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公开(公告)号：US11148991B2
公开(公告)日：2021-10-19
申请号：US16288863
申请日：2019-02-28
发明人： Junbiao Chang , Chuanjun Song
摘要： The present invention discloses 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt include: amorphous 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, crystal form A of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, and crystal form B of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt. The different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt obtained according to the present invention have better stability and water-solubility than the mixed forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, thus is advantageous for pharmaceutical use. Moreover, the different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt possess much better therapeutic effect than 5-bromo-2-(α-hydroxypentyl)benzoic acid potassium salt.
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2.发明申请公开(公告)号：US20200216407A1
公开(公告)日：2020-07-09
申请号：US16733089
申请日：2020-01-02
申请人： SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES , HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
发明人： Xin CAO , Biao YU , Ning WANG , Junwei CHEN
IPC分类号： C07D335/06 , C07C67/343 , C07C233/54 , C07D241/24 , C07C69/76 , C07D409/06 , A61P35/02 , C07D213/85 , C07D409/10 , C07D213/84 , C07D213/79 , C07C229/56 , C07C69/78 , C07C63/70 , A61P35/04 , A61P35/00 , C07D239/28 , C07C69/84
摘要： Disclosed are a retinoid compound, a preparation method therefor, intermediates thereof and an application thereof. The retinoid compound I of the present invention has a good tumor growth inhibition rate.
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公开(公告)号：US10604471B2
公开(公告)日：2020-03-31
申请号：US16452905
申请日：2019-06-26
发明人： Junbiao Chang , Chuanjun Song
摘要： The present invention discloses 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt include: amorphous 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, crystal form A of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, and crystal form B of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt. The different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt obtained according to the present invention have better stability and water-solubility than the mixed forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, thus is advantageous for pharmaceutical use. Moreover, the different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt possess much better therapeutic effect than 5-bromo-2-(α-hydroxypentyl)benzoic acid potassium salt.
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公开(公告)号：US20200089112A1
公开(公告)日：2020-03-19
申请号：US16565804
申请日：2019-09-10
发明人： Jun Hatakeyama , Masaki Ohashi , Takayuki Fujiwara
IPC分类号： G03F7/004 , G03F7/039 , G03F7/038 , C07C381/12 , C07C63/08 , C07C61/135 , C07C59/115 , C07C205/58 , C07C63/70 , C07C311/09 , C07D275/06 , C07C309/19 , C07C59/135 , C07C309/12 , C07C65/05 , C07C65/21 , C07C309/58 , C08F220/16 , C08F212/14
摘要： A resist composition comprising a base polymer and a quencher containing a sulfonium salt having an iodized benzene ring offers a high sensitivity, minimal LWR and improved CDU independent of whether it is of positive or negative tone.
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5.发明授权公开(公告)号：US10556879B2
公开(公告)日：2020-02-11
申请号：US16083879
申请日：2017-01-20
申请人： SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES , HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
发明人： Xin Cao , Biao Yu , Ning Wang , Junwei Chen
IPC分类号： A61K31/385 , C07D335/06 , C07C69/84 , C07D239/28 , A61P35/00 , C07D213/85 , A61P35/02 , C07D409/06 , C07C69/76 , C07D241/24 , C07C233/54 , C07C67/343 , A61P35/04 , C07C63/70 , C07C69/78 , C07C229/56 , C07D213/79 , C07D213/84 , C07D409/10
摘要： Disclosed are a retinoid compound, a preparation method therefor, intermediates thereof and an application thereof. The retinoid compound I of the present invention has a good tumor growth inhibition rate.
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6.发明申请公开(公告)号：US20190194116A1
公开(公告)日：2019-06-27
申请号：US16288863
申请日：2019-02-28
发明人： Junbiao Chang , Chuanjun Song
CPC分类号： C07C63/70 , C07B2200/13 , C07C51/09 , C07C51/60 , C07C65/03
摘要： The present invention discloses 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt include: amorphous 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, crystal form A of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, and crystal form B of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt. The different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt obtained according to the present invention have better stability and water-solubility than the mixed forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, thus is advantageous for pharmaceutical use. Moreover, the different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt possess much better therapeutic effect than 5-bromo-2-(α-hydroxypentyl)benzoic acid potassium salt.
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公开(公告)号：US10196340B2
公开(公告)日：2019-02-05
申请号：US15629617
申请日：2017-06-21
申请人： Finings Co. Ltd.
发明人： Nongyue Wang , Xiongwei Qu , Guohua Li , Jianming Shao , Quanzhong Zhao , Guoqiang Wen
摘要： Clean process for preparing a chloroformyl-substituted benzene by oxidation of a tail gas hydrogen chloride from a chlorination reaction and a chloroacylation reaction and recycling of the resulting oxidation product chlorine gas into the chlorination reaction. The present invention provides a clean process for preparing a polymer-grade chloroformyl-substituted benzene.
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8.发明申请公开(公告)号：US20180127349A1
公开(公告)日：2018-05-10
申请号：US15660395
申请日：2017-07-26
发明人： Junbiao Chang , Chuanjun Song
CPC分类号： C07C63/70 , C07B2200/13 , C07C51/09 , C07C51/60 , C07C65/03
摘要： The present invention discloses 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt include: amorphous 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, crystal form A of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, and crystal form B of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt. The different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt obtained according to the present invention have better stability and water-solubility than the mixed forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt, thus is advantageous for pharmaceutical use. Moreover, the different crystal forms of 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salt possess much better therapeutic effect than 5-bromo-2-(α-hydroxypentyl)benzoic acid potassium salt.
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公开(公告)号：US09215870B2
公开(公告)日：2015-12-22
申请号：US14132853
申请日：2013-12-18
申请人： Dow AgroSciences LLC
发明人： William C. Lo , James E. Hunter , Gerald B. Watson , Akshay Patny , Pravin S. Iyer , Joshodeep Boruwa
IPC分类号： A01N37/18 , A01C1/06 , A61K31/175 , A61K31/17 , A01N43/84 , A01N43/40 , A01N43/36 , A01N43/20 , A01N37/34 , A01N37/10 , C07D295/192 , C07D213/61 , C07D207/16 , C07D331/04 , C07C255/57 , C07C63/70 , C07C233/65 , A01N43/50 , A01N43/08 , A01N43/78 , A01N43/60 , A01N43/16 , A01N43/82 , A01N43/48 , A01N43/90 , C07D401/10 , A01N59/02 , C07C233/66 , C07C275/14 , C07C281/06 , C07C335/08 , C07C337/06 , A61K31/18 , A01N43/54 , A01N43/653 , A01N47/28 , A01N47/34 , A01N53/00 , A01N33/04 , A01N37/20 , A01N37/28 , A01N37/32 , A01N37/46 , A01N43/58 , A01N47/22 , A01N47/32
CPC分类号： A01N37/10 , A01N25/08 , A01N33/04 , A01N37/18 , A01N37/20 , A01N37/28 , A01N37/32 , A01N37/34 , A01N37/46 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/82 , A01N43/84 , A01N47/00 , A01N47/22 , A01N47/28 , A01N47/32 , A01N47/34 , A01N53/00 , A61K31/17 , A61K31/175 , A61K31/18 , C07C63/70 , C07C63/74 , C07C211/29 , C07C233/59 , C07C233/64 , C07C233/65 , C07C233/66 , C07C237/52 , C07C243/38 , C07C255/57 , C07C275/14 , C07C281/06 , C07C327/48 , C07C335/08 , C07C335/14 , C07C337/06 , C07D207/16 , C07D207/27 , C07D209/50 , C07D211/58 , C07D213/40 , C07D213/61 , C07D233/64 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D271/10 , C07D277/30 , C07D277/32 , C07D277/64 , C07D295/192 , C07D295/195 , C07D307/14 , C07D307/16 , C07D307/52 , C07D309/14 , C07D331/04 , C07D401/10 , C07D401/12
摘要： This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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公开(公告)号：US09212163B2
公开(公告)日：2015-12-15
申请号：US14132977
申请日：2013-12-18
申请人： Dow AgroSciences LLC
发明人： William C. Lo , James E. Hunter , Gerald B. Watson , Akshay Patny , Pravin S. Iyer , Joshodeep Boruwa
IPC分类号： C07D401/10 , A01N37/10 , A01N37/34 , A01N37/18 , A01N43/84 , A01N43/40 , A01N43/36 , A01N43/20 , C07C255/57 , C07C233/65 , C07D295/12 , C07D213/61 , C07D207/16 , C07D331/04 , A01N43/50 , A01N43/08 , A01N43/78 , A01N43/60 , A01N43/16 , A01N43/82 , A01N43/48 , A01N43/90 , C07C233/66 , C07C63/70 , A01N43/54 , A01N43/653 , A01N47/32 , A01N53/00 , A61K31/166 , A61K31/17 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4965 , A61K31/505 , A61K31/5375 , C07C243/14 , C07C335/14 , C07D239/26 , C07D241/12 , C07D249/14 , C07D271/10 , C07D277/32 , C07D295/192 , A01N37/20 , A01N37/28 , A01N41/10 , A01N47/22 , A01N47/38 , A01N37/46 , A01N47/10 , A01N47/28 , A01N47/36 , A61K45/06 , A61K31/167 , C07C255/46 , C07C259/08 , C07C271/22 , C07C271/24 , C07C275/24 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C233/13 , C07C233/56 , C07C233/83 , C07C237/06 , C07C237/24 , C07C239/08 , C07C243/22 , C07C243/32 , C07C251/44 , C07C327/46
CPC分类号： C07C233/66 , A01N37/10 , A01N37/18 , A01N37/20 , A01N37/28 , A01N37/34 , A01N37/46 , A01N41/10 , A01N43/08 , A01N43/10 , A01N43/16 , A01N43/20 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/82 , A01N43/84 , A01N47/10 , A01N47/22 , A01N47/28 , A01N47/32 , A01N47/36 , A01N47/38 , A01N53/00 , A01N61/00 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K45/06 , C07C63/70 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/42 , C07C233/13 , C07C233/56 , C07C233/65 , C07C233/83 , C07C237/06 , C07C237/24 , C07C239/08 , C07C243/14 , C07C243/22 , C07C243/32 , C07C251/44 , C07C255/46 , C07C255/57 , C07C259/08 , C07C271/22 , C07C271/24 , C07C275/24 , C07C327/46 , C07C335/14 , C07C2601/02 , C07C2601/04 , C07C2602/08 , C07C2602/10 , C07D207/16 , C07D207/26 , C07D209/08 , C07D209/48 , C07D211/58 , C07D213/40 , C07D213/61 , C07D237/32 , C07D239/26 , C07D241/12 , C07D249/08 , C07D249/14 , C07D271/10 , C07D277/28 , C07D277/32 , C07D277/64 , C07D295/108 , C07D295/12 , C07D295/192 , C07D307/06 , C07D307/52 , C07D331/04 , C07D401/10 , C07D405/04
摘要： This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
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