公开(公告)号：US20240409517A1

公开(公告)日：2024-12-12

申请号：US18699783

申请日：2022-10-13

Applicant: GIVAUDAN SA

Inventor： Stephan HAIBER ,  Esther Maria VREMAN ,  Adri DE KLERK ,  Luis IBANEZ GONZALEZ ,  Abdelmajid KAOUAS ,  Eric KOHLEN ,  Jose LHERONDEL ,  Lisa Maria WIJNEN ,  Cornelis WINKEL

IPC: C07D233/90 ,  A23L27/00 ,  A23L27/20 ,  C07D239/28 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

Abstract: The invention relates to the use of compounds of formula (I) and edible salts thereof, wherein R1 is selected from the group consisting of 2-(1H-4-imidazolyl)-ethenyl, 1H-5-indolyl, 2-(1H-5-imidazolyl)-ethenyl, 1-amino-2-(1H-4-imidazolyl)-ethyl, (1,3-thiazol-2-yl)-ethenyl, 2,3-dihydro-1H-indol-2-yl, 2-(pyrimidin-2-yl)ethenyl, heptadecanyl, 1-heptadec-8-enyl, heptadeca-8,11-dienyl, heptadeca-8,11,14-trienyl, 2-(4H-imidazol-2-yl)-ethenyl, 2-(4H-imidazol-2-yl)-ethyl, 2-phenyl-ethenyl, 2-(furan-2-yl)-ethenyl, 2-(thiophen-2-yl)-ethenyl, 2-(thiophen-3-yl)-ethenyl, 2-but-2-enoyl, 2-butyl, 2,6-dimethylhepta-1,5-dienyl, 1,3-benzothiazol-6-yl; R2 is selected from the group consisting of (1H-imidazol-4-yl)-methyl, (1H-3-indol-3-yl)-methyl, 4-hydroxybenzyl, methylsulfanylethyl, hydroxymethyl, CH2—COOH, (pyridin-4-yl)methyl, (pyridin-2-yl)methyl, 1-(2,6-dimethylhepta-1,5-dienyl), 2-(pyrimidin-2-yl)methyl, (1H-imidazol-5-yl)-methyl, (1H-imidazol-2-yl)-methyl, (1H-pyrrol-2-yl)-methyl, phenyl, pyrimidin-5-yl, pyrazin-2-yl; R3 is selected from the group consisting of H, COOH, or a compound selected from the group consisting of 3-(1H-imidazol-4-yl) prop-2-enamide, methyl 2,3-dihydro-1H-indole-2-carboxylate, and 3,6-bis[(1H-imidazol-4-yl)methyl]piperazine-2,5-dione, as flavor modulating compound, and to flavor compositions and consumer products comprising said compounds.

公开(公告)号：US20240343681A1

公开(公告)日：2024-10-17

申请号：US18551238

申请日：2022-03-22

Applicant: CORTEVA AGRISCIENCE LLC

Inventor： JOSEPH D. ECKELBARGER ,  RONALD J. HEEMSTRA ,  RICKY HUNTER ,  DANIEL KNUEPPEL ,  TIMOTHY P. MARTIN ,  TONY K. TRULLINGER ,  MARTIN J. WALSH

IPC: C07C233/62 ,  A01N53/00 ,  C07D207/16 ,  C07D239/28 ,  C07D261/12 ,  C07D277/56 ,  C07D307/68

CPC classification number: C07C233/62 ,  A01N53/00 ,  C07D207/16 ,  C07D239/28 ,  C07D261/12 ,  C07D277/56 ,  C07D307/68

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

公开(公告)号：US20230247901A1

公开(公告)日：2023-08-03

申请号：US18002008

申请日：2021-06-18

Applicant: Novaled GmbH

Inventor： Max Peter Nüllen ,  Benjamin Schulze ,  Jakob Jacek Wudarczyk

IPC: H10K85/60 ,  C07C255/35 ,  C07C255/51 ,  C07D213/85 ,  C07D213/61 ,  C07D239/28 ,  C07D239/26 ,  C07D251/24

CPC classification number: H10K85/654 ,  H10K85/60 ,  C07C255/35 ,  C07C255/51 ,  C07D213/85 ,  C07D213/61 ,  C07D239/28 ,  C07D239/26 ,  C07D251/24 ,  H10K50/15

Abstract: The present invention relates to a compound of formula (I) and an organic electronic device comprising a charge generation layer which comprises a compound of formula (I).

公开(公告)号：US11685722B2

公开(公告)日：2023-06-27

申请号：US16976147

申请日：2019-02-28

Applicant: Curtana Pharmaceuticals, Inc.

Inventor： Graham Beaton ,  Stanton F. McHardy ,  Ambrosio Lopez, Jr. ,  Bismarck Campos ,  Hua-Yu Leo Wang

IPC: C07D239/24 ,  C07D239/28 ,  C07D239/48 ,  A61K31/17 ,  A61K31/495 ,  A61K31/505 ,  A61P35/00 ,  C07D401/12

CPC classification number: C07D239/48 ,  A61P35/00 ,  C07D401/12

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

公开(公告)号：US11524944B2

公开(公告)日：2022-12-13

申请号：US16765780

申请日：2018-11-16

Applicant: Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft ,  Deutsches Krebsforschungszentrum

Inventor： Julien Lefranc ,  Norbert Schmees ,  Ulrike Röhn ,  Ludwig Zorn ,  Judith Günther ,  Ilona Gutcher ,  Lars Röse ,  Benjamin Bader ,  Detlef Stöckigt ,  Michael Platten

IPC: C07D239/28 ,  A61P35/04 ,  C07D405/12 ,  A61K45/06

Abstract: The present invention covers 2-phenylpyrimidine-4-carboxamide compounds of general formula (I): (I) 5 in which X, Y, Z, R1, R2, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

公开(公告)号：US10995081B2

公开(公告)日：2021-05-04

申请号：US16552032

申请日：2019-08-27

Applicant: MITSUI CHEMICALS, INC.

Inventor： Kei Yoshida ,  Takeo Wakita ,  Hiroyuki Katsuta ,  Akiyoshi Kai ,  Yutaka Chiba ,  Kiyoshi Takahashi ,  Hiroko Kato ,  Nobuyuki Kawahara ,  Michikazu Nomura ,  Hidenori Daido ,  Junji Maki ,  Shinichi Banba

IPC: C07C323/42 ,  C07D333/38 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/78 ,  A01N43/80 ,  C07C237/42 ,  C07C317/40 ,  C07C327/48 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/30 ,  C07D241/24 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D309/08 ,  C07D309/28 ,  C07D317/62 ,  C07D333/68 ,  A01N43/40 ,  A01N37/22 ,  A01N43/60 ,  C07C237/48 ,  C07D207/34 ,  C07D239/28 ,  C07D261/18 ,  C07D307/85 ,  C07D317/46

Abstract: A compound represented by Formula (1): The compound can be used as insecticides.

公开(公告)号：US20210093636A1

公开(公告)日：2021-04-01

申请号：US17082666

申请日：2020-10-28

Applicant: Innovation Pharmaceuticals Inc.

Inventor： Richard W. Scott

IPC: A61K31/506 ,  C07D239/02 ,  C07D239/24 ,  C07D239/28 ,  C07D403/14 ,  A61K9/00 ,  A61K31/74 ,  A61K47/06 ,  A61K47/18 ,  A61K47/38 ,  A61K9/06 ,  A61K9/08 ,  A61K31/573

Abstract: The present invention discloses ophthalmic and otic compositions of facially amphiphilic antimicrobial polymers and oligomers and their uses, including their use in methods for treating and preventing ophthalmic infections and otic infections in humans and animals.

公开(公告)号：US20200377463A1

公开(公告)日：2020-12-03

申请号：US16884679

申请日：2020-05-27

Applicant: Genentech, Inc.

Inventor： Michael F.T. Koehler ,  Peter Andrew Smith ,  Dana Winter ,  Boubacar Sow ,  Claudio Sturino ,  Guillaume Pelletier ,  Jonathan Boudreault

IPC: C07D239/42 ,  A61K45/06 ,  A61K31/505 ,  A61P31/04 ,  A61K31/702 ,  A61K31/4709 ,  A61K31/545 ,  A61K38/14 ,  A61K31/497 ,  A61K31/165 ,  A61K31/351 ,  A61K38/12 ,  A61K31/5377 ,  C07D239/28

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20190382366A1

公开(公告)日：2019-12-19

申请号：US16552032

申请日：2019-08-27

Applicant: MITSUI CHEMICALS, INC.

Inventor： Kei Yoshida ,  Takeo Wakita ,  Hiroyuki Katsuta ,  Akiyoshi Kai ,  Yutaka Chiba ,  Kiyoshi Takahashi ,  Hiroko Kato ,  Nobuyuki Kawahara ,  Michikazu Nomura ,  Hidenori Daido ,  Junji Maki ,  Shinichi Banba

IPC: C07D333/38 ,  C07D317/46 ,  C07D307/85 ,  C07D261/18 ,  C07D239/28 ,  C07D207/34 ,  C07C237/48 ,  A01N43/60 ,  A01N37/22 ,  A01N43/40 ,  C07D333/68 ,  C07D317/62 ,  C07D309/28 ,  C07D309/08 ,  C07D307/84 ,  C07D307/68 ,  C07D307/24 ,  C07D277/56 ,  C07D275/03 ,  C07D263/34 ,  C07D241/24 ,  C07D239/30 ,  C07D231/16 ,  C07D231/14 ,  C07D215/52 ,  C07D213/89 ,  C07D213/82 ,  C07D213/81 ,  C07D213/73 ,  C07D213/64 ,  C07D207/416 ,  C07C327/48 ,  C07C323/42 ,  C07C317/40 ,  C07C237/42 ,  A01N43/80 ,  A01N43/78 ,  A01N43/58 ,  A01N43/56 ,  A01N43/54 ,  A01N43/42 ,  A01N43/30 ,  A01N43/16 ,  A01N43/12 ,  A01N43/10 ,  A01N43/08 ,  A01N37/44

Abstract: A compound represented by Formula (1): The compound can be used as insecticides.

公开(公告)号：US20190292157A1

公开(公告)日：2019-09-26

申请号：US16380256

申请日：2019-04-10

Applicant: Pfizer Inc.

Inventor： Agustin Casimiro-Garcia ,  Jeffrey Scott Condon ,  Andrew Christopher Flick ,  Ariamala Gopalsamy ,  Steven J. Kirincich ,  John Paul Mathias ,  Joseph Walter Strohbach ,  Jason Shaoyun Xiang ,  Li Huang Xing ,  Xiaolun Wang

IPC: C07D239/42 ,  A61P35/00 ,  A61P1/04 ,  A61P1/00 ,  C07D405/10 ,  A61K31/505 ,  C07D401/12 ,  C07D241/14 ,  C07D239/28 ,  C07D403/12

Abstract: Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.