公开(公告)号：US20230085692A1

公开(公告)日：2023-03-23

申请号：US17820845

申请日：2022-08-18

申请人： P2 SCIENCE, INC.

发明人： Patrick FOLEY

IPC分类号： C07D311/78 ,  C07D311/74 ,  C07C61/22 ,  C07C35/14 ,  C07C50/06

摘要： The present disclosure is directed to novel derivatives of naturally occurring cannabinoids, methods of making them, compositions comprising them, and methods for using them.

公开(公告)号：US11597710B2

公开(公告)日：2023-03-07

申请号：US17388343

申请日：2021-07-29

申请人： Tresvertol Inc.

发明人： Jay Carnahan

IPC分类号： C07D311/74 ,  A23L33/00 ,  A23P10/22 ,  A23L33/105 ,  A23L33/115 ,  A23P30/20 ,  A61K31/352 ,  A61K47/44

摘要： A solvent-free method to extract THCA from cannabis, said method comprising: providing a source of THCA-containing cannabis plant; providing a source of natural oil; combining said source of THCA-containing cannabis and said source of natural oil into a blend; milling said blend; optionally, heating the blend during the milling; and extracting a THCA-containing liquid generated during the milling.

公开(公告)号：US20210380551A1

公开(公告)日：2021-12-09

申请号：US17034604

申请日：2020-09-28

申请人： KYOWA KIRIN CO., LTD.

发明人： Tomohiro DANJO ,  Katsuaki FUJIWARA ,  Tomoyuki NISHIKAWA ,  Takahiro NAKAJIMA ,  Nobumasa OTSUBO ,  Toshihiro SEIKE

IPC分类号： C07D311/68 ,  C07D401/04 ,  C07D405/12 ,  C07D311/74 ,  A61K31/5377 ,  A61K31/353 ,  C07D215/38 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/47 ,  C07D213/74 ,  C07D213/75 ,  C07D215/24 ,  C07D401/12

摘要： The present invention provides an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like represented by the following formula (I): [wherein, “A” represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents —O—, —S—, —SO2—, —NRX1— (wherein, RX1 represents hydrogen atom or lower alkyl), —CHRX2— (wherein, RX2 represents hydrogen atom or hydroxy), —CH═CH—, —CO— or —NH—CO—, and n1 and n2 are the same or different, and each represents 0 or 1].

公开(公告)号：US11006626B2

公开(公告)日：2021-05-18

申请号：US16143471

申请日：2018-09-27

申请人： Sulfateq B.V.

发明人： Adrianus Cornelis Van Der Graaf ,  Andre Heeres ,  Johannes Paulus Gerardus Seerden

IPC分类号： A61K31/355 ,  A01N1/02 ,  C07D311/66 ,  C07D311/72 ,  C07D405/06 ,  C07D401/06 ,  C07D311/74

摘要： This invention is related to a compound with the structural formula (I) wherein, R1, and R2 are independently selected from the group consisting of C1-C6 alkyl and is preferably methyl, ethyl, propyl or isopropyl; R3 is selected from the group consisting of CH2NHR9, C(═O)YR10, —CH2OH

公开(公告)号：US20210047284A1

公开(公告)日：2021-02-18

申请号：US17006719

申请日：2020-08-28

申请人： ZYNERBA PHARMACEUTICALS, INC.

发明人： Audra Lynn Stinchcomb ,  Miroslaw Jerzy Golinski ,  Dana Carmel Hammell ,  Jeffrey Lynn Howard

IPC分类号： C07D311/80 ,  A61K31/352 ,  C07D311/74 ,  C07D405/12 ,  C07F9/655 ,  A61K9/00 ,  A61K9/70 ,  A61K47/10

摘要： Described herein are Δ9-THC prodrugs, methods of making Δ9-THC prodrugs, formulations comprising Δ9-THC prodrugs and methods of using Δ9-THC. One embodiment described herein relates to the transdermal administration of a Δ9-THC prodrug for treating and preventing diseases and/or disorders.

公开(公告)号：US20200071494A1

公开(公告)日：2020-03-05

申请号：US16245874

申请日：2019-01-11

申请人： FUJI XEROX CO., LTD.

发明人： Ryo TANAKA ,  Kana MIYAZAKI ,  Kenji YAO

IPC分类号： C08L1/14 ,  C08K5/13 ,  C08K5/524 ,  C08K5/17 ,  C07D311/74 ,  B29C45/00

摘要： A resin composition is provided and includes: a cellulose acylate (A); a cardanol compound (B); and a compound (C), and the compound (C) is at least one selected from the group consisting of a hindered phenol compound, a tocopherol compound, a tocotrienol compound, a phosphite compound, and a hydroxylamine compound.

公开(公告)号：US20190031637A1

公开(公告)日：2019-01-31

申请号：US16053006

申请日：2018-08-02

申请人： ZYNERBA PHARMACEUTICALS

发明人： Audra Lynn Stinchcomb ,  Miroslaw Jerzy Golinski ,  Dana Carmel Hammell ,  Jeffrey Lynn Howard

IPC分类号： C07D311/80 ,  A61K31/352 ,  C07F9/655 ,  C07D405/12 ,  A61K9/70 ,  A61K9/00 ,  A61K47/10 ,  C07D311/74

摘要： Described herein are Δ9-THC prodrugs, methods of making Δ9-THC prodrugs, formulations comprising Δ9-THC prodrugs and methods of using Δ9-THC. One embodiment described herein relates to the transdermal administration of a Δ9-THC prodrug for treating and preventing diseases and/or disorders.

公开(公告)号：US09801850B2

公开(公告)日：2017-10-31

申请号：US13388015

申请日：2010-07-30

申请人： Kunihiro Kaihatsu ,  Yoshimi Matsumoto

发明人： Kunihiro Kaihatsu ,  Yoshimi Matsumoto

IPC分类号： A61K31/35 ,  A61P31/04 ,  C07D311/74 ,  A61K31/353 ,  A01N43/16

CPC分类号： A61K31/353 ,  A01N43/16 ,  Y02A50/473 ,  Y02A50/478

摘要： The present invention provides an epigallocatechin gallate derivative (EGCG derivative) that has excellent safety and antibacterial properties. An epigallocatechin gallate derivative represented by the following chemical formula (1), an isomer thereof, or a salt thereof is used as an antibacterial agent. In the formula, R1 to R6 are each a hydrogen atom, halogen, sodium, potassium, or a straight-chain or branched, saturated or unsaturated acyl group and may be identical to or different from one another. The acyl group may be substituted further with one or more substituents. At least one of the R1 to R6 is the acyl group. R7 to R16 are each a hydrogen atom, halogen, sodium, or potassium and may be identical to or different from one another.

公开(公告)号：US09604900B2

公开(公告)日：2017-03-28

申请号：US14111157

申请日：2012-04-13

申请人： Sophie Chasset ,  Francis Chevreuil ,  Benoit Ledoussal ,  Frédéric Le Strat ,  Richard Benarous

发明人： Sophie Chasset ,  Francis Chevreuil ,  Benoit Ledoussal ,  Frédéric Le Strat ,  Richard Benarous

IPC分类号： A01N43/16 ,  A61K31/35 ,  C07D311/00 ,  C07C57/38 ,  C07C59/66 ,  C07D215/14 ,  C07D311/58 ,  C07D405/04 ,  C07D407/04 ,  A61K31/192 ,  A61K31/352 ,  A61K31/473 ,  C07C215/14 ,  A61K31/353 ,  A61K31/357 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/553 ,  A61K45/06 ,  C07D215/54 ,  C07D311/74 ,  C07D413/04

CPC分类号： C07C57/38 ,  A61K31/192 ,  A61K31/352 ,  A61K31/353 ,  A61K31/357 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/473 ,  A61K31/553 ,  A61K45/06 ,  C07C59/66 ,  C07C215/14 ,  C07D215/14 ,  C07D215/54 ,  C07D311/58 ,  C07D311/74 ,  C07D405/04 ,  C07D407/04 ,  C07D413/04

摘要： The present invention relates to aromatic carbocycle or heterocycle compounds comprising an acid function and being of formula (5), wherein W, Q1, Q2, Q3, Q4, R1, R3, R4, R7, R9, R11, a, c, e, and g are as described in the description; and the use of such compounds in the treatment or the prevention of viral disorders, including HIV.

公开(公告)号：US20160326129A1

公开(公告)日：2016-11-10

申请号：US15107801

申请日：2014-12-18

申请人： KYOTO UNIVERSITY ,  DAINIHON JOCHUGIKU CO., LTD.

发明人： Yukihiro Nishimura ,  Masayuki Sakuma ,  Tamio Ueno ,  Noritada Matsuo ,  Yasuyuki Koutani

IPC分类号： C07D311/74 ,  A01N43/16

CPC分类号： C07D311/74 ,  A01N43/12 ,  A01N43/16 ,  C07D307/88

摘要： Provided is a solution for the problems associated with cockroach aggregation pheromones and cockroach aggregation attractants or cockroach controlling agents containing cockroach aggregation pheromones. In particular, provided is a compound serving as a cockroach attraction-aggregation substance, the compound being represented by general formula or a salt thereof.

摘要翻译： 提供了与蟑螂聚集信息素和蟑螂聚集引诱剂或含有蟑螂聚集信息素的蟑螂控制剂相关的问题的解决方案。 特别是提供作为蟑螂吸引聚集物质的化合物，该化合物由通式或其盐表示。