公开(公告)号：US12098126B2

公开(公告)日：2024-09-24

申请号：US17821314

申请日：2022-08-22

申请人： Versitech Limited ,  Laboratory for Synthetic Chemistry and Chemical Biology Limited

发明人： Chi-Ming Che ,  Tingjie You

IPC分类号： C07D207/06 ,  B01J31/22 ,  C07D207/12 ,  C07D207/14 ,  C07D217/26 ,  C07D221/22 ,  C07D223/18 ,  C07D233/32 ,  C07D401/04 ,  C07D403/10 ,  C07D405/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/22

CPC分类号： C07D207/06 ,  B01J31/2295 ,  C07D207/12 ,  C07D207/14 ,  C07D217/26 ,  C07D221/22 ,  C07D223/18 ,  C07D233/32 ,  C07D401/04 ,  C07D403/10 ,  C07D405/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/22

摘要： Described herein is an iron(II)-phthalocyanine catalyzed C—H bond amination of alkyl azides. The catalyst is effective to produce intramolecular amination of saturated C—H bonds in moderate to excellent yields and the methods are tolerant of a wide scope of substrates. The methods described are useful for the synthesis of natural products derivatives and for the late-stage functionalization of pharmaceuticals.

公开(公告)号：US12030835B2

公开(公告)日：2024-07-09

申请号：US17431091

申请日：2020-02-14

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Dean A. Wacker ,  Susheel Jethanand Nara ,  Srinivas Cheruku ,  Kandhasamy Sarkunam ,  Firoz Ali Jaipuri ,  Soodamani Thangavel ,  Rishikesh Narayan ,  Subba Reddy Bandreddy ,  Srinivas Jogi ,  Pavan Kalyan Kathi

IPC分类号： C07C233/61 ,  C07D205/04 ,  C07D207/06 ,  C07D271/06 ,  C07D277/64 ,  C07D295/04 ,  C07D309/04 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04

CPC分类号： C07C233/61 ,  C07D205/04 ,  C07D207/06 ,  C07D271/06 ,  C07D277/64 ,  C07D295/04 ,  C07D309/04 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04

摘要： Disclosed are compounds of Formula (I) or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof, wherein Q is a 5-membered heterocyclyl or 5-membered heteroaryl having 1 to 4 heteroatoms independently selected from N, O, and S, substituted with zero to 4 R1; and A, X1, X2, X3, X4, Z1, Z2, R1, R2, R3a, R3b, a, b, and d are defined herein. Also disclosed are methods of using these compounds to modulate the activity of farnesoid X receptor (FXR); pharmaceutical compositions comprising these compounds; and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

公开(公告)号：US20230420743A1

公开(公告)日：2023-12-28

申请号：US18240938

申请日：2023-08-31

申请人： UCHICAGO ARGONNE, LLC

发明人： Zhengcheng ZHANG ,  Qian LIU

IPC分类号： H01M10/0569 ,  C07D207/10 ,  C07D211/14 ,  H01M10/0525 ,  C07D207/06

CPC分类号： H01M10/0569 ,  C07D207/10 ,  C07D211/14 ,  H01M10/0525 ,  C07D207/06 ,  H01M2300/0028

摘要： Described herein is a method of preparing an ionic liquid comprising a nitrogen or phosphorus cation and a bis(fluorosulfonyl)imidate (FSI) counter anion; the method comprising contacting a precursor selected from the group consisting of a tertiary amine, a tertiary phosphine, and an aromatic nitrogen heterocycle, with an alkyl bis(fluorosulfonyl)imidate in an aprotic solvent to alkylate the nitrogen or phosphorus of the precursor, and directly form a nitrogen or phosphorus cation with an FSI counter anion.

公开(公告)号：US11643404B2

公开(公告)日：2023-05-09

申请号：US16952863

申请日：2020-11-19

申请人： Nocion Therapeutics, Inc.

发明人： Bridget McCarthy Cole ,  James Lamond Ellis

IPC分类号： C07D207/06 ,  C07D207/08 ,  C07D207/16 ,  C07D211/00 ,  C07D211/14 ,  C07D211/34 ,  C07D213/02 ,  C07D223/04 ,  C07D225/02 ,  C07D231/12 ,  C07D237/04 ,  C07D295/037 ,  C07D401/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/55 ,  A61K31/4425 ,  A61K31/452 ,  A61K31/40 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4025 ,  A61K31/415 ,  C07D401/12 ,  C07D211/60 ,  C07D213/56 ,  A61K45/06

CPC分类号： C07D401/12 ,  C07D207/06 ,  C07D211/14 ,  C07D211/60 ,  C07D213/56 ,  C07D223/04 ,  C07D231/12 ,  A61K45/06

摘要： The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:




The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US11547679B2

公开(公告)日：2023-01-10

申请号：US16670326

申请日：2019-10-31

申请人： LUNELLA BIOTECH, INC.

发明人： Michael P. Lisanti ,  Federica Sotgia

IPC分类号： A61K31/55 ,  C07D403/04 ,  A61P31/00 ,  A61P35/00 ,  A61K31/137 ,  C07D295/135 ,  C07C217/74 ,  C07D223/04 ,  C07D401/04 ,  C07C235/46 ,  C07D491/107 ,  C07C275/24 ,  C07D513/04 ,  C07D207/06 ,  A61P15/16 ,  A61K31/14 ,  A61K31/155 ,  A61K31/66 ,  G16C20/50 ,  A61K9/00 ,  A61K31/40 ,  A61K31/436 ,  A61K31/519 ,  A61K31/5513

摘要： The present disclosure relates to inhibitors of mitochondrial function. Methods of screening compounds for mitochondrial inhibition are disclosed. Also described are methods of using mitochondrial inhibitors called mitoriboscins—mitochondrial-based therapeutic compounds having anti-cancer and antibiotic properties—to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methods of using mitochondrial inhibitors to provide anti-aging benefits. Specific mitoriboscin compounds and groups of mitoriboscins are also disclosed.

公开(公告)号：US20220411367A1

公开(公告)日：2022-12-29

申请号：US17766889

申请日：2020-10-06

申请人： D. E. Shaw Research, LLC

发明人： Fabrizio GIORDANETTO ,  Morten Østergaard JENSEN ,  Vishwanath JOGINI ,  Roger John SNOW

IPC分类号： C07D207/06 ,  C07D471/04 ,  C07D491/107 ,  C07D223/04 ,  C07D205/04 ,  C07D491/113 ,  C07D401/04 ,  C07D401/06 ,  C07D413/06 ,  C07D471/10 ,  C07D405/04 ,  C07D487/04

摘要： A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

公开(公告)号：US11478438B2

公开(公告)日：2022-10-25

申请号：US16787052

申请日：2020-02-11

申请人： National Institute of Biological Sciences, Beijing

发明人： Zhiyuan Zhang ,  Xiaodong Wang ,  Yaning Su ,  Hanying Ruan ,  Yan Ren

IPC分类号： A61K31/165 ,  A61K31/10 ,  A61K31/167 ,  C07C233/01 ,  C07C235/38 ,  C07D231/02 ,  C07D263/04 ,  C07D205/04 ,  C07D265/30 ,  C07D207/12 ,  C07D211/70 ,  C07D231/04 ,  C07D231/08 ,  C07D233/38 ,  C07D405/04 ,  C07D409/04 ,  C07D241/04 ,  C07D417/04 ,  C07D261/02 ,  C07D263/22 ,  C07D203/18 ,  C07D205/08 ,  C07D207/06 ,  C07D207/08 ,  C07D207/20 ,  C07D207/24 ,  C07D207/27 ,  C07D207/333 ,  C07D211/16 ,  C07D211/82 ,  G01C19/5649 ,  G01C19/5747

摘要： The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

公开(公告)号：US11332446B2

公开(公告)日：2022-05-17

申请号：US17197508

申请日：2021-03-10

申请人： Nocion Therapeutics, Inc.

发明人： Bridget Mccarthy Cole ,  James Lamond Ellis

IPC分类号： A61K31/40 ,  A61K31/435 ,  A61K31/55 ,  A61P25/00 ,  C07D207/06 ,  C07D223/04 ,  C07D225/02 ,  C07D295/092 ,  C07D211/14

摘要： The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof. The compounds, compositions, methods and kits of the invention are particularly useful for the treatment of itch and other dermal conditions.

公开(公告)号：US20220023827A1

公开(公告)日：2022-01-27

申请号：US17311394

申请日：2019-11-12

申请人： ExxonMobil Research and Engineering Company

发明人： Ross Mabon ,  Michael A. Marella ,  Allen W. Burton ,  Hilda B. Vroman ,  Kirk D. Schmitt ,  Tom Willhammar ,  Hongyi Xu ,  Xiaodong Zou ,  Simon C. Weston

IPC分类号： B01J20/18 ,  C01B39/48 ,  B01J20/28 ,  B01J20/30 ,  C07D207/06 ,  C10G25/03 ,  B01D53/02

摘要： This disclosure relates to EMM-41 materials, methods for making it, and processes for its use. This disclosure also relates to the structure directing agents used in the methods for making the EMM-41 material as well as the synthesis method used to prepare such structure directing agents.

公开(公告)号：US20220016613A1

公开(公告)日：2022-01-20

申请号：US17276855

申请日：2019-09-19

申请人： President and Fellows of Harvard College

发明人： Theodore Alexander Betley ,  Alexandre Mikhailine ,  Claudia Kleinlein ,  Yuyang Dong ,  Yunjung Baek

IPC分类号： B01J31/18 ,  B01J31/22 ,  C07D471/08 ,  C07D471/04 ,  C07D207/06 ,  C07D211/70 ,  C07D263/04 ,  C07D401/04 ,  C07D209/54 ,  C07D487/08 ,  C07D403/04 ,  C07D209/04 ,  C07D209/44

摘要： Disclosed are compounds, methods, reagents, systems, and kits for the preparation and utilization of monomeric or polymeric metal-based compounds. These metal-based compounds are organometallic catalysts composed of substituted dipyrrin ligands bound to transition metals. C—H bond functionalization catalysis can be performed with the disclosed organometallic catalysts to yield C—N bonds to generate substituted bicyclic, spiro, and fused nitrogen-containing heterocycles, all common motifs in various pharmaceutical and bioactive molecules.