公开(公告)号：US20240398783A1

公开(公告)日：2024-12-05

申请号：US18688859

申请日：2022-09-06

Applicant: Gismo Therapeutics, Inc.

Inventor： Paul GREGOR ,  Myung Hee KIM ,  Brian MARRON

IPC: A61K31/4709 ,  A61K31/4164 ,  A61K31/4706 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  C07D215/42 ,  C07D233/64 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14

Abstract: The disclosure provides quinoline and quinazoline derivative compounds and pharmaceutical compositions thereof. These compounds inhibit the interactions between GAG-binding amyloid peptides (GBAPs) and heparan sulfate glycosaminoglycans (HS-GAGs) and thus may be useful as therapeutics for the treatment and prevention of neurodegenerative diseases associated with amyloidosis, for example Alzheimer's Disease, and for other amyloid disorders. The present disclosure further provides methods of treatment and prevention of neurodegenerative and amyloid diseases, and methods for identifying small organic molecule compounds that can inhibit the interaction of glycosaminoglycans (GAGs) with GAG-binding amyloid peptides (GBAPs).

公开(公告)号：US11873291B2

公开(公告)日：2024-01-16

申请号：US17446951

申请日：2021-09-03

Applicant: ImmuneSensor Therapeutics, Inc. ,  The Board of Regents of the University of Texas System

Inventor： Jian Qiu ,  Qi Wei ,  Matt Tschantz ,  Heping Shi ,  Youtong Wu ,  Hulling Tan ,  Lijun Sun ,  Chuo Chen ,  Zhijian Chen

IPC: C07D215/38 ,  C07D401/14 ,  C07D215/42 ,  C07D215/46 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07F9/6503 ,  C07F9/6506

CPC classification number: C07D401/14 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07F9/6506 ,  C07F9/65031

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20230174492A1

公开(公告)日：2023-06-08

申请号：US17995750

申请日：2021-04-08

Applicant: Bayer Animal Health GmbH

Inventor： Nils GRIEBENOW ,  Daniel KULKE ,  Iring HEISLER ,  Wei ZHUANG

IPC: C07D215/42 ,  C07D405/12 ,  C07D405/14 ,  C07D405/04 ,  A61P33/10

CPC classification number: C07D215/42 ,  C07D405/12 ,  C07D405/14 ,  C07D405/04 ,  A61P33/10

Abstract: The present invention relates to novel anthelmintic compounds of general formula (I):


T-L-A   (I)

wherein A is A1 or A2




#2 indicates the binding position between the group L and A, T is a group T1-T6, L is a group L1-L10, and R1, R2, R3, R4, R5, R6 and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20230002351A1

公开(公告)日：2023-01-05

申请号：US16639051

申请日：2018-08-13

Applicant: GLOBAL BLOOD THERAPEUTICS, INC.

Inventor： ZHE LI ,  MING YU ,  QING XU ,  MANUEL ZANCANELLA

IPC: C07D401/12 ,  C07D215/42 ,  C07D401/14 ,  C07D405/14 ,  C07D491/056 ,  C07D491/044 ,  C07B59/00 ,  C07D487/04 ,  C07D413/12 ,  C07D453/02 ,  C07D487/08

Abstract: The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

公开(公告)号：US11530180B2

公开(公告)日：2022-12-20

申请号：US17117004

申请日：2020-12-09

Applicant: The Regents of the University of California ,  Shanghai ChemPartner Co., Ltd.

Inventor： Dean Sheppard ,  William F. DeGrado ,  Hyunil Jo ,  Aparna Sundaram ,  Richard Beresis

IPC: C07C279/18 ,  C07C279/28 ,  C07C317/14 ,  C07D239/14 ,  C07D265/08 ,  C07D265/16 ,  C07D265/36 ,  C07D295/155 ,  C07D311/68 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/337 ,  A61K31/704 ,  C07D235/16 ,  C07D213/74 ,  C07D233/88 ,  C07D215/42 ,  C07D279/06

Abstract: The disclosure provides, inter alia, alpha-5 beta-1 inhibitors, pharmaceutical compositions comprising alpha-5 beta-1 inhibitors, methods for treating diseases using alpha-5 beta-1 inhibitors, and processes for making alpha-5 beta-1 inhibitors.

公开(公告)号：US20220396581A1

公开(公告)日：2022-12-15

申请号：US17228573

申请日：2021-04-12

Applicant: Janssen BioPharma, Inc.

Inventor： Guangyi WANG ,  Leonid BEIGELMAN ,  Anh TRUONG ,  Carmela NAPOLITANO ,  Daniele ANDREOTTI ,  Haiying HE

IPC: C07D495/04 ,  A61K31/352 ,  A61K31/4196 ,  A61K31/4365 ,  C07C255/66 ,  C07D233/88 ,  C07D261/20 ,  C07D307/40 ,  C07D307/52 ,  C07D333/20 ,  C07D333/58 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/427 ,  A61K31/4375 ,  A61K31/4725 ,  C07D213/50 ,  C07D233/64 ,  C07D333/68 ,  C07D401/12 ,  C07D409/06 ,  A61K31/343 ,  A61K31/382 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/4545 ,  C07C251/84 ,  C07D207/335 ,  C07D215/12 ,  C07D215/42 ,  C07D233/61 ,  C07D401/04 ,  C07D409/14 ,  A61K31/277 ,  A61K31/407 ,  A61K31/423 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  C07C243/34 ,  C07D209/20 ,  C07D209/86 ,  C07D233/38 ,  C07D233/60 ,  C07D277/64 ,  C07D307/81 ,  C07D405/10 ,  C07D417/04 ,  C07D417/12 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4709 ,  C07C243/18 ,  C07D277/56 ,  C07D333/66 ,  C07D413/04 ,  C07D471/04 ,  C07D495/14 ,  A61K31/4427 ,  A61K31/5377 ,  C07D213/42 ,  C07D213/68 ,  C07D215/38 ,  C07D217/24 ,  C07D307/91 ,  C07D311/68 ,  C07D333/16 ,  C07D333/62 ,  C07D401/10 ,  C07D409/12 ,  A61K31/341 ,  A61K31/4164 ,  A61K31/428 ,  A61K31/444 ,  A61K31/4704 ,  A61K31/501 ,  A61K45/06 ,  C07C255/34 ,  C07D209/08 ,  C07D215/14 ,  C07D333/54 ,  C07D335/06 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D413/12 ,  C07D413/14 ,  A61K31/381 ,  A61K31/4155 ,  A61K31/47 ,  A61K31/538 ,  C07C251/80 ,  C07D209/14 ,  C07D213/65 ,  C07D333/50 ,  C07D333/76

Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

公开(公告)号：US20220388962A1

公开(公告)日：2022-12-08

申请号：US17635421

申请日：2020-08-21

Applicant: Biohaven Therapeutics Ltd.

Inventor： Marianne CARLSEN ,  Garry R. SMITH ,  Randall J. BINDER ,  Camille REMEUR ,  Allen B. REITZ ,  Xiao JIN

IPC: C07D215/42 ,  C07D401/12 ,  C07D215/46 ,  C07D487/04 ,  C07D401/10 ,  C07D471/04 ,  C07D487/10 ,  C07D401/14 ,  C07D413/12 ,  C07D405/12 ,  C07D401/04 ,  C07D405/04 ,  C07D413/14 ,  C07D491/056

Abstract: Pharmaceutical compositions of the invention comprise TDP-43 binding agents having a disease-modifying action in the treatment of diseases associated with TDP-43 that include ALS, FTLD, CTE, hippocampal sclerosis of aging (CARTS), Alzheimer's disease, and Alzheimer's disease related disorder, and disease that involve excess amounts of TDP-43 in the cytosol.

公开(公告)号：US11420995B2

公开(公告)日：2022-08-23

申请号：US16490459

申请日：2018-03-02

Applicant: Synovo GmbH ,  Michael W. Burnet

Inventor： Nikolas Pietrzik ,  Michael W. Burnet ,  Christiane Baeuerlein ,  Mary Eggers ,  Jan-Hinrich Guse ,  Ulrike Hahn ,  Simon Strass

IPC: C07H17/08 ,  C07C217/40 ,  C07D215/42 ,  C07D401/04 ,  A61K45/06

Abstract: Lysosomally accumulated substances that release a nitroxy group, or a short chain fatty acid or a product of anaerobic metabolism or a thiol or a sulfide often from an ester or similar labile linkage have anti-inflammatory, anti-cancer and anti-bacterial activity. They are useful in treating infectious, inflammatory and malignant disease.

公开(公告)号：US20220064159A1

公开(公告)日：2022-03-03

申请号：US17415309

申请日：2019-12-13

Applicant: Elanco Tiergesundheit AG

Inventor： Chouaib Tahtaoui ,  Denise Rageot ,  Francois Pautrat ,  Pierre Ducray

IPC: C07D471/04 ,  C07D405/12 ,  C07D215/42 ,  C07D311/74

Abstract: The present invention provides compounds of formula (I): which are useful in the control of endoparasites, for example heartworms, in warm-blooded animals.

公开(公告)号：US20210188793A1

公开(公告)日：2021-06-24

申请号：US17195351

申请日：2021-03-08

Applicant: Lundbeck La Jolla Research Center, Inc. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES ,  Micah J. NIPHAKIS ,  Jae Won CHANG ,  Kenneth M. LUM ,  Benjamin F. CRAVATT

IPC: C07D295/205 ,  C07C271/12 ,  C07D317/46 ,  C07D317/58 ,  C07D231/12 ,  C07D231/16 ,  C07D231/56 ,  C07D241/04 ,  C07D471/04 ,  C07D471/10 ,  C07D261/08 ,  C07D487/04 ,  C07D263/32 ,  C07D205/04 ,  C07D491/107 ,  C07D207/14 ,  C07D271/06 ,  C07D307/79 ,  C07D405/14 ,  C07D215/42 ,  C07D213/40 ,  A61P25/22 ,  C07D295/26 ,  C07D213/55 ,  C07D401/04 ,  C07D407/06 ,  C07D413/06 ,  C07C271/10 ,  C07D207/09 ,  C07D213/38 ,  C07D215/46 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.