公开(公告)号：US12127560B2

公开(公告)日：2024-10-29

申请号：US17645666

申请日：2021-12-22

Applicant: Adama Makhteshim Ltd.

Inventor： W. John Owen ,  Chenglin Yao ,  Beth Lorsbach

IPC: A61K31/513 ,  A01N37/34 ,  A01N37/50 ,  A01N43/40 ,  A01N43/54 ,  A01N43/56 ,  A01N43/653 ,  A01N43/88 ,  A01N45/02 ,  A01N47/04 ,  A01N47/08 ,  A01N47/14 ,  A01N47/24 ,  C07D239/47

CPC classification number: A01N43/54 ,  A01N37/34 ,  A01N37/50 ,  A01N43/40 ,  A01N43/56 ,  A01N43/653 ,  A01N43/88 ,  A01N45/02 ,  A01N47/04 ,  A01N47/08 ,  A01N47/14 ,  A01N47/24 ,  A01N43/54 ,  A01N37/34 ,  A01N37/50 ,  A01N43/40 ,  A01N43/54 ,  A01N43/56 ,  A01N43/653 ,  A01N43/88 ,  A01N45/02 ,  A01N47/14 ,  A01N43/54 ,  A01N37/34 ,  A01N37/50 ,  A01N43/40 ,  A01N43/54 ,  A01N43/88 ,  A01N47/04 ,  A01N47/14 ,  A01N47/24

Abstract: A fungicidal composition containing a fungicidally effective amount of the compound of Formula I:




5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1H)-one, and at least one fungicide to provide synergistic control of selected fungi, wherein the at least one fungicide is a succinate dehydrogenase-inhibitor.

公开(公告)号：US11773067B2

公开(公告)日：2023-10-03

申请号：US17872185

申请日：2022-07-25

Applicant: Eli Lilly and Company

Inventor： Daryl Lynn Smith ,  Leonard Larry Winneroski, Jr.

IPC: C07D239/47 ,  A61K31/505

CPC classification number: C07D239/47 ,  A61K31/505

Abstract: The present invention provides a compound of Formula I:






wherein R1 is hydrogen or methyl; and
R2 is:








or a pharmaceutically acceptable salt thereof, useful for treating pain, including chronic pain, chronic lower back pain, diabetic peripheral neuropathic pain, and osteoarthritis pain.

公开(公告)号：US20230150946A1

公开(公告)日：2023-05-18

申请号：US17909162

申请日：2021-03-05

Applicant: JANPIX LIMITED

Inventor： Roman FLECK ,  John PROUDFOOT ,  Krishna Kumar GNANASEKARAN ,  Patrick Thomas GUNNING ,  Alford Antoine JOHN ,  Angel Sampedro PALERM ,  Alla DARWISH ,  Dziyana KRASKOUSKAYA

IPC: C07D239/47

CPC classification number: C07D239/47

Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer and pancreatic cancer.

公开(公告)号：US20220380378A1

公开(公告)日：2022-12-01

申请号：US17727054

申请日：2022-04-22

Applicant: ESSA Pharma, Inc.

Inventor： Han-Jie ZHOU ,  Peter Virsik ,  Berenger Biannic

IPC: C07D487/10 ,  C07D239/47 ,  C07D403/12 ,  C07D405/12 ,  C07D239/42 ,  C07D403/04 ,  C07D471/04 ,  C07D413/12 ,  C07D405/14 ,  C07D471/10

Abstract: The present invention relates to compounds of formula (A), (A-I), (A-II), (A-III), (B), (B-I), (C), (D), (E), (E-I), (F), (G), (H), (J), and (K), or any subgenera thereof, or a pharmaceutically acceptable salt, tautomer or stereoisomer. The compounds of the present disclosure are useful in modulating androgen receptor activity and for treating cancer, including prostate cancer.

公开(公告)号：US20220380344A1

公开(公告)日：2022-12-01

申请号：US17873966

申请日：2022-07-26

Applicant: YUHAN CORPORATION

Inventor： Ja-Heouk KHOO ,  Doo-Byung LEE ,  Jun-Sup LEE ,  Hyun JU ,  Woo-Seob SHIN

IPC: C07D403/04 ,  C07D239/47

Abstract: The present invention provides a novel process for preparing a diaminopyrimidine derivative or acid addition salt thereof having an activity as a 5-HT4 receptor agonist. And also, the present invention provides novel crystalline forms of a hydrochloride of the diaminopyrimidine derivative and processes for preparing the same.

公开(公告)号：US20220354949A1

公开(公告)日：2022-11-10

申请号：US17270665

申请日：2019-08-23

Applicant: XENIOPRO GmbH

Inventor： Viktoria REINMÜLLER ,  Roman MARTY ,  Olivier WAGNIÈRES ,  Jean-Baptiste GUALTIEROTTI ,  Verena KÜPPERS

IPC: A61K39/39 ,  C07C311/51 ,  C07D213/89 ,  C07C261/04 ,  C07C259/10 ,  C07C325/02 ,  C07D405/04 ,  C07C217/58 ,  C07C239/12 ,  C07C255/43 ,  C07D309/06 ,  C07D211/22 ,  C07D295/092 ,  C07D453/02 ,  C07D205/04 ,  C07D491/107 ,  C07D401/12 ,  C07D405/12 ,  C07D519/00 ,  C07D407/12 ,  C07D331/04 ,  C07D409/12 ,  C07D211/28 ,  C07D305/04 ,  C07C69/78 ,  C07C47/198 ,  C07D213/80 ,  C07D213/643 ,  C07D237/04 ,  C07D239/47 ,  C07D239/52

Abstract: The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the haematopoietic system including the haematologic system in human and veterinary medicine.

公开(公告)号：US20220324845A1

公开(公告)日：2022-10-13

申请号：US17702600

申请日：2022-03-23

Applicant: Halia Therapeutics, Inc.

Inventor： David James Bearss ,  John Sai Keong Kauwe, III ,  Alexis Henri Abel Mollard

IPC: C07D403/14 ,  C07D403/12 ,  C07D239/47 ,  C07D401/14 ,  C07D413/14 ,  C07D413/12 ,  C07D405/14 ,  C07D498/08 ,  C07D491/107

Abstract: Compounds having activity as inhibitors of LRRK2 kinase are provided. The compounds have Structure (I): or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein A, B, R1a, R1b, R2 and L are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of LRRK2 kinase are also provided.

公开(公告)号：US20220272976A1

公开(公告)日：2022-09-01

申请号：US17614086

申请日：2020-05-27

Applicant: SYNGENTA CROP PROTECTION AG

Inventor： Stefano RENDINE ,  Mattia Riccardo MONACO ,  Daniel STIERLI ,  David BURNS ,  Mathias BLUM ,  Andrew EDMUNDS ,  Farhan BOU HAMDAN

IPC: A01N43/40 ,  C07D213/81 ,  C07D417/12 ,  C07D239/47 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04 ,  C07D413/12 ,  C07D409/12 ,  C07D401/14 ,  A01N43/78 ,  A01N43/54 ,  A01N43/80 ,  A01N43/50 ,  A01N43/76 ,  A01N43/647 ,  A01P3/00 ,  A01N43/90

Abstract: Compounds of the formula (I), wherein the substituents are as defined in claim 1, useful as pesticides, and especially fungicides.

公开(公告)号：US11351168B1

公开(公告)日：2022-06-07

申请号：US16825285

申请日：2020-03-20

Applicant: Celgene CAR LLC

Inventor： Juswinder Singh ,  Russell C. Petter ,  Richland Wayne Tester ,  Arthur F. Kluge ,  Hormoz Mazdiyasni ,  William Frederick Westlin, III ,  Deqiang Niu ,  Lixin Qiao

IPC: C07D239/30 ,  A61K31/505 ,  C07D495/04 ,  C07D239/48 ,  C07D401/14 ,  C07D403/12 ,  C07D407/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/18 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K45/06 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D487/08 ,  C07D239/47

Abstract: The present invention provides 2,4-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.

公开(公告)号：US11339145B2

公开(公告)日：2022-05-24

申请号：US17076356

申请日：2020-10-21

Applicant: Alexion Pharmaceuticals, Inc.

Inventor： Anjali Pandey ,  Arvinder Sran ,  Ying Chen ,  Daniele Poggiali ,  Tiziano Fumagalli

IPC: C07D239/42 ,  C07D403/12 ,  C07D239/47 ,  C07D239/48

Abstract: The present disclosure provides processes for the preparation of cerdulatinib, which is of formula I: or a salt thereof. The disclosure also provides intermediates and processes for the preparation of the intermediates useful in the preparation of cerdulatinib or a salt thereof.