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公开(公告)号:US07288544B2
公开(公告)日:2007-10-30
申请号:US10387543
申请日:2003-03-14
申请人: Seiji Ohno , Kayo Otani , Seiji Niwa , Satoshi Iwayama , Akira Takahara , Hajime Koganei , Yukitsugu Ono , Shinichi Fujita , Tomoko Takeda , Masako Hagihara , Akiko Okajima
发明人: Seiji Ohno , Kayo Otani , Seiji Niwa , Satoshi Iwayama , Akira Takahara , Hajime Koganei , Yukitsugu Ono , Shinichi Fujita , Tomoko Takeda , Masako Hagihara , Akiko Okajima
IPC分类号: C07D239/338 , C07D403/04 , A61K31/505
CPC分类号: C07D213/80 , A61K31/455 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/42 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
摘要: Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels
摘要翻译: 下列通式或其类似物的手性嘧啶衍生物和吡啶衍生物具有选择性的N型钙通道拮抗活性,口服时显示镇痛作用。 它们可用作与N型钙通道相关的疼痛和各种疾病的治疗剂