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公开(公告)号:US5719290A
公开(公告)日:1998-02-17
申请号:US744348
申请日:1996-11-04
申请人: Sean T. Nugent , Richard A. Mueller
发明人: Sean T. Nugent , Richard A. Mueller
IPC分类号: C07C45/00 , C07C49/175 , C07C235/06 , C07C235/12 , C07C237/22 , C07C255/16 , C07C271/22 , C07D209/20 , C07D233/64 , C07D257/04 , C07D255/03
CPC分类号: C07D257/04 , C07C235/06 , C07C235/12 , C07C237/22 , C07C255/16 , C07C271/22 , C07C45/004 , C07C49/175 , C07D209/20
摘要: Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitriles thereof. These compounds are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, and as anti-viral and anti-fungal agents or pro-drugs of such agents. Illustrative of the disclosed compounds are fatty acid amino acid analogs of the structure ##STR1## in which X is the ethyl or t-butyl ester of an amino acid such as Gly, L-Ala, L-Ile, L-Phe, L-Try, L-Thr, or an amide such as NHCH.sub.2 C.sub.6 H.sub.5 or NH(CH.sub.2).sub.2 C.sub.6 H.sub.5.
摘要翻译: 公开了脂肪酸部分中具有1至3个可以是氧,硫或氮的杂原子的脂肪酸类似物的新型衍生物,其中羧基末端已被修饰以形成各种酰胺,酯,酮,醇,醇 酯和腈。 这些化合物可用作N-肉豆蔻酰转移酶(NMT)和/或其酰基辅酶的底物,以及作为这种药剂的抗病毒和抗真菌剂或前药。 所公开的化合物的实例是其结构为“IMAGE”的脂肪酸氨基酸类似物,其中X是氨基酸的乙基或叔丁基酯,例如Gly,L-Ala,L-Ile,L-Phe, 尝试,L-Thr或酰胺如NHCH2C6H5或NH(CH2)2C6H5。
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公开(公告)号:US07279478B2
公开(公告)日:2007-10-09
申请号:US10525264
申请日:2003-09-03
申请人: Michael Boyd , Marc Gagnon , Cheuk Lau , Christophe Mellon , John Scheigetz
发明人: Michael Boyd , Marc Gagnon , Cheuk Lau , Christophe Mellon , John Scheigetz
IPC分类号: A61K31/5375 , A61K31/4965 , A61K31/505 , A61K31/47 , A61K31/44 , A61K31/41 , A61K31/4164 , A61K31/277 , C07D265/30 , C07D239/26 , C07D241/12 , C07D215/04 , C07D213/06 , C07D255/03
CPC分类号: C07C255/29 , C07C255/25 , C07C255/54 , C07C259/10 , C07C311/29 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/19 , C07C323/22 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07D211/22 , C07D211/94 , C07D213/30 , C07D213/61 , C07D213/79 , C07D213/89 , C07D215/14 , C07D215/60 , C07D233/22 , C07D239/26 , C07D241/16 , C07D277/24 , C07D295/088 , C07D295/192 , C07D295/205 , C07D295/26 , C07D333/16 , C07D401/04
摘要: This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. They have the following structure: Formula (I)
摘要翻译: 本发明涉及半胱氨酸蛋白酶抑制剂的类别,包括但不限于组织蛋白酶K,L,S和B的抑制剂。这些化合物可用于治疗其中表示骨吸收抑制的疾病,例如骨质疏松症。 它们具有以下结构:式(I)
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公开(公告)号:US07973037B2
公开(公告)日:2011-07-05
申请号:US12082104
申请日:2008-04-08
申请人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号: A61K31/535 , A61K31/497 , A61K31/435 , A61K31/385 , C07D265/30 , C07D241/04 , C07D211/08 , C07D333/02 , C07D255/03
CPC分类号: C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译: 本发明涉及一类新的化合物,它们是半胱氨酸蛋白酶抑制剂,包括但不限于组织蛋白酶K,L,S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病,例如 骨质疏松症
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公开(公告)号:US07109238B2
公开(公告)日:2006-09-19
申请号:US10761986
申请日:2004-01-21
申请人: Maria Amparo Lago , James Francis Callahan , Pradip Kumar Bhatnagar , Eric G. Del Mar , William M. Bryan , Joelle L. Burgess
发明人: Maria Amparo Lago , James Francis Callahan , Pradip Kumar Bhatnagar , Eric G. Del Mar , William M. Bryan , Joelle L. Burgess
IPC分类号: A61K31/335 , A61K31/195 , C07C303/08 , C07C63/04 , C07D255/03
CPC分类号: C07D303/22 , C07C33/34 , C07C69/616 , C07C69/738 , C07C211/26 , C07C211/30 , C07C229/36 , C07C233/05 , C07C251/48 , C07C255/57 , C07C255/58 , C07C2602/08
摘要: Novel calcilytic compounds and methods of using them are provided.
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