公开(公告)号：US20240306490A1

公开(公告)日：2024-09-12

申请号：US18645413

申请日：2024-04-25

Applicant: IDEMITSU KOSAN CO.,LTD.

Inventor： Ryota TAKAHASHI ,  Tomoki KATO ,  Hirokatsu ITO ,  Masahiro KAWAMURA ,  Masakazu FUNAHASHI ,  Hiroyuki SAITO ,  Yuichiro KAWAMURA ,  Yoshiaki TAKAHASHI ,  Tetsuya MASUDA ,  Hitoshi KUMA

IPC: H10K85/60 ,  C07C211/61 ,  C07D209/86 ,  C07D213/16 ,  C07D213/22 ,  C07D231/56 ,  C07D235/18 ,  C07D237/08 ,  C07D239/26 ,  C07D239/74 ,  C07D241/12 ,  C07D251/24 ,  C07D307/92 ,  C07D333/74 ,  C07D333/76 ,  C07D471/04 ,  C09K11/06 ,  H10K50/11 ,  H10K50/15 ,  H10K50/16 ,  H10K50/165 ,  H10K50/18 ,  H10K71/00 ,  H10K71/16 ,  H10K101/00 ,  H10K101/10 ,  H10K102/00

CPC classification number: H10K85/624 ,  C07C211/61 ,  C07D209/86 ,  C07D213/16 ,  C07D213/22 ,  C07D231/56 ,  C07D235/18 ,  C07D237/08 ,  C07D239/26 ,  C07D239/74 ,  C07D241/12 ,  C07D251/24 ,  C07D307/92 ,  C07D333/74 ,  C07D333/76 ,  C07D471/04 ,  C09K11/06 ,  H10K85/623 ,  H10K85/633 ,  H10K85/654 ,  C07C2603/18 ,  C07C2603/52 ,  C07C2603/94 ,  C07C2603/97 ,  C09K2211/1018 ,  H10K50/11 ,  H10K50/15 ,  H10K50/156 ,  H10K50/165 ,  H10K50/166 ,  H10K50/18 ,  H10K71/00 ,  H10K71/164 ,  H10K2101/10 ,  H10K2101/27 ,  H10K2102/351

Abstract: Compounds of formulae (2-7) or (2-9) are provided:




Also provided are organic electroluminescence (EL) devices containing the compounds having a high emission efficiency when operated at low voltage and a long lifetime and electronic devices including such organic EL devices.

公开(公告)号：US20240254079A1

公开(公告)日：2024-08-01

申请号：US18239892

申请日：2023-08-30

Applicant: ARCUS BIOSCIENCES, INC.

Inventor： Joel Worley BEATTY ,  Samuel Lawrie DREW ,  Matthew EPPLIN ,  Jeremy Thomas Andre FOURNIER ,  Balint GAL ,  Tezcan GUNEY ,  Karl T. HAELSIG ,  Clayton HARDMAN ,  Steven Donald JACOB ,  Jenna Leigh JEFFREY ,  Jaroslaw KALISIAK ,  Kenneth Victor LAWSON ,  Manmohan Reddy LELETI ,  Erick Allen LINDSEY ,  Artur Karenovich MAILYAN ,  Debashis MANDAL ,  Guillaume MATA ,  Hyunyoung MOON ,  Jay Patrick POWERS ,  Brandon Reid ROSEN ,  Yongli SU ,  Anh Thu TRAN ,  Zhang WANG ,  Xuelei YAN ,  Kai YU

IPC: C07C317/32 ,  A61K31/10 ,  A61K31/277 ,  A61K31/343 ,  A61K31/353 ,  A61K31/365 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4174 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/505 ,  A61K31/519 ,  A61K31/538 ,  A61K39/395 ,  A61K45/06 ,  C07C255/53 ,  C07C317/22 ,  C07C317/36 ,  C07D209/34 ,  C07D211/86 ,  C07D213/57 ,  C07D213/71 ,  C07D213/73 ,  C07D213/74 ,  C07D213/84 ,  C07D215/48 ,  C07D217/04 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D237/20 ,  C07D239/42 ,  C07D241/12 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D263/57 ,  C07D265/36 ,  C07D277/30 ,  C07D277/56 ,  C07D277/64 ,  C07D307/83 ,  C07D311/22 ,  C07D333/64 ,  C07D401/04 ,  C07D401/10 ,  C07D409/10 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07C317/32 ,  A61K31/10 ,  A61K31/277 ,  A61K31/343 ,  A61K31/353 ,  A61K31/365 ,  A61K31/381 ,  A61K31/404 ,  A61K31/415 ,  A61K31/416 ,  A61K31/4174 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/5025 ,  A61K31/505 ,  A61K31/519 ,  A61K31/538 ,  A61K39/3955 ,  A61K45/06 ,  C07C255/53 ,  C07C317/22 ,  C07C317/36 ,  C07D209/34 ,  C07D211/86 ,  C07D213/57 ,  C07D213/71 ,  C07D213/73 ,  C07D213/74 ,  C07D213/84 ,  C07D215/48 ,  C07D217/04 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D237/20 ,  C07D239/42 ,  C07D241/12 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D263/57 ,  C07D265/36 ,  C07D277/30 ,  C07D277/56 ,  C07D277/64 ,  C07D307/83 ,  C07D311/22 ,  C07D333/64 ,  C07D401/04 ,  C07D401/10 ,  C07D409/10 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04 ,  C07C2602/08 ,  C07C2602/10

Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.

公开(公告)号：US20240140905A1

公开(公告)日：2024-05-02

申请号：US18342397

申请日：2023-06-27

Applicant: YMT CO., LTD.

Inventor： Dea Geun KIM ,  Sung Wook CHUN ,  Bo Mook CHUNG ,  Nak Eun KO

IPC: C25D3/38 ,  C07D233/64 ,  C07D241/12

CPC classification number: C25D3/38 ,  C07D233/64 ,  C07D241/12

Abstract: The present invention relates to a leveler capable of efficiently filling the inside of via holes formed during the manufacturing process of a printed circuit board, and an electroplating composition comprising the same. When via holes on a substrate are filled with the electroplating composition according to the present invention, the via holes can be filled in a relatively short time while minimizing the formation of dimples or voids.

公开(公告)号：US20240138255A1

公开(公告)日：2024-04-25

申请号：US18265294

申请日：2022-02-28

Applicant: LG CHEM, LTD.

Inventor： Dong Uk HEO ,  Heekyung YUN ,  Miyeon HAN ,  Jae Tak LEE ,  Jung Min YOON ,  Hoyoon PARK ,  Sung Kil HONG

IPC: H10K85/60 ,  C07D237/08 ,  C07D239/26 ,  C07D239/74 ,  C07D241/12 ,  C07D251/24 ,  C07D257/08 ,  C09K11/06

CPC classification number: H10K85/654 ,  C07D237/08 ,  C07D239/26 ,  C07D239/74 ,  C07D241/12 ,  C07D251/24 ,  C07D257/08 ,  C09K11/06 ,  H10K85/626 ,  H10K50/16

Abstract: Provided is a compound of Chemical Formula 1 or 2:






wherein: R1 to R4 are each independently hydrogen or deuterium; n1 to n4 are an integer of 1 to 4; L1 and L2 are each independently a direct bond or a substituted or unsubstituted C6-60 arylene; and Ar1 and Ar2 are each independently a substituent of Chemical Formula 3:










wherein X1 to X5 are each independently N or C(R5), wherein at least two of X1 to X5 are N; and each R5 is independently hydrogen, deuterium, a substituted or unsubstituted C1-20 alkyl, a substituted or unsubstituted C6-60 aryl, or a substituted or unsubstituted C2-60 heteroaryl containing at least one of N, O and S, or two adjacent R5s combine to form a benzene ring; and an organic light emitting device including the same. The device exhibits significantly superior efficiency and lifespan.

公开(公告)号：US20230399302A1

公开(公告)日：2023-12-14

申请号：US18034439

申请日：2021-10-29

Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

Inventor： Justin M. Lopchuk ,  Zachary P. SHULTZ ,  Thomas SCATTOLIN

IPC: C07D239/38 ,  C07D405/04 ,  C07D403/04 ,  C07D405/12 ,  C07D401/12 ,  C07D417/06 ,  C07D409/04 ,  C07D411/04 ,  C07D417/04 ,  C07D239/30 ,  C07D239/42 ,  C07D471/04 ,  C07D241/12 ,  C07D213/34 ,  C07D213/803 ,  C07D213/80 ,  C07D213/61 ,  C07D215/12 ,  C07D487/04 ,  C07D473/00 ,  C07D495/04 ,  C07D277/64

CPC classification number: C07D239/38 ,  C07D405/04 ,  C07D403/04 ,  C07D405/12 ,  C07D401/12 ,  C07D417/06 ,  C07D409/04 ,  C07D411/04 ,  C07D417/04 ,  C07D239/30 ,  C07D239/42 ,  C07D471/04 ,  C07D241/12 ,  C07D213/34 ,  C07D213/803 ,  C07D213/80 ,  C07D213/61 ,  C07D215/12 ,  C07D487/04 ,  C07D473/00 ,  C07D495/04 ,  C07D277/64

Abstract: The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.

公开(公告)号：US11834416B2

公开(公告)日：2023-12-05

申请号：US16698332

申请日：2019-11-27

Applicant: Board of Trustees of Southern Illinois University ,  Vanderbilt University

Inventor： Boyd M. Goodson ,  Eduard Y. Chekmenev ,  Bryce E. Kidd ,  Jamil A. Mashni ,  Miranda Limbach ,  Yuqing Hou ,  Fan Shi

IPC: C07D233/60 ,  G01R33/28 ,  C07D401/06 ,  C07D241/12 ,  C07D213/63 ,  C07F9/6506 ,  B01J31/12 ,  C07D213/46 ,  G01R33/46

CPC classification number: C07D233/60 ,  B01J31/12 ,  C07D213/46 ,  C07D213/63 ,  C07D241/12 ,  C07D401/06 ,  C07F9/6506 ,  G01R33/282 ,  B01J2531/827 ,  G01R33/46

Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.

公开(公告)号：US11793821B2

公开(公告)日：2023-10-24

申请号：US17193550

申请日：2021-03-05

Applicant: Merck Sharp & Dohme LLC

Inventor： Brendan M. Crowley ,  Ian M. Bell ,  Andrew John Harvey

IPC: A61K31/695 ,  A61K31/198 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/34 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12 ,  C07D249/08 ,  C07D271/06 ,  C07D401/04 ,  C07D413/04 ,  C07F7/08

CPC classification number: A61K31/695 ,  A61K31/198 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/34 ,  C07D233/64 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12 ,  C07D249/08 ,  C07D271/06 ,  C07D401/04 ,  C07D413/04 ,  C07F7/0812

Abstract: The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation

公开(公告)号：US11739073B2

公开(公告)日：2023-08-29

申请号：US17259483

申请日：2019-07-09

Applicant: ABIVAX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE MONTPELLIER ,  INSTITUT CURIE

Inventor： Didier Scherrer ,  Jamal Tazi ,  Florence Mahuteau-Betzer ,  Romain Najman ,  Julien Santo ,  Cécile Apolit

IPC: C07D401/12 ,  C07C237/40 ,  C07C255/50 ,  C07C311/16 ,  C07D205/04 ,  C07D213/74 ,  C07D213/81 ,  C07D405/12 ,  C07D413/12 ,  C07F7/18 ,  A61P31/12 ,  C07C233/65 ,  C07D213/38 ,  C07D213/75 ,  C07D239/42 ,  C07D241/12 ,  C07D239/16 ,  C07D239/22 ,  C07D403/12

CPC classification number: C07D401/12 ,  A61P31/12 ,  C07C233/65 ,  C07C237/40 ,  C07C255/50 ,  C07C311/16 ,  C07D205/04 ,  C07D213/38 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D239/16 ,  C07D239/22 ,  C07D239/42 ,  C07D241/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07F7/1804

Abstract: A compound:




wherein X1 represents an alkenylene group, a —NH—CO— group, a —CO—NH— group, Y1 represents an aryl group selected from pyridyl, pyrazinyl or pyrimidinyl, X2 represents —O—, —CO—NH—, —NH—CO—NH—, —OCH2—, —NH—CO—, a divalent 5-membered heteroaromatic ring comprising 1 to 4 heteroatoms or —SO2—NH—, and Y2 represents a hydrogen atom, a hydroxyl group, a morpholinyl group, a piperidinyl group, optionally substituted by a (C1-C4)alkyl group, a piperazinyl group, optionally substituted by a (C1-C4)alkyl group, or —CR1R2R3 or alternatively X2—Y2 represents —CONRcRd, wherein Rc and Rd form, together with the nitrogen atom a heterocyclic ring, optionally substituted by one or two (C1-C4)alkyl group, by a cyclopentyl group thus forming a spirocyclopentyl, or by a trifluoromethyl group, or any of its pharmaceutically acceptable salt, for use in the treatment and/or prevention of a RNA virus infection caused by a RNA virus belonging to group IV or V of the Baltimore classification.

公开(公告)号：US20230024283A1

公开(公告)日：2023-01-26

申请号：US17790080

申请日：2020-12-24

Applicant: SYNGENTA CROP PROTECTION AG

Inventor： James Alan MORRIS ,  Katharine Mary INGRAM ,  Suzanna Jane DALE ,  David BURNS

IPC: C07D231/12 ,  C07D213/84 ,  C07C255/55 ,  C07D277/587 ,  C07C255/53 ,  C07D271/06 ,  C07D239/26 ,  C07D213/64 ,  C07D213/57 ,  C07C323/31 ,  C07D491/056 ,  C07D317/60 ,  C07C317/14 ,  C07D213/71 ,  C07D333/24 ,  C07D213/69 ,  C07D333/28 ,  C07D249/08 ,  C07D275/02 ,  C07D263/32 ,  C07D241/12 ,  C07D237/08 ,  C07D285/08 ,  C07D307/54 ,  C07D249/06 ,  A01P13/00 ,  A01N43/56 ,  A01N43/40 ,  A01N37/34 ,  A01N43/78 ,  A01N43/82 ,  A01N43/54 ,  A01N43/90 ,  A01N43/30 ,  A01N37/52 ,  A01N43/10 ,  A01N43/653 ,  A01N43/76 ,  A01N43/80 ,  A01N43/60 ,  A01N43/58 ,  A01N43/647 ,  A01N43/08

Abstract: The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.

公开(公告)号：US11552251B2

公开(公告)日：2023-01-10

申请号：US16077966

申请日：2017-02-13

Applicant: IDEMITSU KOSAN CO., LTD.

Inventor： Ryota Takahashi ,  Tomoki Kato ,  Hirokatsu Ito ,  Masahiro Kawamura ,  Masakazu Funahashi ,  Hiroyuki Saito ,  Yuichiro Kawamura ,  Yoshiaki Takahashi ,  Tetsuya Masuda ,  Hitoshi Kuma

IPC: H01L51/50 ,  H01L51/00 ,  C07C211/61 ,  C07D251/24 ,  C09K11/06 ,  C07D239/26 ,  C07D239/74 ,  C07D213/16 ,  C07D241/12 ,  C07D333/76 ,  C07D307/92 ,  C07D231/56 ,  C07D333/74 ,  C07D213/22 ,  C07D237/08 ,  C07D209/86 ,  C07D471/04 ,  C07D235/18 ,  H01L51/56

Abstract: The compound represented by formula (1): wherein A, B, R1, and R2 are as defined in the description, provides organic electroluminescence (EL) devices having a high emission efficiency when operated at low voltage and a long lifetime and electronic devices including such organic EL devices.