公开(公告)号：US12195429B2

公开(公告)日：2025-01-14

申请号：US17626516

申请日：2020-07-10

Applicant: CANOPY GROWTH CORPORATION

Inventor： Siawash Ahmar ,  Jeffrey Alan Omeara ,  Peter Martin Dove

IPC: C07D213/30 ,  C07C39/24 ,  C07C43/205 ,  C07C43/225 ,  C07C255/53 ,  C07D203/10 ,  C07D207/333 ,  C07D209/12 ,  C07D231/12 ,  C07D235/18 ,  C07D239/26 ,  C07D241/12 ,  C07D249/08 ,  C07D257/04 ,  C07D261/08 ,  C07D263/14 ,  C07D271/06 ,  C07D271/113 ,  C07D277/26 ,  C07D295/033 ,  C07D303/14 ,  C07D305/06 ,  C07D307/42 ,  C07D309/32 ,  C07D333/16 ,  C07D333/56 ,  C07D473/00

Abstract: The current application relates to cannabinoid derivatives of formula (I) and pharmaceutical compositions comprising the same. The cannabinoid derivative can be used for the treatment of diseases associated with cannabinoid receptor such as pain, ADHD/ADD, alcohol use disorder, anxiety disorder, and dementias.

公开(公告)号：US12065407B2

公开(公告)日：2024-08-20

申请号：US16640919

申请日：2018-08-21

Applicant: PLEX PHARMACEUTICALS, INC.

Inventor： Surya Kanta De ,  Sridhar G. Prasad ,  Marshall C. Peterman

IPC: C07D213/30 ,  A61K31/4184 ,  A61K47/30 ,  C07C237/22 ,  C07D209/42 ,  C07D231/56 ,  C07D235/08 ,  C07D235/10 ,  C07D235/14 ,  C07D235/30 ,  A61K9/00

CPC classification number: C07D213/30 ,  A61K47/30 ,  C07C237/22 ,  C07D209/42 ,  C07D231/56 ,  C07D235/10 ,  C07D235/14 ,  C07D235/30 ,  A61K9/0043

Abstract: Provided are novel compounds of Formulas (I) and (II), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful as dual FKBP12/FKABP inhibitors. Also provided are pharmaceutical compositions comprising the novel compounds of Formulas (I) and (II) and their use in treating Parkinson's disease.

公开(公告)号：US20240254066A1

公开(公告)日：2024-08-01

申请号：US18560341

申请日：2022-05-12

Applicant: GW Research Limited

Inventor： Alan James SILCOCK ,  Karen Ka-Yen TSE ,  Paul Stuart HINCHLIFFE ,  Andrew SHARPE ,  Iain David SIMPSON ,  Joanne PEACH ,  Stefano LEVANTO ,  Antoine MILLET ,  Inderjit Singh MANN

IPC: C07C43/295 ,  A61K31/05 ,  A61K31/055 ,  A61K31/075 ,  A61K31/085 ,  A61K31/137 ,  A61K31/277 ,  A61K31/351 ,  A61K31/36 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/505 ,  A61P25/08 ,  C07C29/143 ,  C07C35/18 ,  C07C37/48 ,  C07C37/56 ,  C07C39/23 ,  C07C39/42 ,  C07C41/03 ,  C07C41/26 ,  C07C41/30 ,  C07C43/23 ,  C07C67/08 ,  C07C67/287 ,  C07C69/94 ,  C07C213/08 ,  C07C215/50 ,  C07C253/30 ,  C07C255/36 ,  C07C303/30 ,  C07C309/87 ,  C07D211/70 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D231/12 ,  C07D239/34 ,  C07D261/08 ,  C07D277/24 ,  C07D309/22 ,  C07D317/54

CPC classification number: C07C43/295 ,  A61K31/05 ,  A61K31/055 ,  A61K31/075 ,  A61K31/085 ,  A61K31/137 ,  A61K31/277 ,  A61K31/351 ,  A61K31/36 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/505 ,  A61P25/08 ,  C07C29/143 ,  C07C35/18 ,  C07C37/48 ,  C07C37/56 ,  C07C39/23 ,  C07C39/42 ,  C07C41/03 ,  C07C41/26 ,  C07C41/30 ,  C07C43/23 ,  C07C67/08 ,  C07C67/287 ,  C07C69/94 ,  C07C213/08 ,  C07C215/50 ,  C07C253/30 ,  C07C255/36 ,  C07C303/30 ,  C07C309/87 ,  C07D211/70 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/65 ,  C07D231/12 ,  C07D239/34 ,  C07D261/08 ,  C07D277/24 ,  C07D309/22 ,  C07D317/54 ,  C07C2601/02 ,  C07C2601/10 ,  C07C2601/16

Abstract: The present invention relates to a group of resorcinol derivatives as a pharmaceutically active compounds and methods of preparation thereof. Resorcinol derivatives have been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the resorcinol derivative of the invention.

公开(公告)号：US20240166652A1

公开(公告)日：2024-05-23

申请号：US18324901

申请日：2023-05-26

Applicant: Calico Life Sciences LLC ,  AbbVie Inc.

Inventor： Kathleen Ann Martin ,  Carmela Sidrauski ,  Marina Pliushchev ,  Jennifer M. Frost ,  Yunsong Tong ,  Lawrence A. Black ,  Xiangdong Xu ,  Lei Shi ,  Qingwei Zhang ,  SeungWon Chung ,  Zhaoming Xiong ,  Ramzi Farah Sweis ,  Michael J. Dart ,  Brian S. Brown ,  Kathleen J. Murauski

IPC: C07D487/04 ,  C07C235/22 ,  C07D213/30 ,  C07D213/643 ,  C07D213/73 ,  C07D231/56 ,  C07D241/18 ,  C07D261/20 ,  C07D271/07 ,  C07D271/113

CPC classification number: C07D487/04 ,  C07C235/22 ,  C07D213/30 ,  C07D213/643 ,  C07D213/73 ,  C07D231/56 ,  C07D241/18 ,  C07D261/20 ,  C07D271/07 ,  C07D271/113

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

公开(公告)号：US20240083839A1

公开(公告)日：2024-03-14

申请号：US18030686

申请日：2021-10-06

Applicant: The Regents of the University of California

Inventor： Varghese John ,  Jesus Campagna ,  Michael E. Jung ,  Barbara Jagodzinska

IPC: C07C229/08 ,  C07D223/16 ,  C07D233/32 ,  C07C237/06 ,  C07C237/04 ,  C07D209/48 ,  C07D213/40 ,  C07D223/12 ,  C07D211/60 ,  C07D207/16 ,  C07D207/12 ,  C07C237/20 ,  C07D213/30 ,  C07D211/50 ,  A61P25/28

CPC classification number: C07C229/08 ,  C07D223/16 ,  C07D233/32 ,  C07C237/06 ,  C07C237/04 ,  C07D209/48 ,  C07D213/40 ,  C07D223/12 ,  C07D211/60 ,  C07D207/16 ,  C07D207/12 ,  C07C237/20 ,  C07D213/30 ,  C07D211/50 ,  A61P25/28 ,  C07C2602/10 ,  C07C2601/08 ,  C07B2200/07 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/08

Abstract: The present disclosure relates to compounds that are capable of inhibiting PRMT8 and/or upregulating SirT1. The disclosure further relates to methods of treating neurodegenerative diseases and disorders (e.g., Alzheimer's disease).

公开(公告)号：US20230399282A1

公开(公告)日：2023-12-14

申请号：US18238905

申请日：2023-08-28

Applicant: Unigen, Inc.

Inventor： Sandip K. Nandy ,  Jiyun Liu ,  Alexandre Mikhailovitch Nesterov ,  Carmen Hertel ,  Abeysinghe Arrachchigae Papmapiya

IPC: C07C43/295 ,  A23B7/154 ,  A23L3/3481 ,  A61K8/49 ,  A61Q19/02 ,  C07C39/11 ,  C07C39/15 ,  C07C43/23 ,  C07C45/67 ,  C07C45/74 ,  C07C49/83 ,  C07D213/30 ,  C07D307/12 ,  C07D307/42 ,  C07D317/54 ,  A61K8/34 ,  A61K31/09 ,  A61K31/341 ,  A61K31/357 ,  A61K31/4406 ,  A61Q19/08 ,  C07D213/64 ,  C07D263/57

CPC classification number: C07C43/295 ,  A23B7/154 ,  A23L3/3481 ,  A61K8/4926 ,  A61K8/4973 ,  A61Q19/02 ,  C07C39/11 ,  C07C39/15 ,  C07C43/23 ,  C07C45/673 ,  C07C45/74 ,  C07C49/83 ,  C07D213/30 ,  C07D307/12 ,  C07D307/42 ,  C07D317/54 ,  A61K8/347 ,  A61K8/345 ,  A61K31/09 ,  A61K31/341 ,  A61K31/357 ,  A61K31/4406 ,  A61Q19/08 ,  C07D213/64 ,  C07D263/57 ,  A61K2800/782

Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.

公开(公告)号：US20230339890A1

公开(公告)日：2023-10-26

申请号：US18007812

申请日：2021-06-03

Applicant: Kineta, Inc.

Inventor： Iwona WRONA ,  Kerem OZBOYA ,  Bertrand LE BOURDONNEC ,  Vanessa KURIA ,  Madeline MACDONNELL ,  Matthew LUCAS ,  Byron DELABARRE

IPC: C07D401/12 ,  C07D213/30 ,  C07D405/12 ,  C07D405/14 ,  C07D237/08 ,  C07D417/12 ,  C07D241/12 ,  C07D401/14

CPC classification number: C07D401/12 ,  C07D213/30 ,  C07D237/08 ,  C07D241/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12

Abstract: The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

公开(公告)号：US20230255963A1

公开(公告)日：2023-08-17

申请号：US18137210

申请日：2023-04-20

Applicant: Global Blood Therapeutics, Inc. ,  The Regents of the University of California

Inventor： Brian Metcalf ,  Chihyuan Chuang ,  Jeffrey Warrington ,  Matthew P. Jacobson

IPC: A61K31/4985 ,  C07D213/80 ,  C07D231/56 ,  C07D401/04 ,  C07D257/04 ,  C07D211/62 ,  C07D213/30 ,  C07C69/76 ,  C07C65/30 ,  C07D215/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/192 ,  A61K31/235 ,  A61K31/41 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/47

CPC classification number: A61K31/4985 ,  C07D213/80 ,  C07D231/56 ,  C07D401/04 ,  C07D257/04 ,  C07D211/62 ,  C07D213/30 ,  C07C69/76 ,  C07C65/30 ,  C07D215/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/192 ,  A61K31/235 ,  A61K31/41 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/47

Abstract: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

公开(公告)号：US20230131535A1

公开(公告)日：2023-04-27

申请号：US17766879

申请日：2020-10-06

Applicant: D. E. Shaw Research, LLC

Inventor： Fabrizio GIORDANETTO ,  Morten Østergaard JENSEN ,  Vishwanath JOGINI ,  Roger John SNOW

IPC: C07D213/30 ,  C07D213/73 ,  C07C215/50 ,  C07D213/82 ,  C07D213/38 ,  C07D231/12 ,  C07D401/12 ,  C07C237/30 ,  C07D213/64 ,  C07D213/40 ,  C07D209/44 ,  C07D213/81 ,  C07D213/84 ,  C07D213/56 ,  C07D209/08 ,  C07D241/12 ,  C07D213/50 ,  C07D205/04 ,  C07D211/60 ,  C07C235/08 ,  C07D211/62 ,  C07D265/30 ,  C07D207/16

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

公开(公告)号：US20230127289A1

公开(公告)日：2023-04-27

申请号：US17990714

申请日：2022-11-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Robert Hahn ,  Dieter Heindl ,  Thomas Hoffmann ,  Hans-Peter Josel ,  Uwe Kobold ,  Hannes Kuchelmeister ,  Simon Ferdinand Loibl ,  Daniela Mazzier ,  Jelena Milic ,  Giuseppe Prencipe ,  Martin Rempt ,  Christoph Seidel

IPC: C07D213/56 ,  C07D401/04 ,  C07D213/74 ,  C07D213/30 ,  H01J49/00

Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.