公开(公告)号：US20240150330A1

公开(公告)日：2024-05-09

申请号：US18554214

申请日：2022-04-06

申请人： Sunovion Pharmaceuticals Inc.

发明人： Dario DOLLER ,  Hongbing HUANG ,  Linghong XIE

IPC分类号： C07D405/04 ,  C07D311/04 ,  C07D413/04 ,  C07D417/04

CPC分类号： C07D405/04 ,  C07D311/04 ,  C07D413/04 ,  C07D417/04

摘要： Provided herein are compounds, pharmaceutical compositions, and methods of use thereof, including methods of treating a neurological or psychiatric disease or disorder. For example, provided herein is a compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., Ring A, X1, R1, R2, R3, R4, and R5) are as disclosed herein. The compounds disclosed herein (e.g., compounds of Formula I, or pharmaceutically acceptable salts thereof) and pharmaceutical compositions can be used to treat a neurological or psychiatric disease or disorder.

公开(公告)号：US20230226062A1

公开(公告)日：2023-07-20

申请号：US17952460

申请日：2022-09-26

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Ding-Quan Qian ,  Liang Lu ,  Neil Lajkiewicz ,  Leah C. Konkol ,  Zhenwu Li ,  Fenglei Zhang ,  Jingwei Li ,  Haisheng Wang ,  Meizhong Xu ,  Kaijiong Xiao ,  Wenqing Yao

IPC分类号： A61K31/519 ,  A61K31/4985 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/445 ,  A61K31/4375 ,  A61K31/437 ,  A61K31/4355 ,  A61K31/429 ,  A61K31/426 ,  A61K31/4196 ,  A61K31/4162 ,  A61K31/4155 ,  A61K31/421 ,  A61K31/404 ,  A61K31/357 ,  A61K31/353 ,  A61K31/133 ,  A61P31/00 ,  A61P35/00 ,  A61K31/5025 ,  C07D513/04 ,  C07D217/04 ,  C07D211/60 ,  C07D403/06 ,  C07D209/44 ,  C07C215/28 ,  C07D495/04 ,  C07D401/06 ,  C07D211/56 ,  C07D217/02 ,  C07D213/74 ,  C07D209/14 ,  C07D311/04 ,  C07D401/12 ,  C07D211/58 ,  C07D471/10 ,  C07C215/08 ,  C07D487/04 ,  C07D295/02 ,  A61P37/00 ,  C07D213/38

CPC分类号： A61K31/519 ,  A61K31/4985 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/445 ,  A61K31/4375 ,  A61K31/437 ,  A61K31/4355 ,  A61K31/429 ,  A61K31/426 ,  A61K31/4196 ,  A61K31/4162 ,  A61K31/4155 ,  A61K31/421 ,  A61K31/404 ,  A61K31/357 ,  A61K31/353 ,  A61K31/133 ,  A61P31/00 ,  A61P35/00 ,  A61K31/5025 ,  C07D513/04 ,  C07D217/04 ,  C07D211/60 ,  C07D403/06 ,  C07D209/44 ,  C07C215/28 ,  C07D495/04 ,  C07D401/06 ,  C07D211/56 ,  C07D217/02 ,  C07D213/74 ,  C07D209/14 ,  C07D311/04 ,  C07D401/12 ,  C07D211/58 ,  C07D471/10 ,  C07C215/08 ,  C07D487/04 ,  C07D295/02 ,  A61P37/00 ,  C07D213/38 ,  A61K2300/00

摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds inhibit PD-1/PD-L1 interaction and are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US20210163438A1

公开(公告)日：2021-06-03

申请号：US16639194

申请日：2018-08-16

申请人： THE UNIVERSITY OF SYDNEY

发明人： Tristan Reekie ,  Michael Scott ,  Michael Kassiou

IPC分类号： C07D311/80 ,  C07D311/04 ,  C07C51/09 ,  C07C65/19

摘要： A method for demethylating a methylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: Formula I Formula II wherein: R1 is selected from the group consisting of: substituted or unsubstituted C1-C5 alkyl; R2 is selected from the group consisting of: OH or O, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C2-C8 alkene, or a substituted or unsubstituted C2-C8 dialkene; or R2 is O, and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes: heating a reaction mixture comprising the methylated phytocannabinoid compounds and a polar aprotic solvent in the presence of a dissolved inorganic alkaline salt for a time sufficient to demethylate at least a portion of the methylated phytocannabinoid compounds and form the phytocannabinoid compound.

公开(公告)号：US20210085805A1

公开(公告)日：2021-03-25

申请号：US17027286

申请日：2020-09-21

申请人： HOWARD HUGHES MEDICAL INSTITUTE

发明人： Luke D. LAVIS ,  Qinsi ZHENG

IPC分类号： A61K49/00 ,  C07D311/04 ,  C07F7/08 ,  G01N21/64

摘要： The presently-disclosed subject matter includes fluorescent compounds of the following formula: The compounds can be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.

公开(公告)号：US10669282B2

公开(公告)日：2020-06-02

申请号：US16339288

申请日：2017-09-27

申请人： GLACEUM, INC.

发明人： Sang Ku Yoo ,  Jin Wook Chung ,  In Geun Jo ,  Ji Young Kim ,  Jeong Ho Im ,  Ku Suk Kang ,  Jin Young Kim

IPC分类号： C07D493/04 ,  C07D311/04

摘要： The present invention relates to a method for synthesizing a 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and an optical isomer thereof, and an intermediate Compound which may be used for the synthesis method, and when the method and the intermediate Compound are used, the 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and the optical isomer thereof may be effectively synthesized.

公开(公告)号：US20200048272A1

公开(公告)日：2020-02-13

申请号：US16339288

申请日：2017-09-27

申请人： GLACEUM, INC.

发明人： Sang Ku YOO ,  Jin Wook CHUNG ,  In Geun JO ,  Ji Young KIM ,  Jeong Ho IM ,  Ku Suk KANG ,  Jin Young KIM

IPC分类号： C07D493/04 ,  C07D311/04

摘要： The present invention relates to a method for synthesizing a 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and an optical isomer thereof, and an intermediate Compound which may be used for the synthesis method, and when the method and the intermediate Compound are used, the 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and the optical isomer thereof may be effectively synthesized.

公开(公告)号：US10428017B2

公开(公告)日：2019-10-01

申请号：US15902802

申请日：2018-02-22

申请人： AbbVie S.à.r.l. ,  Galapagos NV

发明人： Robert J. Altenbach ,  Andrew Bogdan ,  Nicolas Desroy ,  Gregory A. Gfesser ,  Stephen N. Greszler ,  Philip R. Kym ,  Bo Liu ,  Karine Fabienne Malagu ,  Nuria Merayo Merayo ,  Mathieu Rafaël Pizzonero ,  Xenia B. Searle ,  Steven Emiel Van der Plas ,  Xueqing Wang ,  Ming C. Yeung ,  Gang Zhao

IPC分类号： C07D405/12 ,  C07C311/51 ,  A61P11/00 ,  C07D215/48 ,  C07D307/81 ,  C07D311/04 ,  C07D311/76 ,  C07D317/68 ,  C07D319/22 ,  C07C317/14 ,  C07D407/12 ,  C07D307/16

摘要： The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

公开(公告)号：US20180319763A1

公开(公告)日：2018-11-08

申请号：US16034876

申请日：2018-07-13

申请人： Noramco, Inc.

发明人： Lukas Dialer ,  Denis Petrovic ,  Ulrich Weigl

IPC分类号： C07D311/78 ,  C07D311/04 ,  C07D311/80 ,  C07C37/14 ,  C07D205/04 ,  C07C37/11

CPC分类号： C07D311/78 ,  C07C37/11 ,  C07C37/14 ,  C07D205/04 ,  C07D311/04 ,  C07D311/80

摘要： The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be prepared by an acid-catalyzed reaction of a suitably selected and substituted di-halo-olivetol or derivative thereof with a suitably selected and substituted cyclic alkene to produce a dihalo-cannabidiol compound or derivative thereof. The dihalo-cannabidiol compound or derivative thereof can be produced in high yield, high stereospecificity, or both. It can then be converted under reducing conditions to a cannabidiol compound or derivatives thereof.

公开(公告)号：US20170174672A1

公开(公告)日：2017-06-22

申请号：US15388516

申请日：2016-12-22

申请人： AbbVie Deutschland GmbH & Co. KG

发明人： Wilhelm Amberg ,  Udo Lange ,  Herve Geneste ,  Michael Ochse ,  Ralf Biesinger ,  Frank Oellien

IPC分类号： C07D413/12 ,  C07D205/04 ,  C07C229/48 ,  C07C229/46 ,  C07D211/62 ,  C07D261/12 ,  C07D209/52 ,  C07D207/16 ,  C07D207/08 ,  C07D265/36 ,  C07C59/72 ,  C07D405/04 ,  C07D311/04

CPC分类号： C07D413/12 ,  C07C59/72 ,  C07C229/30 ,  C07C229/36 ,  C07C229/46 ,  C07C229/48 ,  C07C229/50 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/10 ,  C07C2602/38 ,  C07D205/04 ,  C07D207/06 ,  C07D207/08 ,  C07D207/16 ,  C07D209/52 ,  C07D209/94 ,  C07D211/32 ,  C07D211/62 ,  C07D261/12 ,  C07D265/36 ,  C07D265/38 ,  C07D311/04 ,  C07D311/58 ,  C07D405/04 ,  C07D405/14

摘要： The invention relates to (hetero)cyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.

公开(公告)号：US09617213B2

公开(公告)日：2017-04-11

申请号：US14782623

申请日：2014-04-07

申请人： UNIVERSITA' DI PISA ,  AZIENDA OSPEDALIERA ARCISPEDALE SANTA MARIA NUOVA / IRCCS ISTITUTO IN TECNOLOGIE AVANZATE E MODELLI ASSISTENZIALI IN ONCOLOGIA

发明人： Armando Rossello ,  Elisa Nuti ,  Elisabetta Orlandini ,  Susanna Nencetti ,  Adriana Albini ,  Anna Rita Cantelmo ,  Desiree Bartolini ,  Douglas M. Noonan ,  Cristina Gallo

IPC分类号： C07D213/50 ,  C07C205/45 ,  C07C311/29 ,  C07C49/84 ,  C07D213/61 ,  C07D311/58 ,  C07C311/08 ,  C07C311/51 ,  C07C233/33 ,  C07C205/61 ,  C07C233/55 ,  C07D311/04

CPC分类号： C07D213/50 ,  C07C49/84 ,  C07C205/45 ,  C07C205/61 ,  C07C233/33 ,  C07C233/55 ,  C07C311/08 ,  C07C311/29 ,  C07C311/51 ,  C07D213/61 ,  C07D311/04 ,  C07D311/58

摘要： The present invention relates to novel synthetic analogs of xanthohumol and the use thereof.