公开(公告)号：US12049460B2

公开(公告)日：2024-07-30

申请号：US17445280

申请日：2021-08-17

申请人： Recurium IP Holdings, LLC

发明人： Kevin Duane Bunker ,  Peter Qinhua Huang ,  Sunny Abraham ,  Joseph Robert Pinchman ,  Chad Daniel Hopkins ,  Deborah Helen Slee

IPC分类号： C07D403/04 ,  A61K31/506 ,  A61P35/00 ,  C07C13/36 ,  C07D209/04 ,  C07D403/14 ,  C07D471/04

CPC分类号： C07D403/04 ,  A61K31/506 ,  A61P35/00 ,  C07C13/36 ,  C07D209/04 ,  C07D403/14 ,  C07D471/04

摘要： Disclosed herein are nitrogen-containing bicyclic compounds of Formula (I), including pharmaceutically acceptable salts thereof, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

公开(公告)号：US11918984B2

公开(公告)日：2024-03-05

申请号：US17276855

申请日：2019-09-19

申请人： President and Fellows of Harvard College

发明人： Theodore Alexander Betley ,  Alexandre Mikhailine ,  Claudia Kleinlein ,  Yuyang Dong ,  Yunjung Baek

IPC分类号： B01J31/18 ,  B01J31/22 ,  C07D207/06 ,  C07D209/04 ,  C07D209/44 ,  C07D209/54 ,  C07D211/70 ,  C07D263/04 ,  C07D401/04 ,  C07D403/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/08

CPC分类号： B01J31/1815 ,  B01J31/2243 ,  C07D207/06 ,  C07D209/04 ,  C07D209/44 ,  C07D209/54 ,  C07D211/70 ,  C07D263/04 ,  C07D401/04 ,  C07D403/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/08 ,  B01J2231/4283 ,  B01J2531/0216 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  B01J2540/66

摘要： Disclosed are compounds, methods, reagents, systems, and kits for the preparation and utilization of monomeric or polymeric metal-based compounds. These metal-based compounds are organometallic catalysts composed of substituted dipyrrin ligands bound to transition metals. C—H bond functionalization catalysis can be performed with the disclosed organometallic catalysts to yield C—N bonds to generate substituted bicyclic, spiro, and fused nitrogen-containing heterocycles, all common motifs in various pharmaceutical and bioactive molecules.

公开(公告)号：US11873292B2

公开(公告)日：2024-01-16

申请号：US16306751

申请日：2017-06-02

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： Hong Liu ,  Jia Li ,  Wei Zhu ,  Yubo Zhou ,  Jiang Wang ,  Mingbo Su ,  Shuni Wang ,  Wei Xu ,  Chunpu Li ,  Weijuan Kan ,  Hualiang Jiang ,  Kaixian Chen

IPC分类号： C07D403/12 ,  C07D215/58 ,  C07D209/04 ,  C07D215/00 ,  C07D487/04 ,  C07D209/08 ,  C07D401/12 ,  C07D405/12 ,  A61P35/00

CPC分类号： C07D403/12 ,  A61P35/00 ,  C07D209/04 ,  C07D209/08 ,  C07D215/00 ,  C07D215/58 ,  C07D401/12 ,  C07D405/12 ,  C07D487/04 ,  Y02P20/55

摘要： The present invention relates to the fields of medicinal chemistry and pharmacotherapy, and specifically relates to the chemical compound of formula (I), and its racemate, R-isomer, S-isomer, pharmaceutically acceptable salt, and mixtures thereof, as well as its method for preparation, a pharmaceutical composition containing said chemical compound, and use as a lysine-specific demethylase 1 (LSD 1) inhibitor. The cyclopropylamine chemical compound to which the present invention relates may be used in the treatment of cancer.

公开(公告)号：US20230098702A1

公开(公告)日：2023-03-30

申请号：US17798841

申请日：2020-02-10

申请人： C-BIOMEX Co., Ltd.

发明人： Jun-Hoe CHA ,  Hak-Soo CHOI

IPC分类号： C07D209/04 ,  C09K11/56

摘要： The present invention provides an amphoteric fluorescent substance capable of being attached to biomaterials.

公开(公告)号：US20230067644A1

公开(公告)日：2023-03-02

申请号：US17904423

申请日：2021-02-17

申请人： BAHCESEHIR UNIVERSITESI

发明人： Serdar DURDAGI ,  Muge ORHAN ,  Timucin AVSAR ,  Maide PAKSOY ,  Gulsah AYDIN ,  Mine YURTSEVER

IPC分类号： C07D209/04 ,  A61K45/06

摘要： The invention relates to compound shown with formula (I) or a pharmaceutically acceptable derivative thereof for use as a novel inhibitor of MDM2 activity.

公开(公告)号：US11299457B2

公开(公告)日：2022-04-12

申请号：US16872949

申请日：2020-05-12

申请人： GlaxoSmithKline Intellectual Property (No. 2) Limited

发明人： Philip Stewart Turnbull ,  Rodolfo Cadilla

IPC分类号： A61K31/404 ,  A61P21/06 ,  C07D209/08 ,  C07D209/14 ,  C07D209/42 ,  C07D401/06 ,  C07D209/10 ,  C07D209/04

摘要： This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

公开(公告)号：US11208398B2

公开(公告)日：2021-12-28

申请号：US17260393

申请日：2019-07-15

申请人： NOVARTIS AG

发明人： Peng Fu ,  Yu Gai ,  Feng Gao ,  Weiyong Kong ,  Yadong Lu ,  Zhongcheng Min ,  Shaofeng Rong ,  Chutian Shu ,  Can Wang ,  Ruidong Wang ,  Jibin Zhao ,  Xianglin Zhao ,  Yi Zhao ,  Jianguang Zhou ,  Benjamin Martin

IPC分类号： C07D401/06 ,  C07D209/04 ,  C07D211/74

摘要： The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11098030B2

公开(公告)日：2021-08-24

申请号：US16703544

申请日：2019-12-04

申请人： Recurium IP Holdings, LLC

发明人： Kevin Duane Bunker ,  Peter Qinhua Huang ,  Sunny Abraham ,  Joseph Robert Pinchman ,  Chad Daniel Hopkins ,  Deborah Helen Slee

IPC分类号： C07D209/04 ,  C07C13/36 ,  C07D403/04 ,  A61P35/00 ,  A61K31/506 ,  C07D403/14 ,  C07D471/04

摘要： Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

公开(公告)号：US10964966B2

公开(公告)日：2021-03-30

申请号：US16469766

申请日：2017-12-15

申请人： LOCKHEED MARTIN ENERGY, LLC

发明人： Zachariah M. Norman ,  Matthew Millard ,  Emily Grace Nelson ,  Scott Thomas Humbarger

IPC分类号： H01M4/36 ,  H01M8/18 ,  C07D209/04 ,  C07D209/46 ,  C07D221/00 ,  C07D279/12 ,  C07F1/00 ,  C07F3/00 ,  H01M4/60

摘要： Flow batteries can include a first half-cell containing a first aqueous electrolyte solution, a second half-cell containing a second aqueous electrolyte solution, and a separator disposed between the first half-cell and the second half-cell. The first aqueous electrolyte solution contains a first redox-active material, and the second aqueous electrolyte solution contains a second redox-active material. At least one of the first redox-active material and the second redox-active material is a nitroxide compound or a salt thereof. Particular nitroxide compounds can include a doubly bonded oxygen contained in a ring bearing the nitroxide group, a doubly bonded oxygen appended to a ring bearing the nitroxide group, sulfate or phosphate groups appended to a ring bearing the nitroxide group, various heterocyclic rings bearing the nitroxide group, or acyclic nitroxide compounds.

公开(公告)号：US10696632B2

公开(公告)日：2020-06-30

申请号：US15571930

申请日：2016-05-04

申请人： Janssen Pharmaceuticals, Inc. ,  Katholieke Universiteit Leuven

发明人： Bart Rudolf Romanie Kesteleyn ,  Jean-François Bonfanti ,  Tim Hugo Maria Jonckers ,  Pierre Jean-Marie Bernard Raboisson ,  Dorothée Alice Marie-Eve Bardiot ,  Arnaud Didier M Marchand

IPC分类号： C07D487/08 ,  C07D471/08 ,  C07D513/08 ,  C07D209/14 ,  C07D209/04 ,  A61P31/14 ,  A61K31/404 ,  A61K45/06

摘要： The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.