamine or a thiamine salt and by ascorbic acid in a form which is free or salified or an organic acid salt of an alkaline metal, preferably sodium acetate, potassium tartrate, sodium succinate, or a reductone, preferably 2-hydroxypropanedial or 2,3-dihydroxycyclopent-2-ene-1-one in an organic solvent.
-
公开(公告)号：US09604891B2
公开(公告)日：2017-03-28
申请号：US14660401
申请日：2015-03-17
发明人： Hitoshi Oomuro , Ryo Nadano , Masafumi Hirotsu
IPC分类号： C07C29/141 , C07C45/72 , C07C67/08 , C08F220/22 , C08F220/28 , C08L33/14 , G03F7/00
CPC分类号： C07C29/141 , C07C45/72 , C07C67/08 , C08F220/22 , C08F220/28 , C08L33/14 , G03F7/00 , G03F7/0046 , G03F7/0397 , C07C47/195 , C07C31/42 , C07C69/653 , C08F2220/185 , C08F2220/282 , C08F2220/1883 , C08K5/42
摘要： As shown by the following reaction formula, disclosed is a fluorine-containing hydroxyaldehyde production method, including the step of obtaining a fluorine-containing hydroxyaldehyde represented by the general formula (1) by reacting a fluorine-containing ketone represented by the general formula (4) and an aldehyde represented by the general formula (5) in the presence of an organic base selected from a heterocyclic compound which contains a nitrogen atom in its ring or a tertiary amine. By this production method, it is possible to obtain the fluorine-containing hydroxyaldehyde in a high yield. Furthermore, it is possible to easily obtain in high yields a fluorine-containing propanediol, which is a derivative of this fluorine-containing hydroxyaldehyde, and a fluorine-containing alcohol monomer by using the same.
-
-
-
-
-
-
-
-
-
搜索结果
626 条记录 (耗时 0.026 秒)
