公开(公告)号：US12113177B2

公开(公告)日：2024-10-08

申请号：US18225960

申请日：2023-07-25

申请人： Electrochem Solutions Inc.

发明人： Yufei Wang ,  John S. Miller ,  John Hession ,  Arden P Johnson

IPC分类号： H01M10/0587 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K45/06 ,  C07D213/75 ,  C07D239/42 ,  C07D241/20 ,  C07D285/135 ,  C07D401/04 ,  C07D401/12 ,  C07D417/06 ,  C07D417/08 ,  C07D417/14 ,  H01M4/134 ,  H01M4/36 ,  H01M4/38 ,  H01M4/58 ,  H01M4/62 ,  H01M4/66 ,  H01M10/052 ,  H01M10/0568 ,  H01M10/0569 ,  H01M50/119 ,  H01M50/131 ,  H01M50/138 ,  H01M50/148 ,  H01M50/159 ,  H01M50/186 ,  H01M50/188 ,  H01M50/191 ,  H01M50/466

CPC分类号： H01M10/0587 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K45/06 ,  C07D213/75 ,  C07D239/42 ,  C07D241/20 ,  C07D285/135 ,  C07D401/04 ,  C07D401/12 ,  C07D417/06 ,  C07D417/08 ,  C07D417/14 ,  H01M4/134 ,  H01M4/368 ,  H01M4/382 ,  H01M4/582 ,  H01M4/623 ,  H01M4/625 ,  H01M4/662 ,  H01M10/052 ,  H01M10/0568 ,  H01M10/0569 ,  H01M50/119 ,  H01M50/138 ,  H01M50/1535 ,  H01M50/159 ,  H01M50/186 ,  H01M50/188 ,  H01M50/191 ,  H01M50/466 ,  H01M50/131 ,  H01M2300/0031 ,  Y02A50/30

摘要： A novel wound electrode assembly for a lithium oxyhalide electrochemical cell is described. The electrode assembly comprises an elongate cathode of an electrochemically non-active but electrically conductive carbonaceous material disposed between an inner elongate portion and an outer elongate portion of a unitary lithium anode. That way, lithium faces the entire length of the opposed major sides of the cathode. This inner anode portion/cathode/outer anode portion configuration is rolled into a wound-shaped electrode assembly that is housed inside a cylindrically-shaped casing. A cylindrically-shaped sheet-type spring centered in the electrode assembly presses outwardly to limit axial movement of the electrode assembly. In one embodiment, all the non-active components, except for the cathode current collector, which is nickel, are made of stainless-steel. This provides the cell with a low magnetic signature without adversely affecting the cell's high-rate capability.

公开(公告)号：US20240279191A1

公开(公告)日：2024-08-22

申请号：US18694815

申请日：2022-09-22

申请人： The General Hospital Corporation

发明人： Xu Wu ,  Lu Hu

IPC分类号： C07D295/192 ,  A61P35/00 ,  C07D211/22 ,  C07D213/30 ,  C07D213/75 ,  C07D239/42 ,  C07D249/06 ,  C07D295/26 ,  C07D305/08 ,  C07D309/06

CPC分类号： C07D295/192 ,  A61P35/00 ,  C07D211/22 ,  C07D213/30 ,  C07D213/75 ,  C07D239/42 ,  C07D249/06 ,  C07D295/26 ,  C07D305/08 ,  C07D309/06

摘要： The present disclosure relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, compositions comprising same, and methods of using the compounds and compositions to treat various cancers.

公开(公告)号：US20240254075A1

公开(公告)日：2024-08-01

申请号：US18558726

申请日：2022-05-06

申请人： Autobahn Therapeutics, Inc.

发明人： Brian Andrew STEARNS ,  Jill Melissa BACCEI ,  Jason Randall HARRIS

IPC分类号： C07C235/20 ,  A61K31/16 ,  A61K31/165 ,  A61K31/397 ,  A61K31/40 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/455 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5375 ,  A61P25/00 ,  C07C235/16 ,  C07C235/22 ,  C07C235/24 ,  C07C243/28 ,  C07C255/29 ,  C07C259/06 ,  C07C313/02 ,  C07C317/28 ,  C07D205/04 ,  C07D213/75 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D295/18 ,  C07D305/08

CPC分类号： C07C235/20 ,  A61K31/16 ,  A61K31/165 ,  A61K31/397 ,  A61K31/40 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/455 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5375 ,  A61P25/00 ,  C07C235/16 ,  C07C235/22 ,  C07C235/24 ,  C07C243/28 ,  C07C255/29 ,  C07C259/06 ,  C07C313/02 ,  C07C317/28 ,  C07D205/04 ,  C07D213/75 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D295/18 ,  C07D305/08 ,  C07C2601/02 ,  C07C2601/14

摘要： Provided herein are fatty acid amide (FAAH) cleavable prodrugs of thyromimetics and pharmaceutical compositions comprising these compounds with at least one pharmaceutically acceptable excipient further comprising a peripherally restricted FAAH inhibitor.

公开(公告)号：US12024509B2

公开(公告)日：2024-07-02

申请号：US16814328

申请日：2020-03-10

申请人： C4X Discovery Limited

发明人： Emma Louise Blaney ,  Barrie Phillip Martin ,  Thorsten Nowak ,  Martin John Watson

IPC分类号： C07D471/04 ,  A61K31/4192 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/47 ,  A61P3/04 ,  A61P19/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  A61P43/00 ,  C07C233/69 ,  C07C233/78 ,  C07C275/28 ,  C07C275/40 ,  C07D213/63 ,  C07D213/64 ,  C07D213/74 ,  C07D231/38 ,  C07D235/26 ,  C07D235/30 ,  C07D239/34 ,  C07D239/42 ,  C07D239/80 ,  C07D239/84 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D471/04 ,  C07C233/69 ,  C07C233/78 ,  C07C275/28 ,  C07C275/40 ,  C07D213/63 ,  C07D213/64 ,  C07D213/74 ,  C07D231/38 ,  C07D235/26 ,  C07D235/30 ,  C07D239/34 ,  C07D239/42 ,  C07D239/80 ,  C07D239/84 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

公开(公告)号：US20240166645A1

公开(公告)日：2024-05-23

申请号：US18264424

申请日：2022-02-08

申请人： Wuhan Humanwell Innovative Drug Research and Development Center Limited Company

发明人： Xuejun ZHANG ,  Shaohua CHANG ,  Xueqiang LI ,  Dabing YE ,  Hongqiang WANG ,  Hongna SUN ,  Jun YANG ,  Li'e LI

IPC分类号： C07D471/04 ,  A61K31/505 ,  A61K31/519 ,  A61P35/00 ,  C07D239/42

CPC分类号： C07D471/04 ,  A61K31/505 ,  A61K31/519 ,  A61P35/00 ,  C07D239/42

摘要： A pyridopyrimidinone derivative as represented by formula I, and a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt thereof or a prodrug thereof. The pyridopyrimidinone derivative has a good SOS1 inhibitory effect.

公开(公告)号：US11974571B1

公开(公告)日：2024-05-07

申请号：US18394977

申请日：2023-12-22

申请人： KING FAISAL UNIVERSITY

发明人： Hany Mohamed Abd El-Lateef Ahmed ,  Mai Mostafa Khalaf Ali ,  Antar Ahmed Abdelhamid Ahmed ,  Mohamed A. Gad

IPC分类号： A01N43/54 ,  A01P7/04 ,  C07D239/42

CPC分类号： A01N43/54 ,  A01P7/04 ,  C07D239/42

摘要： Synthesis of a compound 3,5-dinitro-N-(pyrimidin-2-ylcarbamothioyl)benzamide and its use as an insecticidal agent.

公开(公告)号：US11970482B2

公开(公告)日：2024-04-30

申请号：US16960681

申请日：2019-01-08

申请人： Ligand Pharmaceuticals Incorporated

发明人： Lin Zhi

IPC分类号： C07D405/14 ,  C07D239/42 ,  C07D405/06 ,  A61K31/397 ,  A61K45/06

CPC分类号： C07D405/14 ,  C07D239/42 ,  C07D405/06 ,  A61K31/397 ,  A61K45/06

摘要： Disclosed herein are acetal and cyclic acetal compounds, compositions, their preparation, and their uses. Some embodiments relate to their use as liver-targeting compounds.

公开(公告)号：US11969002B2

公开(公告)日：2024-04-30

申请号：US17284441

申请日：2019-10-09

申请人： LUCTA, S.A.

发明人： José Solá Parera ,  Montserrat Argelagués Feu ,  Thomas Hofmann ,  Oliver Frank ,  Laura Brehm

IPC分类号： A23L27/00 ,  A23K20/137 ,  A23L27/20 ,  C07D239/42 ,  C07D403/12 ,  C07D405/12

CPC分类号： A23L27/88 ,  A23K20/137 ,  A23L27/2054 ,  A23L27/2056 ,  C07D239/42 ,  C07D403/12 ,  C07D405/12 ,  A23V2002/00

摘要： The present invention relates to a compound of formula (I1); to a mixture comprising an amount from 86% to 99% by weight measured by quantitative proton-NMR of a compound of formula (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH) and (IJ); and an edible composition and an edible article comprising them. The invention also relates to processes for their preparation and their use as a savoury and mouthfulness taste enhancer; particularly kokumi and/or umami taste enhancer. Formulae (I′) (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ).

公开(公告)号：US20240124780A1

公开(公告)日：2024-04-18

申请号：US18267661

申请日：2021-12-13

申请人： MERCK PATENT GMBH

发明人： Amir Hossain PARHAM ,  Constanze BROCKE ,  Carsten FRITZSCH ,  Dagmar KLASS

IPC分类号： C09K19/34 ,  C07D213/72 ,  C07D213/73 ,  C07D239/42 ,  C07D405/10

CPC分类号： C09K19/3469 ,  C07D213/72 ,  C07D213/73 ,  C07D239/42 ,  C07D405/10 ,  C09K19/3444 ,  H01Q23/00

摘要： The present invention relates to heteroaromatic isothiocyanates of formula N




as defined in claim 1, to liquid-crystalline media comprising one or more compounds of formula N and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.

公开(公告)号：US11944099B2

公开(公告)日：2024-04-02

申请号：US17173229

申请日：2021-02-11

申请人： CORTEVA AGRISCIENCE LLC

发明人： Ronald J. Heemstra ,  Ronald Ross, Jr. ,  Timothy P. Martin ,  Nicolaas Vermeulen ,  John F. Daeuble, Sr. ,  Joseph D. Eckelbarger ,  Alex Nolan ,  Kaitlyn Gray ,  David A. Demeter ,  Ricky Hunter ,  Tony K. Trullinger

IPC分类号： A01N53/00 ,  C07C237/42 ,  C07C237/52 ,  C07C243/38 ,  C07C255/19 ,  C07C255/46 ,  C07C255/58 ,  C07C255/60 ,  C07C271/18 ,  C07C271/22 ,  C07C271/28 ,  C07C271/66 ,  C07C281/02 ,  C07C281/06 ,  C07C311/09 ,  C07C311/10 ,  C07C311/21 ,  C07C311/48 ,  C07C317/24 ,  C07C337/06 ,  C07C381/00 ,  C07D213/77 ,  C07D213/81 ,  C07D237/20 ,  C07D239/42 ,  C07D307/68 ,  C07D333/38

CPC分类号： A01N53/00 ,  C07C237/42 ,  C07C237/52 ,  C07C243/38 ,  C07C255/19 ,  C07C255/46 ,  C07C255/58 ,  C07C255/60 ,  C07C271/18 ,  C07C271/22 ,  C07C271/28 ,  C07C271/66 ,  C07C281/02 ,  C07C281/06 ,  C07C311/09 ,  C07C311/10 ,  C07C311/21 ,  C07C311/48 ,  C07C317/24 ,  C07C337/06 ,  C07C381/00 ,  C07D213/77 ,  C07D213/81 ,  C07D237/20 ,  C07D239/42 ,  C07D307/68 ,  C07D333/38 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/16

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).