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公开(公告)号：US20240269206A1
公开(公告)日：2024-08-15
申请号：US18683202
申请日：2022-08-11
发明人： Brian Tancowny
IPC分类号： A61K36/07 , A61K9/00 , A61K9/70 , A61K31/341 , A61K31/42 , A61K31/425 , A61K45/06 , A61P25/00 , C07D261/12 , C07D275/03 , C07D307/20
CPC分类号： A61K36/07 , A61K9/0014 , A61K9/006 , A61K9/7023 , A61K31/341 , A61K31/42 , A61K31/425 , A61K45/06 , A61P25/00 , C07D261/12 , C07D275/03 , C07D307/20
摘要： Provided are beneficial and therapeutic Amanita muscaria compositions. In some embodiments, the provided A. muscaria compositions comprise A. muscaria extracts. In some embodiments, the provided A. muscaria compositions comprise one or more compounds from A. muscaria such as muscimol and muscarine, as well as analogs thereof. In some aspects, the provided A. muscaria compositions are used to promote health and wellness, such as to enhance calmness in a subject. In some aspects, the provided A. muscaria compositions are used to treat mental health conditions and physical health conditions in a subject.
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公开(公告)号：US20230331691A1
公开(公告)日：2023-10-19
申请号：US17965914
申请日：2022-10-14
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D321/00 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , C07D307/20 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07D317/40 , C07C219/16 , C07D453/02 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C59/72 , C07C69/74 , C07C69/96 , A61K9/70
CPC分类号： C07D321/00 , A61K9/0014 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/341 , A61K31/365 , A61K45/06 , C07C59/72 , C07C69/712 , C07C69/734 , C07C69/74 , C07C69/96 , C07C219/16 , C07C235/20 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D453/02 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/14
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US11746123B2
公开(公告)日：2023-09-05
申请号：US16908416
申请日：2020-06-22
发明人： Marie Eugenie Migaud , Philip Redpath , Kerri Crossey , Richard Cunningham , Aron Erickson , Richard Nygaard , Amanda Storjohann
IPC分类号： C07H19/048 , C07D307/20 , C07H19/20 , C07H19/04
CPC分类号： C07H19/048 , C07D307/20 , C07H19/20 , C07B2200/13 , C07H19/04
摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I):
wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.-
公开(公告)号：US11505535B2
公开(公告)日：2022-11-22
申请号：US17214460
申请日：2021-03-26
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D321/00 , C07C59/72 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , C07D307/20 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07D317/40 , C07C219/16 , C07D453/02 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C69/74 , C07C69/96 , A61K9/70
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US11498892B2
公开(公告)日：2022-11-15
申请号：US16628419
申请日：2018-05-09
IPC分类号： C07C45/45 , C07C67/343 , C07D307/20 , C07F7/18 , C07C69/738 , C07D319/06 , C07D309/10
摘要： Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated (“Fe/Cu-mediated”) coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecules, such as halichondrins and analogs thereof. In particular, the Fe/Cu-mediated ketolization reactions described herein are useful in the preparation of intermediates en route to halichondrins.
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公开(公告)号：US20220112173A1
公开(公告)日：2022-04-14
申请号：US17214460
申请日：2021-03-26
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D321/00 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , C07D307/20 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07D317/40 , C07C219/16 , C07D453/02 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C59/72 , C07C69/74 , C07C69/96 , A61K9/70
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US20220064134A1
公开(公告)日：2022-03-03
申请号：US17415018
申请日：2019-12-20
申请人： LEONARDO S.p.A.
IPC分类号： C07D307/20
摘要： A composite material, in particular for aeronautical applications, comprising: a first pre-impregnated layer having a resin-based matrix reinforced with fibres to give the first layer predefined mechanical properties; and a second layer of magnetic field intensifier material, superimposed on a face of the first layer and joined to the first layer along that face; the second layer comprises electrically conductive fibres, preferably of carbon, dispersed in the second layer in at least two directions with different orientations and having equivalent electrical resistivity, parallel to the aforementioned face, of less than 600 μΩm, preferably less than 200 μΩm and even more preferably less than 100 μΩm, so as to facilitate localized heating by electromagnetic induction; the first and second layers joined together define a lamina of super-weldable composite material.
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公开(公告)号：US20220017480A1
公开(公告)日：2022-01-20
申请号：US17374509
申请日：2021-07-13
申请人： Cepheid
发明人： Alexander A. Gall , Ivan Baraznenok
IPC分类号： C07D307/20
摘要： Non-ionic polyether surfactants with improved resistance to hydrolysis are provided.
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公开(公告)号：US20210363168A1
公开(公告)日：2021-11-25
申请号：US17246090
申请日：2021-04-30
发明人： Marie Eugenie Migaud , Philip Redpath , Kerri Crossey , Richard Cunningham , Aron Erickson , Richard Nygaard , Amanda Storjohann
IPC分类号： C07H19/048 , C07D307/20 , C07H19/20
摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
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公开(公告)号：US20210347806A1
公开(公告)日：2021-11-11
申请号：US16908416
申请日：2020-06-22
发明人： Marie Eugenie Migaud , Philip Redpath , Kerri Crossey , Richard Cunningham , Aron Erickson , Richard Nygaard , Amanda Storjohann
IPC分类号： C07H19/048 , C07D307/20 , C07H19/20
摘要： The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X−, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
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