公开(公告)号：US20240327334A1

公开(公告)日：2024-10-03

申请号：US18390287

申请日：2023-12-20

申请人： Enanta Pharmaceuticals, Inc.

发明人： Xuri GAO ,  Bin WANG ,  Hui CAO ,  Jiajun ZHANG ,  Yuk Ming SIU ,  Jiang LONG ,  Wei LI ,  Matthew C. RHODES ,  Xuechao XING ,  Jianming YU ,  Scott MITCHELL ,  Yat Sun OR

IPC分类号： C07C233/56 ,  A61K31/166 ,  A61K31/277 ,  A61K31/337 ,  A61K31/365 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/416 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/506 ,  A61K31/535 ,  A61K31/662 ,  A61P31/14 ,  C07C243/30 ,  C07C255/46 ,  C07C255/66 ,  C07D205/04 ,  C07D207/16 ,  C07D209/52 ,  C07D209/56 ,  C07D213/40 ,  C07D215/12 ,  C07D231/08 ,  C07D231/12 ,  C07D231/56 ,  C07D239/26 ,  C07D241/12 ,  C07D249/06 ,  C07D263/32 ,  C07D263/34 ,  C07D265/02 ,  C07D277/28 ,  C07D295/185 ,  C07D305/08 ,  C07D307/58 ,  C07D333/20 ,  C07D333/24 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07F9/40

CPC分类号： C07C233/56 ,  A61K31/166 ,  A61K31/277 ,  A61K31/337 ,  A61K31/365 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/416 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/506 ,  A61K31/535 ,  A61K31/662 ,  A61P31/14 ,  C07C243/30 ,  C07C255/46 ,  C07C255/66 ,  C07D205/04 ,  C07D207/16 ,  C07D209/52 ,  C07D209/56 ,  C07D213/40 ,  C07D215/12 ,  C07D231/08 ,  C07D231/12 ,  C07D231/56 ,  C07D239/26 ,  C07D241/12 ,  C07D249/06 ,  C07D263/32 ,  C07D263/34 ,  C07D265/02 ,  C07D277/28 ,  C07D295/185 ,  C07D305/08 ,  C07D307/58 ,  C07D333/20 ,  C07D333/24 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07F9/4015

摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof:




which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US12075785B2

公开(公告)日：2024-09-03

申请号：US17834252

申请日：2022-06-07

申请人： Pro Farm Group, Inc.

发明人： Ratnakar N. Asolkar ,  Marja Koivunen ,  Pamela G. Marrone ,  Ana Lucia Cordova-Kreylos ,  Huazhang Huang

IPC分类号： A01N43/16 ,  A01N43/76 ,  A01N43/86 ,  A01N43/90 ,  A01N57/20 ,  A01N63/20 ,  C07D263/32 ,  C07D263/34 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12N1/20 ,  C12P17/04 ,  C12P17/06 ,  C12P17/14 ,  C12P17/16 ,  C12P17/18 ,  A01N43/00 ,  C12N1/00 ,  C12R1/00 ,  C12R1/01

CPC分类号： A01N63/20 ,  A01N43/16 ,  A01N43/76 ,  A01N43/86 ,  A01N43/90 ,  A01N57/20 ,  C07D263/32 ,  C07D263/34 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12N1/20 ,  C12N1/205 ,  C12P17/04 ,  C12P17/06 ,  C12P17/14 ,  C12P17/16 ,  C12P17/18 ,  A01N43/00 ,  C12N1/00 ,  C12R2001/00 ,  C12R2001/01 ,  A01N63/20 ,  A01N43/16 ,  A01N43/74 ,  A01N43/76 ,  A01N43/90

摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.

公开(公告)号：US20230357221A1

公开(公告)日：2023-11-09

申请号：US18343319

申请日：2023-06-28

申请人： UNIVERSITÉ DE MONTRÉAL

发明人： Yves GAREAU ,  Stéphane GINGRAS ,  Yves CHANTIGNY ,  Gaoqiang YANG ,  Guy SAUVAGEAU ,  Irène BACCELLI ,  Anne MARINIER

IPC分类号： C07D417/12 ,  C07D249/04 ,  C07D263/32 ,  C07D263/34 ,  C07D277/24 ,  C07D413/12 ,  G01N33/50

CPC分类号： C07D417/12 ,  C07D249/04 ,  C07D263/32 ,  C07D263/34 ,  C07D277/24 ,  C07D413/12 ,  G01N33/5011

摘要： Heterocyclic compounds of Formula I:




and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly cancers sensitive to mitochondrial activity inhibition and increased reactive oxygen species (ROS) levels, is also disclosed. Such cancers include acute myeloid leukemia (AML), preferably AML characterized by certain features, such as high level of expression of one or more Homeobox (HOX)-network genes, high and/or low expression of specific genes, the presence of one or more cytogenetic or molecular risk factors such as intermediate cytogenetic risk, Normal Karyotype (NK), mutated NPM1, mutated CEBPA, mutated FLT3, mutated DNMT3A, mutated TET2, mutated IDH1, mutated IDH2, mutated RUNX1, mutated WT1, mutated SRSF2, intermediate cytogenetic risk with abnormal karyotype (intern(abnK)), trisomy 8 (+8) and/or abnormal chromosome (5/7), and/or a high leukemic stem cell (LSC) frequency.

公开(公告)号：US11760754B2

公开(公告)日：2023-09-19

申请号：US16761210

申请日：2018-11-02

申请人： UNIVERSITÉ DE MONTRÉAL

发明人： Yves Gareau ,  Stéphane Gingras ,  Yves Chantigny ,  Gaoqiang Yang ,  Guy Sauvageau ,  Irène Baccelli ,  Anne Marinier

IPC分类号： C07D413/12 ,  C07D263/32 ,  C07D263/34 ,  C07D417/12 ,  A61K31/421 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61P35/02 ,  C07D249/04 ,  C07D277/24 ,  G01N33/50

CPC分类号： C07D417/12 ,  C07D249/04 ,  C07D263/32 ,  C07D263/34 ,  C07D277/24 ,  C07D413/12 ,  G01N33/5011

摘要： Heterocyclic compounds of Formula (I) and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly cancers sensitive to mitochondrial activity inhibition and increased reactive oxygen species (ROS) levels, is also disclosed. Such cancers include acute myeloid leukemia (AML), preferably AML characterized by certain features, such as high level of expression of one or more Homeobox (HOX)-network genes, high and/or low expression of specific genes, the presence of one or more cytogenetic or molecular risk factors such as intermediate cytogenetic risk, Normal Karyotype (A/K), mutated NPM1, mutated CEBPA, mutated FLT3, mutated DNMT3A, mutated TET2, mutated IDH1, mutated IDH2, mutated RUNX1, mutated WT1, mutated SRSF2, intermediate cytogenetic risk with abnormal karyotype (intern(abnK)), trisomy 8 (+8) and/or abnormal chromosome (5/7), and/or a high leukemic stem cell (LSC) frequency.

公开(公告)号：US11760742B2

公开(公告)日：2023-09-19

申请号：US17208474

申请日：2021-03-22

申请人： MITSUI CHEMICALS, INC.

发明人： Kei Yoshida ,  Takeo Wakita ,  Hiroyuki Katsuta ,  Akiyoshi Kai ,  Yutaka Chiba ,  Kiyoshi Takahashi ,  Hiroko Kato ,  Nobuyuki Kawahara ,  Michikazu Nomura ,  Hidenori Daido ,  Junji Maki ,  Shinichi Banba

IPC分类号： C07C237/42 ,  C07D333/38 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/78 ,  A01N43/80 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/30 ,  C07D241/24 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D309/08 ,  C07D309/28 ,  C07D317/62 ,  C07D333/68 ,  A01N43/40 ,  A01N37/22 ,  A01N43/60 ,  C07C237/48 ,  C07D207/34 ,  C07D239/28 ,  C07D261/18 ,  C07D307/85 ,  C07D317/46

CPC分类号： C07D333/38 ,  A01N37/22 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/78 ,  A01N43/80 ,  C07C237/42 ,  C07C237/48 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/34 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/28 ,  C07D239/30 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D307/85 ,  C07D309/08 ,  C07D309/28 ,  C07D317/46 ,  C07D317/62 ,  C07D333/68

摘要： A compound represented by Formula (1):




The compound can be used as insecticides.

公开(公告)号：US11613536B2

公开(公告)日：2023-03-28

申请号：US17307547

申请日：2021-05-04

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Fenglei Zhang ,  Song Mei ,  Wenqing Yao

IPC分类号： C07D417/14 ,  C07D403/06 ,  C07D231/14 ,  C07D233/90 ,  C07D263/34 ,  C07D277/56 ,  C07D401/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/06

摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US11434492B2

公开(公告)日：2022-09-06

申请号：US16915362

申请日：2020-06-29

申请人： Sidney Hecht ,  Larisa (Liza) Dedkova ,  Rumit Maini ,  Sandipan Roy Chowdhury ,  Rakesh Paul

发明人： Sidney Hecht ,  Larisa (Liza) Dedkova ,  Rumit Maini ,  Sandipan Roy Chowdhury ,  Rakesh Paul

IPC分类号： C12N15/67 ,  C12N15/11 ,  C07D263/34 ,  C07D277/593 ,  C12N9/06

摘要： Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.

公开(公告)号：US11382331B2

公开(公告)日：2022-07-12

申请号：US16449871

申请日：2019-06-24

申请人： MARRONE BIO INNOVATIONS, INC.

发明人： Ratnakar Asolkar ,  Marja Koivunen ,  Pamela G. Marrone ,  Ana Lucia Cordova-Kreylos ,  Huazhang Huang

IPC分类号： A01N63/20 ,  A01N43/00 ,  A01N43/16 ,  A01N43/76 ,  A01N43/86 ,  A01N43/90 ,  C12N1/20 ,  C12P17/06 ,  C12P17/14 ,  C12P17/16 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D263/32 ,  C07D263/34 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12P17/04 ,  C12N1/00 ,  C12R1/01 ,  C12R1/00

摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.

公开(公告)号：US20210387980A1

公开(公告)日：2021-12-16

申请号：US16761210

申请日：2018-11-02

申请人： UNIVERSITÉ DE MONTRÉAL

发明人： Yves Gareau ,  Stéphane Gingras ,  Yves Chantigny ,  Gaoqiang Yang ,  Guy Sauvageau ,  Irène Baccelli ,  Anne Marinier

IPC分类号： C07D417/12 ,  C07D413/12 ,  C07D263/32 ,  C07D249/04 ,  C07D263/34 ,  C07D277/24 ,  G01N33/50

摘要： Heterocyclic compounds of Formula (I) and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly cancers sensitive to mitochondrial activity inhibition and increased reactive oxygen species (ROS) levels, is also disclosed. Such cancers include acute myeloid leukemia (AML), preferably AML characterized by certain features, such as high level of expression of one or more Homeobox (HOX)-network genes, high and/or low expression of specific genes, the presence of one or more cytogenetic or molecular risk factors such as intermediate cytogenetic risk, Normal Karyotype (A/K), mutated NPM1, mutated CEBPA, mutated FLT3, mutated DNMT3A, mutated TET2, mutated IDH1, mutated IDH2, mutated RUNX1, mutated WT1, mutated SRSF2, intermediate cytogenetic risk with abnormal karyotype (intern(abnK)), trisomy 8 (+8) and/or abnormal chromosome (5/7), and/or a high leukemic stem cell (LSC) frequency.

公开(公告)号：US11172684B2

公开(公告)日：2021-11-16

申请号：US16177641

申请日：2018-11-01

申请人： MARRONE BIO INNOVATIONS, INC.

发明人： Ratnakar Asolkar ,  Marja Koivunen ,  Pamela G. Marrone ,  Ana-Lucia Cordova-Kreylos ,  Huazhang Huang

IPC分类号： A01N63/20 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D263/32 ,  C07D263/34 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  A01N25/12 ,  A01N25/14

摘要： Provided is the use of or compositions or formulations comprising Burkholderia species, filtrate, supernatant, extract, pesticidally active compound or metabolite derived therefrom as an insecticide, particularly against infestation of Corn Rootworm larvae, and/or as crop yield enhancer.